Proteins > Geranylgeranyl transferase type-1 subunit beta
Page last updated: 2024-08-07 17:12:58
Geranylgeranyl transferase type-1 subunit beta
A geranylgeranyl transferase type-1 subunit beta that is encoded in the genome of cow. [OMA:Q5EAD5, PRO:DNx]
Synonyms
EC 2.5.1.59;
Geranylgeranyl transferase type I subunit beta;
GGTase-I-beta;
Type I protein geranyl-geranyltransferase subunit beta
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| r115777 | Bos taurus (cattle) | IC50 | 0.5503 | 2 | 4 |
| lonafarnib | Bos taurus (cattle) | IC50 | 10.0000 | 2 | 2 |
| tipifarnib | Bos taurus (cattle) | IC50 | 2.8800 | 5 | 5 |
| lonafarnib | Bos taurus (cattle) | IC50 | 5.0041 | 2 | 4 |
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005