Page last updated: 2024-08-07 16:24:10

UMP-CMP kinase

A UMP-CMP kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30085]

Synonyms

EC 2.7.4.14;
Deoxycytidylate kinase;
CK;
dCMP kinase;
Nucleoside-diphosphate kinase;
2.7.4.6;
Uridine monophosphate/cytidine monophosphate kinase;
UMP/CMP kinase;
UMP/CMPK

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Compounds (120)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fasudilHomo sapiens (human)Kd30.000011
4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazolineHomo sapiens (human)Kd30.000011
imatinibHomo sapiens (human)Kd30.000011
triciribine phosphateHomo sapiens (human)Kd30.000011
picropodophyllinHomo sapiens (human)Kd30.000012
gefitinibHomo sapiens (human)Kd30.000011
lestaurtinibHomo sapiens (human)Kd30.000011
perifosineHomo sapiens (human)Kd30.000011
canertinibHomo sapiens (human)Kd30.000011
cyc 202Homo sapiens (human)Kd30.000011
lapatinibHomo sapiens (human)Kd30.000011
s 1033Homo sapiens (human)Kd30.000011
bms 387032Homo sapiens (human)Kd30.000011
dasatinibHomo sapiens (human)Kd30.000011
ha 1100Homo sapiens (human)Kd30.000011
zd 6474Homo sapiens (human)Kd30.000011
sirolimusHomo sapiens (human)Kd30.000012
alvocidibHomo sapiens (human)Kd30.000011
su 11248Homo sapiens (human)Kd30.000011
vx680Homo sapiens (human)Kd30.000011
cyc 116Homo sapiens (human)Kd30.000011
everolimusHomo sapiens (human)Kd30.000011
ekb 569Homo sapiens (human)Kd30.000011
axitinibHomo sapiens (human)Kd30.000011
temsirolimusHomo sapiens (human)Kd30.000011
lenvatinibHomo sapiens (human)Kd30.000012
scio-469Homo sapiens (human)Kd30.000011
tivozanibHomo sapiens (human)Kd30.000011
cediranibHomo sapiens (human)Kd30.000011
masitinibHomo sapiens (human)Kd30.000011
azd 6244Homo sapiens (human)Kd30.000011
binimetinibHomo sapiens (human)Kd30.000011
vx 702Homo sapiens (human)Kd30.000011
crenolanibHomo sapiens (human)Kd0.003011
volasertibHomo sapiens (human)Kd30.000011
azd 7762Homo sapiens (human)Kd30.000011
regorafenibHomo sapiens (human)Kd30.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd30.000011
brivanibHomo sapiens (human)Kd30.000011
mp470Homo sapiens (human)Kd30.000011
rgb 286638Homo sapiens (human)Kd30.000011
at 7519Homo sapiens (human)Kd30.000011
bi 2536Homo sapiens (human)Kd30.000011
inno-406Homo sapiens (human)Kd30.000011
kw 2449Homo sapiens (human)Kd30.000011
danusertibHomo sapiens (human)Kd30.000011
abt 869Homo sapiens (human)Kd0.006011
arq 197Homo sapiens (human)Kd30.000012
pf 00299804Homo sapiens (human)Kd30.000011
crizotinibHomo sapiens (human)Kd30.000011
motesanibHomo sapiens (human)Kd30.000011
fostamatinibHomo sapiens (human)Kd30.000012
trametinibHomo sapiens (human)Kd30.000011
mln8054Homo sapiens (human)Kd30.000011
pf-562,271Homo sapiens (human)Kd30.000011
dactolisibHomo sapiens (human)Kd30.000011
bgt226Homo sapiens (human)Kd30.000011
azd 1152-hqpaHomo sapiens (human)Kd30.000011
enmd 2076Homo sapiens (human)Kd30.000011
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinoneHomo sapiens (human)Kd30.000012
azd 1480Homo sapiens (human)Kd30.000012
azd8330Homo sapiens (human)Kd30.000012
fedratinibHomo sapiens (human)Kd30.000011
gsk690693Homo sapiens (human)Kd30.000012
azd5438Homo sapiens (human)Kd30.000011
pf 04217903Homo sapiens (human)Kd30.000011
icotinibHomo sapiens (human)Kd30.000011
kx-01Homo sapiens (human)Kd30.000011
mk 5108Homo sapiens (human)Kd30.000011
arry-614Homo sapiens (human)Kd30.000011
mln 8237Homo sapiens (human)Kd30.000011
sgx 523Homo sapiens (human)Kd30.000011
sgi 1776Homo sapiens (human)Kd30.000011
amg 900Homo sapiens (human)Kd30.000011
mk-1775Homo sapiens (human)Kd30.000011
AMG-208Homo sapiens (human)Kd30.000011
quizartinibHomo sapiens (human)Kd30.000011
at13148Homo sapiens (human)Kd30.000011
mk 2206Homo sapiens (human)Kd30.000011
sns 314Homo sapiens (human)Kd30.000011
lucitanibHomo sapiens (human)Kd30.000011
pf-04691502Homo sapiens (human)Kd30.000011
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamideHomo sapiens (human)Kd30.000011
cabozantinibHomo sapiens (human)Kd30.000011
ly2584702Homo sapiens (human)Kd30.000011
gsk 2126458Homo sapiens (human)Kd30.000011
emd1214063Homo sapiens (human)Kd30.000011
pf 3758309Homo sapiens (human)Kd30.000011
azd2014Homo sapiens (human)Kd30.000011
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolHomo sapiens (human)Kd30.000011
plx4032Homo sapiens (human)Kd30.000011
gsk 1363089Homo sapiens (human)Kd30.000011
kin-193Homo sapiens (human)Kd30.000011
mk 2461Homo sapiens (human)Kd30.000011
as 703026Homo sapiens (human)Kd30.000011
baricitinibHomo sapiens (human)Kd30.000011
dabrafenibHomo sapiens (human)Kd30.000011
pki 587Homo sapiens (human)Kd30.000011
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamideHomo sapiens (human)Kd30.000011
mk-8033Homo sapiens (human)Kd30.000011
pha 793887Homo sapiens (human)Kd30.000011
mk-8776Homo sapiens (human)Kd30.000011
dinaciclibHomo sapiens (human)Kd30.000011
alectinibHomo sapiens (human)Kd30.000011
glpg0634Homo sapiens (human)Kd30.000011
encorafenibHomo sapiens (human)Kd30.000011
bms-911543Homo sapiens (human)Kd30.000011
gsk2141795Homo sapiens (human)Kd30.000011
byl719Homo sapiens (human)Kd30.000011
cep-32496Homo sapiens (human)Kd30.000011
azd1208Homo sapiens (human)Kd30.000011
debio 1347Homo sapiens (human)Kd30.000011
volitinibHomo sapiens (human)Kd30.000011
osimertinibHomo sapiens (human)Kd30.000011
at 9283Homo sapiens (human)Kd30.000011
otssp167Homo sapiens (human)Kd30.000011
osi 027Homo sapiens (human)Kd30.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
uridine monophosphateHomo sapiens (human)Km151.000022
cytidine monophosphateHomo sapiens (human)Km56.000011
deoxycytidine monophosphateHomo sapiens (human)Km837.000011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
nucleoside diphosphate kinase activitymolecular functionCatalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]
uridine kinase activitymolecular functionCatalysis of the reaction: ATP + uridine = ADP + UMP. [RHEA:16825]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
UMP kinase activitymolecular functionCatalysis of the reaction: ATP + UMP = ADP + UDP. [EC:2.7.4.22]
CMP kinase activitymolecular functionCatalysis of the reaction: ATP + CMP = ADP + CDP. [RHEA:11600]
dCMP kinase activitymolecular functionCatalysis of the reaction: ATP + dCMP = ADP + dCDP. [RHEA:25094]
nucleoside monophosphate kinase activitymolecular functionCatalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. [GOC:ai, ISBN:0198506732]
cytidylate kinase activitymolecular functionCatalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. [EC:2.7.4.14]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nucleoluscellular componentA small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
'de novo' pyrimidine nucleobase biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. [GOC:mah, ISBN:0716720094]
UMP biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. [ISBN:0198506732]
UDP biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate. [ISBN:0198506732]
pyrimidine ribonucleotide biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]
nucleobase-containing small molecule interconversionbiological processThe chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. [GOC:mah, ISBN:0306444747, ISBN:0471394831]
nucleoside monophosphate phosphorylationbiological processThe process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. [GOC:ai]
CDP biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate. [GOC:ai]