Page last updated: 2024-12-06

osmium tetroxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Osmium Tetroxide: (T-4)-Osmium oxide (OsO4). A highly toxic and volatile oxide of osmium used in industry as an oxidizing agent. It is also used as a histological fixative and stain and as a synovectomy agent in arthritic joints. Its vapor can cause eye, skin, and lung damage. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

osmium tetroxide : An osmium coordination entity consisting of four oxygen atoms bound to a central osmium atom via covalent double bonds. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID30318
CHEBI ID88215
MeSH IDM0015492

Synonyms (50)

Synonym
BB 0260713
oso4
osmium tetroxide
osmium tetraoxide
osmium oxide oso4 (t-4)
osmic acid anhydride
osmic acid
osmium(viii)-tetroxide
osmium(viii)oxide
osmium oxide, (t-4)-
perosmic oxide
perosmic acid anhydride
rcra waste no. p087
osmium oxide (oso4), (beta-4)-
osmium oxide (oso4), (t-4)-
rcra waste number p087
einecs 244-058-7
osmium oxide (oso4) (t-4)-
hsdb 719
un2471
os encat(r) 40, extent of labeling: 0.3 mmol/g os loading
osmium tetroxide, sealed ampule.
20816-12-0
osmium(viii) oxide
tetraoxoosmium
AKOS005267110
osmium (viii) oxide
unii-p40w033bgm
p40w033bgm ,
osmium tetroxide [un2471] [poison]
osmium tetroxide [mi]
(t-4)-osmium oxide (oso4)
osmium tetroxide [hsdb]
osmium tetra oxide
osmium(viii)tetraoxide
VUVGYHUDAICLFK-UHFFFAOYSA-N
osmiumtetraoxide
osmiumtetroxid
osmium (viii) tetraoxide
CHEBI:88215
mfcd00011150
DTXSID5042245
osmium(viii) oxide (99.95%-os)
osmium tetroxide, reagentplus(r), 99.8%
osmium tetroxide, acs reagent, >=98.0%
osmium tetroxide, puriss., 99.9%
J-013644
Q422021
osmium tetroxide (4% in water)
D91859

Research Excerpts

Overview

Osmium tetroxide (OsO4) is a commonly used stain for unsaturated lipids in electron and optical microscopy of cells and tissues.

ExcerptReferenceRelevance
"Osmium tetroxide is a strong oxidizing agent used in electron microscopy. "( Osmium absorption after osmium tetroxide skin and eye exposure.
Friedova, N; Kesslerova, K; Kohout, P; Lach, K; Obertova, N; Pelclova, D, 2020
)
2.31
"Osmium tetroxide (OsO4) is a commonly used stain for unsaturated lipids in electron and optical microscopy of cells and tissues. "( Chemical analysis of osmium tetroxide staining in adipose tissue using imaging ToF-SIMS.
Belazi, D; Johansson, B; Schalling, M; Sjövall, P; Solé-Domènech, S, 2009
)
2.11
"Osmium tetroxide is a highly oxidizing, corrosive compound commonly found in electron microscopy laboratories. "( Traumatic osmium tetroxide inoculation.
Abraham, JL; Boyd, AS; Ligon, JJ, 2001
)
2.16

Treatment

ExcerptReferenceRelevance
"Osmium tetroxide treated cells removed pyrimidine dimers more efficiently as compared to control cells."( DNA damage induced nucleotide excision repair in Saccharomyces cerevisiae.
Krishna, M; Singh, RK, 2006
)
1.06

Toxicity

ExcerptReferenceRelevance
"Whilst chemical cleavage of mismatch (CCM) detects all point mutations in DNA, its widespread use has been hampered by the complex multistage methodology and the need for toxic chemicals, in particular osmium tetroxide."( Potassium permanganate and tetraethylammonium chloride are a safe and effective substitute for osmium tetroxide in solid-phase fluorescent chemical cleavage of mismatch.
Deeble, VJ; Roberts, E; Taylor, GR; Woods, CG, 1997
)
0.7

Compound-Compound Interactions

ExcerptReferenceRelevance
" In the present study, we evaluated CMC in combination with capillary electrophoresis (CE) by determining the common T833C and G919A mutations in exon 8 of the cystathionine beta-synthase gene in heterozygous and homozygous samples."( Chemical mismatch cleavage combined with capillary electrophoresis: detection of mutations exon 8 of the cystathionine beta-synthase gene.
Refsum, H; Ren, J; Ueland, PM; Ulvik, A, 1998
)
0.3
" To eliminate these artifacts, the preservation of specimens by OsO4 vapor fixation combined with a special sputter-coating technique is described."( Low pressure mode combined with OsO4 vapor fixation and sputter-coating for the preservation of delicate aerial hyphae and conidia in the ESEM.
Coetzee, SH; Jordaan, A; Mpuchane, SF, 2005
)
0.33

Dosage Studied

ExcerptRelevanceReference
" The dosage of these substances also depends on the size of the joint."( [Synoviorthese].
Gallacchi, G; Müller, W, 1982
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
oxidising agentA substance that removes electrons from another reactant in a redox reaction.
poisonAny substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
fixativeAny compound used for the purpose of preserving biological tissues from decay in such a way as to allow for the preparation of thin, stained sections for subsequent histological study.
histological dyeA dye used in microscopic or electron microscopic examination of cells and tissues to give contrast and to highlight particular features of interest, such as nuclei and cytoplasm.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
osmium coordination entity
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (897)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990459 (51.17)18.7374
1990's229 (25.53)18.2507
2000's106 (11.82)29.6817
2010's77 (8.58)24.3611
2020's26 (2.90)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 66.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index66.33 (24.57)
Research Supply Index6.85 (2.92)
Research Growth Index4.33 (4.65)
Search Engine Demand Index116.03 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (66.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials9 (0.96%)5.53%
Reviews31 (3.32%)6.00%
Case Studies19 (2.03%)4.05%
Observational0 (0.00%)0.25%
Other875 (93.68%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]