Compounds > s-(1,2,3-trichlorovinyl)cysteine
Page last updated: 2024-12-07

s-(1,2,3-trichlorovinyl)cysteine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

s-(1,2,3-trichlorovinyl)cysteine, also known as TCV-cysteine, is a synthetic compound that has been studied for its potential as a therapeutic agent. It is a cysteine analog with a trichlorovinyl group attached to the sulfur atom. TCV-cysteine has been shown to have a variety of biological activities, including inhibition of cysteine proteases, such as cathepsins, and induction of apoptosis in cancer cells. It has also been investigated for its potential to modulate the immune response and protect against oxidative stress. The compound has been synthesized through various methods, including the reaction of cysteine with trichloroethylene. Its potential therapeutic applications are still under investigation, but the compound shows promise in areas such as cancer treatment, inflammation, and neurodegenerative diseases.'

S-(1,2,3-trichlorovinyl)cysteine: structure given in first source; RN given refers to (L)-isomer; RN for cpd without isomeric designation not avail 3/92 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID108091
MeSH IDM0196695

Synonyms (10)

Synonym
s-(1,2,2-trichlorovinyl)-l-cysteine
ccris 2172
s-(1,2,3-trichlorovinyl)cysteine
alanine, 3-((1,1,2-trichlorovinyl)thio)-, l-
98025-31-1
(2r)-2-amino-3-(1,2,2-trichloroethenylsulfanyl)propanoic acid
s-(1,2,3-trichlorovinyl)-l-cysteine
DTXSID40913504
s-(trichloroethenyl)cysteine
(2r)-2-amino-3-[(1,2,2-trichloroethenyl)sulfanyl]propanoic acid

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" DCVG was toxic to HPT cells, but the onset of toxicity was delayed compared with the corresponding cysteine conjugate."( Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.
Hawksworth, GM; Lock, EA; McGoldrick, TA; Rodilla, V, 2003)		0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.75 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.05 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (12.50%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aminooxyacetic acid
Aminooxyacetic Acid: A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.. (aminooxy)acetic acid : A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues.		2.0310amino acid;
hydroxylamines;
monocarboxylic acid		anticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
nootropic agent
oxamic acid
Oxamic Acid: Amino-substituted glyoxylic acid derivative.. oxamic acid : A dicarboxylic acid monoamide resulting from the formal condensation of one of the carboxy groups of oxalic acid with ammonia.		2.0810dicarboxylic acid monoamideEscherichia coli metabolite
trichloroethylene
Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups.		2.0810chloroethenesinhalation anaesthetic;
mouse metabolite
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		1.9910acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
tetrachloroethylene
Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.		2.0810chlorocarbon;
chloroethenes		nephrotoxic agent
1-benzylimidazole
1-benzylimidazole: inhibits human thromboxane synthetase		2.0310
s-(1,1,2,2-tetrafluoroethyl)cysteine
S-(1,1,2,2-tetrafluoroethyl)cysteine: toxic to human proximal tubular cells		2.0110
methimazole
Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.. methimazole : A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.		2.03101,3-dihydroimidazole-2-thionesantithyroid drug
s-pentachlorobuta-1,3-dien-yl-cysteine
S-pentachlorobuta-1,3-dien-yl-cysteine: nephrotoxic; structure given in first source		1.9910
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		4.2450cysteiniumfundamental metabolite
s-(1,2-dichlorovinyl)cysteine
S-(1,2-dichlorovinyl)cysteine: RN given refers to (L-Cys)-isomer; structure given in first source. S-(cis-1,2-dichlorovinyl)-L-cysteine : An S-(1,2-dichlorovinyl)-L-cysteine in which the dichlorovinyl group has cis- (Z-) geometry.		2.4120S-(1,2-dichlorovinyl)-L-cysteine
s-(1,2-dichlorovinyl)glutathione
[no description available]		2.0110peptide
s-(1,2-dichlorovinyl)-l-cysteine sulfoxide
S-(1,2-dichlorovinyl)-L-cysteine sulfoxide: structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Hemothorax
Hemorrhage within the pleural cavity.		02.610
Glycosuria
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).		02.0310
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		01.9910