Sulfotransferase 2A1

A sulfotransferase 2A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06520]

Synonyms

ST2A1;
EC 2.8.2.2;
Bile salt sulfotransferase;
2.8.2.14;
Dehydroepiandrosterone sulfotransferase;
DHEA-ST;
DHEA-ST8;
Hydroxysteroid Sulfotransferase;
HST;
ST2;
SULT2A3

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amoxapine	Homo sapiens (human)	Ki	80.0000	1	2
protriptyline	Homo sapiens (human)	Ki	65.5000	1	4

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-naphthol	Homo sapiens (human)	Km	254.0000	1	0

Enables

This protein enables 6 target(s):

Target	Category	Definition
alcohol sulfotransferase activity	molecular function	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. [EC:2.8.2.2]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
sulfotransferase activity	molecular function	Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators]
bile-salt sulfotransferase activity	molecular function	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN]
steroid sulfotransferase activity	molecular function	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. [MetaCyc:STEROID-SULFOTRANSFERASE-RXN, RHEA:68460]
3'-phosphoadenosine 5'-phosphosulfate binding	molecular function	Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
ethanol catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
cholesterol metabolic process	biological process	The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732]
lipid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
bile acid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators]
thyroid hormone metabolic process	biological process	The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:jl, ISBN:0198506732]
3'-phosphoadenosine 5'-phosphosulfate metabolic process	biological process	The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732]
sulfation	biological process	The addition of a sulfate group to a molecule. [Wikipedia:Sulfation]

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