Proteins > Platelet-activating factor receptor
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Platelet-activating factor receptor
A mammalian-type platelet-activating factor receptor that is encoded in the genome of guinea pig. [OMA:P21556, PRO:DNx]
Synonyms
PAF-R;
PAFr
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 16 (80.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (21)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| edelfosine | Cavia porcellus (domestic guinea pig) | IC50 | 1.8000 | 1 | 1 |
| miltefosine | Cavia porcellus (domestic guinea pig) | IC50 | 200.0000 | 1 | 1 |
| nitrendipine | Cavia porcellus (domestic guinea pig) | Ki | 73.3100 | 1 | 1 |
| pca 4248 | Cavia porcellus (domestic guinea pig) | Ki | 0.0151 | 1 | 1 |
| web 2086 | Cavia porcellus (domestic guinea pig) | IC50 | 0.1093 | 3 | 3 |
| web 2086 | Cavia porcellus (domestic guinea pig) | Ki | 0.0678 | 3 | 3 |
| bepafant | Cavia porcellus (domestic guinea pig) | IC50 | 0.0730 | 2 | 2 |
| bepafant | Cavia porcellus (domestic guinea pig) | Ki | 0.0292 | 1 | 1 |
| rp 59227 | Cavia porcellus (domestic guinea pig) | Ki | 0.0318 | 1 | 2 |
| galgravin | Cavia porcellus (domestic guinea pig) | IC50 | 4.5000 | 1 | 1 |
| cv 3988 | Cavia porcellus (domestic guinea pig) | IC50 | 7.8000 | 1 | 1 |
| cv 6209 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0330 | 3 | 3 |
| kadsurenone | Cavia porcellus (domestic guinea pig) | IC50 | 0.1650 | 4 | 4 |
| modipafant | Cavia porcellus (domestic guinea pig) | IC50 | 0.0043 | 3 | 3 |
| modipafant | Cavia porcellus (domestic guinea pig) | Ki | 0.0071 | 1 | 1 |
| mk 287 | Cavia porcellus (domestic guinea pig) | Ki | 0.0135 | 1 | 1 |
| cl 184005 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5400 | 1 | 1 |
| n-(3-chlorophenyl)-3-(3-pyridinyl)-1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide | Cavia porcellus (domestic guinea pig) | Ki | 0.2738 | 1 | 1 |
| pms 601 | Cavia porcellus (domestic guinea pig) | IC50 | 25.8000 | 1 | 1 |
| abbott 41988 | Cavia porcellus (domestic guinea pig) | Ki | 3.2500 | 1 | 1 |
| ginkgolide b | Cavia porcellus (domestic guinea pig) | IC50 | 0.7400 | 1 | 1 |
| ginkgolide b | Cavia porcellus (domestic guinea pig) | Ki | 0.8800 | 1 | 1 |
| l 652731 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0220 | 2 | 2 |
| lexipafant | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 1 | 1 |
| abt 299 | Cavia porcellus (domestic guinea pig) | Ki | 0.0038 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ginkgolide b | Cavia porcellus (domestic guinea pig) | EC50 | 0.1800 | 1 | 1 |
Development of a novel series of trialkoxyaryl derivatives as specific and competitive antagonists of platelet activating factor.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists.Journal of medicinal chemistry, , Oct-01, Volume: 36, Issue:20, 1993
(Pyridylcyanomethyl)piperazines as orally active PAF antagonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists.Journal of medicinal chemistry, , May-29, Volume: 35, Issue:11, 1992
1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists.Journal of medicinal chemistry, , Feb-21, Volume: 35, Issue:4, 1992
Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Platelet activating factor antagonists: synthesis and structure-activity studies of novel PAF analogues modified in the phosphorylcholine moiety.Journal of medicinal chemistry, , Volume: 32, Issue:1, 1989
Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines.Journal of medicinal chemistry, , Apr-16, Volume: 36, Issue:8, 1993