Proteins > Steroid 17-alpha-hydroxylase/17,20 lyase
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Steroid 17-alpha-hydroxylase/17,20 lyase
A cytochrome P450 17A1 that is encoded in the genome of rat. [OMA:P11715, PRO:DNx]
Synonyms
EC 1.14.14.19;
17-alpha-hydroxyprogesterone aldolase;
1.14.14.32;
CYPXVII;
Cytochrome P450 17A1;
Cytochrome P450-C17;
Cytochrome P450c17;
Steroid 17-alpha-monooxygenase
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Synthesis of novel 17-(4'-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17α-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents depending on the substitution pattern of the heteroring.European journal of medicinal chemistry, , Sep-14, Volume: 120, 2016
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 19, Issue:16, 2009
Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.Journal of medicinal chemistry, , Volume: 33, Issue:9, 1990
Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors.European journal of medicinal chemistry, , May-26, Volume: 132, 2017
Synthesis of novel 17-(4'-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17α-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents depending on the substitution pattern of the heteroring.European journal of medicinal chemistry, , Sep-14, Volume: 120, 2016
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008