Proteins > Casein kinase II subunit alpha 3
Page last updated: 2024-08-08 00:38:06

Casein kinase II subunit alpha 3

A protein that is a translation product of the CSNK2A3 gene in human. [PRO:DNx, UniProtKB:Q8NEV1]

Synonyms

CK II alpha 3;
EC 2.7.11.1;
Casein kinase II alpha 1 polypeptide pseudogene

Research

Bioassay Publications (14)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's2 (14.29)29.6817
2010's5 (35.71)24.3611
2020's6 (42.86)2.80

Compounds (22)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4,5,6,7-tetrabromo-2-azabenzimidazoleHomo sapiens (human)IC500.866733
4,5,6,7-tetrabromo-2-azabenzimidazoleHomo sapiens (human)Ki0.400011
chromone-2-carboxylic acidHomo sapiens (human)IC505.980011
emodinHomo sapiens (human)Ki1.900011
mitoxantroneHomo sapiens (human)IC500.660011
boldineHomo sapiens (human)IC500.700011
purvalanol bHomo sapiens (human)IC5010.000011
purvalanol aHomo sapiens (human)IC5010.000011
4,5,6,7-tetrabromobenzimidazoleHomo sapiens (human)IC500.930011
quercetinHomo sapiens (human)IC500.550011
quercetinHomo sapiens (human)Ki1.180011
apigeninHomo sapiens (human)IC500.800011
luteolinHomo sapiens (human)IC500.500011
kaempferolHomo sapiens (human)IC500.400011
baicaleinHomo sapiens (human)IC5010.000011
chrysinHomo sapiens (human)IC509.000011
fisetinHomo sapiens (human)IC500.350011
morinHomo sapiens (human)IC5010.000011
myricetinHomo sapiens (human)IC500.900011
coumestrolHomo sapiens (human)IC500.200011
coumestrolHomo sapiens (human)Ki7.670011
casein kinase iiHomo sapiens (human)IC500.140011
casein kinase iiHomo sapiens (human)Ki0.040011
cx 4945Homo sapiens (human)IC502.201355
cx 4945Homo sapiens (human)Ki0.000411
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)Homo sapiens (human)IC500.510011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pd 184352Homo sapiens (human)EC500.100011
cx 4945Homo sapiens (human)EC503.150022

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
protein serine/threonine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
protein kinase CK2 complexcellular componentA protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. [GOC:mah, PMID:10994779]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
positive regulation of cell growthbiological processAny process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
positive regulation of protein catabolic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators]
peptidyl-threonine phosphorylationbiological processThe phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]
peptidyl-serine phosphorylationbiological processThe phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
regulation of cell cyclebiological processAny process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]