Proteins > Aldehyde dehydrogenase, mitochondrial
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Aldehyde dehydrogenase, mitochondrial
An aldehyde dehydrogenase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05091]
Synonyms
EC 1.2.1.3;
ALDH class 2;
ALDH-E2;
ALDHI
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
[no title available]Journal of medicinal chemistry, , 03-23, Volume: 60, Issue:6, 2017
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Enables
This protein enables 8 target(s):
| Target | Category | Definition |
|---|
| aldehyde dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. [EC:1.2.1.3] |
| aldehyde dehydrogenase [NAD(P)+] activity | molecular function | Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. [EC:1.2.1.5] |
| phenylacetaldehyde dehydrogenase activity | molecular function | Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+. [EC:1.2.1.39] |
| electron transfer activity | molecular function | A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer] |
| nitroglycerin reductase activity | molecular function | Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative. [UM-BBD_enzymeID:e0038] |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity | molecular function | Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+. [PMID:9497334] |
| NAD binding | molecular function | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai] |
| carboxylesterase activity | molecular function | Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. [RHEA:21164] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| carbohydrate metabolic process | biological process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732] |
| alcohol metabolic process | biological process | The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [ISBN:0198506732] |
| ethanol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732] |
| aldehyde catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. [GOC:ai] |
| regulation of dopamine biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of dopamine biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] |
| regulation of serotonin biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] |