Page last updated: 2024-08-07 17:13:25
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of mouse. [OMA:Q61239, PRO:DNx]
Synonyms
EC 2.5.1.58;
EC 2.5.1.59;
CAAX farnesyltransferase subunit alpha;
FTase-alpha;
Ras proteins prenyltransferase subunit alpha;
Type I protein geranyl-geranyltransferase subunit alpha;
GGTase-I-alpha
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| fti 276 | Mus musculus (house mouse) | IC50 | 1.0000 | 1 | 1 |
| ggti 298 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| ggti 2147 | Mus musculus (house mouse) | IC50 | 30.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| lonafarnib | Mus musculus (house mouse) | EC50 | 0.1000 | 1 | 1 |
| tipifarnib | Mus musculus (house mouse) | EC50 | 0.0262 | 4 | 4 |
| a 228839 | Mus musculus (house mouse) | EC50 | 0.0160 | 2 | 2 |