Proteins > Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
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Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of mouse. [OMA:Q61239, PRO:DNx]
Synonyms
EC 2.5.1.58;
EC 2.5.1.59;
CAAX farnesyltransferase subunit alpha;
FTase-alpha;
Ras proteins prenyltransferase subunit alpha;
Type I protein geranyl-geranyltransferase subunit alpha;
GGTase-I-alpha
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fti 276 | Mus musculus (house mouse) | IC50 | 1.0000 | 1 | 1 |
| ggti 298 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| ggti 2147 | Mus musculus (house mouse) | IC50 | 30.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| lonafarnib | Mus musculus (house mouse) | EC50 | 0.1000 | 1 | 1 |
| tipifarnib | Mus musculus (house mouse) | EC50 | 0.0262 | 4 | 4 |
| a 228839 | Mus musculus (house mouse) | EC50 | 0.0160 | 2 | 2 |
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.Bioorganic & medicinal chemistry letters, , Jan-03, Volume: 15, Issue:1, 2005
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003