Page last updated: 2024-08-07 16:59:32
Voltage-dependent L-type calcium channel subunit alpha-1S
A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of rat. [OMA:Q02485, PRO:DNx]
Synonyms
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle;
ROB1;
Voltage-gated calcium channel subunit alpha Cav1.1
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gallopamil | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| carbinoxamine | Rattus norvegicus (Norway rat) | Ki | 1.0800 | 1 | 1 |
| nicardipine | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| nifedipine | Rattus norvegicus (Norway rat) | Ki | 0.0038 | 2 | 4 |
| nitrendipine | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 1 | 1 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| dexpropranolol | Rattus norvegicus (Norway rat) | Ki | 14.5000 | 1 | 1 |
| diltiazem | Rattus norvegicus (Norway rat) | IC50 | 0.8960 | 3 | 3 |
| diltiazem | Rattus norvegicus (Norway rat) | Ki | 0.0585 | 2 | 2 |
| ryodipine | Rattus norvegicus (Norway rat) | IC50 | 6,000,000.0000 | 1 | 2 |
| eplerenone | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| curcumin | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| dexniguldipine | Rattus norvegicus (Norway rat) | Ki | 0.0597 | 1 | 1 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 7.7000 | 2 | 2 |
| mebudipine | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| nitd 609 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| XL413 | Rattus norvegicus (Norway rat) | IC50 | 28.4500 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bay-k-8644 | Rattus norvegicus (Norway rat) | Concentration | 3.0000 | 1 | 1 |