ropivacaine profile

Ropivacaine: An anilide used as a long-acting local anesthetic. It has a differential blocking effect on sensory and motor neurons. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ropivacaine : The piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

(S)-ropivacaine : A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	175805
CHEMBL ID	1077896
CHEBI ID	8890
SCHEMBL ID	33292
MeSH ID	M0113809
PubMed CID	175804
CHEMBL ID	1889140
CHEBI ID	60803
SCHEMBL ID	236432
MeSH ID	M0113809

Synonym
BIDD:GT0203
lea-103
ropivacaine
84057-95-4
C07532
(s)-(-)-1-propyl-2',6'-pipecoloxylidide
l-n-n-propylpipecolic acid-2,6-xylidide
(s)-ropivacaine
DB00296
ropivacaina [inn-spanish]
al-381
ropivacainum [inn-latin]
lea 103
(-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilid
(-)-1-propyl-2',6'-pipecoloxylidide
ropivacaina [spanish]
ropivacaine [inn]
1-propyl-2',6'-pipecoloxylidide
(2s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
D08490
ropivacaine (inn)
naropin (tn)
CHEMBL1077896
chebi:8890 ,
ropivicaine
tlc590
tlc-590
(2s)-n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide
A840710
(2s)-n-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide
ropivacaine [inn:ban]
narop
noropine
unii-7io5lya57n
7io5lya57n ,
s-ropivacaine
ropivacaina
ropivacainum
(-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide
ropivacaine [usp-rs]
ropivacaine [mi]
(s)-(-)-1-propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)amide
ropivacaine [who-dd]
(s)-(-)-1-propyl-2',6'-pipecoloxylidine
ropivacaine [vandf]
S5504
AKOS017343283
gtpl7602
AB00698466-07
SCHEMBL33292
ZKMNUMMKYBVTFN-HNNXBMFYSA-N
Q-201677
2-piperidinecarboxamide, n-(2,6-dimethylphenyl)-1-propyl-, (2s)-
(s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
AB00698466_10
DTXSID4040187 ,
lea-103 hcl
mfcd00864425
HY-B0563
CS-0009514
BBL102321
STL556120
ropivacaine base
Q279504
AS-35173
CCG-267197
1 propyl 2',6' pipecoloxylidide
narop; noropine; lea-103
EN300-7436767
R0251
(s)-n-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide
Z2235811359
dtxcid2020187
ropivacaine (usp-rs)
ropivacainum (inn-latin)
ropivacaina (inn-spanish)
n01bb09
98717-15-8
ropivacaine hydrochloride
naropin
ropivacaine monohydrochloride
2-piperidinecarboxamide, n-(2,6-dimethylphenyl)-1-propyl-, monohydrochloride, (s)-
ropivacaine hcl
smr000469137
MLS001401363
NCGC00164597-01
(2s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide; hydron; chloride
35504lbe2t ,
unii-35504lbe2t
dtxsid2048379 ,
dtxcid2028353
cas-98717-15-8
tox21_112221
S4058
mfcd02102164
AKOS015994752
CCG-101108
CHEBI:60803 ,
AKOS015900322
(s)-(-)-1-propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)amide hydrochloride
ropivacaine hydrochloride [mi]
ropivacaine hydrochloride [mart.]
ropivacaine hydrochloride anhydrous
ropivacaine hydrochloride [who-dd]
(s)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride
CHEMBL1889140
SCHEMBL236432
NC00358
NDNSIBYYUOEUSV-RSAXXLAASA-N
tox21_112221_1
NCGC00164597-02
KS-5134
(s)-ropivacaine hydrochloride
Q-201678
(2s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrochloride
F19623
(s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
SW197738-2
Q27128599
ropivacaine (hydrochloride)
CS-0013146
HY-B0563B
phosphorylcholine (chloride calcium)
phosphocholine (chloride calcium)
2-piperidinecarboxamide, n-(2,6-dimethylphenyl)-1-propyl-,monohydrochloride, (2s)-
EN300-18608390

Excerpt	Reference	Relevance
" There were no significant differences between the two groups of animals in the doses and plasma concentrations of ropivacaine associated with each toxic manifestations."	( Systemic toxicity of ropivacaine during ovine pregnancy. Arthur, GR; Covino, BG; Finster, M; Morishima, HO; Pedersen, H; Santos, AC, 1991)	0.28
" They were familiarized with the central nervous system (CNS) toxic effects of local anesthetics by receiving a preliminary intravenous injection of lidocaine."	( Acute toxicity of ropivacaine compared with that of bupivacaine. Bloomfield, P; Bowler, GM; Fagan, D; Lee, A; Lundh, R; Scott, DB, 1989)	0.28
" Arterial blood samples were obtained before infusion and at the onset of toxic manifestations, which appeared in the following sequence: convulsions, hypotension, apnea, and circulatory collapse."	( Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Arthur, GR; De Armas, P; Finster, M; Morishima, HO; Santos, AC; Wlody, D, 1995)	0.29
"There were no significant differences between non-pregnant and pregnant animals in the doses or serum concentrations of either drug required to elicit toxic manifestations."	( Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Arthur, GR; De Armas, P; Finster, M; Morishima, HO; Santos, AC; Wlody, D, 1995)	0.29
" Greater doses of ropivacaine, as compared to bupivacaine, are needed to produce toxic manifestations in pregnant animals."	( Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Arthur, GR; De Armas, P; Finster, M; Morishima, HO; Santos, AC; Wlody, D, 1995)	0.29
" No unexpected adverse events were registered."	( Spinal anesthesia with ropivacaine: a double-blind study on the efficacy and safety of 0.5% and 0.75% solutions in patients undergoing minor lower limb surgery. Burm, AG; van Kleef, JW; Veering, BT, 1994)	0.29
" The results suggest an increased safety margin before onset of toxic side effects after treatment with ropivacaine, compared to bupivacaine, in pregnant rase."	( Toxicity of bupivacaine and ropivacaine in relation to free plasma concentrations in pregnant rats: a comparative study. Arvidsson, T; Böö, EL; Danielson, MK; Danielsson, BR; Halldin, MM, 1997)	0.3
" These high doses, however, resulted in severe toxic CNS symptoms."	( Two instances of central nervous system toxicity in the same patient following repeated ropivacaine-induced brachial plexus block. Ala-Kokko, TI; Alahuhta, S; Löppönen, A, 2000)	0.31
" The timing of the occurrence of local anesthetic-induced toxic events (defined as the first QRS modification, dysrhythmia, seizures, moderate and severe bradycardia and hypotension, final systole) was recorded and the dose calculated."	( The comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats. Cuignet, O; De Kock, M; Dewinde, V; Dony, P; Gautier, P; Lavand'homme, P; Legrand, E; Vanderick, B, 2000)	0.31
" Additionally, they are less toxic to the CNS than bupivacaine judging by the larger doses tolerated before the onset of seizures."	( Cardiotoxicity with modern local anaesthetics: is there a safer choice? Chang, DH; Mather, LE, 2001)	0.31
" Arterial blood samples were obtained before infusion and at the onset of toxic manifestations."	( Systemic toxicity of levobupivacaine, bupivacaine, and ropivacaine during continuous intravenous infusion to nonpregnant and pregnant ewes. DeArmas, PI; Santos, AC, 2001)	0.31
" The mean cumulative dose and serum concentration at each toxic manifestation was lowest for bupivacaine, intermediate for levobupivacaine, and highest for ropivacaine in both pregnant and nonpregnant animals."	( Systemic toxicity of levobupivacaine, bupivacaine, and ropivacaine during continuous intravenous infusion to nonpregnant and pregnant ewes. DeArmas, PI; Santos, AC, 2001)	0.31
"Central and regional block procedures have a well-defined role as safe and effective methods in modern anesthesia and analgesia with long-acting local anesthetics."	( The cardiotoxicity of local anesthetics: the place of ropivacaine. Graf, BM, 2001)	0.31
" Vital signs and any adverse effects related to spinal anesthesia were also recorded."	( Spinal anesthesia with two different dosages of 0.75% glucose-free ropivacaine: a comparison of efficacy and safety in Chinese parturients undergoing cesarean section. Cheu, NW; Leung, PO; Tan, TD; Tseng, KF; Wong, JO, 2003)	0.32
" Otherwise, there were no differences in adverse effects during or after surgery."	( Spinal anesthesia with two different dosages of 0.75% glucose-free ropivacaine: a comparison of efficacy and safety in Chinese parturients undergoing cesarean section. Cheu, NW; Leung, PO; Tan, TD; Tseng, KF; Wong, JO, 2003)	0.32
" Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression."	( Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine. Gonos, ES; Kalfakakou, V; Kolettas, E; Kontargiris, E; Trougakos, IP; Vadalouca, A, 2004)	0.32
"5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects."	( Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004)	0.32
" In this limited sample, extending the infusion period from the presently approved 48 hours to 96 hours seems to be a safe alternative and/or adjunct to standard opiate analgesia after colorectal surgery using a right lateral transverse incision, hence reducing the incidence of opiate adverse effects and enhancing recovery."	( Safety of 96-hour incision-site continuous infusion of ropivacaine for postoperative analgesia after bowel cancer resection. Corso, OH; Hewett, PJ; Karatassas, A; Morris, RG, 2007)	0.34
" Aim of this short paper is to describe, primarily from a subjective point of view, CNS symptoms a patient (one of the Authors) suffered by an acute toxic reaction during an epidural block, and to stress the need to pay attention to safety measures in the practice of loco-regional anaesthesia and epidural blockade."	( Ropivacaine induced acute neurotoxicity after epidural injection. Anastasi, F; Rodolà, F; Vergari, A, )	0.13
"To investigate the toxic effects of ropivacaine on corneal endothelium by using the impression cytological method."	( Investigation of the toxic effects of ropivacaine corneal endothelium by the impression cytological method. Buyukbayram, H; Cakmak, S; Nergiz, Y; Olmez, G; Soker, S, 2007)	0.34
"Blurring at cell membrane borders, vacuolization at cell cytoplasm, hydropic degeneration and increase in toxic granulation were observed in the 1% ropivacaine group."	( Investigation of the toxic effects of ropivacaine corneal endothelium by the impression cytological method. Buyukbayram, H; Cakmak, S; Nergiz, Y; Olmez, G; Soker, S, 2007)	0.34
" However, the toxic threshold of ropivacaine remains unclear, and the dose should be calculated in relation to the weight of the patient to prevent severe toxic complications."	( Ropivacaine-induced toxicity with overdose suspected after axillary brachial plexus block. Kamada, Y; Kimura, A; Kimura, Y; Orimo, K, 2007)	0.34
" Experience from this case suggests that local anesthesia toxicity can happen within safe dose limits and without intravascular placement despite careful attention to needle and catheter placement, fractionated dosing and frequent aspirations."	( Case report: ropivacaine neurotoxicity at clinical doses in interscalene brachial plexus block. Athwal, GS; Dhir, S; Ganapathy, S; Lindsay, P, 2007)	0.34
"General anesthesia produced physiological perturbations, exacerbated local anesthetic-induced cardiovascular depression, and changed the pharmacokinetics of toxic doses of local anesthetics."	( The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008)	0.35
" We investigated the hypotheses that these drugs (A) are less neurotoxic than the prototype local anesthetic, lidocaine (B) are selectively toxic for subcategories of dorsal root ganglion neurons and (C) induce activation of either p38 MAPK or related enzymes, such as the c-jun terminal N-kinase (JNK) and extracellular signal-regulated kinase (ERK)."	( In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity. Colvin, HP; Gerner, P; Haller, I; Klimaschewski, L; Lang, L; Lirk, P; Tomaselli, B, 2008)	0.35
" Patients tolerated the treatment well, with no adverse outcomes."	( Safety of combined use of local anesthetic infiltration and reinfusion drains in total knee arthroplasty. Coolican, MR; Dewall, MJ; Graham, DA; Mather, LE; Parker, DA, 2009)	0.35
" The present article provides a concise review of the toxic potencies of levobupivacaine and ropivacaine."	( The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine. Graf, BM; Zink, W, 2008)	0.35
" Experimental studies and case reports confirm this hypothesis, showing that ropivacaine is characterized by fewer (cardio) toxic effects and, most probably, a greater margin of safety."	( The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine. Graf, BM; Zink, W, 2008)	0.35
" Despite the differences between these preclinical studies and clinical conditions, we suggest RVC(LUV) as a potential new formulation, since RVC is a new and safe local anaesthetic agent."	( Pharmacological and local toxicity studies of a liposomal formulation for the novel local anaesthetic ropivacaine. Braga, Ade F; Brunetto, GB; Cereda, CM; de Araujo, DR; de Oliveira, AL; de Paula, E; Fraceto, LF; Neto, HS; Pierucci, A; Vomero, VU, 2008)	0.35
" Only one previous study has reported adverse events of CPNB in a high number of pediatric cases."	( Continuous peripheral nerve blocks for postoperative analgesia in children: feasibility and side effects in a cohort study of 339 catheters. Bringuier, S; Canaud, N; Capdevila, X; Dadure, C; Lubrano-Lavadera, JF; Raux, O; Rochette, A; Troncin, R, 2009)	0.35
" In the postoperative period, demographic data, quality of analgesia, amount of rescue analgesic medication, child/parent satisfaction, and adverse events were recorded in our Departmental Regional Anesthesia registry."	( Continuous peripheral nerve blocks for postoperative analgesia in children: feasibility and side effects in a cohort study of 339 catheters. Bringuier, S; Canaud, N; Capdevila, X; Dadure, C; Lubrano-Lavadera, JF; Raux, O; Rochette, A; Troncin, R, 2009)	0.35
" There were no major adverse events."	( Continuous peripheral nerve blocks for postoperative analgesia in children: feasibility and side effects in a cohort study of 339 catheters. Bringuier, S; Canaud, N; Capdevila, X; Dadure, C; Lubrano-Lavadera, JF; Raux, O; Rochette, A; Troncin, R, 2009)	0.35
" Our results demonstrate that CPNBs are feasible in the pediatric setting, and in skilled hands, they promote prolonged analgesia in the majority of patients without major adverse events."	( Continuous peripheral nerve blocks for postoperative analgesia in children: feasibility and side effects in a cohort study of 339 catheters. Bringuier, S; Canaud, N; Capdevila, X; Dadure, C; Lubrano-Lavadera, JF; Raux, O; Rochette, A; Troncin, R, 2009)	0.35
" All children were assessed for pain, sedation, time until first oral intake, and adverse effects for 48 h postoperatively."	( Incisional continuous fascia iliaca block provides more effective pain relief and fewer side effects than opioids after pelvic osteotomy in children. Gardeniers, J; Lako, SJ; Staals, LM; Steegers, MA; van Egmond, J; van Geffen, GJ, 2009)	0.35
"The use of a combined prilocaine/ ropivacaine (300 mg/75 mg) dose regimen in patients given single dose for brachial plexus blockade can generally be regarded as safe with regard to peak plasma concentrations and cardiovascular toxicity and this holds true for patients with a higher perioperative risk profile (ASA III grading, American Society of Anesthesiologists)."	( Pharmacokinetics and clinical toxicity of prilocaine and ropivacaine following combined drug administration in brachial plexus anesthesia. Huschak, G; Kaisers, UX; Meinecke, CD; Preiss, R; Regenthal, R; Rüffert, H; Taubert, MH; Wehner, M, 2009)	0.35
"Although 2 patients demonstrated isolated serum ropivacaine concentration spikes into a previously identified toxic range, continuous peripheral nerve block catheter management and local anesthetic doses as practiced at Walter Reed Army Medical Center did not result in clinically evident systemic ropivacaine toxicity."	( Serum ropivacaine concentrations and systemic local anesthetic toxicity in trauma patients receiving long-term continuous peripheral nerve block catheters. Bina, S; Bleckner, LL; Buckenmaier, CC; Dragovich, A; Kwon, KH; McKnight, G, 2010)	0.36
" The onset of toxic manifestations (seizure, dysrhythmia, and cardiac arrest) was recorded, and then the doses of local anesthetics were calculated."	( Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats. Bo, YL; Li, HB; Li, WZ; Wan, QX, 2010)	0.36
" We highlight how these toxic effects have motivated the search for a safe and long-acting local anesthetic."	( Local anesthetic systemic toxicity. Dillane, D; Finucane, BT, 2010)	0.36
" Local anaesthesia is however associated with potential risks and adverse reactions including toxicity."	( Local anaesthetic toxicity. Maher, AJ; Metcalfe, SA; Parr, S, 2008)	0.35
"Local anaesthesia although safe has the potential to cause serious harm in the event of toxicity."	( Local anaesthetic toxicity. Maher, AJ; Metcalfe, SA; Parr, S, 2008)	0.35
" This concentration was a factor of 6 below the published safe level."	( Is peri-articular multimodal drug infiltration in knee arthroplasty safe when used in conjunction with autologous retransfusion drains? Busch, CA; Gallagher, K; Gill, I, 2010)	0.36
"The theoretical risk of local anaesthesia toxicity when these systems are used together is negligible and we conclude that peri-articular multimodal drug infiltration is safe in conjunction with the use of autotransfusion drains."	( Is peri-articular multimodal drug infiltration in knee arthroplasty safe when used in conjunction with autologous retransfusion drains? Busch, CA; Gallagher, K; Gill, I, 2010)	0.36
" Adverse effects were rare and unrelated to the choice of drug."	( Evidence-based clinical update: Which local anesthetic drug for pediatric caudal block provides optimal efficacy with the fewest side effects? Cox, RG; Dobereiner, EF; Ewen, A; Lardner, DR, 2010)	0.36
" Adverse effects in human studies are rare, mild, and unrelated to the choice of drug."	( Evidence-based clinical update: Which local anesthetic drug for pediatric caudal block provides optimal efficacy with the fewest side effects? Cox, RG; Dobereiner, EF; Ewen, A; Lardner, DR, 2010)	0.36
" Knowing that morphine provides comparable to even prolonged pain reduction after ACL reconstruction, the presented in vitro study suggests morphine as a potentially less toxic analgetic drug for intraarticular application in clinical practice."	( Bupivacaine, ropivacaine, and morphine: comparison of toxicity on human hamstring-derived stem/progenitor cells. Docheva, D; Grote, S; Haasters, F; Kohler, J; Mutschler, W; Polzer, H; Prall, WC; Saller, MM; Schieker, M, 2011)	0.37
" However, recent studies have confirmed the toxic effect of lidocaine on ganglion cells."	( Cataract surgery complications: an in vitro model of toxic effects of ropivacaine and lidocaine. Nebbioso, M; Pescosolido, N; Scarsella, G; Tafani, M, 2011)	0.37
"Our in vitro studies confirm that ropivacaine is less toxic than lidocaine to these cells."	( Cataract surgery complications: an in vitro model of toxic effects of ropivacaine and lidocaine. Nebbioso, M; Pescosolido, N; Scarsella, G; Tafani, M, 2011)	0.37
" A 30-minute exposure to lidocaine alone was significantly toxic to the tenocytes in a dose-dependent manner, but a 30-minute exposure to ropivacaine or dexamethasone alone was not significantly toxic."	( A comparison of lidocaine, ropivacaine and dexamethasone toxicity on bovine tenocytes in culture. Feeley, BT; Kim, HT; Laron, D; Liu, X; Manzano, G; Pattnaik, T; Piper, SL, 2012)	0.38
" In this study, we assessed whether PVB via an intrathoracic approach was also safe for the patients ineligible for epidural block because of, for example, anticoagulation or antiplatelet therapy."	( Safety of the paravertebral block in patients ineligible for epidural block undergoing pulmonary resection. Hamaishi, M; Hirai, S; Katayama, T; Kobayashi, R; Mitsui, N; Okada, T, 2012)	0.38
"This study suggests that PVB is safe in patients ineligible for epidural block and can contribute to their pain relief following pulmonary resection procedure including video-assisted thoracic surgery."	( Safety of the paravertebral block in patients ineligible for epidural block undergoing pulmonary resection. Hamaishi, M; Hirai, S; Katayama, T; Kobayashi, R; Mitsui, N; Okada, T, 2012)	0.38
" It appears to be safe to transfuse autologous blood in combination with LIA."	( Safety of retransfusing shed blood after local infiltration analgesia in total knee arthroplasty. in 't Veld, BA; Pool, L; Stienstra, R; Thomassen, BJ; Van Der Flier, R, 2012)	0.38
" The neurotoxicity of apoptosis with concomitant cell death, mediated by ropivacaine, may offer an explanation for its adverse effects (e."	( In vivo and in vitro evidence of the neurotoxic effects of ropivacaine: the role of the Akt signaling pathway. Guo, Q; Liu, H; Sun, Z; Wang, N; Xu, X; Zhang, Z, 2012)	0.38
"To assess the effects of lipid on ropivacaine-induced convulsion and LD50 in rats and compare with those of the traditional anticonvulsants midazolam and propofol."	( [Effects of pretreatment of lipid, midazolam and propofol on ropivacaine-induced convulsion and LD50 in rats]. Lü, XL; Wan, FH; Zuo, YX, 2012)	0.38
" Protocol 2: Additional 100 male SD rats were used for the measurements of ropivacaine LD50 with different pretreatments including lipid, midazolam, propofol and saline through the up-and-down method."	( [Effects of pretreatment of lipid, midazolam and propofol on ropivacaine-induced convulsion and LD50 in rats]. Lü, XL; Wan, FH; Zuo, YX, 2012)	0.38
" The LD50 of ropivacaine in group C was 64."	( [Effects of pretreatment of lipid, midazolam and propofol on ropivacaine-induced convulsion and LD50 in rats]. Lü, XL; Wan, FH; Zuo, YX, 2012)	0.38
" Previous studies have shown that the commonly used drugs lidocaine, ropivacaine, and bupivacaine can be toxic to human chondrocytes."	( Cytotoxicity of local anesthetics on human mesenchymal stem cells. Dang, AC; Kim, HT; Kuo, AC; Rahnama, R; Wang, M, 2013)	0.39
"79), and 2% lidocaine was found to be significantly more toxic than all doses of bupivacaine and ropivacaine."	( Cytotoxicity of local anesthetics on human mesenchymal stem cells. Dang, AC; Kim, HT; Kuo, AC; Rahnama, R; Wang, M, 2013)	0.39
" Since other studies have shown ropivacaine to be less toxic to chondrocytes than bupivacaine, ropivacaine may be a safer intra-articular anesthetic."	( Cytotoxicity of local anesthetics on human mesenchymal stem cells. Dang, AC; Kim, HT; Kuo, AC; Rahnama, R; Wang, M, 2013)	0.39
" The incidence of adverse events was compared with the chi-square or Fisher test."	( Comparative study related to cardiovascular safety between bupivacaine (S75-R25) and ropivacaine in brachial plexus block. Auler, JO; de Rezende, MR; Hamaji, A; Mattar, R; Vieira, JE, )	0.13
" In addition, the results showed that lidocaine was the most toxic of the three local anesthetics and that ropivacaine presented less cytotoxicity than lidocaine and bupivacaine."	( Comparison of toxicity effects of ropivacaine, bupivacaine, and lidocaine on rabbit intervertebral disc cells in vitro. Cai, XY; Ding, F; Gao, F; Shao, ZW; Xie, M; Xiong, LM; Yang, SH, 2014)	0.4
" We report a case of Leriche's syndrome treated with safe and effective analgesia after laparotomy by abdominal wall block and continuous infusion."	( [Case of Leriche's syndrome treated with safe and effective analgesia after laparotomy by transversus abdominis plane block, rectus sheath block, and continuous wound infusion with ropivacaine]. Hakata, S; Hotta, A; Kukida, A; Nakamoto, A; Oohira, N; Shimizu, M; Tatekawa, S; Tsumura, Y; Yagi, Y; Yoshikawa, N, 2013)	0.39
" The incidence of adverse events was compared with the chi-square or Fisher test."	( Comparative study related to cardiovascular safety between bupivacaine (S75-R25) and ropivacaine in brachial plexus block. Auler, JO; Hamaji, A; Mattar, R; Rezende, MR; Vieira, JE, )	0.13
"Labor analgesia by patient-controlled lumbar epidural combined anesthesia accompanied with Doula with ropivacaine and sufentanil is effective, safe, reliable, has no adverse effects, and reduces cesarean section rate."	( Investigation on delivery analgesia effect of combined spinal epidural anesthesia plus Doula and safety of mother and baby. Feng, BB; Wang, L; Zhai, JJ, 2013)	0.39
" The outcomes of clinical safety were measured using plasma concentration of local anesthetics and occurrence of toxic symptoms."	( [Analgesic efficacy and clinical safety of intraperitoneal instillation combined with rectus sheath block using ropivacaine for pain relief after laparoscopic gynecological surgery]. Hashimoto, H; Hirota, K; Kitayama, M; Kudo, M; Kudo, T; Niwa, H; Yakoshi, C, 2014)	0.4
"5% ropivacaine, none of analyzed concentrations was above the toxic ones."	( [Analgesic efficacy and clinical safety of intraperitoneal instillation combined with rectus sheath block using ropivacaine for pain relief after laparoscopic gynecological surgery]. Hashimoto, H; Hirota, K; Kitayama, M; Kudo, M; Kudo, T; Niwa, H; Yakoshi, C, 2014)	0.4
"The present study showed that the combination of rectus sheath block with intraperitoneal instillation of ropivacaine was safe and potent enough to relieve pain after laparoscopic surgery."	( [Analgesic efficacy and clinical safety of intraperitoneal instillation combined with rectus sheath block using ropivacaine for pain relief after laparoscopic gynecological surgery]. Hashimoto, H; Hirota, K; Kitayama, M; Kudo, M; Kudo, T; Niwa, H; Yakoshi, C, 2014)	0.4
"Ropivacaine is not safe when intrathecally administered with lidocaine at the concentrations used in this study."	( Intrathecal lidocaine neurotoxicity: combination with bupivacaine and ropivacaine and effect of nerve growth factor. Chen, W; Ding, X; Guo, Y; Zhao, G, 2014)	0.4
" Of the evaluated anesthetics, ropivacaine is the least toxic in the clinically used concentration."	( Cytotoxic effects of ropivacaine, bupivacaine, and lidocaine on rotator cuff tenofibroblasts. Hah, YS; Kim, JS; Kim, RJ; Lee, SJ; Nam, JB; Park, HB; Sung, CM, 2014)	0.4
"To compare the anesthetic efficacy and adverse effects associated with peribulbar injection of ropivacaine (1% solution) performed with and without ultrasound guidance (UG) in dogs."	( Comparison of anesthetic efficacy and adverse effects associated with peribulbar injection of ropivacaine performed with and without ultrasound guidance in dogs. Deschk, M; Ferreira, JZ; Fioravanti, H; Floriano, BP; Gasparello, IF; Oliva, VN; Wagatsuma, JT, 2014)	0.4
"Scalp block with a mixture of lidocaine and ropivacaine seems to provide effective and safe anesthetic management in patients undergoing awake craniotomy."	( Efficacy and Safety of a Lidocaine and Ropivacaine Mixture for Scalp Nerve Block and Local Infiltration Anesthesia in Patients Undergoing Awake Craniotomy. Chaki, T; Hatakeyama, Y; Hayase, T; Ishioka, Y; Janicki, PK; Kaneuchi-Yamashita, M; Kohri, N; Sugino, S; Yamakage, M, 2016)	0.43
" In addition to these 12 patients, 3 other patients had adverse events related to the interscalene CPNB."	( Safety of pediatric continuous interscalene block catheters placed under general anesthesia: a single center's experience. Cucchiaro, G; Ganesh, A; Gurnaney, H; Kraemer, FW; Muhly, WT, 2015)	0.42
"Use of intrathecal admixtures is widespread, but compounding these is sometimes challenging and may result in errors and complications causing super-potency or sub potency adverse events in patients or malfunctions in the pump itself."	( Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice. Bazin, C; Boré, F; Devys, C; Dubois, PY; Dupoiron, D; Folliard, C; Kieffer, H; Lebrec, N, )	0.13
"This study is monocentric and limitations include also its non-randomized nature with no clinical comparison of the rate of adverse events with a refill process without control of each component concentrations."	( Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice. Bazin, C; Boré, F; Devys, C; Dubois, PY; Dupoiron, D; Folliard, C; Kieffer, H; Lebrec, N, )	0.13
" Secondary outcomes were pain scores from 24 to 72 h, intraoperative and postoperative opioid consumption, time to onset of bowel movement and side effect profiles."	( Comparison of efficacy and safety of lateral-to-medial continuous transversus abdominis plane block with thoracic epidural analgesia in patients undergoing abdominal surgery: A randomised, open-label feasibility study. Brookes, J; Das Adhikary, S; Ganapathy, S; Sondekoppam, RV; Subramanian, L; Terlecki, M, 2015)	0.42
"Although intrathecal drug infusion has been commonly adopted for terminal cancer pain relief, its adverse effects have made many clinicians reluctant to employ it for intractable cancer pain."	( Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer. Huang, Y; Li, X; Lin, J; Tao, G; Zhu, T, 2015)	0.42
" Adverse effects and complications on postoperative days 1, 3, 7, and 15 were also analyzed."	( Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer. Huang, Y; Li, X; Lin, J; Tao, G; Zhu, T, 2015)	0.42
"Morphine and ropivacaine administration through intrathecal access ports is efficacious and safe and significantly improves quality of life."	( Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer. Huang, Y; Li, X; Lin, J; Tao, G; Zhu, T, 2015)	0.42
" We observed a significant reduction in morphine adverse effects (31% versus 69% for groups R and P, respectively; P<0."	( Impact of preoperative continuous femoral blockades on morphine consumption and morphine side effects in hip-fracture patients: A randomized, placebo-controlled study. Bouhours, G; Chaudet, A; Hamel, JF; Lasocki, S; Leblanc, D; Rineau, E; Steiger, V, 2016)	0.43
" The patients' satisfaction, heart rate, the chages of blood pressure before and after the block, detachment of tubes, and adverse drug reaction were recorded."	( [Stellate ganglion catheter retention with discontinuous block on efficacy and safety in the treatment of sudden deafness]. Gao, H; Guo, W; Zhang, G; Zhang, Z, 2015)	0.42
" Moreover, no adverse drug reaction and detachment of tubes were observed."	( [Stellate ganglion catheter retention with discontinuous block on efficacy and safety in the treatment of sudden deafness]. Gao, H; Guo, W; Zhang, G; Zhang, Z, 2015)	0.42
"It is a safe and effective administration of stellate ganglion catheter retention with interrupted ropivacaine block."	( [Stellate ganglion catheter retention with discontinuous block on efficacy and safety in the treatment of sudden deafness]. Gao, H; Guo, W; Zhang, G; Zhang, Z, 2015)	0.42
" Moreover, in spite of boluses that were within the manufacturer's recommendation for epidural and major nerve blocks, and an infusion rate that was only slightly higher than what appeared to be safe for epidural infusion, potentially toxic total plasma ropivacaine concentrations were common."	( Local anaesthetic toxicity after bilateral thoracic paravertebral block in patients undergoing coronary artery bypass surgery. Chan, SK; Ho, AM; Joynt, GM; Karmakar, MK; Ng, CS; Ng, SK; Wan, S; Wong, RH, 2016)	0.43
" There were no adverse events such as postoperative nausea and vomiting."	( Preoperative flap-site injection with ropivacaine and epinephrine in BABA robotic and endoscopic thyroidectomy safely reduces postoperative pain: A CONSORT-compliant double-blinded randomized controlled study (PAIN-BREKOR trial). Choi, JY; Kwon, H; Lee, JH; Lee, KE; Song, RY; Suh, YJ; Yi, JW; Yu, HW, 2017)	0.46
" However, its practical use is highly limited by certain drawbacks including high viscosity, involved toxic organic solvents and fast drug release."	( An in situ-forming phospholipid-based phase transition gel prolongs the duration of local anesthesia for ropivacaine with minimal toxicity. Deng, J; Fu, Q; Lan, L; Li, H; Liu, T; Shi, S; Wu, W; Zhu, Y, 2017)	0.46
"The peak total ropivacaine concentration was below quoted toxic concentrations (2."	( Plasma Ropivacaine Concentrations Following Local Infiltration Analgesia in Total Knee Arthroplasty: A Pharmacokinetic Study to Determine Safety Following Fixed-Dose Administration. Cameron, AJ; Dimech, J; Lightfoot, NJ; Miller, RJ; Orec, RJ, 2018)	0.48
" Rectus sheath block reduces the pain intensity and the consumption of opioids and declines the incidence of the adverse effects, therefore improving the quality of analgesia and postoperative comfort ofpatient."	( EFFICIENCY AND SAFETY OF BILATERAL ULTRASOUND RECTUS SHEATH BLOCK IN URGENT LAPAROTOMY. Antipin, EE; Karpunov, AA; Lovkov, IA; Nedashkovskiv, EV; Ushakov, AA; Uvarov, DN, 2017)	0.46
"BACKGROUND Regional nerve blocks ideally provide safe and effective post-operative pain control, decrease opiate requirements, and enhance recovery from intense pain following major thoracic, abdominal, and musculoskeletal surgeries."	( Safe and Effective Use of Bilateral Erector Spinae Block in Patient Suffering from Post-Operative Coagulopathy Following Hepatectomy. Fernandez, L; Johnson, C; Kazior, MR; Maarouf, R; Maddineni, U, 2020)	0.56
"Continuous TAP blockade is an effective and safe technique."	( Effectiveness and Safety of Continuous Transverse Abdominal Plane Blocks vs Epidural Analgesia in Donor Nephroureterectomy. Calixto-Flores, A; Díaz-Angúlo, W, 2020)	0.56
"Infiltration of ropivacaine and Diprospan can achieve satisfactory postoperative pain relief after craniotomy; it is a simple, easy, and safe technique, worth clinical promotion."	( Postoperative Analgesic Efficacy and Safety of Ropivacaine Plus Diprospan for Preemptive Scalp Infiltration in Patients Undergoing Craniotomy: A Prospective Randomized Controlled Trial. Han, X; Ji, N; Luo, F; Ren, T; Wang, Y, 2022)	0.72
"Sufentanil combined with ropivacaine is commonly used for epidural labor analgesia, but it may cause some adverse effects."	( Efficacy and safety of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine for epidural labor analgesia: a randomized controlled trial. Cao, R; Fan, M; Hu, L; Li, J; Lu, S, 2022)	0.72
" Secondary outcomes included the duration of labor stages and adverse reactions of parturient women and newborns."	( Efficacy and safety of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine for epidural labor analgesia: a randomized controlled trial. Cao, R; Fan, M; Hu, L; Li, J; Lu, S, 2022)	0.72
" The incidence of adverse reactions in parturient women and newborns was low in both groups."	( Efficacy and safety of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine for epidural labor analgesia: a randomized controlled trial. Cao, R; Fan, M; Hu, L; Li, J; Lu, S, 2022)	0.72
"4 min, but exacerbating ropivacaine adverse effects (reduced survival by 13."	( Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics. Coles, JG; Estrada, M; Lonnqvist, PA; Maynes, JT; Plakhotnik, J; Zhang, L, 2022)	0.72
"4%) of severe itching in women, in group I such an adverse reaction was absent."	( SAFETY OF USING DURAL PUNCTURE EPIDURAL ANALGESIA AS A METHOD OF LABOR ANALGESIA. Loskutov, OA; Sulimenko, YM; Zhezher, AO, 2022)	0.72
"Day stay surgery for anterior cruciate ligament (ACL) reconstructions is an increasingly common practice and has driven clinicians to develop postoperative pain regimes that allow same day mobilization and a safe and timely discharge."	( Safety and efficacy of intraosseous ropivacaine in lower extremity (SORE) study. Hannam, J; Nicholson, L; Rahardja, R; Stowers, MDJ; Svirskis, D; Young, SW, 2023)	0.91
"This study demonstrates that IO ropivacaine is both safe and effective in reducing perioperative pain in patients undergoing ACL reconstruction."	( Safety and efficacy of intraosseous ropivacaine in lower extremity (SORE) study. Hannam, J; Nicholson, L; Rahardja, R; Stowers, MDJ; Svirskis, D; Young, SW, 2023)	0.91
" Secondary outcomes were intraoperative VAS scores assessed at multiple timepoints; intraoperative rescue analgesic requirement; postoperative VAS scores; disability scale; patients' satisfaction with anesthesia; adverse events; and radiographic outcomes."	( Effectiveness and safety of intrathecal morphine for percutaneous endoscopic lumbar discectomy under low-dose ropivacaine: a prospective, randomized, double-blind clinical trial. Lin, Z; Mu, G; Shang, M; Sun, H; Yue, L; Zhang, F, 2023)	0.91
" For adverse events, 8/43 of ITM and 1/44 of control participants experienced pruritus (p=."	( Effectiveness and safety of intrathecal morphine for percutaneous endoscopic lumbar discectomy under low-dose ropivacaine: a prospective, randomized, double-blind clinical trial. Lin, Z; Mu, G; Shang, M; Sun, H; Yue, L; Zhang, F, 2023)	0.91
"Subcutaneous CLIA is a technically feasible and safe procedure without major adverse events but with reduced postoperative pain scores (at rest and during mobilization) and opioid consumption."	( The efficacy and safety of subcutaneous continuous local infiltration analgesia with ropivacaine in patients undergoing total knee arthroplasty: a comparative study. Al-Mohrej, OA; Al-Saati, MF; Alaqaili, SI; Albaiz, AA; Alshammari, FA; ElRaei, MAN; Tushinski, D, 2023)	0.91
"The local analgesic efficacy and adverse effects of a new Long-acting Ropivacaine formulation were examined based on pharmacokinetic-pharmacodynamic (PK-PD) modelling in Bama minipigs."	( LC-MS/MS quantification of ropivacaine and local analgesic and adverse effects of Long-acting Ropivacaine Injection based on pharmacokinetic-pharmacodynamic modelling in Bama minipigs. Bian, J; Cai, C; Chen, R; Chen, Y; Cui, H; Lyu, L; Xu, S; Xu, ZR, 2023)	0.91
" Pharmacokinetic data are needed to guide safe dosing."	( Population pharmacokinetic and safety analysis of ropivacaine used for erector spinae plane blocks. Abulfathi, AA; Baratta, JL; Gebhart, A; Kaushal, G; Lam, E; Mohamod, D; Rochani, A; Roy, AB; Sarna, RR; Schmidt, S; Schwenk, ES; Viscusi, ER; Witzeling, SD; Zhao, JL, 2023)	0.91
"Spontaneous reports notified to the French Pharmacovigilance Network were retrieved and followed by a case-by-case review, according to the following criteria: LA as suspected drug, age < 18 years, adverse drug reactions related to nervous system, cardiac, respiratory, psychiatric or general disorders."	( Local anesthetics systemic toxicity in children: analysis of the French pharmacovigilance database. Bouazza, N; Boyer-Gervoise, M; Callot, D; Chouchana, L; Lesage, F; Oualha, M; Paret, N; Schweitzer-Chaput, A; Treluyer, JM, 2023)	0.91
" Using the lowest possible dose of anesthetic that provides painless delivery with the lowest adverse events is a major concern."	( Safety and efficacy of combined ropivacaine and sufentanil compared with ropivacaine for cesarean sections: A systematic review and meta-analysis. Abdalla, AM; Albadrani, MS; Azeem, FM; El-Amin, EI; Elhusein, AM; Elhussain, MY; Fadlalmola, HA; Masada, HK, 2023)	0.91
" The primary endpoint was a safe dose or a maximum dose of ropivacaine (400 mg)."	( A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects. Cao, YX; Chi, P; Dong, JP; Hui, MQ; Jiao, YQ; Lu, WD; Ma, B; Tian, Y; Wang, MX; Yang, B; Yang, Y; Zhang, HB; Zhang, M; Zhao, DL, 2023)	0.91
" Multineedle subcutaneous injection of RODD in the abdomens of subjects was safe, and all adverse events were no more severe than grade II."	( A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects. Cao, YX; Chi, P; Dong, JP; Hui, MQ; Jiao, YQ; Lu, WD; Ma, B; Tian, Y; Wang, MX; Yang, B; Yang, Y; Zhang, HB; Zhang, M; Zhao, DL, 2023)	0.91
" Efficacy indicators consisting of maternal vital signs, obstetric transfer, neonatal prognostic indicators, and adverse effects were recorded before and after analgesia across groups."	( Cytochrome P4503A4 gene polymorphisms guide safe sufentanil analgesic doses in pregnant Chinese mothers: a multicenter, randomized, prospective study. Chi, L; Shu, X; Yan, Y; Yu, J, 2024)	1.44

Excerpt	Reference	Relevance
" Pharmacokinetic parameters were derived using serum concentration-time data."	( Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans. Bridenbaugh, PO; Denson, DD; Helton, SH; Katz, JA; Knarr, DC, 1990)	0.28
" Thus the difference in the elimination half-life was only minimal: 74."	( Pharmacokinetics of ropivacaine in nonpregnant and pregnant ewes. Arthur, GR; Covino, BG; Finster, M; Johnson, HV; Morishima, HO; Pedersen, H; Sallusto, JA; Santos, AC, 1990)	0.28
" After epidural injections (ropivacaine n = 6; bupivacaine n = 5), a dose-related increase in Cmax was observed with both drugs."	( Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic. Arthur, GR; Covino, BG; Feldman, HS, 1988)	0.27
"The clinical and pharmacokinetic properties of ropivacaine and bupivacaine, both 5 mg/mL, used in axillary plexus block were compared in 60 patients in this randomized, double-blind, parallel-group study."	( A clinical and pharmacokinetic comparison of ropivacaine and bupivacaine in axillary plexus block. Haavisto, ET; Hollmén, AI; Huha, TM; Jozwiak, HM; Korpi, KJ; Magnusson, AA; Nuutinen, LS; Vainionpää, VA, 1995)	0.29
" The purpose of this study was to determine the pharmacokinetic properties of ropivacaine and bupivacaine after bilateral intercostal blockade."	( Pharmacokinetics of ropivacaine and bupivacaine for bilateral intercostal blockade in healthy male volunteers. Carpenter, RL; Emanuelsson, BM; Kopacz, DJ; Stephenson, CA; Thompson, GE, 1994)	0.29
" The terminal half-life (t1/2 beta) of ropivacaine (2."	( Pharmacokinetics of ropivacaine and bupivacaine for bilateral intercostal blockade in healthy male volunteers. Carpenter, RL; Emanuelsson, BM; Kopacz, DJ; Stephenson, CA; Thompson, GE, 1994)	0.29
" The concentration of bupivacaine in patients determined by this method agreed well with the values obtained from an alternative method, making the technique applicable for pharmacokinetic studies in humans."	( Direct injection of large volumes of plasma in a column-switching system for the analysis of local anaesthetics. II. Determination of bupivacaine in human plasma with an alkyldiol silica precolumn. Westerlund, D; Yu, Z, 1996)	0.29
" The relationship between V(d)beta and CL was such that the elimination half-life (T(1/2)beta) was not altered."	( Comparative pharmacokinetics of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Arthur, GR; Finster, M; Lehning, EJ; Santos, AC, 1997)	0.3
" Arterial blood samples were drawn for serum drug concentration determinations and pharmacokinetic analysis."	( Comparative local anesthetic efficacy and pharmacokinetics of epidurally administered ropivacaine and bupivacaine in the sheep. Ask, AL; Doucette, AM; Dvoskin, S; Feldman, HS; Halldin, MH, )	0.13
" Study parameters included sensory and motor blockade, circulatory response, intraoperative pain and discomfort, neonatal evaluation and pharmacokinetic determinations."	( Ropivacaine 7.5 mg/ml for elective caesarean section. A clinical and pharmacokinetic comparison of 150 mg and 187.5 mg. Ekblom, A; Emanuelsson, BM; Irestedt, L; Olofsson, C; Reventlid, H, 1997)	0.3
" In the pharmacokinetic part of this study the objectives were to 1) determine the dose proportionality in the pharmacokinetics of epidural ropivacaine, and 2) compare the pharmacokinetics of 125 mg ropivacaine and 125 mg bupivacaine."	( Pharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine. Arlander, E; Callahan-Enright, SO; Chan, V; Finucane, BT; Friedlander, M; Milner, A; Muzyka, D; Sandler, AN; Taddio, A, 1998)	0.3
" Pharmacokinetic variables were derived from plasma concentration-time curve data."	( Pharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine. Arlander, E; Callahan-Enright, SO; Chan, V; Finucane, BT; Friedlander, M; Milner, A; Muzyka, D; Sandler, AN; Taddio, A, 1998)	0.3
" Apparent plasma clearance (CL) and the terminal half-life (t1/2) were similar in the three ropivacaine groups."	( Pharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine. Arlander, E; Callahan-Enright, SO; Chan, V; Finucane, BT; Friedlander, M; Milner, A; Muzyka, D; Sandler, AN; Taddio, A, 1998)	0.3
"Epidural ropivacaine displays dose-proportional pharmacokinetic behaviour for doses of 125 mg to 250 mg."	( Pharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine. Arlander, E; Callahan-Enright, SO; Chan, V; Finucane, BT; Friedlander, M; Milner, A; Muzyka, D; Sandler, AN; Taddio, A, 1998)	0.3
" The relevant pharmacokinetic differences include a lower lipid solubility, a slightly higher plasma clearance and shorter elimination half-life (t 1/2 beta) compared with racemic bupivacaine, with a similar degree of plasma protein binding."	( Recent advances in the pharmacokinetics of local anaesthetics. Long-acting amide enantiomers and continuous infusions. Schug, SA; Thomas, JM, 1999)	0.3
" Pharmacokinetic data were obtained from 22 subjects."	( Clinical efficacy and pharmacokinetics of 1% ropivacaine and 0.75% bupivacaine in peribulbar anaesthesia for cataract surgery. Ala-Kokko, TI; Alahuhta, S; Huha, T; Salomäki, T, 1999)	0.3
" However, the pharmacokinetic results obtained suggest that even larger doses (0."	( Pharmacokinetics and pharmacodynamics of ropivacaine 2 mg/mL, 5 mg/mL, or 7.5 mg/mL after ilioinguinal blockade for inguinal hernia repair in adults. Behnke, H; Böhle, AS; Worthmann, F; Wulf, H, 1999)	0.3
" We therefore designed this study to determine the pharmacokinetic variables of ropivacaine relevant to the risk of toxicity, after caudal administration in children."	( Pharmacokinetics of ropivacaine following caudal analgesia in children. Bergesio, R; Habre, W; Hackett, P; Johnson, C; Joyce, D; Sims, C, 2000)	0.31
" There were no significant changes in the pharmacokinetic parameters of the parent ropivacaine after ingestion of clarithromycin or itraconazole."	( Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine. Ahonen, J; Jokinen, MJ; Neuvonen, PJ; Olkkola, KT, 2001)	0.31
" Population pharmacokinetic modeling was performed to yield estimates of clearance, volume of distribution, and absorption rate constant."	( Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations. Bergesio, R; Hackett, LP; Hansen, TG; Ilett, KF; Lim, SI; Reid, C, 2001)	0.31
" Pharmacokinetic variables of the total population were best described by a one-compartment model with first-order absorption."	( Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations. Bergesio, R; Hackett, LP; Hansen, TG; Ilett, KF; Lim, SI; Reid, C, 2001)	0.31
"The pharmacokinetic variables of ropivacaine were characterized after epidural bolus injection in pediatric patients."	( The pharmacokinetics of epidural ropivacaine in infants and young children. Auble, SG; Berde, CB; Hope, T; Mazoit, JX; McCann, ME; Rifai, N; Sakamoto, M; Sethna, NF; Sullivan, L, 2001)	0.31
"This study revealed that the pharmacokinetic variables of lumbar epidural bolus ropivacaine in pediatric patients aged 3 to 48 mo are similar to those of adults, except that drug clearance was less in infants compared with older children."	( The pharmacokinetics of epidural ropivacaine in infants and young children. Auble, SG; Berde, CB; Hope, T; Mazoit, JX; McCann, ME; Rifai, N; Sakamoto, M; Sethna, NF; Sullivan, L, 2001)	0.31
" Pharmacokinetic parameters were calculated with noncompartmental methods, and t tests were used for comparisons between the phases and between the smokers and nonsmokers."	( Effect of rifampin and tobacco smoking on the pharmacokinetics of ropivacaine. Ahonen, J; Jokinen, MJ; Neuvonen, PJ; Olkkola, KT, 2001)	0.31
"There were no statistically significant differences in the area under the plasma concentration-time curve (AUC), plasma clearance (CL), or half-life (t(1/2)) of ropivacaine between the smokers and nonsmokers."	( Effect of rifampin and tobacco smoking on the pharmacokinetics of ropivacaine. Ahonen, J; Jokinen, MJ; Neuvonen, PJ; Olkkola, KT, 2001)	0.31
" Fifteen venous blood samples were obtained from each patient for pharmacokinetic measurements over a 24-h period."	( Pharmacokinetics and efficacy of 40 ml ropivacaine 7.5 mg/ml (300 mg), for axillary brachial plexus block--an open pilot study. Büttner, J; Emanuelson, BM; Maier, KR; Selander, D; Wank, W, )	0.13
" Maximal concentration (C(max)) and time to peak concentration (T(max)) were obtained from the data, terminal half-life (T(1/2z)), clearance (Cl) and volume of distribution (Vd) were estimated by a non-compartmental approach."	( In children, the addition of epinephrine modifies the pharmacokinetics of ropivacaine injected caudally. Roelants, FA; Van Obbergh, LJ; Verbeeck, RK; Veyckemans, F, )	0.13
" The tmax and toxicity data were obtained from the literature."	( Lipophilicity affects the pharmacokinetics and toxicity of local anaesthetic agents administered by caudal block. Bello-Ramírez, AM; Nava-Ocampo, AA, )	0.13
" The elimination half-life of ropivacaine was significantly less than that of bupivacaine (5."	( [Clinical effects and pharmacokinetics of ropivacaine and bupivacaine for epidural analgesia during labor]. Barros Núñez, C; Cánovas Martínez, L; Castro Méndez, A; Gallardo, E; González González, D; López Piñeiro, S, 2004)	0.32
" Pharmacokinetic data were characterized by population analysis."	( Ropivacaine in neonates and infants: a population pharmacokinetic evaluation following single caudal block. Austin, S; Boos, K; Gädeke, V; Gustafsson, U; Huledal, G; Krohn, S; Larsson, LE; Molnár, V; Motsch, J; Rapp, HJ; Williams, DG, 2004)	0.32
" Apparent volume of distribution is unchanged, apparent unbound clearance increases and the terminal half-life decreases with age in 0-12-month-old neonates and infants."	( Ropivacaine in neonates and infants: a population pharmacokinetic evaluation following single caudal block. Austin, S; Boos, K; Gädeke, V; Gustafsson, U; Huledal, G; Krohn, S; Larsson, LE; Molnár, V; Motsch, J; Rapp, HJ; Williams, DG, 2004)	0.32
"Epinephrine reduced the peak plasma concentrations and delayed the time of peak concentration of ropivacaine in both the arterial and venous blood."	( Arterial and venous pharmacokinetics of ropivacaine with and without epinephrine after thoracic paravertebral block. Gin, T; Ho, AM; Karmakar, MK; Law, BK; Shafer, SL; Wong, AS, 2005)	0.33
" Our preliminary pharmacokinetic data showed that ropivacaine viscous could be used safely based on the plasma ropivacaine concentrations (C(max): 89-125 ng/ml) for pain relief in oral mucosa."	( Liquid chromatographic determination of plasma ropivacaine for assessing pharmacokinetics of the viscous preparation. Homma, M; Inomata, S; Kakiuchi, Y; Kawata, T; Kobayashi, D; Kohda, Y; Miyabe, M; Morimoto, Y, 2005)	0.33
"2-fold longer half-life (P<0."	( Pharmacokinetics of ropivacaine in patients with chronic end-stage liver disease. Ahonen, J; Askemark, Y; Breuer, O; Höckerstedt, K; Jokinen, MJ; Lindgren, L; Neuvonen, PJ; Olkkola, KT; Sjövall, J, 2007)	0.34
" Resulting dialysate and plasma concentrations were used to calculate pharmacokinetic parameters for ropivacaine and bupivacaine."	( Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep. Chevanne, F; Dollo, G; Ecoffey, C; Estebe, JP; Le Corre, P; Malinovsky, JM; Ratajczak-Enselme, M; Rose, FX; Wodey, E, 2007)	0.34
" Plasma Cmax for bupivacaine was decreased."	( Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep. Chevanne, F; Dollo, G; Ecoffey, C; Estebe, JP; Le Corre, P; Malinovsky, JM; Ratajczak-Enselme, M; Rose, FX; Wodey, E, 2007)	0.34
" pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data."	( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008)	0.35
"After epidural administration of ropivacaine-loaded microspheres, Cmax in plasma was around 100 ng/ml while epidural and intrathecal Cmax of ropivacaine were close to 600 and 150 microg/ml, respectively."	( Epidural, intrathecal and plasma pharmacokinetic study of epidural ropivacaine in PLGA-microspheres in sheep model. Bec, D; Chevanne, F; Dollo, G; Ecoffey, C; Estebe, JP; Le Corre, P; Malinovsky, JM; Ratajczak-Enselme, M, 2009)	0.35
"During orthopaedic surgery of the limb, we performed a prospective, double blind controlled study on three parallel groups in 30 patients to evaluate the pharmacokinetic and pharmacodynamic effect of infiltration of the iliac crest bone graft harvest site with 20 ml of bupivacaine (100 mg), ropivacaine (150 mg) or saline as control group (n = 10 in each group)."	( Local anaesthetic use for the iliac crest-donor site: pharmacokinetic and pharmacodynamic evaluations. Chevanne, F; Ecoffey, C; Eliat, C; Estebe, JP; Husson, JL; Le Corre, P; Le Naoures, A, 2009)	0.35
" The main pharmacokinetic parameters in group A and B were: Cmax (3."	( [Clinical efficacy and pharmacokinetics of different concentrations of ropivacaine with the same dosage on blocking lumbar plexus with sciatic nerves]. Cao, W; Xu, HW; Zhang, L; Zhang, WS; Zhang, X, 2009)	0.35
" The plasma concentration-time curve for ropivacaine fits into a two-compartment pharmacokinetic model."	( [Clinical efficacy and pharmacokinetics of different concentrations of ropivacaine with the same dosage on blocking lumbar plexus with sciatic nerves]. Cao, W; Xu, HW; Zhang, L; Zhang, WS; Zhang, X, 2009)	0.35
" After blood samples collection, ropivacaine serum concentrations and pharmacokinetic parameters were determined."	( Effects of induced hyperthermia on pharmacokinetics of ropivacaine in rats. Boulamery, A; Bruguerolle, B; Deluca, B; Deturmeny, E; Guilhaumou, R, 2010)	0.36
" Pharmacokinetic parameters were calculated using both noncompartmental and compartmental analysis."	( The pharmacokinetics of ropivacaine after intraperitoneal administration: instillation versus nebulization. Betton, D; Diemunsch, P; Greib, N; Joshi, GP; Schlotterbeck, H; Ubeaud-Sequier, G, 2010)	0.36
"The pharmacokinetic profile of ropivacaine nebulization is similar to direct intraperitoneal instillation, but with a lower absorption rate."	( The pharmacokinetics of ropivacaine after intraperitoneal administration: instillation versus nebulization. Betton, D; Diemunsch, P; Greib, N; Joshi, GP; Schlotterbeck, H; Ubeaud-Sequier, G, 2010)	0.36
" The relationship between pharmacokinetic parameters and creatinine clearance (CL(CR)) was assessed."	( Pharmacokinetics of ropivacaine in patients with chronic renal failure. Ekstrand, A; Henriksson, J; Honkanen, E; Pere, PJ; Rosenberg, PH; Salonen, M; Sjövall, J, 2011)	0.37
"One-compartment first-order pharmacokinetic models incorporating linear binding of ropivacaine and PPX to α(1)-acid glycoprotein were used."	( Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children. Aarons, L; Henriksson, J; Molnár, V; Pitsiu, M; Sadler, B; Sjövall, J, 2011)	0.37
"To investigate the pharmacokinetic profile of ropivacaine after bilateral TAP blocks."	( Potentially toxic concentrations in blood of total ropivacaine after bilateral transversus abdominis plane blocks; a pharmacokinetic study. Breindahl, T; Hansen, EG; Mitchell, AU; Møller, AM; Rosenberg, J; Torup, H, 2012)	0.38
"Prospective observational pharmacokinetic study."	( Potentially toxic concentrations in blood of total ropivacaine after bilateral transversus abdominis plane blocks; a pharmacokinetic study. Breindahl, T; Hansen, EG; Mitchell, AU; Møller, AM; Rosenberg, J; Torup, H, 2012)	0.38
"No pharmacokinetic data exist on doses of ropivacaine larger than 300 mg for peripheral nerve block in man, although in clinical practice higher doses are frequently used."	( Pharmacokinetics of 450 mg ropivacaine with and without epinephrine for combined femoral and sciatic nerve block in lower extremity surgery. A pilot study. Jack, NT; Schoenmakers, KP; Stienstra, R; van den Bemt, B; van Limbeek, J; Vree, TB, 2013)	0.39
" Pharmacokinetic parameters were calculated using a non-compartmental approach."	( Pharmacokinetics of 450 mg ropivacaine with and without epinephrine for combined femoral and sciatic nerve block in lower extremity surgery. A pilot study. Jack, NT; Schoenmakers, KP; Stienstra, R; van den Bemt, B; van Limbeek, J; Vree, TB, 2013)	0.39
" The purpose of this study was to develop a population pharmacokinetic model for ropivacaine after loco-regional administration and to identify patient characteristics that may influence the drug's absorption and disposition."	( A population pharmacokinetic model for the complex systemic absorption of ropivacaine after femoral nerve block in patients undergoing knee surgery. Drolet, P; Fallaha, M; Gaudreault, F; Varin, F, 2012)	0.38
" Pharmacokinetic parameters were calculated using noncompartmental analysis."	( Pharmacokinetics and efficacy of ropivacaine in Chinese patients following intra-articular administration. Chen, S; Chen, Z; Jin, Y; Lin, J; Lin, X; Tian, Z; Xu, L; Xu, S; Zhu, M, 2013)	0.39
"Ropivacaine 150 mg provided satisfactory postoperative pain relief and can be safely administered by intraarticular injection in Chinese patients after arthroscopic knee surgery and the pharmacokinetic profiles of ropivacaine exhibited marked variability among the subjects."	( Pharmacokinetics and efficacy of ropivacaine in Chinese patients following intra-articular administration. Chen, S; Chen, Z; Jin, Y; Lin, J; Lin, X; Tian, Z; Xu, L; Xu, S; Zhu, M, 2013)	0.39
"The aim of this study was to develop a pharmacokinetic model in order to characterize the free and total ropivacaine concentrations after transversus abdominis plane block in a population of patients undergoing liver resection surgery."	( Population pharmacokinetic model of free and total ropivacaine after transversus abdominis plane nerve block in patients undergoing liver resection. Beauchesne, B; Bonnet, C; Delavenne, X; Heritier, F; Hodin, S; Molliex, S; Ollier, E, 2015)	0.42
" A pharmacokinetic model was built using a nonlinear mixed-effect modelling approach."	( Population pharmacokinetic model of free and total ropivacaine after transversus abdominis plane nerve block in patients undergoing liver resection. Beauchesne, B; Bonnet, C; Delavenne, X; Heritier, F; Hodin, S; Molliex, S; Ollier, E, 2015)	0.42
"Although large liver resections were associated with lower free ropivacaine clearance, the ropivacaine pharmacokinetic profile remained within the safe range after this type of surgery."	( Population pharmacokinetic model of free and total ropivacaine after transversus abdominis plane nerve block in patients undergoing liver resection. Beauchesne, B; Bonnet, C; Delavenne, X; Heritier, F; Hodin, S; Molliex, S; Ollier, E, 2015)	0.42
" There are no pharmacodynamic data regarding the addition of dexmedetomidine to local anaesthetics for perineural administration."	( A pharmacodynamic evaluation of dexmedetomidine as an additive drug to ropivacaine for peripheral nerve blockade: A randomised, triple-blind, controlled study in volunteers. Keplinger, M; Kettner, SC; Kimberger, O; Marhofer, D; Marhofer, P; Zeitlinger, M, 2015)	0.42
" Typical ke0 half-life was 34."	( Modeling the anesthetic effect of ropivacaine after a femoral nerve block in orthopedic patients: a population pharmacokinetic-pharmacodynamic analysis. Drolet, P; Fallaha, M; Gaudreault, F; Varin, F, 2015)	0.42
" The safety profile of different drugs can be better estimated by comparing their pharmacokinetic profiles than by considering their objective side effects."	( A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial. Allegri, M; Braschi, A; Cusato, M; De Andrés, J; Fanelli, G; Ingelmo, P; Niebel, TL; Perotti, L; Regazzi, M; Riva, F; Somaini, M; Tinelli, C, 2015)	0.42
" The plasma concentrations of ropivacaine approached the Cmax significantly faster than those of levobupivacaine."	( A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial. Allegri, M; Braschi, A; Cusato, M; De Andrés, J; Fanelli, G; Ingelmo, P; Niebel, TL; Perotti, L; Regazzi, M; Riva, F; Somaini, M; Tinelli, C, 2015)	0.42
" Adjusting for weight and sex further improved the propofol pharmacokinetic model."	( Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients. Dahan, A; Lesman, A; Olofsen, E; Sitsen, E; Vuyk, J, 2016)	0.43
" An epidural-induced reduction in hepatic and/or renal blood flow may explain this pharmacokinetic interaction."	( Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients. Dahan, A; Lesman, A; Olofsen, E; Sitsen, E; Vuyk, J, 2016)	0.43
"There was no difference in Cmax (2."	( A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs. Aharon, A; Davidson, EM; Ginosar, Y; Haroutounian, S; Kagan, L; Naveh, M, 2016)	0.43
" In this study, we present both pharmacodynamic and pharmacokinetic data in healthy volunteers after subcutaneous injection of this novel proliposomal preparation of ropivacaine."	( Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers. Aharon, A; Davidson, EM; Ginosar, Y; Haroutounian, S; Kagan, L; Naveh, M, 2016)	0.43
"The prolonged pharmacodynamic effect of proliposomal ropivacaine, together with its delayed elimination and prolonged redistribution to plasma, is compatible to depot-related slow-release and similar to the performance of other liposomal local anesthetics."	( Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers. Aharon, A; Davidson, EM; Ginosar, Y; Haroutounian, S; Kagan, L; Naveh, M, 2016)	0.43
" This reservation is due to anatomical concerns and lack of pharmacokinetic data."	( Feasibility and pharmacokinetics of caudal blockade in children and adolescents with 30-50 kg of body weight. Keplinger, M; Kettner, SC; Klug, W; Korf, L; Marhofer, D; Marhofer, P; Reiter, B; Stimpfl, T; Triffterer, L; Zeitlinger, M, 2016)	0.43
"Based on our pharmacodynamic and pharmacokinetic results, we suggest that the body weight of 50 kg it is feasible to perform effective and safe caudal blockade in children up to 50 kg body weight."	( Feasibility and pharmacokinetics of caudal blockade in children and adolescents with 30-50 kg of body weight. Keplinger, M; Kettner, SC; Klug, W; Korf, L; Marhofer, D; Marhofer, P; Reiter, B; Stimpfl, T; Triffterer, L; Zeitlinger, M, 2016)	0.43
" Peak concentration was decreased by 26 to 30% in the subjects receiving Intralipid®."	( Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study. Benhamou, D; Charbit, B; Dureau, P; Mazoit, JX; Nicolas, N, 2016)	0.43
" To observe the safety of administering different doses of ropivacaine for cesarean section and its pharmacodynamic mechanism, we randomly divided 180 pregnant women undergoing cesarean section into three groups: group A, 10 mg ropivacaine (0."	( Safety and pharmacodynamic mechanism of ropivacaine lumbar anesthesia in Cesarean section. Li, ML; Liu, Q; Qin, CW; Wang, JJ; Wang, YQ; Yan, HY, )	0.13
" Despite the high doses of ropivacaine, LIA is considered safe, and this perception is sustained by pharmacokinetic data demonstrating that maximum concentrations of ropivacaine stay well below the toxic threshold in plasma."	( Pharmacokinetics of 400 mg Locally Infiltrated Ropivacaine After Total Knee Arthroplasty Without Perioperative Tourniquet Use. Bakker, SMK; Fenten, MGE; Heesterbeek, PJC; Scheffer, GJ; Stienstra, R; Touw, DJ; van den Bemt, BJF, 2018)	0.48
" A population pharmacokinetic model was built using non-linear mixed-effects models."	( Population pharmacokinetics of ropivacaine used for local infiltration anaesthesia during primary total unilateral and simultaneous bilateral knee arthroplasty. Foss, NB; Grassin-Delyle, S; Gromov, K; Husted, H; Lamy, E; Nielsen, CS; Pedersen, LM; Troelsen, A; Urien, S, 2021)	0.62
"Therapeutic agents with a short half-life need to be administered frequently to achieve sustained and effective concentrations."	( Population pharmacokinetic analysis of ropivacaine extended-release from a temperature-responsive hydrogel in rats. Bang, JY; Choi, BM; Hwang, CS; Lee, EK; Nam, S, 2021)	0.62
" Pharmacokinetic data are needed to guide safe dosing."	( Population pharmacokinetic and safety analysis of ropivacaine used for erector spinae plane blocks. Abulfathi, AA; Baratta, JL; Gebhart, A; Kaushal, G; Lam, E; Mohamod, D; Rochani, A; Roy, AB; Sarna, RR; Schmidt, S; Schwenk, ES; Viscusi, ER; Witzeling, SD; Zhao, JL, 2023)	0.91
" Second, the ropivacaine concentrations in plasma were determined, pharmacokinetic parameters were calculated, and the anesthetic effects of RODD were studied, including RODD onset time, duration and intensity of nerve block."	( A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects. Cao, YX; Chi, P; Dong, JP; Hui, MQ; Jiao, YQ; Lu, WD; Ma, B; Tian, Y; Wang, MX; Yang, B; Yang, Y; Zhang, HB; Zhang, M; Zhao, DL, 2023)	0.91
" Compared with the 150 mg RHI group, Tmax was longer in the RODD groups."	( A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects. Cao, YX; Chi, P; Dong, JP; Hui, MQ; Jiao, YQ; Lu, WD; Ma, B; Tian, Y; Wang, MX; Yang, B; Yang, Y; Zhang, HB; Zhang, M; Zhao, DL, 2023)	0.91
" Compared with the RHI group, Tmax was delayed in the RODD groups, and the duration of nerve block was long."	( A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects. Cao, YX; Chi, P; Dong, JP; Hui, MQ; Jiao, YQ; Lu, WD; Ma, B; Tian, Y; Wang, MX; Yang, B; Yang, Y; Zhang, HB; Zhang, M; Zhao, DL, 2023)	0.91

Excerpt	Reference	Relevance
"Our aim in this prospective, randomized, double-blinded study was to compare the analgesic effectiveness and side effects of epidural infusions with ropivacaine 2 mg/mL alone (Group R; n = 60) and in combination with fentanyl 1 microg/mL (R1F; n = 59), 2 microg/mL (R2F; n = 62), and 4 microg/mL (R4F; n = 63) for up to 72 h after major abdominal surgery."	( A comparison of epidural ropivacaine infusion alone and in combination with 1, 2, and 4 microg/mL fentanyl for seventy-two hours of postoperative analgesia after major abdominal surgery. Blake, D; Buckland, M; Etches, R; Gustafsson, U; Halliwell, R; Huizar, K; Marsland, C; Merridew, G; Murphy, D; Paech, M; Schug, SA; Scott, DA; Turner, G; Walker, S, 1999)	0.3
" Epidural catheters were inserted at T8-T9 (upper abdominal surgery) or T9-T11 (lower abdominal surgery) and ropivacaine 0,5% 7-9 ml (upper abdominal surgery) or 10-12 ml (lower abdominal surgery) combined with sufentanil 30 mcg (group S, n=30) or with morphine 2 mg (group M, n=30) was injected."	( [Sufentanil vs morphine combined with ropivacaine for thoracic epidural analgesia in major abdominal surgery]. Borghi, B; Clara, ME; De Paolis, P; Gianferrari, P; Marzullo, A; Montone, N; Voltolina, M, 2001)	0.31
"Continuous administration of epidural ropivacaine combined with sufentanil or with morphine resulted in good analgesia."	( [Sufentanil vs morphine combined with ropivacaine for thoracic epidural analgesia in major abdominal surgery]. Borghi, B; Clara, ME; De Paolis, P; Gianferrari, P; Marzullo, A; Montone, N; Voltolina, M, 2001)	0.31
" An opioid can be combined with local anaesthetic to reduce the incidence of side-effects and to improve analgesia for the relief of labour pain."	( Comparison of bupivacaine 0.2% and ropivacaine 0.2% combined with fentanyl for epidural analgesia during labour. Alkiş, N; Aşik, I; Göktuğ, A; Gülay, I; Uysalel, A, 2002)	0.31
"2% combined with fentanyl produced equivalent analgesia for pain relief during labour and delivery."	( Comparison of bupivacaine 0.2% and ropivacaine 0.2% combined with fentanyl for epidural analgesia during labour. Alkiş, N; Aşik, I; Göktuğ, A; Gülay, I; Uysalel, A, 2002)	0.31
" Few data are available concerning dose requirements of epidural ROPI when combined with morphine."	( A comparison of 0.1% and 0.2% ropivacaine and bupivacaine combined with morphine for postoperative patient-controlled epidural analgesia after major abdominal surgery. Joris, JL; Lahaye-Goffart, B; Lamy, ML; Ledoux, D; Senard, M; Toussaint, PJ, 2002)	0.31
"To investigate the pain-relieving effects of ropivacaine or its combination with fentanyl in postoperative patient-controlled epidural analgesia."	( [Ropivacaine or its combination with fentanyl for postoperative patient-controlled epidural analgesia]. Chen, M; Chen, YM; Gu, MN; Liang, SW; Lin, CS; Xiao, JF, 2003)	0.32
" In this study, we compared the efficacy, dose requirements, side effects, and motor block observed with epidural levobupivacaine and ropivacaine when given in combination with small-dose morphine for 60 h after major abdominal surgery."	( Epidural levobupivacaine 0.1% or ropivacaine 0.1% combined with morphine provides comparable analgesia after abdominal surgery. Geortay, MN; Honoré, PD; Jacquemin, MJ; Joris, JL; Kaba, A; Lamy, ML; Maquoi, LM; Senard, M, 2004)	0.32
"1%) of epidural levobupivacaine and ropivacaine combined with morphine (0."	( Epidural levobupivacaine 0.1% or ropivacaine 0.1% combined with morphine provides comparable analgesia after abdominal surgery. Geortay, MN; Honoré, PD; Jacquemin, MJ; Joris, JL; Kaba, A; Lamy, ML; Maquoi, LM; Senard, M, 2004)	0.32
"Using ropivacaine combined with sufentanil, we determined the analgesic efficacy of parturient-controlled epidural analgesia (PCEA) with or without (demand-only PCEA) continuous background infusion in reducing labor pain in 66 parturients."	( Comparison of continuous background infusion plus demand dose and demand-only parturient-controlled epidural analgesia (PCEA) using ropivacaine combined with sufentanil for labor and delivery. Ackermann, HH; Bremerich, DH; Byhahn, C; Meininger, D; Mierdl, S; Waibel, HJ; Zwissler, BC, 2005)	0.33
" Thoracic epidural anesthesia (TEA) is one of the regional anesthetic techniques that can be done by using a low dose of local anesthetic in combination with ipsilateral brachial plexus block (BPB) for axillary node dissection."	( Thoracic epidural anesthesia (TEA) with 0.2% ropivacaine in combination with ipsilateral brachial plexus block (BPB) for modified radical mastectomy (MRM). Kongdan, Y; Pasutharnchat, K; Sundarathiti, P; Suranutkarin, PE, 2005)	0.33
"To compare and estimate the safety and efficacy of a new viscoelastic substance combined with anaesthetic used in phacoemulsification surgery."	( The use of a new viscoelastic substance combined with anaesthetic in cataract surgery by phacoemulsification. Bournas, P; Condilis, N; Kanellas, D; Lioumi, D; Syndikakis, K; Vaikoussis, E, )	0.13
"To investigate the effects, side-effects and security of bupivacaine, ropivacaine combined with fentanyl in postoperative continuous epidural analgesia."	( [Security evaluation of bupivacaine, ropivacaine combined with fentanyl in postoperative continuous epidural analgesia]. Huang, HQ; Huang, QQ; Su, MX; Wan, LJ; Wan, XH, 2006)	0.33
" The current trial describes the dose-response relation of levobupivacaine, ropivacaine, and bupivacaine, combined with sufentanil, when used for intrathecal labor analgesia."	( Determination of the full dose-response relation of intrathecal bupivacaine, levobupivacaine, and ropivacaine, combined with sufentanil, for labor analgesia. Deprest, J; Dreelinck, R; Dubois, J; Kumar, A; Lewi, L; Van de Velde, M; Vandermeersch, E, 2007)	0.34
"Although caudal morphine may result in more sustained initial analgesia, caudal clonidine combined with nurse-controlled analgesia appears to provide comparable analgesia with fewer side effects."	( A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation. Carvallo, D; Johnson, JL; Mazurek, MS; Presson, RG; Vetter, TR, 2007)	0.34
"125%), all in combination with sufentanil 1 microg/mL with regard to postoperative pain relief and absence of motor block in a patient-controlled epidural analgesia setting."	( Postoperative epidural analgesia after total knee arthroplasty with sufentanil 1 microg/ml combined with ropivacaine 0.2%, ropivacaine 0.125%, or levobupivacaine 0.125%: a randomized, double-blind comparison. Dahan, A; Rose, L; Sitsen, E; Stienstra, R; van Alphen, W; van Poorten, F, )	0.13
"To investigate the effect of epidural ropivacaine in combination with fentanyl for labor analgesia on the clinical outcome of labor."	( [Influence of epidural ropivacaine in combination with fentanyl for labor analgesia on the clinical outcome of labor]. Chen, TM; Li, CX; Li, Q; Liu, Y; Xue, WN, 2008)	0.35
"15% ropivacaine in combination with fentany (1microg/ml) and 175 without epidural analgesia."	( [Influence of epidural ropivacaine in combination with fentanyl for labor analgesia on the clinical outcome of labor]. Chen, TM; Li, CX; Li, Q; Liu, Y; Xue, WN, 2008)	0.35
"Epidural ropivacaine in combination with fentanyl in labor can decrease the incidence of cesarean section, and the duration of the active stage can be shortened with application of ocytocin."	( [Influence of epidural ropivacaine in combination with fentanyl for labor analgesia on the clinical outcome of labor]. Chen, TM; Li, CX; Li, Q; Liu, Y; Xue, WN, 2008)	0.35
"This study evaluated the effectiveness of a continuous interscalene block (CISB) by comparing it with that of a single interscalene block combined with a continuous intra-bursal infusion of ropivacaine (ISB-IB) after arthroscopic rotator cuff repair."	( Comparison of analgesic efficacy between single interscalene block combined with a continuous intra-bursal infusion of ropivacaine and continuous interscalene block after arthroscopic rotator cuff repair. Kim, SH; Lee, JW; Lee, PB; Lee, SJ; Oh, JH; Rhee, KY, 2009)	0.35
"In interscalene block combined with lidocaine, ropivacaine had slower onset of motor block and longer duration of both blocks than bupivacaine."	( Comparison of the motor and sensory block by ropivacaine and bupivacaine in combination with lidocaine in interscalene block. Nishiyama, T, 2012)	0.38
" We designed this study to investigate whether epidural anaesthesia with a goal-directed approach, when combined with general anaesthesia, improved haemodynamic stability in elderly patients undergoing major abdominal surgery."	( Epidural anaesthesia with goal-directed administration of ropivacaine improves haemodynamic stability when combined with general anaesthesia in elderly patients undergoing major abdominal surgery. Xiao, WP; Yun, X; Zhou, QH, 2013)	0.39
"To compare haemodynamic effects of general anaesthesia in combination with epidural block and without it during kidney transplantation in Pediatric patients."	( [Haemodynamics during kidney transplantation and general anaesthesia in combination with epidural block and without it in pediatric patients]. Ectov, DB; Kochkin, VS; Lazarev, VV; Salmasi, KG; Tsypin, LE; Valov, AL, )	0.13
"1 mg kg(-1) dexamethasone combined with ropivacaine improves analgesic efficacy in children undergoing day-case orchiopexy."	( Analgesic efficacy of caudal dexamethasone combined with ropivacaine in children undergoing orchiopexy. Im, YJ; Kim, EM; Koo, BN; Lee, JH; Lee, JR; Oh, HJ, 2014)	0.4
"The aim of this study was to evaluate the analgesic efficacy and safety of rectus sheath block combined with intraperitoneal instillation using two doses of ropivacaine in patients undergoing laparoscopic gynecological surgery."	( [Analgesic efficacy and clinical safety of intraperitoneal instillation combined with rectus sheath block using ropivacaine for pain relief after laparoscopic gynecological surgery]. Hashimoto, H; Hirota, K; Kitayama, M; Kudo, M; Kudo, T; Niwa, H; Yakoshi, C, 2014)	0.4
"The aim of this study was to compare the results of ultrasonographically guided axillary nerve block (ANB) combined with suprascapular nerve block (SSNB) with those of SSNB alone on postoperative pain and satisfaction within the first 48 hours after arthroscopic rotator cuff repair."	( Effect of ultrasonographically guided axillary nerve block combined with suprascapular nerve block in arthroscopic rotator cuff repair: a randomized controlled trial. Hwang, JT; Hwang, SM; Jo, YG; Kim, DY; Kim, GH; Lee, JJ; Lee, SS, 2014)	0.4
"Ultrasonographically guided ANB combined with SSNB in arthroscopic rotator cuff repair showed an improved mean VAS in the first 24 hours after surgery compared with SSNB alone."	( Effect of ultrasonographically guided axillary nerve block combined with suprascapular nerve block in arthroscopic rotator cuff repair: a randomized controlled trial. Hwang, JT; Hwang, SM; Jo, YG; Kim, DY; Kim, GH; Lee, JJ; Lee, SS, 2014)	0.4
" The purpose of this systematic review and meta-analysis is to compare the efficacy and safety of bupivacaine with ropivacaine and levobupivacaine in combination with sufentanil (BUPI-, ROPI-, and LBUPI-SUF respectively) in epidural analgesia for labor."	( Efficacy and safety of local anesthetics bupivacaine, ropivacaine and levobupivacaine in combination with sufentanil in epidural anesthesia for labor and delivery: a meta-analysis. Fang, F; Lv, BS; Mi, WD; Wang, JH; Wang, W; Wang, XW; Wang, ZQ, 2014)	0.4
"The neurotoxicity of lidocaine was significantly increased when combined with ropivacaine."	( Intrathecal lidocaine neurotoxicity: combination with bupivacaine and ropivacaine and effect of nerve growth factor. Chen, W; Ding, X; Guo, Y; Zhao, G, 2014)	0.4
"Ropivacaine is not safe when intrathecally administered with lidocaine at the concentrations used in this study."	( Intrathecal lidocaine neurotoxicity: combination with bupivacaine and ropivacaine and effect of nerve growth factor. Chen, W; Ding, X; Guo, Y; Zhao, G, 2014)	0.4
"To explore the anesthetic effect and neonatal effects of dexmedetomidine combined with ropivacaine in the cesarean section under epidural anesthesia."	( [Application of dexmedetomidine combined with ropivacaine in the cesarean section under epidural anesthesia]. Ding, Z; Han, C; Jiang, X; Wu, X, 2014)	0.4
"Administration of dexmedetomidine combined with ropivacaine can provide early onset, establishment of sensory anesthesia, much better sedation levels, decrease the degree of traction reaction and the incidence of shivering, and without adverse neonatal effects."	( [Application of dexmedetomidine combined with ropivacaine in the cesarean section under epidural anesthesia]. Ding, Z; Han, C; Jiang, X; Wu, X, 2014)	0.4
"To investigate cardiorespiratory effects and serum concentration of ropivacaine combined with morphine at different doses."	( Effects of ropivacaine combined with morphine at 0.15 and 0.2 mg kg(-1) in bitches undergoing epidural anesthesia. Albuquerque, VB; Araújo, MA; Arruda, AM; Ferreira, GT; Fonseca, MW; Oliva, VN; ShiChen, L, 2015)	0.42
"In combination with fentanyl, bupivacaine and ropivacaine exhibit comparable efficacy and safety."	( Epidural analgesia with amide local anesthetics, bupivacaine, and ropivacaine in combination with fentanyl for labor pain relief: a meta-analysis. Fan, Y; Hu, C; Li, Y; Wang, H; Xu, H, 2015)	0.42
" We investigated the efficacy of the continuous intravenous infuion of fentanyl combined with intercostal nerve block, in comparison with the continuous epidural analgesia."	( [Postoperative Analgesia for Video-assisted Thoracoscopic Surgery--Continuous Intravenous Infusion of Fentanyl Combined with Intercostal Nerve Block v.s. Continuous Epidural Analgesia]. Hiro, K; Kurata, M; Oi, Y; Okuda, M; Sugiyama, T, 2016)	0.43
"Continuous intravenous infusion of fentanyl combined with intercostal nerve block is effective in the postoperative analgesia for VATS, as well as continuous epidural analgesia."	( [Postoperative Analgesia for Video-assisted Thoracoscopic Surgery--Continuous Intravenous Infusion of Fentanyl Combined with Intercostal Nerve Block v.s. Continuous Epidural Analgesia]. Hiro, K; Kurata, M; Oi, Y; Okuda, M; Sugiyama, T, 2016)	0.43
"Low-dose ropivacaine combined with intrathecal fentanyl can provide adequate anaesthesia with minimal haemodynamic variation."	( EFFECT OF PREOPERATIVE INTRAVENOUS OXYCODONE ON LOW-DOSE ROPIVACAINE SPINAL ANESTHESIA COMBINED WITH INTRATHECAL FENTANYL. Fu, Y; Wang, J; Wang, N; Zhang, S, 2016)	0.43
"To assess the efficacy of preoperative intravenous oxycodone on transurethral resection of prostate (TURP) under 10 mg ropivacaine spinal anaesthesia combined with intrathecal 25 pg fentanyl."	( EFFECT OF PREOPERATIVE INTRAVENOUS OXYCODONE ON LOW-DOSE ROPIVACAINE SPINAL ANESTHESIA COMBINED WITH INTRATHECAL FENTANYL. Fu, Y; Wang, J; Wang, N; Zhang, S, 2016)	0.43
"125%) combined with dexmedetomidine (0."	( Effect of Epidural Dexmedetomidine Combined With Ropivacaine in Labor Analgesia: A Randomized Double-Blinded Controlled Study. Liu, Y; Xin, Y; Yi, X; Zhao, Y, 2017)	0.46
" The incidence of adverse events and the analgesic effect of ropivacaine combined with dexmedetomidine for incision infiltration were recorded."	( The Analgesic Effect of Ropivacaine Combined With Dexmedetomidine for Incision Infiltration After Laparoscopic Cholecystectomy. Dong, CS; Lu, Y; Sun, H; Wu, C; Yu, JM; Zhang, Y, 2016)	0.43
" They were randomly divided into 2 groups (n=50 each): CFNB group, CFNB combined with PLIA group (PLIA group)."	( [Effect of continuous femoral nerve block combined with periarticular local infiltration analgesia on early operative functional recovery after total knee arthroplasty: a randomized double-blind controlled study]. Deng, Y; Guo, XY; Jiang, TL; Li, M; Wang, J; Yang, XX, 2017)	0.46
"To observe the anesthetic effect and safety of different doses of dexmedetomidine combined with ropivacaine for brachial plexus nerve block in children undergoing polydactyly surgery."	( [Effects of different doses of dexmedetomidine combined with ropivacaine for brachial plexus nerve block in children undergoing polydactyly surgery]. Chen, XN; Li, YL; Qi, DM; Sun, WG; Sun, YJ; Yang, SH, 2017)	0.46
" The aim of this study was to observe clinical and imaging outcomes of application of gelatin sponge impregnated with a mixture of 3 drugs to intraoperative nerve root block combined with robot-assisted minimally invasive transforaminal lumbar interbody fusion surgery in to treat adult degenerative lumbar scoliosis."	( Application of Gelatin Sponge Impregnated with a Mixture of 3 Drugs to Intraoperative Nerve Root Block Combined with Robot-Assisted Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery in the Treatment of Adult Degenerative Scoliosis: A Clini Chang Liu, S; Du, JP; Fan, Y; Hao, D; Liu, JJ; Zhang, JN, 2017)	0.46
"From January 2012 to November 2014, 108 patients with adult degenerative lumbar scoliosis were treated with robot-assisted minimally invasive transforaminal lumbar interbody fusion surgery combined with intraoperative gelatin sponge impregnated with a mixture of 3 drugs."	( Application of Gelatin Sponge Impregnated with a Mixture of 3 Drugs to Intraoperative Nerve Root Block Combined with Robot-Assisted Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery in the Treatment of Adult Degenerative Scoliosis: A Clini Chang Liu, S; Du, JP; Fan, Y; Hao, D; Liu, JJ; Zhang, JN, 2017)	0.46
"Application of gelatin sponge impregnated with 3 drugs combined with robot-assisted minimally invasive transforaminal lumbar interbody fusion for treatment of adult degenerative lumbar scoliosis is safe and feasible with advantages of good short-term analgesia effect, minimal invasiveness, short length of stay, and good long-term clinical outcomes."	( Application of Gelatin Sponge Impregnated with a Mixture of 3 Drugs to Intraoperative Nerve Root Block Combined with Robot-Assisted Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery in the Treatment of Adult Degenerative Scoliosis: A Clini Chang Liu, S; Du, JP; Fan, Y; Hao, D; Liu, JJ; Zhang, JN, 2017)	0.46
"This study assessed the utility of ultrasound-guided lateral transversus abdominis plane (TAP) block combined with rectus sheath (RS) block for peritoneal dialysis catheter placement surgery."	( Ultrasound-guided left lateral transversus abdominis plane block combined with rectus sheath block in peritoneal dialysis catheter placement. Dai, W; Liu, J; Liu, X; Lu, Y; Mei, B; Tang, L, 2018)	0.48
"This randomized controlled study investigated the analgesic effect of ropivacaine in combination with dexmedetomidine versus ropivacaine alone on brachial plexus block to provide alternative anesthetic means for upper limb trauma surgery."	( Analgesic effect of Ropivacaine combined with Dexmedetomidine on brachial plexus block. Hua, H; Jiang, M; Liu, Z; Xu, T, 2018)	0.48
" The patients were randomized to ropivacaine alone (the control group) or ropivacaine combined with dexmedetomidine (the combination group)."	( Analgesic effect of Ropivacaine combined with Dexmedetomidine on brachial plexus block. Hua, H; Jiang, M; Liu, Z; Xu, T, 2018)	0.48
"The brachial plexus blocking effect of ropivacaine combined with dexmedetomidine was superior to that of ropivacaine alone, mainly intra-operatively and postoperatively."	( Analgesic effect of Ropivacaine combined with Dexmedetomidine on brachial plexus block. Hua, H; Jiang, M; Liu, Z; Xu, T, 2018)	0.48
"Analgesic Effect of Ropivacaine Combined with Dexmedetomidine on Brachial Plexus Block, ChiCTR1800017372, retrospectively registered on July 26, 2018."	( Analgesic effect of Ropivacaine combined with Dexmedetomidine on brachial plexus block. Hua, H; Jiang, M; Liu, Z; Xu, T, 2018)	0.48
"The aim of the current study was to evaluate the clinical effects of the regular intermittent epidural injection combined with different puncture points (RIEI-dPP) in suppressing breakthrough pain during a labour analgesia."	( Clinical observation of regular intermittent epidural injection combined with different puncture points in suppressing breakthrough pain in labour analgesia. Jiang, H; Shi, B; Wu, C, 2019)	0.51
"BACKGROUND This study aimed to investigate the effectiveness of perioperative parecoxib sodium combined with transversus abdominis plane (TAP) block on postoperative pain management following hepatectomy in patients with hepatocellular carcinoma (HCC)."	( Effectiveness of Parecoxib Sodium Combined with Transversus Abdominis Plane Block for Pain Management After Hepatectomy for Hepatocellular Carcinoma: A Prospective Controlled Study. Jia, WD; Li, YQ; Lv, JG; Qiao, XF; Zhou, H, 2019)	0.51
"This study aims to investigate the clinical effect of dexmedetomidine (DEX) combined with low concentrations of ropivacaine in ultrasound-guided continuous fem-oral nerve block for postoperative analgesia in elderly patients with total knee arthroplasty (TKA)."	( Ultrasound-Guided Continuous Femoral Nerve Block with Dexmedetomidine Combined with Low Concentrations of Ropivacaine for Postoperative Analgesia in Elderly Knee Arthroplasty. Bai, XL; Cheng, ZJ; Guo, Z; Jia, PY; Li, YN; Yang, JX; Zhang, EF; Zhao, XY, 2019)	0.51
"To explore the effect of local infiltration of ropivacaine combined with multimodal analgesia with parecoxib for perioperative pain management in patients undergoing pancreaticoduodenectomy."	( [Efficacy of local infiltration of ropivacaine combined with multimodal analgesia with parecoxib for perioperative analgesia in patients undergoing pancreaticoduodenectomy]. Feng, H; Feng, J; Gao, M; Han, Q; Li, K; Xu, R, 2019)	0.51
"In patients undergoing pancreaticoduodenectomy, local infiltration of ropivacaine combined with multimodal analgesia with ropivacaine can effectively relieve perioperative pain, reduce the use of relief analgesics, lower the incidence of adverse reactions, and promote the recovery after the surgery."	( [Efficacy of local infiltration of ropivacaine combined with multimodal analgesia with parecoxib for perioperative analgesia in patients undergoing pancreaticoduodenectomy]. Feng, H; Feng, J; Gao, M; Han, Q; Li, K; Xu, R, 2019)	0.51
"To explore the analgesic effect of dizocine combined with ropivacaine on recurrent neuropathic pain in rat model of peripheral nerve compression."	( Analgesic Effect of Dizocine Combined with Ropivacaine on Recurrent Neuropathic Pain in Peripheral Nerve Compression Rats. Chu, C; Liu, Z; Ma, C; Sun, J; Zhang, X, 2020)	0.56
" The aim of this study was to compare the effects of DEX combined with ISB with ISB alone on postoperative pain, satisfaction, and pain-related cytokines within the first 48 h after arthroscopic rotator cuff repair."	( Dexmedetomidine combined with interscalene brachial plexus block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair. Hwang, JT; Hwang, SM; Jang, JS; Kim, DY; Kim, YB; Lee, HN; Lee, JJ; Lee, S; Lee, SS; Song, DK, 2020)	0.56
"To compare the application and efficacy of ropivacaine combined with sufentanil for continuous epidural anesthesia (CEA) and combined spinal-epidural anesthesia (CSEA) in labor analgesia."	( Comparison of ropivacaine combined with sufentanil for epidural anesthesia and spinal-epidural anesthesia in labor analgesia. Wang, Y; Xu, M, 2020)	0.56
" Ropivacaine combined with sufentanil were used in all subjects."	( Comparison of ropivacaine combined with sufentanil for epidural anesthesia and spinal-epidural anesthesia in labor analgesia. Wang, Y; Xu, M, 2020)	0.56
"Considering ropivacaine combined with sufentanil for CSEA achieved a shorter onset time and labor period, significant analgesic effect, lower adverse drug reactions rates and higher subject satisfaction than CEA, it may be worthy of clinical promotion and application."	( Comparison of ropivacaine combined with sufentanil for epidural anesthesia and spinal-epidural anesthesia in labor analgesia. Wang, Y; Xu, M, 2020)	0.56
" In this current study, we aimed to explore the effect of tumescence solution (TS) combined with negative pressure wound therapy (NPWT) on the relief of subcutaneous ecchymosis and pain after THLS of great saphenous vein."	( Effectiveness of tumescent solution combined with negative pressure wound therapy in traditional high ligation and stripping of the great saphenous vein. Cheng, L; Su, F; Tong, Q, 2020)	0.56
"Infiltration of the surgical site with local anesthetics combined with nonsteroidal anti-inflammatory drugs may play an important role in improving perioperative pain control."	( Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy. Bruno, TS; Cassu, RN; Costa Júnior, JS; de O L Carapeba, G; Giuffrida, R; Nicácio, GM; Nicácio, IPGA; Stelle, ABF; Teixeira Neto, FJ, 2020)	0.56
"To evaluate ultrasound-guided inactivation of myofascial trigger points (MTrPs) combined with abdominal muscle fascia stripping by liquid knife in the treatment of postherpetic neuralgia (PHN) complicated with abdominal myofascial pain syndrome (AMPS)."	( Ultrasound-Guided Inactivation of Trigger Points Combined with Muscle Fascia Stripping by Liquid Knife in Treatment of Postherpetic Neuralgia Complicated with Abdominal Myofascial Pain Syndrome: A Prospective and Controlled Clinical Study. Chang, XL; Gou, XJ; Liu, SL; Lu, XH; Xu, JY, 2020)	0.56
" However, patients with PHN complicated with AMPS need to be treated with ultrasound-guided MTrPs inactivation combined with muscle fascia stripping by liquid knife as soon as possible."	( Ultrasound-Guided Inactivation of Trigger Points Combined with Muscle Fascia Stripping by Liquid Knife in Treatment of Postherpetic Neuralgia Complicated with Abdominal Myofascial Pain Syndrome: A Prospective and Controlled Clinical Study. Chang, XL; Gou, XJ; Liu, SL; Lu, XH; Xu, JY, 2020)	0.56
"This prospective, randomized, controlled study aimed to explore the efficacy of dexmedetomidine combined with epidural blockade on postoperative recovery of elderly patients after radical resection for colorectal cancer."	( Protective effect of dexmedetomidine infusion combined with epidural blockade on postoperative complications after surgery: A prospective randomized controlled clinical trial. He, Z; Liu, Y; Sun, Z; Wu, X; Zhong, J; Zhu, X, 2020)	0.56
"To understand the effectiveness and safety of LA combined with ropivacaine in pain control for ankle arthroscopy."	( Local anesthesia combined with intra-articular ropivacaine can provide satisfactory pain control in ankle arthroscopic surgery: A retrospective cohort study. An, M; Dong, C; Gao, F; Hu, B; Li, C; Liu, Y; Qi, W; Su, X; Wei, M; Zhang, B, )	0.13
"This study aimed to investigate the effect of dexmedetomidine combined with ropivacaine on inflammatory factors in children with axillary brachial plexus block."	( Application of dexmedetomidine combined with ropivacaine in axillary brachial plexus block in children and its effect on inflammatory factors. Fan, W; Sun, J; Wang, B; Yang, H; Yang, Y; Zhang, H; Zhou, J, 2020)	0.56
"08% epidural ropivacaine via the DPE and CEI techniques combined with the PIEB mode of maintenance."	( A randomized trial of the dural puncture epidural technique combined with programmed intermittent epidural boluses for labor analgesia. Wang, J; Wang, Y; Xiao, P; Zhang, L; Zheng, L; Zhou, M, 2021)	0.62
" This study compared the effectiveness of epidural nalbuphine and sufentanil in combination with ropivacaine for labor analgesia, respectively."	( The Effect of Epidural Nalbuphine Combined With Ropivacaine on Epidural Analgesia During Labor: A Multicenter, Randomized, Double-blind, Controlled Study. Cao, R; Chen, Z; Huang, S; Sun, X; Tang, S; Zhou, M; Zhou, Q, 2021)	0.62
" We compared the efficiency and safety of ropivacaine alone (R group) and ropivacaine combined with dexmedetomidine (RD group)."	( Evaluation of ropivacaine combined with dexmedetomidine versus ropivacaine alone for epidural anesthesia: A meta-analysis. Deng, F; Liao, C; Wang, L; Wu, Q; Zhang, W; Zhao, J, 2021)	0.62
"This study aimed to evaluate the impact of Infiltration between the Popliteal Artery and Capsule of the posterior Knee (IPACK) combined with an adductor canal block under the guidance of ultrasound on early motor function after Total Knee Arthroplasty (TKA)."	( The impact of IPACK combined with adductor canal block under ultrasound guidance on early motor function after total knee arthroplasty. Chu, HC; Huang, H; Liu, YB; Liu, YZ; Ma, XJ; Xu, S; Zheng, FY, )	0.13
"A sample of 60 cases who were scheduled for elective unilateral TKA were divided into two groups using random number table method: a group with IPACK combined with an adductor canal block (I group, n = 30), and a group with femoral nerve block combined with superior popliteal sciatic nerve block (FS group, n = 30)."	( The impact of IPACK combined with adductor canal block under ultrasound guidance on early motor function after total knee arthroplasty. Chu, HC; Huang, H; Liu, YB; Liu, YZ; Ma, XJ; Xu, S; Zheng, FY, )	0.13
"Compared with femoral nerve block combined with superior popliteal sciatic nerve block, IPACK combined with adductor canal block had a mild impact on early motor functions after TKA."	( The impact of IPACK combined with adductor canal block under ultrasound guidance on early motor function after total knee arthroplasty. Chu, HC; Huang, H; Liu, YB; Liu, YZ; Ma, XJ; Xu, S; Zheng, FY, )	0.13
"To evaluate the effects of using ropivacaine combined with dexmedetomidine for sciatic and saphenous nerve blocks in dogs."	( Effects of perineural administration of ropivacaine combined with perineural or intravenous administration of dexmedetomidine for sciatic and saphenous nerve blocks in dogs. Ida, KK; Markuszewski, MJ; Marolf, V; Sandersen, C; Siluk, D; Struck-Lewicka, W, 2021)	0.62
"5% ropivacaine in combination with dexmedetomidine (1 μg/kg) for locoregional anesthesia in dogs seemed to balance the benefit of prolonging sensory nerve blockade while minimizing adverse effects."	( Effects of perineural administration of ropivacaine combined with perineural or intravenous administration of dexmedetomidine for sciatic and saphenous nerve blocks in dogs. Ida, KK; Markuszewski, MJ; Marolf, V; Sandersen, C; Siluk, D; Struck-Lewicka, W, 2021)	0.62
"Whether epidural administered sufentanil combined with low-concentration ropivacaine affected labor progress as well as maternal and neonatal outcomes still remained unknown."	( Impact of epidural labor analgesia using sufentanil combined with low-concentration ropivacaine on maternal and neonatal outcomes: a retrospective cohort study. Li, Y; Xu, C; Zhang, L, 2021)	0.62
"To study the effects of dexmedetomidine in combination with ropivacaine in patients undergoing craniocerebral surgery and their efficiency on cognitive function and inflammatory response of patients."	( Effect of Dexmedetomidine Combined with Ropivacaine on Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Craniocerebral Surgery. Liu, Y; Zhang, H; Zhang, W, 2021)	0.62
"Dexmedetomidine combined with ropivacaine has high application value in craniocerebral surgery."	( Effect of Dexmedetomidine Combined with Ropivacaine on Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Craniocerebral Surgery. Liu, Y; Zhang, H; Zhang, W, 2021)	0.62
"This research was aimed to study CT image features based on the backprojection filtering reconstruction algorithm and evaluate the effect of ropivacaine combined with dexamethasone and dexmedetomidine on assisted thoracoscopic lobectomy to provide reference for clinical diagnosis."	( Computerized Tomography Image Features under the Reconstruction Algorithm in the Evaluation of the Effect of Ropivacaine Combined with Dexamethasone and Dexmedetomidine on Assisted Thoracoscopic Lobectomy. Cui, Y; Lei, J; Sun, Y; Xia, M; Yao, D, 2021)	0.62
"Total knee arthroplasty (TKA) is a severe traumatic procedure, and femoral nerve block (FNB) combined with a sciatic nerve block (SNB) is widely used in TKA."	( Dexmedetomidine Combined with Femoral Nerve Block Provides Effective Analgesia Similar to Femoral Nerve Combined with Sciatic Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study. Jin, XB; Liu, C; Liu, LF; Luo, YR; Xiao, R; Xu, GH; Zhou, W, 2022)	0.72
"DEX combined with FNB could provide effective analgesia similar to SNB combined with FNB in TKA."	( Dexmedetomidine Combined with Femoral Nerve Block Provides Effective Analgesia Similar to Femoral Nerve Combined with Sciatic Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study. Jin, XB; Liu, C; Liu, LF; Luo, YR; Xiao, R; Xu, GH; Zhou, W, 2022)	0.72
" This study aimed to observe the analgesic effect of dexmedetomidine combined with ropivacaine erector spinae plane block (ESPB) used in posterior lumbar spine surgery."	( Dexmedetomidine combined with ropivacaine for erector spinae plane block after posterior lumbar spine surgery: a randomized controlled trial. Jie-Ting, L; Jun, L; Min, W; Rong, T; Sheng-Hui, H; Yan, Z; Yi, L; Yi-Han, W, 2022)	0.72
"To evaluate the efficacy of a perineural injection of dexmedetomidine combined with ropivacaine for reducing postoperative methadone requirements in dogs after tibial plateau levelling osteotomy (TPLO)."	( Effects of perineural dexmedetomidine combined with ropivacaine on postoperative methadone requirements in dogs after tibial plateau levelling osteotomy: a two-centre study. Marolf, V; Picavet, P; Sandersen, C; Selz, J; Spadavecchia, C; Tutunaru, A, 2022)	0.72
"Perineural dexmedetomidine combined with ropivacaine did not reduce postoperative methadone requirements in dogs after TPLO, but results may differ from one centre to another."	( Effects of perineural dexmedetomidine combined with ropivacaine on postoperative methadone requirements in dogs after tibial plateau levelling osteotomy: a two-centre study. Marolf, V; Picavet, P; Sandersen, C; Selz, J; Spadavecchia, C; Tutunaru, A, 2022)	0.72
"This review and meta-analysis comprehensively elaborated the analgesic and sedative effects of ropivacaine combined with dexmedetomidine in epidural labor analgesia, and its possible resulting motor block and adverse reactions."	( Evaluation of the effect of dexmedetomidine combined with ropivacaine in epidural labor analgesia: a systematic review and meta-analysis. Guo, G; Liu, W; Wen, J; Zhao, Y; Zhou, H, 2022)	0.72
"PubMed, Web of science, Cochrane, China National Knowledge Infrastructure and WANFANG DATA were searched for randomized controlled trials (RCTs) on the efficacy and safety of ropivacaine combined with dexmedetomidine in epidural labor analgesia."	( Evaluation of the effect of dexmedetomidine combined with ropivacaine in epidural labor analgesia: a systematic review and meta-analysis. Guo, G; Liu, W; Wen, J; Zhao, Y; Zhou, H, 2022)	0.72
"The present study aimed to investigate whether intratracheal dexmedetomidine combined with ropivacaine reduces the severity and incidence of postoperative sore throat after tracheal intubation under general anaesthesia."	( Effect of intratracheal dexmedetomidine combined with ropivacaine on postoperative sore throat: a prospective randomised double-blinded controlled trial. He, Y; Hu, R; Ning, R; Niu, J; Sun, H; Yang, N; Yu, J, 2022)	0.72
" The purpose of this study was to evaluate whether ACB combined with a LIA cocktail of ropivacaine, morphine, and betamethasone has superior analgesic effect than LIA for TKA."	( Adductor canal block combined with local infiltration analgesia with morphine and betamethasone show superior analgesic effect than local infiltration analgesia alone for total knee arthroplasty: a prospective randomized controlled trial. Chen, X; Luo, ZY; Wang, HY; Xiao, Q; Yu, QP; Zeng, WN; Zhou, Z, 2022)	0.72
" ACB combined with LIA had significantly lower resting and active VAS pain scores, better ROM, better sleeping quality and higher satisfaction rates than LIA alone within 72 h postoperatively (P < 0."	( Adductor canal block combined with local infiltration analgesia with morphine and betamethasone show superior analgesic effect than local infiltration analgesia alone for total knee arthroplasty: a prospective randomized controlled trial. Chen, X; Luo, ZY; Wang, HY; Xiao, Q; Yu, QP; Zeng, WN; Zhou, Z, 2022)	0.72
"Adductor canal block combined with Local infiltration analgesia provide better early pain control."	( Adductor canal block combined with local infiltration analgesia with morphine and betamethasone show superior analgesic effect than local infiltration analgesia alone for total knee arthroplasty: a prospective randomized controlled trial. Chen, X; Luo, ZY; Wang, HY; Xiao, Q; Yu, QP; Zeng, WN; Zhou, Z, 2022)	0.72
"This study aimed to investigate the effect of ropivacaine with dexmedetomidine or dexamethasone in a thoracic paravertebral nerve block (TPVB) combined with an erector spinae plane block (ESPB) for thoracoscopic lobectomy analgesia."	( Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial. Feng, XY; Lei, YJ; Wang, XR; Wang, ZH; Yang, J; Zhang, JW; Zhang, XR; Zhao, M, 2022)	0.72
" Ultrasound-guided TPVB combined with an erector spinae plane block was given after anesthesia induction."	( Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial. Feng, XY; Lei, YJ; Wang, XR; Wang, ZH; Yang, J; Zhang, JW; Zhang, XR; Zhao, M, 2022)	0.72
"Ropivacaine with dexmedetomidine or dexamethasone in TPVB combined with ESPB could prolong the time to first postoperative remedial analgesia, reduce perioperative sufentanil and postoperative remedial analgesic drug consumption, and decrease the postoperative NRS score in patients undergoing thoracoscopic lobectomy."	( Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial. Feng, XY; Lei, YJ; Wang, XR; Wang, ZH; Yang, J; Zhang, JW; Zhang, XR; Zhao, M, 2022)	0.72
"This study aimed to investigate the clinical effect of ultrasound-guided ropivacaine combined with butorphanol continuous paravertebral block in preventing postoperative pain syndrome of breast cancer."	( Study of ultrasound-guided ropivacaine combined with butorphanol continuous paravertebral block to prevent pain syndrome by evaluating ccl2 gene expression after radical mastectomy. Cui, W; Ji, X; Liu, X; Shan, S; Wang, L; Zhang, B, 2022)	0.72
" All patients who received ACB and iPACK block were randomly divided into a dexamethasone group (Group D, ropivacaine combined with dexamethasone) and a control group (Group C, ropivacaine only)."	( Adding Dexamethasone to Adductor Canal Block Combined With iPACK Block Improve Postoperative Analgesia of Total Knee Arthroplasty. Hu, J; Wang, Q; Yang, J; Zeng, Y, 2022)	0.72
"Compared with using ropivacaine alone, ultrasonic-guided ACB combined with iPACK using ropivacaine and dexamethasone could prolong the duration of postoperative analgesia and strength analgesic intensity and promote the early rehabilitation exercise of patients undergoing TKA."	( Adding Dexamethasone to Adductor Canal Block Combined With iPACK Block Improve Postoperative Analgesia of Total Knee Arthroplasty. Hu, J; Wang, Q; Yang, J; Zeng, Y, 2022)	0.72
"To investigate the analgesic effect and rehabilitation quality of patients undergoing thoracoscopic wedge resection of the lung under erector spinae plane (ESP) block with dexmedetomidine combined with the same dose and different concentrations of ropivacaine."	( Effects of ultrasound-guided erector spinae plane block with dexmedetomidine combined with ropivacaine of the same dose and different concentrations on analgesic effect and rehabilitation quality of patients undergoing thoracoscopic wedge resection of the Fu, H; Jian, C; Shen, Y; Yu, L, 2022)	0.72
" We aimed to determine the optimal dose of dexmedetomidine for preemptive analgesia when combined with TAP block after colon cancer surgery."	( Optimal Dose of Dexmedetomidine for Preemptive Analgesia Combined with Transversus Abdominis Plane Block after Colon Cancer Surgery. Hao, D; Zhang, Z, 2022)	0.72
"The analgesic effect of IV self-controlled analgesia combined with ropivacaine is quick, but the maintenance time is short."	( Methylene Blue Combined with Ropivacaine for Intercostal Nerve Block After Autologous Costal Cartilage Removal in Juvenile Patients. Chen, Z; Liu, Y; Lu, X; Ren, J; Sun, P, 2022)	0.72
" These findings implied that the application of dexmedetomidine in combination with RO in TPVB has a good postoperative analgesic effect, as well as anti-inflammatory and immune-enhancing effects."	( Postoperative analgesic effect of dexmedetomidine combined with TPVB applied to open gastrectomy for gastric cancer. Hou, Z; Qiu, Q; Wan, W, 2023)	0.91
"To observe the effect of methylene blue combined with ropivacaine intercostal nerve block on postoperative analgesia after autologous costal cartilage augmentation rhinoplasty."	( Application of methylene blue combined with ropivacaine intercostal nerve block in postoperative analgesia of autologous costal cartilage augmentation rhinoplasty. Guoyu, J; Tao, W; Xi, Y, 2022)	0.72
" In the experimental group methylene blue was combined with ropivacaine intercostal nerve block as patient controlled intravenous analgesia (PCIA), and the control group was ropivacaine intercostal nerve block combined with PCIA."	( Application of methylene blue combined with ropivacaine intercostal nerve block in postoperative analgesia of autologous costal cartilage augmentation rhinoplasty. Guoyu, J; Tao, W; Xi, Y, 2022)	0.72
"Intercostal nerve block with methylene blue combined with ropivacaine can achieve good postoperative analgesic effects in augmentation rhinoplasty with autologous costal cartilage."	( Application of methylene blue combined with ropivacaine intercostal nerve block in postoperative analgesia of autologous costal cartilage augmentation rhinoplasty. Guoyu, J; Tao, W; Xi, Y, 2022)	0.72
"This review aimed to conduct a meta-analysis of published randomized controlled studies (RCTs) comparing the effectiveness of dexmedetomidine (DEX) combined with ropivacaine versus single ropivacaine in transversus abdominis plane block (TAPB) for postoperative analgesia after laparoscopic cholecystectomy (LC)."	( Analgesic Effects of Ropivacaine Combined With Dexmedetomidine in Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis. Sun, W; Zhu, M, 2023)	0.91
"Five electronic database systems were searched for RCTs on the effects of DEX combined with ropivacaine (joint group) and single ropivacaine on postoperative analgesia in LC."	( Analgesic Effects of Ropivacaine Combined With Dexmedetomidine in Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis. Sun, W; Zhu, M, 2023)	0.91
" The results showed that compared with single ropivacaine, DEX combined with ropivacaine in TAPB had better analgesia and lighter sedative effect in patients after LC."	( Analgesic Effects of Ropivacaine Combined With Dexmedetomidine in Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis. Sun, W; Zhu, M, 2023)	0.91
" This study compared the analgesic effect and early rehabilitation quality between adductor canal block combined with general analgesia (ACB + GA) and single general analgesia (SGA) after recurrent patellar dislocation (RPD) for "3-in-1" procedure surgery."	( Adductor Canal Block Combined with General Analgesia for Patients with Recurrent Patellar Dislocation Undergoing "3-in-1" Procedure Surgery: A Prospective Randomized Controlled Trial. Li, J; Li, Q; Li, S; Li, X; Lin, Y; Wang, D; Xiong, Y, 2023)	0.91
"This study aims to evaluate the onset, maintenance, side effects s and the effect on newborns of dural puncture epidural (DPE) technique combined with programmed intermittent epidural bolus (PIEB) mode for labor analgesia as compared to conventional epidural (EP) technique combined with continuous epidural infusion (CEI) mode."	( Application of dural puncture epidural technique combined with programmed intermittent epidural bolus mode in labor analgesia: A randomized clinical trial. Cui, E; Sun, J; Wang, Q; Yan, M; Zhang, Y; Zhou, J, 2023)	0.91
"DPE technique can provide faster analgesia than conventional EP technique, combined with PIEB mode maybe superior to traditional methods as a labor analgesia regimen."	( Application of dural puncture epidural technique combined with programmed intermittent epidural bolus mode in labor analgesia: A randomized clinical trial. Cui, E; Sun, J; Wang, Q; Yan, M; Zhang, Y; Zhou, J, 2023)	0.91
"To investigate the effects of a single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery."	( Single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery: a prospective randomized comparative trial. Cheng, Y; Duan, Y; He, M; Jiang, M; Qin, D; Wang, Y; Zhou, A, 2023)	0.91
"The application of the single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery is beneficial because it shortens the operation time, has a faster onset, produces a more effective block and prolongs the longer analgesia time."	( Single injection technique with ultrasound-guided superficial cervical fascia block combined with brachial plexus block in clavicular surgery: a prospective randomized comparative trial. Cheng, Y; Duan, Y; He, M; Jiang, M; Qin, D; Wang, Y; Zhou, A, 2023)	0.91

Excerpt	Reference	Relevance
" Ropivacaine's biphasic absorption and bioavailability are similar to those of other amide local anesthetics."	( Pharmacokinetics of intravenous and epidural ropivacaine in the rhesus monkey. Bridenbaugh, PO; Coyle, D; Denson, DD; Katz, JA; Sehlhorst, CS; Thompson, GA, 1993)	0.29
" However, alkalinization of local anesthetic solutions may cause precipitation, thereby decreasing bioavailability and anesthetic activity."	( Alkalinization and precipitation characteristics of 0.2% ropivacaine. Fulling, PD; Peterfreund, RA, )	0.13
" Population pharmacokinetic modeling was performed to yield estimates of clearance, volume of distribution, and absorption rate constant."	( Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations. Bergesio, R; Hackett, LP; Hansen, TG; Ilett, KF; Lim, SI; Reid, C, 2001)	0.31
") absolute bioavailability (%F) was 56 (18)%."	( Rectal ropivacaine is absorbed proportionally to the dose, with low intraindividual variability. Arlander, E; Gustafsson, LL; Norsten-Höög, C; Sjövall, J; Sörstad, J, 2003)	0.32
" Mean bioavailability was about 60% and not influenced by variations in the enema volume."	( Rectal ropivacaine is absorbed proportionally to the dose, with low intraindividual variability. Arlander, E; Gustafsson, LL; Norsten-Höög, C; Sjövall, J; Sörstad, J, 2003)	0.32
" Subsequently, in order to determine the absorption rate (Ka) and to reduce to number of blood samples, 25 other children, receiving plain R and another group of 25 receiving the E solution were studied using a population approach (NONMEM)."	( In children, the addition of epinephrine modifies the pharmacokinetics of ropivacaine injected caudally. Roelants, FA; Van Obbergh, LJ; Verbeeck, RK; Veyckemans, F, )	0.13
" The median bioavailability of the rapid component was approximately 20% higher when epinephrine was not used."	( Arterial and venous pharmacokinetics of ropivacaine with and without epinephrine after thoracic paravertebral block. Gin, T; Ho, AM; Karmakar, MK; Law, BK; Shafer, SL; Wong, AS, 2005)	0.33
" The intrathecal bioavailability after epidural administration was 11."	( Epidural, intrathecal pharmacokinetics, and intrathecal bioavailability of ropivacaine. Bec, D; Chevanne, F; Dollo, G; Ecoffey, C; Estebe, JP; Le Corre, P; Malinovsky, JM; Ratajczak, M; Rose, FX; Wodey, E, 2007)	0.34
"Using an animal model, we showed that drug dispositions in the intrathecal and epidural compartments are different, and that the intrathecal bioavailability of ropivacaine after epidural administration is low, and highly variable."	( Epidural, intrathecal pharmacokinetics, and intrathecal bioavailability of ropivacaine. Bec, D; Chevanne, F; Dollo, G; Ecoffey, C; Estebe, JP; Le Corre, P; Malinovsky, JM; Ratajczak, M; Rose, FX; Wodey, E, 2007)	0.34
" Maximum plasma concentrations (C(max)), time to C(max) (t(max)), the absorption rate constant (k(a)), the speed of rise of the plasma concentration at Time 0 (dC(0)/dt), and area under the curve value (AUC) were determined."	( Ultrasound versus landmark-based technique for ilioinguinal-iliohypogastric nerve blockade in children: the implications on plasma levels of ropivacaine. Bsenberg, A; Kapral, S; Kettner, SC; Koppatz, K; Lönnqvist, PA; Lundblad, M; Marhofer, P; Turnheim, K; Weintraud, M; Willschke, H, 2009)	0.35
"Following epidural administration, cerebrospinal fluid bioavailability of local anesthetics is low, one major limiting factor being diffusion across the arachnoid mater barrier."	( Ex vivo and in vivo diffusion of ropivacaine through spinal meninges: influence of absorption enhancers. Brandhonneur, N; Chevanne, F; Deniau, AL; Dollo, G; Estèbe, JP; Le Corre, P; Legrand, A; Ratajczak-Enselme, M, 2011)	0.37
" The apparent infusion dosing half-life t(1/2,DP) is the most appropriate parameter to predict drug accumulation upon epidural infusion since it appears to better reflect the interplay interference between volume distribution and absorption rate during the accumulation phase."	( Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate. Allegri, M; Braschi, A; Broglia, M; Cusato, M; Ingelmo, P; Niebel, T; Regazzi, M, 2011)	0.37
" Population pharmacokinetic modeling was performed to yield estimates of clearance, volume of distribution, and absorption rate constant."	( Pharmacokinetics and efficacy of ropivacaine in Chinese patients following intra-articular administration. Chen, S; Chen, Z; Jin, Y; Lin, J; Lin, X; Tian, Z; Xu, L; Xu, S; Zhu, M, 2013)	0.39
" Peak plasma dexmedetomidine concentrations were reached after 15 minutes with DEX1PN (mean ± SD, 348 ± 200 pg/mL) and after 30 minutes DEX2PN (816 ± 607 pg/mL), and bioavailability was 54 ± 40% and 73 ± 43%, respectively."	( Effects of perineural administration of ropivacaine combined with perineural or intravenous administration of dexmedetomidine for sciatic and saphenous nerve blocks in dogs. Ida, KK; Markuszewski, MJ; Marolf, V; Sandersen, C; Siluk, D; Struck-Lewicka, W, 2021)	0.62
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Excerpt	Relevance	Reference
" In this controlled double-blind study in man, the dose-response relation of ropivacaine was examined in peripheral nerve block and its potency was compared to that of bupivacaine."	( Local anesthetic efficacy of ropivacaine (LEA 103) in ulnar nerve block. Edström, HH; Fruhstorfer, H; Nolte, H, )	0.13
" Although both drugs caused evidence of depression of conductivity and contractility, these appeared at lower dosage and lower plasma concentrations with bupivacaine than with ropivacaine."	( Acute toxicity of ropivacaine compared with that of bupivacaine. Bloomfield, P; Bowler, GM; Fagan, D; Lee, A; Lundh, R; Scott, DB, 1989)	0.28
" At high K+ concentration, both local anaesthetics induced effects similar to those observed with low K+, but the dose-response curves for contractility and dV/dtmax were shifted leftward."	( [The potential dependence of the effect of bupivacaine and ropivacaine on the heart. In-vitro studies on the effect of local anesthetics on the force of contraction and the action potential in left guinea pig atria]. Gödicke, J; Petry, A; Wulf, H, 1993)	0.29
" The main aim of this study was to investigate the dose-response relationship of extradural infusion of ropivacaine."	( Postoperative analgesia by continuous extradural infusion of ropivacaine after upper abdominal surgery. Hägglöf, B; Mooney, PH; Payne, J; Schug, SA; Scott, DA, 1996)	0.29
" The purpose of this double-blind study was: to investigate the dose-response relationship of increasing doses of ropivacaine on the quality of anaesthesia and the duration of both motor and sensory blockade, and to compare these results with an established local anaesthetic, bupivacaine."	( A double-blind comparison of ropivacaine 0.5%, 0.75%, 1.0% and bupivacaine 0.5%, injected epidurally, in patients undergoing abdominal hysterectomy. Chan, V; Finucane, BT; Friedlander, M; McKenna, J; Milner, AL; Muzyka, D; O'Callaghan-Enright, S; Reid, D; Sandler, AN, 1996)	0.29
" The greater degree of separation between motor and sensory blockade seen with ropivacaine relative to bupivacaine is more apparent at the lower end of the dosage scale."	( Ropivacaine. A review of its pharmacology and therapeutic use in regional anaesthesia. Faulds, D; Markham, A, 1996)	0.29
" The objective of this study was the investigation of the efficacy and appropriate dosage of isobaric ropivacaine for spinal anaesthesia in humans."	( [Ropivacaine for spinal anesthesia. A dose-finding study]. Klein, P; Nolte, H; Wahedi, W, 1996)	0.29
"To assess the effect of preoperative local anaesthesia with ropivacaine and find out if there was a dose-response relationship with postoperative pain after inguinal hernia repair."	( Preoperative local infiltration with ropivacaine for postoperative pain relief after inguinal hernia repair. A randomised controlled trial. Edwin, B; Glise, H; Hallerbäck, B; Janbu, T; Johansson, B; Solhaug, JH; Stubberöd, A, 1997)	0.3
"We have assessed the dose-response relationship of a solution of ropivacaine 2 mg ml-1, given as a continuous extradural infusion to women in labour."	( Continuous extradural infusion of ropivacaine 2 mg ml-1 for pain relief during labour. Benhamou, D; Dailland, P; Eledjam, JJ; Hamza, J; Heeroma, K; Milon, D; Palot, M; Seebacher, J, 1997)	0.3
"3 to 26 mg/kg) were selected based upon the proposed human dosage and the known pharmacological activity of the compounds."	( Toxicity of bupivacaine and ropivacaine in relation to free plasma concentrations in pregnant rats: a comparative study. Arvidsson, T; Böö, EL; Danielson, MK; Danielsson, BR; Halldin, MM, 1997)	0.3
" The present pilot study was undertaken to find indications for an optimal dosage by comparing the clinical effects, quality of anaesthesia and pharmacokinetics of ropivacaine 150 mg (lower dose = LD) vs 187."	( Ropivacaine 7.5 mg/ml for elective caesarean section. A clinical and pharmacokinetic comparison of 150 mg and 187.5 mg. Ekblom, A; Emanuelsson, BM; Irestedt, L; Olofsson, C; Reventlid, H, 1997)	0.3
" However, its relative potency to bupivacaine and its dose-response characteristics are unknown."	( Hyperbaric spinal ropivacaine: a comparison to bupivacaine in volunteers. Kopacz, DJ; Liu, SS; McDonald, SB; Stephenson, CA, 1999)	0.3
" As the surgical wound was being closed, the catheters were dosed with fentanyl and hydromorphone followed by a continuous infusion of ropivacaine plus hydromorphone."	( A dual epidural catheter technique to provide analgesia following posterior spinal fusion for scoliosis in children and adolescents. Bildner, C; Gaines, RW; Kittle, D; Lowry, KJ; Tobias, JD, 2001)	0.31
" We hypothesised that the use of a very low concentration technique (ropivacaine/fentanyl) might result in excessive dosing in the PCEA group, more motor blockade and a negative impact on spontaneous delivery rate."	( Ropivacaine 1 mg/ml, plus fentanyl 2 microg/ml for epidural analgesia during labour. Is mode of administration important? Gjessing, L; Smedvig, JP; Soreide, E, 2001)	0.31
" However, there have been few formal dose-response studies of ropivacaine in this setting."	( Dose-response study of epidural ropivacaine for labor analgesia. Lee, BB; Liu, JY; Ngan Kee, WD; Wong, EL, 2001)	0.31
"In a traditional dose-response study, the ED50 of ropivacaine required to initiate epidural analgesia in early labor was found to be 18."	( Dose-response study of epidural ropivacaine for labor analgesia. Lee, BB; Liu, JY; Ngan Kee, WD; Wong, EL, 2001)	0.31
"To present the authors' technique for epidural catheter placement and dosing protocol, and to demonstrate the results from postoperative pain control after anterior spinal instrumented fusion for 10 consecutive patients."	( Postoperative pain control using epidural catheters after anterior spinal fusion for adolescent scoliosis. Burd, T; Gaines, RW; Kittle, D; Lowry, KJ; Tobias, J, 2001)	0.31
" The authors believe that this lack of consensus stems from varied epidural dosing protocols and techniques in catheter placement, which they have witnessed anecdotally at their own institution."	( Postoperative pain control using epidural catheters after anterior spinal fusion for adolescent scoliosis. Burd, T; Gaines, RW; Kittle, D; Lowry, KJ; Tobias, J, 2001)	0.31
" Dosing consisted of fentanyl (1 microg/kg) and hydromorphone (5 microg/kg) diluted in preservative-free saline (0."	( Postoperative pain control using epidural catheters after anterior spinal fusion for adolescent scoliosis. Burd, T; Gaines, RW; Kittle, D; Lowry, KJ; Tobias, J, 2001)	0.31
"By following the dosing protocol described, epidural catheters can be used safely and effectively to control postoperative pain after anterior instrumentation and spinal fusion for adolescent scoliosis."	( Postoperative pain control using epidural catheters after anterior spinal fusion for adolescent scoliosis. Burd, T; Gaines, RW; Kittle, D; Lowry, KJ; Tobias, J, 2001)	0.31
" We investigated the dose-response relationship for epidural clonidine when added to a continuous postoperative epidural infusion of ropivacaine."	( The dose-response relationship for clonidine added to a postoperative continuous epidural infusion of ropivacaine in children. De Negri, P; De Vivo, P; Ivani, G; Lonnqvist, PA; Visconti, C, 2001)	0.31
"The dose-response relation for spinal ropivacaine is undetermined, and there are few data available for obstetric patients."	( Spinal ropivacaine for cesarean section: a dose-finding study. Chung, R; Khaw, KS; Liu, JY; Ngan Kee, WD; Wong, EL, 2001)	0.31
" A sigmoid dose-response curve and a probit log dose-response plot were obtained, and the authors determined the ED50 (95% confidence interval) to be 16."	( Spinal ropivacaine for cesarean section: a dose-finding study. Chung, R; Khaw, KS; Liu, JY; Ngan Kee, WD; Wong, EL, 2001)	0.31
" Because the smaller dosage (2 x 50 mg) provided similar analgesia and was associated with significantly smaller plasma concentrations than the larger dosage (2 x 150 mg), this smaller dosage seems more appropriate."	( The clinical efficacy and pharmacokinetics of intraperitoneal ropivacaine for laparoscopic cholecystectomy. Benhamou, D; Franco, D; Labaille, T; Mazoit, JX; Paqueron, X, 2002)	0.31
" Peripheral venous plasma samples and urine were collected over 12 h after dosing and analysed for ropivacaine base by gas chromatography and (2H3)ropivacaine by gas chromatography-mass spectrometry."	( Rectal ropivacaine is absorbed proportionally to the dose, with low intraindividual variability. Arlander, E; Gustafsson, LL; Norsten-Höög, C; Sjövall, J; Sörstad, J, 2003)	0.32
" Varying clinical dosage recommendations exist."	( Increasing the injection volume by dilution improves the onset of motor blockade, but not sensory blockade of ropivacaine for brachial plexus block. Balogh, B; Deusch, E; Fitzgerald, RD; Jellinek, H; Krenn, H; Oczenski, W; Plainer-Zöchling, E, 2003)	0.32
" This study was undertaken to seek for a suitable dosage of ropivacaine in postoperative analgesia for Taiwanese patients whose average physicality is not entirely compatible with the pharmacopeially recommended dosage for western people."	( Epidural ropivacaine for postoperative analgesia in Taiwanese patients. Au, CF; Lee, LS; Lee, WK; Li, CH; Tang, CS; Yu, KL, 2003)	0.32
"In the dosage used here, epinephrine did not improve epidural lumbar analgesia."	( Epinephrine added to a lumbar epidural infusion of a small-dose ropivacaine-fentanyl mixture after arterial bypass surgery of the lower extremities. Aromaa, U; Förster, JG; Neuvonen, PJ; Niemi, TT; Rosenberg, PH; Seppälä, TA, 2003)	0.32
"2% ropivacaine delivered as a continuous infusion combined with patient-controlled bolus doses via an infraclavicular perineural catheter optimizes analgesia while minimizing oral analgesic use compared with basal- or bolus-only dosing regimens."	( Infraclavicular perineural local anesthetic infusion: a comparison of three dosing regimens for postoperative analgesia. Enneking, FK; Ilfeld, BM; Morey, TE, 2004)	0.32
" In view of these results, we recommend the use of lower ropivacaine dosage during FIC block in children."	( High plasma ropivacaine concentrations after fascia iliaca compartment block in children. Bruguerolle, B; Camboulives, J; Lacroix, F; Lavrut, T; Meyrieux, V; Paut, O; Schreiber, E; Simon, N, 2004)	0.32
" Sufentanil is a widely used opioid agent, but its optimal dosage has not yet been defined."	( Epidural analgesia in abdominal surgery: 0.2% ropivacaine with sufentanil. Adducci, E; Beccia, G; De Cosmo, G; Fiorenti, M; Primieri, P, 2004)	0.32
"Continuous spinal anaesthesia with spinal catheters allows incremental dosing of local anaesthetic and, consequently, less haemodynamic changes."	( Minimum effective local anaesthetic dose of isobaric levobupivacaine and ropivacaine administered via a spinal catheter for hip replacement surgery. Aantaa, R; Jalonen, J; Olkkola, KT; Sell, A, 2005)	0.33
" The myocardial depressant potential of these drugs in sublethal dosage is unknown."	( The myocardial and vascular effects of bupivacaine, levobupivacaine, and ropivacaine using pressure volume loops. Royse, AG; Royse, CF, 2005)	0.33
" The cumulative dose-response relations of contraction and intracellular Ca2+ concentration to ropivacaine were tested, using isometric force transducers and a fluorometer, respectively."	( Involvement of Ca2+ sensitization in ropivacaine-induced contraction of rat aortic smooth muscle. Hatano, Y; Kuriyama, T; Mizumoto, K; Tokinaga, Y; Uematsu, N; Yu, J, 2005)	0.33
" The dose-response relation for spinal hyperbaric ropivacaine is undetermined."	( Dose-response study of spinal hyperbaric ropivacaine for cesarean section. Chen, H; Chen, XZ; Lou, AF; Lü, CC, 2006)	0.33
" Because of wide interindividual differences in pharmacokinetics in patients with liver disease, no definitive dosing instructions can be given."	( Pharmacokinetics of ropivacaine in patients with chronic end-stage liver disease. Ahonen, J; Askemark, Y; Breuer, O; Höckerstedt, K; Jokinen, MJ; Lindgren, L; Neuvonen, PJ; Olkkola, KT; Sjövall, J, 2007)	0.34
" Although minimum local analgesic concentration studies suggested that they are less potent than bupivacaine, full dose-response studies have not been performed."	( Determination of the full dose-response relation of intrathecal bupivacaine, levobupivacaine, and ropivacaine, combined with sufentanil, for labor analgesia. Deprest, J; Dreelinck, R; Dubois, J; Kumar, A; Lewi, L; Van de Velde, M; Vandermeersch, E, 2007)	0.34
" Group-specific dose-response curves were constructed using a probit regression model."	( Determination of the full dose-response relation of intrathecal bupivacaine, levobupivacaine, and ropivacaine, combined with sufentanil, for labor analgesia. Deprest, J; Dreelinck, R; Dubois, J; Kumar, A; Lewi, L; Van de Velde, M; Vandermeersch, E, 2007)	0.34
"This full dose-response study suggests that ropivacaine and levobupivacaine are of similar potency, whereas bupivacaine is more potent than both other drugs."	( Determination of the full dose-response relation of intrathecal bupivacaine, levobupivacaine, and ropivacaine, combined with sufentanil, for labor analgesia. Deprest, J; Dreelinck, R; Dubois, J; Kumar, A; Lewi, L; Van de Velde, M; Vandermeersch, E, 2007)	0.34
" Secondary aims were to determine the dose-response curve for spinal anesthesia including the clinically relevant ED95 dose and to describe the duration of motor block following ropivacaine spinal anesthesia."	( Ropivacaine spinal anesthesia in neonates: a dose range finding study. Frawley, G; Skinner, A; Smith, S; Thomas, J, 2007)	0.34
"2% ropivacaine hydrochloride per hour with 10-mL bolus) epidural dosing groups."	( Hemodynamic stability during labor and delivery with continuous epidural infusion. Gerhardt, MA; Gunka, VB; Miller, RJ, 2006)	0.33
"2% ropivacaine hydrochloride without bolus administration reduces the incidence of hypotension by 67% and is safer than traditional bolus dosing for routine labor."	( Hemodynamic stability during labor and delivery with continuous epidural infusion. Gerhardt, MA; Gunka, VB; Miller, RJ, 2006)	0.33
" During this period, the side effects, the dosage of rescue analgesia required, and the range of knee flexion were recorded for each group."	( Intra-synovial ropivacaine and morphine for pain relief after total knee arthroplasty: a prospective, randomized, double blind study. Han, CD; Lee, DH; Yang, IH, 2007)	0.34
" Further studies of dosage (high/low) and duration of intraarticular treatment are warranted."	( Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients. Andersen, KV; Haraldsted, V; Pfeiffer-Jensen, M; Søballe, K, 2007)	0.34
"The dose-response relationship for spinal ropivacaine in patients undergoing surgery of the lower extremity has not been fully determined."	( Spinal ropivacaine for lower limb surgery: a dose response study. Chang, HK; Gin, T; Lee, YY; Ngan Kee, WD; So, CL, 2007)	0.34
"75% with 5 doses each side, total dosage 40 mL (300 mg), via parasternal intercostal injection or saline before insertion of the sternal wires and closure of the sternal wound."	( Parasternal intercostal block with ropivacaine for pain management after cardiac surgery: a double-blind, randomized, controlled trial. Almeida, AA; Barr, AM; Tutungi, E, 2007)	0.34
" Experience from this case suggests that local anesthesia toxicity can happen within safe dose limits and without intravascular placement despite careful attention to needle and catheter placement, fractionated dosing and frequent aspirations."	( Case report: ropivacaine neurotoxicity at clinical doses in interscalene brachial plexus block. Athwal, GS; Dhir, S; Ganapathy, S; Lindsay, P, 2007)	0.34
" The initial dose was 10 mg of bupivacaine or 20 mg of ropivacaine; the dosing intervals were 1 mg and 2 mg, respectively."	( Median effective local anesthetic doses of plain bupivacaine and ropivacaine for spinal anesthesia administered via a spinal catheter for brachytherapy of the lower abdomen. Chiari, A; Deusch, E; Heinzl, H; Kozek-Langenecker, SA; Michalek-Sauberer, A, )	0.13
" The hypotheses that no toxic plasma concentrations of ropivacaine would be reached and that proportionality exists among plasma concentrations and dosage used were tested."	( Continuous extrapleural infusion of ropivacaine 0.2% after cardiovascular surgery via the lateral thoracotomy approach. Blumenthal, S; Maurer, K; Rentsch, KM; Schmid, ER, 2008)	0.35
" No proportionality of plasma concentrations of ropivacaine existed when the 2 dosing regimens were compared."	( Continuous extrapleural infusion of ropivacaine 0.2% after cardiovascular surgery via the lateral thoracotomy approach. Blumenthal, S; Maurer, K; Rentsch, KM; Schmid, ER, 2008)	0.35
" Immediately after surgery, there was less pain, higher satisfaction, and lower morphine use among patients on continuous FNB regardless of ropivacaine dosage used."	( Continuous femoral nerve block in total knee arthroplasty: immediate and two-year outcomes. Chong, HC; Lo, NN; Shum, CF; Yang, KY; Yeo, SJ; Yeo, SN, 2009)	0.35
" Doppler ultrasound indices of vascular resistance were assessed at baseline and after each 24 h dosing period in both uterine arteries."	( Antepartum continuous epidural ropivacaine therapy reduces uterine artery vascular resistance in pre-eclampsia: a randomized, dose-ranging, placebo-controlled study. Davidson, EM; Elchalal, U; Firman, N; Ginosar, Y; Hoffman, A; Nadjari, M; Rosen, L; Weiniger, CF; Weissman, C, 2009)	0.35
" Therefore, we performed a prospective, randomized, double-blind study to determine the minimum local analgesic concentrations of a caudal single shot of ropivacaine and levobupivacaine in children and to describe the upper dose-response curve."	( Relative analgesic potencies of levobupivacaine and ropivacaine for caudal anesthesia in children. Astuto, M; Disma, N; Donath, S; Duffy, C; Frawley, G; Fumagalli, R; Gullo, A; Ingelmo, P; Rosano, G, 2009)	0.35
"We performed a two-stage prospective, randomized, double-blind study comparing the dose-response curves of caudal ropivacaine and levobupivacaine in children."	( Relative analgesic potencies of levobupivacaine and ropivacaine for caudal anesthesia in children. Astuto, M; Disma, N; Donath, S; Duffy, C; Frawley, G; Fumagalli, R; Gullo, A; Ingelmo, P; Rosano, G, 2009)	0.35
" Cumulative dose-response curves were generated with concentrations of 10(-5) to 10(-3) M ropivacaine enantiomer in the presence or absence of quinacrine dihydrochloride, nordihydroguaiaretic acid, quinacrine dihydrochloride plus nordihydroguaiaretic acid, indomethacin, fluconazole, AA-861, and verapamil."	( Direct effect of ropivacaine involves lipoxygenase pathway activation in rat aortic smooth muscle. Baik, JS; Hwang, EM; Ogawa, K; Park, JY; Sohn, JT; Sung, HJ, 2009)	0.35
"To test the clinical efficacy and pharmacokinetics of different concentrations of ropivacaine with the same dosage on blocking lumbar plexus with sciatic nerves."	( [Clinical efficacy and pharmacokinetics of different concentrations of ropivacaine with the same dosage on blocking lumbar plexus with sciatic nerves]. Cao, W; Xu, HW; Zhang, L; Zhang, WS; Zhang, X, 2009)	0.35
" The dose for the first patient in each group was 8 mg, and the dosing increment was set at 1 mg."	( The median effective dose of bupivacaine, levobupivacaine, and ropivacaine after intrathecal injection in lower limb surgery. Fong, SY; Gin, T; Lee, YY; Liu, JT; Ngan Kee, WD, 2009)	0.35
" In phase 2, a further 70 patients were randomly allocated to receive spinal anaesthesia with doses in the upper dose-response range to define the ED95."	( Relative potencies of bupivacaine, levobupivacaine, and ropivacaine for neonatal spinal anaesthesia. Frawley, G; Ingelmo, P; Smith, KR, 2009)	0.35
") analgesia in labor is well recognized, but information on dosing is limited."	( On the ropivacaine-reducing effect of low-dose sufentanil in intrathecal labor analgesia. Faybik, P; Grabovica, J; Gustorff, B; Kimberger, O; Ortner, CM; Posch, M; Roessler, B; Rützler, K, 2010)	0.36
" In phase one, sufentanil dose-response was calculated using logistic regression."	( On the ropivacaine-reducing effect of low-dose sufentanil in intrathecal labor analgesia. Faybik, P; Grabovica, J; Gustorff, B; Kimberger, O; Ortner, CM; Posch, M; Roessler, B; Rützler, K, 2010)	0.36
" Increasing dosage implicates no clinical benefit."	( On the ropivacaine-reducing effect of low-dose sufentanil in intrathecal labor analgesia. Faybik, P; Grabovica, J; Gustorff, B; Kimberger, O; Ortner, CM; Posch, M; Roessler, B; Rützler, K, 2010)	0.36
" These findings may have implications for dosing of local anesthetics in diabetic patients undergoing regional analgesia with nerve blocks."	( Local anesthetic sciatic nerve block and nerve fiber damage in diabetic rats. Buvanendran, A; Kerns, JM; Kroin, JS; Moric, M; Tuman, KJ; Wagenaar, B; Williams, DK, )	0.13
"The potencies of bupivacaine and ropivacaine have been compared using up-and-down methodology, but their complete dose-response curves have not been compared."	( Determination and comparison of graded dose-response curves for epidural bupivacaine and ropivacaine for analgesia in laboring nulliparous women. Gin, T; Khaw, KS; Lee, A; Ng, FF; Ngan Kee, WD, 2010)	0.36
" Response was defined by the percentage decrease in pain score from baseline at 30 min, and dose-response data were analyzed by using nonlinear regression."	( Determination and comparison of graded dose-response curves for epidural bupivacaine and ropivacaine for analgesia in laboring nulliparous women. Gin, T; Khaw, KS; Lee, A; Ng, FF; Ngan Kee, WD, 2010)	0.36
"Ropivacaine is less potent than bupivacaine, but otherwise they have similar dose-response characteristics."	( Determination and comparison of graded dose-response curves for epidural bupivacaine and ropivacaine for analgesia in laboring nulliparous women. Gin, T; Khaw, KS; Lee, A; Ng, FF; Ngan Kee, WD, 2010)	0.36
" The infusion dosing period half-life (t(1/2,DP)=0."	( Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate. Allegri, M; Braschi, A; Broglia, M; Cusato, M; Ingelmo, P; Niebel, T; Regazzi, M, 2011)	0.37
" The apparent infusion dosing half-life t(1/2,DP) is the most appropriate parameter to predict drug accumulation upon epidural infusion since it appears to better reflect the interplay interference between volume distribution and absorption rate during the accumulation phase."	( Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate. Allegri, M; Braschi, A; Broglia, M; Cusato, M; Ingelmo, P; Niebel, T; Regazzi, M, 2011)	0.37
"The presence of cases of subtotal anaesthetic coverage (with necessity to recur to general anaesthesia), and others with good anaesthetic coverage, but difficultly treatable hypotensions show that the best dosage of these local anaesthetics is to be found yet."	( [Ropivacaina 0.5% vs Levobupivacaina 0.5 endoscopic urological surgery]. Baldini, C; Fasciolo, A, )	0.13
" Baseline tissue oxygen saturation values were obtained prior to dosing of the nerve block, and measurements were recorded every 5 min thereafter."	( Noninvasive tissue oxygen saturation determined by near-infrared spectroscopy following peripheral nerve block. Boezaart, AP; Elliott, CE; Lucas, SD; Tighe, PJ, 2011)	0.37
"We investigated the safety and efficacy of the bilateral periarticular multimodal drug injection (PMDI) at a reduced dosage in patients undergoing simultaneous bilateral total knee arthroplasty (SBTKA)."	( Use of reduced-dose periarticular injection for pain management in simultaneous bilateral total knee arthroplasty. Chang, CB; Jeon, YT; Kang, YG; Kim, TK; Koh, IJ; Song, J, 2012)	0.38
" Only the age-effect was considered as relevant for possible dosing adjustments."	( A population pharmacokinetic model for the complex systemic absorption of ropivacaine after femoral nerve block in patients undergoing knee surgery. Drolet, P; Fallaha, M; Gaudreault, F; Varin, F, 2012)	0.38
"Describing the relationship between magnitude of response, probability of response, dose and time is difficult using traditional two-dimensional dose-response curves."	( Multi-dimensional response-probability-dose curves for bupivacaine and ropivacaine epidural labour analgesia. Lee, A; Ngan Kee, WD, 2013)	0.39
" However, the protocol was amended for the subsequent 16 subjects, to a weight-based dosing regimen."	( Plasma ropivacaine concentrations during bilateral transversus abdominis plane infusions. Bjorksten, AR; Evans, BE; Hessian, EC; Kinkel, E; Taylor, DJ; Woods, JA, 2013)	0.39
"Given the potential for high plasma concentrations from a bilateral TAP infusion technique, attention should be paid to individualized dosing strategies."	( Plasma ropivacaine concentrations during bilateral transversus abdominis plane infusions. Bjorksten, AR; Evans, BE; Hessian, EC; Kinkel, E; Taylor, DJ; Woods, JA, 2013)	0.39
"This prospective randomized single-blinded study was conducted to determine whether there were differences in consumption, demand dosing and postoperative analgesia quality between PCEA using ropivacaine and levobupivacaine."	( The effectiveness of patient-controlled epidural analgesia with ropivacaine 0.165% with fentanyl 2.0 miroc g/ml or levobupivacaine 0.125% with fentanyl 2.0 micro g/ml as a method of postoperative analgesia after major orthopaedic surgery. Misiran, KB; Yahaya, LS, 2013)	0.39
" Nonlinear regression analysis was used to describe the dose-response relationships for the aepEX, the BIS, and propofol plasma concentrations (Cp)."	( Evaluation of the aepEX™ monitor of hypnotic depth in pediatric patients receiving propofol-remifentanil anesthesia. Cheung, YM; Hoeks, SE; Scoones, GP; Stolker, RJ; Weber, F, 2013)	0.39
" Ropivacaine could make dose-response curve of the GABA up, EC50 is 23."	( [Effects of ropivacaine on GABA-activated currents in isolated dorsal root ganglion neurons in rats]. Cheng, HJ; Fan, C; Li, L; Ma, KT; Si, JQ; Yang, Y, 2013)	0.39
" Total postoperative ropivacaine dosage and analgesic consumption were recorded."	( Catheter-based distal sciatic nerve block in patients with Charcot-Marie-Tooth disease. Huber, H; Huberth, S; Münster, T; Schmitt, HJ, 2014)	0.4
" Despite this, an ideal approach and dosing regimen for cervical plexus block remain elusive."	( Ropivacaine 0.375% vs. 0.75% with prilocaine for intermediate cervical plexus block for carotid endarterectomy: A randomised trial. Felder, TK; Gerner, P; Koköfer, A; Mader, N; Nawratil, J; Stundner, O, 2015)	0.42
"This was a prospective randomized double-blind dose-response study."	( Sparing effects of sufentanil on epidural ropivacaine in elderly patients undergoing transurethral resection of prostate surgery. He, R; Li, H; Li, Y, 2015)	0.42
" The analgesic effect of dexmedetomidine (2 μg/kg body weight) as an adjunct to ropivacaine in knee arthroscopic knee procedures was studied to determine whether this would achieve longer post-operative analgesia and whether the study dosage of dexmedetomidine was safe and free of adverse effects."	( Intra-articular Adjuvant Analgesics following Knee Arthroscopy: Comparison between Single and Double Dose Dexmedetomidine and Ropivacaine A Multicenter Prospective Double-blind Trial. Mahapatra, AK; Palo, N; Panigrahi, R; Prasad, A; Priyadarshi, A; Roy, R, 2015)	0.42
" This study was to determine the dose-response of intrathecal ropivacaine in patients with scarred uterus undergoing cesarean delivery under combined spinal-epidural anesthesia."	( The Dose-response of Intrathecal Ropivacaine Co-administered with Sufentanil for Cesarean Delivery under Combined Spinal-epidural Anesthesia in Patients with Scarred Uterus. Liu, L; Liu, X; Wang, LZ; Xiao, F; Xu, WP; Zhang, YF, 2015)	0.42
" At an epidural ropivacaine dose that blocks 20 segments, the propofol dosage or target concentration may be reduced by 30% compared with when no epidural blockade is present."	( Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients. Dahan, A; Lesman, A; Olofsen, E; Sitsen, E; Vuyk, J, 2016)	0.43
"To compare the effect of interscalene brachial plexus block (ISBPB) on the incidence of diaphragmatic paralysis, respiratory function and post-operative pain control using same dosage of local anesthetics diluted into two different volume and concentrations."	( [A study on diaphragm function after interscalene brachial plexus block using a fixed dose of ropivacaine with different concentrations]. Guo, XY; Li, M; Wang, XD; Zhai, WW, 2016)	0.43
" However, we believe that the bolus dosage and the injection rate we used for BTPB were both too high, and caution other clinicians against the use of these doses."	( Local anaesthetic toxicity after bilateral thoracic paravertebral block in patients undergoing coronary artery bypass surgery. Chan, SK; Ho, AM; Joynt, GM; Karmakar, MK; Ng, CS; Ng, SK; Wan, S; Wong, RH, 2016)	0.43
" Future studies should focus on tailoring ropivacaine and epinephrine dosage for individuals."	( Preoperative flap-site injection with ropivacaine and epinephrine in BABA robotic and endoscopic thyroidectomy safely reduces postoperative pain: A CONSORT-compliant double-blinded randomized controlled study (PAIN-BREKOR trial). Choi, JY; Kwon, H; Lee, JH; Lee, KE; Song, RY; Suh, YJ; Yi, JW; Yu, HW, 2017)	0.46
" Subjects in both groups were further randomly assigned to one of nine subgroups based on the dosage of intrathecal isobaric ropivacaine to be administered (7, 8, 9, 10, 11, 12, 13, 14 or 15 mg respectively)."	( Body height and the spread of spinal anaesthesia for caesarean section: a prospective controlled trial. She, YJ; Song, XR; Tan, YH; Zeng, MT; Zhao, BS; Zheng, X, 2017)	0.46
"These results indicate that TAT-decorated NCs systems are useful for overcoming the barrier function of the skin, decreasing the dosage of RVC and enhancing the anesthetic effect."	( A novel local anesthetic system: transcriptional transactivator peptide-decorated nanocarriers for skin delivery of ropivacaine. Chen, C; You, P, 2017)	0.46
"This was a retrospective analysis of data previously collected during dose-response studies of levobupivacaine and ropivacaine spinal anesthetics."	( Infant spinal anesthesia: Do girls need a larger dose of local anesthetic? Frawley, G; Huque, MH, 2017)	0.46
"Bupivacaine, levobupivacaine, and ropivacaine are often given intrathecally for labor analgesia, but limited data are available for their dose-response properties in this context."	( Dose-Response Curves for Intrathecal Bupivacaine, Levobupivacaine, and Ropivacaine Given for Labor Analgesia in Nulliparous Women. Khaw, KS; Koo, AGP; Ng, FF; Ngan Kee, WD; Tang, SPY, )	0.13
" Logistic sigmoidal dose-response curves were fitted to the data using nonlinear regression, and D50 values were calculated for each drug."	( Dose-Response Curves for Intrathecal Bupivacaine, Levobupivacaine, and Ropivacaine Given for Labor Analgesia in Nulliparous Women. Khaw, KS; Koo, AGP; Ng, FF; Ngan Kee, WD; Tang, SPY, )	0.13
" The results suggested that adding a small dosage of DEM could improve the anesthesia efficacy of RVP to a large content."	( Local anaesthetic pain relief therapy: In vitro and in vivo evaluation of a nanotechnological formulation co-loaded with ropivacaine and dexamethasone. Chang, M; Yue, Y; Zhang, Y, 2017)	0.46
"The aim of the present study was to evaluate the optimum dose of ropivacaine by comparing three different dosing regimens of isobaric ropivacaine 1% (naropin 10 mg/ml, Astra Zeneca) administered intrathecally and to demonstrate the effects of anesthesia in pregnant women scheduled for cesarean section."	( Intrathecal ropivacaine in cesarean delivery. Ateser, RY; Kayacan, N, 2017)	0.46
"Ropivacaine administration produced rapid induction of anesthesia and satisfactory anesthesia level, ropivacaine 15 mg and 20 mg dosing regimens are satisfactory for spinal anesthesia."	( Intrathecal ropivacaine in cesarean delivery. Ateser, RY; Kayacan, N, 2017)	0.46
" Local anesthetics have been commonly used in interventional procedures for alleviating pain, but local anesthetics may have negative impact on MSC dosing because of cytotoxicity or other biological effects."	( Cytotoxicity of Local Anesthetics in Mesenchymal Stem Cells. Erwin, PJ; Nie, H; Qu, W; Smith, J; van Wijnen, AJ; Wang, Z; Wu, T, 2018)	0.48
"Ultrasound-guided OSTAP block with ropivacaine can significantly decrease the perioperative cumulative dosage of analgesics and improve analgesic effect without obvious side effects for the patients who underwent an open liver resection with Mercedes incision when compared tothe ultrasound-guided OSTAP block with saline."	( The analgesic efficacy of subcostal transversus abdominis plane block with Mercedes incision. Feng, ZY; Guo, JG; Li, HL; Pei, QQ, 2018)	0.48
"Intraoperative ropivacaine injection into both uterosacral ligaments during LM can reduce the dosage of opioid analgesics."	( Postoperative pain control with ropivacaine following laparoscopic myomectomy: A randomized double-blind, pilot study. Ahn, KH; Kwack, JY; Kwon, YS, 2019)	0.51
" Secondary outcomes were dosage of remedial analgesics, time to perform the block, side effects and satisfaction of patients."	( Comparison between ultrasound-guided paravertebral nerve block and subarachnoid block for elderly male patients under unilateral-opened inguinal hernia repair operation: A randomised controlled trial. Li, ZF; Wu, YM; Xie, PC; Yang, JL; Zhang, NN, 2019)	0.51
" Few data deal with the initial dosage of each drug."	( Optimizing Initial Intrathecal Drug Ratio for Refractory Cancer-Related Pain for Early Pain Relief. A Retrospective Monocentric Study. Bore, F; Carvajal, G; Delorme, T; Demelliez-Merceron, S; Dubois, PY; Dupoiron, D; Jubier-Hamon, S; Leblanc, D; Lebrec, N; Pechard, M; Robard, S; Seegers, V, 2019)	0.51
" The present study tested the hypothesis that multimodal analgesia with combined ropivacaine wound infiltration and intravenous flurbiprofen axetil after radical thyroidectomy provided better analgesia than a single dosage of tramadol."	( Multimodal analgesia with ropivacaine wound infiltration and intravenous flurbiprofen axetil provides enhanced analgesic effects after radical thyroidectomy: a randomized controlled trial. Li, X; Tan, H; Yang, J; Yu, L, 2019)	0.51
" The in vivo anesthesia antinociception study displayed that NLCs showed stronger and longer anesthesia antinociceptive effect when compared with single drugs loaded NLCs and drugs solution even at a lower dosage of drugs."	( Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer. Chao, L; Liu, Y; Qiu, D; Yang, Y, 2019)	0.51
" The dosage of 10 mg improves the quality of the anesthesia with less incidence of side effects."	( Efficacy of Nalbuphine as an Adjuvant to Ropivacaine in Ultrasound-guided Supraclavicular Brachial Block: A Prospective Randomized Controlled Study. Kalika, P; Ran, R; Xiao, Y; Xue, R; Zhen, M; Zheng, J, 2020)	0.56
" Secondary endpoints include pain intensity as assessed with the numerical rating scale (NRS) for pain, time to return of intestinal function (defined as the time to first flatus and the time to the first postoperative intake of solid food), time to first mobilization, the incidence of postoperative nausea and vomiting during the first 24 h, length of stay on the post anesthesia care unit (PACU) and in the hospital, the extent of sensory block at two time points (admission to and discharge from the PACU), the doses of morphine IV as requested by the patient from the PCA pump, the total dosage of morphine administered IV, the need for and dose of rescue analgesics (ketamine, clonidine), free plasma ropivacaine levels after induction and at discharge from the PACU, and the incidence of adverse events during treatment (in particular, signs of local anesthetic systemic toxicity (LAST))."	( Transmuscular quadratus lumborum (TQL) block for laparoscopic colorectal surgery: study protocol for a double-blind, prospective randomized placebo-controlled trial. Coppens, S; D'Hoore, A; Dewinter, G; Fieuws, S; Neyrinck, A; Rex, S, 2020)	0.56
" The primary endpoint was the total dosage of oxycodone."	( Changes of Opioid Consumption After Lumbar Fusion Using Ultrasound-Guided Lumbar Erector Spinae Plane Block: A Randomized Controlled Trial. Chen, L; Li, J; Wang, M; Wang, X; Wang, Y; Zhu, L, 2021)	0.62
" However, there is no unified consensus on the exact dosage of sufentanil with the combination of ropivacaine in the induction of epidural analgesia in the early first stage of labor."	( The 90% Effective Dose of Sufentanil for Epidural Analgesia in the Early First Stage of Labor: A Double-blind, Sequential Dose-Finding Study. Shen, T; Shen, Y; Xu, T; Xu, Z; Zhang, C; Zheng, J, 2021)	0.62
"Sufentanil at a dosage of 2 μg is recommended for the administration of epidural analgesia in parturients in the early first stage of labor."	( The 90% Effective Dose of Sufentanil for Epidural Analgesia in the Early First Stage of Labor: A Double-blind, Sequential Dose-Finding Study. Shen, T; Shen, Y; Xu, T; Xu, Z; Zhang, C; Zheng, J, 2021)	0.62
"The main objective of the study was to evaluate the safety, efficacy by pain assessment, to analyze drug dosage changes, to report adverse events (AEs) and conversion ratios switching from ropivacaine to bupivacaine."	( First Evaluation Switching From Ropivacaine to Highly Concentrated Bupivacaine in Intrathecal Mixtures for Cancer Pain. Bellanger, M; Bienfait, F; Boré, F; Delorme, T; Dupoiron, D; Jaoul, V; Jubier-Hamon, S; Lebrec, N; Pluchon, YM; Robert, J; Seegers, V; Sorrieul, J, 2021)	0.62
"The IAI does not appear to reduce postoperative pain scores or MMEs dosed for THA patients."	( Does the Use of an Intra-Articular Local Anesthetic Injection During Total Hip Arthroplasty Reduce Patient Reported Pain Scores or Patient Opioid Consumption? Geiselmann, MT; Goldberg, LK; Strecker, SE; Witmer, DK, 2022)	0.72
" The objective of this study was to determine the dose-response relationship of epidural dexmedetomidine (combined with ropivacaine) for labor analgesia."	( Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia. Feng, JL; Mei, Z; Ni, JX; Ni, LF; Qian, XW; Song, CZ; Song, SB; Yao, SJ; Yu, J, 2022)	0.72
" The dose-response relationship of dexmedetomidine (with ropivacaine) for epidural labor analgesia was performed using probit regression."	( Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia. Feng, JL; Mei, Z; Ni, JX; Ni, LF; Qian, XW; Song, CZ; Song, SB; Yao, SJ; Yu, J, 2022)	0.72
" There was also a significant increase in intraoperative esmolol dosage in the CFNB group (65."	( Combined femoral artery block and femoral nerve block reduces thigh tourniquet-induced hypertension. Gao, F; Li, W; Li, Y; Wang, Q; Wang, X; Xu, F; Yin, C; Yu, J; Zhu, L, 2023)	0.91
"The present study demonstrated that modified femoral nerve block reduced intraoperative esmolol dosage and the incidence of TH."	( Combined femoral artery block and femoral nerve block reduces thigh tourniquet-induced hypertension. Gao, F; Li, W; Li, Y; Wang, Q; Wang, X; Xu, F; Yin, C; Yu, J; Zhu, L, 2023)	0.91
" The dosing of sufentanil was determined by the assessor when the NRS score was 1 to 3 points."	( Could C3, 4, and 5 Nerve Root Block be a Better Alternative to Interscalene Block Plus Intermediate Cervical Plexus Block for Patients Undergoing Surgery for Midshaft and Medial Clavicle Fractures? A Randomized Controlled Trial. Gu, C; Han, J; Shan, Y; Wang, A; Xie, Y; Xu, Y, 2023)	0.91
" Larger studies are needed to confirm the findings, with accurate records of the dosage and administration route of local anesthetics."	( Postmortem concentrations of ropivacaine, bupivacaine, and lidocaine in femoral venous blood after hip fracture surgery. Kriikku, P; Nurkkala, J; Ojanperä, I; Oura, P; Virtanen, A, 2023)	0.91
" Arterial blood samples were obtained over 12 hours and analyzed using non-linear mixed effects modeling, which allowed for conducting simulations of clinically relevant dosing scenarios."	( Population pharmacokinetic and safety analysis of ropivacaine used for erector spinae plane blocks. Abulfathi, AA; Baratta, JL; Gebhart, A; Kaushal, G; Lam, E; Mohamod, D; Rochani, A; Roy, AB; Sarna, RR; Schmidt, S; Schwenk, ES; Viscusi, ER; Witzeling, SD; Zhao, JL, 2023)	0.91
" Weight-based ropivacaine dosing could reduce toxicity risk."	( Population pharmacokinetic and safety analysis of ropivacaine used for erector spinae plane blocks. Abulfathi, AA; Baratta, JL; Gebhart, A; Kaushal, G; Lam, E; Mohamod, D; Rochani, A; Roy, AB; Sarna, RR; Schmidt, S; Schwenk, ES; Viscusi, ER; Witzeling, SD; Zhao, JL, 2023)	0.91
" However, the optimal dosage regimen for intrathecal dexmedetomidine combined with plain ropivacaine for cesarean section (CS) remains undetermined."	( Intrathecal dexmedetomidine as an adjuvant to plain ropivacaine for spinal anesthesia during cesarean section: a prospective, double-blinded, randomized trial for ED Chen, J; Feng, J; Huang, F; Mo, X; Wu, X; Zeng, J, 2023)	0.91

Role	Description
local anaesthetic	Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block.
local anaesthetic	Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
piperidinecarboxamide
ropivacaine	The piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline.
hydrochloride	A salt formally resulting from the reaction of hydrochloric acid with an organic base.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Ropivacaine Action Pathway	31	11

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
lamin isoform A-delta10	Homo sapiens (human)	Potency	2.5119	0.8913	12.0676	28.1838	AID1487
TDP1 protein	Homo sapiens (human)	Potency	23.7150	0.0008	11.3822	44.6684	AID686979
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	25.1567	0.0010	22.6508	76.6163	AID1224838; AID1224893
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	20.4485	0.0123	7.9835	43.2770	AID1346984; AID1645841
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	6.0070	0.0002	14.3764	60.0339	AID720691
cytochrome P450 2D6	Homo sapiens (human)	Potency	4.8975	0.0010	8.3798	61.1304	AID1645840
chromobox protein homolog 1	Homo sapiens (human)	Potency	100.0000	0.0060	26.1688	89.1251	AID540317
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	31.6228	0.0178	9.6374	44.6684	AID588834
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	11.2202	0.7943	21.2757	50.1187	AID624246
geminin	Homo sapiens (human)	Potency	0.9200	0.0046	11.3741	33.4983	AID624296
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Potassium channel subfamily K member 3	Homo sapiens (human)	IC50 (µMol)	53.0000	0.0070	0.8985	5.1000	AID1525553
Bile salt export pump	Homo sapiens (human)	IC50 (µMol)	646.4000	0.1100	7.1903	10.0000	AID1449628
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
potassium ion transport	Potassium channel subfamily K member 3	Homo sapiens (human)
chemical synaptic transmission	Potassium channel subfamily K member 3	Homo sapiens (human)
response to xenobiotic stimulus	Potassium channel subfamily K member 3	Homo sapiens (human)
monoatomic ion transmembrane transport	Potassium channel subfamily K member 3	Homo sapiens (human)
negative regulation of cytosolic calcium ion concentration	Potassium channel subfamily K member 3	Homo sapiens (human)
regulation of resting membrane potential	Potassium channel subfamily K member 3	Homo sapiens (human)
cellular response to zinc ion	Potassium channel subfamily K member 3	Homo sapiens (human)
cellular response to hypoxia	Potassium channel subfamily K member 3	Homo sapiens (human)
cochlea development	Potassium channel subfamily K member 3	Homo sapiens (human)
potassium ion transmembrane transport	Potassium channel subfamily K member 3	Homo sapiens (human)
stabilization of membrane potential	Potassium channel subfamily K member 3	Homo sapiens (human)
fatty acid metabolic process	Bile salt export pump	Homo sapiens (human)
bile acid biosynthetic process	Bile salt export pump	Homo sapiens (human)
xenobiotic metabolic process	Bile salt export pump	Homo sapiens (human)
xenobiotic transmembrane transport	Bile salt export pump	Homo sapiens (human)
response to oxidative stress	Bile salt export pump	Homo sapiens (human)
bile acid metabolic process	Bile salt export pump	Homo sapiens (human)
response to organic cyclic compound	Bile salt export pump	Homo sapiens (human)
bile acid and bile salt transport	Bile salt export pump	Homo sapiens (human)
canalicular bile acid transport	Bile salt export pump	Homo sapiens (human)
protein ubiquitination	Bile salt export pump	Homo sapiens (human)
regulation of fatty acid beta-oxidation	Bile salt export pump	Homo sapiens (human)
carbohydrate transmembrane transport	Bile salt export pump	Homo sapiens (human)
bile acid signaling pathway	Bile salt export pump	Homo sapiens (human)
cholesterol homeostasis	Bile salt export pump	Homo sapiens (human)
response to estrogen	Bile salt export pump	Homo sapiens (human)
response to ethanol	Bile salt export pump	Homo sapiens (human)
xenobiotic export from cell	Bile salt export pump	Homo sapiens (human)
lipid homeostasis	Bile salt export pump	Homo sapiens (human)
phospholipid homeostasis	Bile salt export pump	Homo sapiens (human)
positive regulation of bile acid secretion	Bile salt export pump	Homo sapiens (human)
regulation of bile acid metabolic process	Bile salt export pump	Homo sapiens (human)
transmembrane transport	Bile salt export pump	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
monoatomic ion channel activity	Potassium channel subfamily K member 3	Homo sapiens (human)
open rectifier potassium channel activity	Potassium channel subfamily K member 3	Homo sapiens (human)
potassium channel activity	Potassium channel subfamily K member 3	Homo sapiens (human)
potassium ion leak channel activity	Potassium channel subfamily K member 3	Homo sapiens (human)
S100 protein binding	Potassium channel subfamily K member 3	Homo sapiens (human)
outward rectifier potassium channel activity	Potassium channel subfamily K member 3	Homo sapiens (human)
protein binding	Bile salt export pump	Homo sapiens (human)
ATP binding	Bile salt export pump	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Bile salt export pump	Homo sapiens (human)
bile acid transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
canalicular bile acid transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
carbohydrate transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
ABC-type bile acid transporter activity	Bile salt export pump	Homo sapiens (human)
ATP hydrolysis activity	Bile salt export pump	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Potassium channel subfamily K member 3	Homo sapiens (human)
synapse	Potassium channel subfamily K member 3	Homo sapiens (human)
plasma membrane	Potassium channel subfamily K member 3	Homo sapiens (human)
basolateral plasma membrane	Bile salt export pump	Homo sapiens (human)
Golgi membrane	Bile salt export pump	Homo sapiens (human)
endosome	Bile salt export pump	Homo sapiens (human)
plasma membrane	Bile salt export pump	Homo sapiens (human)
cell surface	Bile salt export pump	Homo sapiens (human)
apical plasma membrane	Bile salt export pump	Homo sapiens (human)
intercellular canaliculus	Bile salt export pump	Homo sapiens (human)
intracellular canaliculus	Bile salt export pump	Homo sapiens (human)
recycling endosome	Bile salt export pump	Homo sapiens (human)
recycling endosome membrane	Bile salt export pump	Homo sapiens (human)
extracellular exosome	Bile salt export pump	Homo sapiens (human)
membrane	Bile salt export pump	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID588219	FDA HLAED, gamma-glutamyl transferase (GGT) increase	2004	Current drug discovery technologies, Dec, Volume: 1, Issue:4	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID625281	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625288	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID748682	Antiarrhythmic activity in iv dosed Swiss albino mouse assessed as inhibition of calcium chloride-induced cardiac arrhythmia after 15 mins	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID625290	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID540212	Mean residence time in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID613109	Cardiotoxicity in dog assessed as free plasma concentration causing cardiovascular collapse measured after 20 mins	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes.
AID588214	FDA HLAED, liver enzyme composite activity	2004	Current drug discovery technologies, Dec, Volume: 1, Issue:4	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID467613	Volume of distribution at steady state in human	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
AID625280	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID467611	Dissociation constant, pKa of the compound	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
AID588216	FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase	2004	Current drug discovery technologies, Dec, Volume: 1, Issue:4	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID625291	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625285	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID540211	Fraction unbound in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID625286	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID588215	FDA HLAED, alkaline phosphatase increase	2004	Current drug discovery technologies, Dec, Volume: 1, Issue:4	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID625289	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625283	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID748686	Anesthetic effect in Wistar rat assessed as time taken for blockage of muscle contraction by infiltration local anaesthetic activity assay	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID748680	Anesthetic effect in Wistar rat assessed as duration of blockage of muscle contraction by infiltration local anaesthetic activity assay	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID588217	FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase	2004	Current drug discovery technologies, Dec, Volume: 1, Issue:4	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID1525553	Inhibition of human TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	TASK Channels Pharmacology: New Challenges in Drug Design.
AID540209	Volume of distribution at steady state in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID613103	Cardiotoxicity in dog assessed as total plasma concentration causing cardiovascular collapse measured after 20 mins	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes.
AID588218	FDA HLAED, lactate dehydrogenase (LDH) increase	2004	Current drug discovery technologies, Dec, Volume: 1, Issue:4	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID625292	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625282	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625287	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID540213	Half life in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID540210	Clearance in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID748683	Toxicity in iv dosed Swiss albino mouse after 72 hrs	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID625284	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID467612	Fraction unbound in human plasma	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
AID748681	Antiarrhythmic index, ratio of LD50 for Swiss albino mouse to ED50 for calcium chloride-induced Swiss albino mouse	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID625279	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID613104	Increase in membrane fluidity in DPH-labeled liposomal membrane containing 40 mol% cholesterol assessed as change in DPH fluorescence polarization at 200 uM after 5 mins by spectrofluorometry relative to control	2011	Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11	Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes.
AID748685	Anesthetic effect in Wistar rat assessed as duration of complete blockage of muscle contraction by infiltration local anaesthetic activity assay	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID1449628	Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method	2012	Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12	Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
AID748687	Surface anesthetic effect in New Zealand white rabbit assessed as time duration	2013	European journal of medicinal chemistry, May, Volume: 63	Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
AID504749	qHTS profiling for inhibitors of Plasmodium falciparum proliferation	2011	Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043	Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1346758	Human Nav1.5 (Voltage-gated sodium channels)	2015	Anesthesia and analgesia, Jun, Volume: 120, Issue:6	A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1347095	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347101	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347098	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347096	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1347104	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347108	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424	RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)	2019	The Journal of biological chemistry, 11-15, Volume: 294, Issue:46	Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347097	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347092	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347094	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347425	Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)	2019	The Journal of biological chemistry, 11-15, Volume: 294, Issue:46	Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	15 (0.43)	18.7374
1990's	238 (6.88)	18.2507
2000's	1204 (34.83)	29.6817
2010's	1420 (41.08)	24.3611
2020's	580 (16.78)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1,982 (51.23%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	133 (3.44%)	6.00%
Reviews	0 (0.00%)	6.00%
Case Studies	405 (10.47%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	50 (1.29%)	0.25%
Observational	0 (0.00%)	0.25%
Other	1,299 (33.57%)	84.16%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (962)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo [NCT03657979]	Phase 4	50 participants (Actual)	Interventional	2011-09-05	Completed
Pilot Study: Extended Regional Anesthesia to Prevent Chronic Pain After Ankle Fracture Surgery [NCT02950558]	Phase 4	14 participants (Actual)	Interventional	2018-05-29	Completed
Ultrasound Guided Transversus Abdominus Plane Block for Patients Undergoing Laparoscopic Hand-assisted Nephrectomy. [NCT01054469]		21 participants (Actual)	Interventional	2010-03-31	Completed
Local Anesthetic Activity of Liposomal Formulations in Dentistry [NCT01054547]	Phase 1	80 participants (Actual)	Interventional	2006-09-30	Completed
A Preemptive Epidural Ropivacaine for Postoperative Pain Relief in Degenerative Lumbar Spine Surgery: A Prospective Randomized Study [NCT01117610]	Phase 4	60 participants (Anticipated)	Interventional	2010-05-31	Not yet recruiting
Perioperative Analgetic Therapy After Knee Arthroplasty [NCT01225484]	Phase 4	123 participants (Anticipated)	Interventional	2010-10-31	Recruiting
RePPAIR -Reducing Procedural Pain and Improving Recovery of Quality of Life in Pediatric Neuroblastoma Patients Undergoing Bone Marrow Procedures: A Prospective Randomized Cross-over Clinical Trial [NCT02924324]		56 participants (Actual)	Interventional	2016-10-31	Completed
Postoperative Analgesic Efficacy of Local Infiltration Analgesia Versus Adductor Canal Block After Anterior Cruciate Ligament Reconstruction: A Randomised Controlled Double-blinded Trial [NCT02524652]	Phase 4	104 participants (Actual)	Interventional	2015-09-30	Completed
Evaluation of Optimal Dose of Local Anesthetics for Patient Controlled Continuous Femoral Nerve Block With Sciatic Nerve Block After Total Knee Arthroplasty [NCT01198340]		60 participants (Anticipated)	Interventional	2010-09-30	Recruiting
A Phase-4, Multicenter, Randomized, Active-Controlled Study to Evaluate the Efficacy and Safety of EXPAREL When Administered Via Fascia Iliaca Compartment Block Versus Fascia Iliaca Compartment Block With Continuous Infusion of Ropivacaine Per Standard of [NCT03955458]	Phase 4	0 participants (Actual)	Interventional	2019-08-26	Withdrawn(stopped due to Recruitment difficulties)
Erectus Nerve Block for Lumbar Spine Surgery : a Prospective Randomized Study [NCT04473508]	Phase 3	50 participants (Actual)	Interventional	2019-11-27	Completed
Effect of Continuous Paravertebral Block on Postoperative Quality of Recovery After Hepatectomy [NCT03777644]		76 participants (Actual)	Interventional	2018-11-01	Completed
Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage [NCT06008795]	Phase 2	195 participants (Anticipated)	Interventional	2023-11-27	Recruiting
Regional Block for Postoperative Free Flap Care [NCT04080739]	Phase 4	100 participants (Actual)	Interventional	2020-01-13	Completed
The Effect of Adductor-Canal-Block (ACB) in Patients After Anterior Cruciate Ligament (ACL) Reconstruction in Day Case Surgery [NCT01212666]	Phase 4	50 participants (Actual)	Interventional	2010-05-31	Completed
Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study- [NCT01234272]	Phase 4	59 participants (Actual)	Interventional	2010-08-31	Completed
Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries [NCT05843344]		90 participants (Anticipated)	Interventional	2023-05-01	Not yet recruiting
Trial Evaluating the Efficacy of the Combination of ROpivacaine With Reference XYlocaine in the Evaluation of Pain During the Installation of Percutaneous Radiological GASTrostomy [NCT04250805]	Phase 2	124 participants (Anticipated)	Interventional	2020-10-27	Recruiting
Do Peritoneal Nebulization of Ropivacaine Reduce the Use of Morphine After Short Gynecologic Laparoscopic Surgery? [NCT01142622]	Phase 3	140 participants (Anticipated)	Interventional	2010-04-30	Completed
Pharmacokinetic Profile and Dermatomal Coverage of the Erector Spinae Plane Block: a Comparison of Bolus Dosing and Continuous Infusion [NCT03874806]	Phase 4	0 participants (Actual)	Interventional	2019-07-01	Withdrawn(stopped due to Did not receive funding)
Transversus Abdominis Plane Blocks in Patients Scheduled for an Abdominoplasty. A Prospective, Randomized, Double Blind, Comparison Between the Posterior Approach and Placebo. [NCT01278264]	Phase 4	60 participants (Anticipated)	Interventional	2011-06-30	Not yet recruiting
A Randomized Controlled Trial Comparing Intraoperative Surgeon-Performed Versus Anesthesiologist-Performed Adductor Canal Blockade After Primary Total Knee Arthroplasty [NCT03864588]	Phase 4	164 participants (Anticipated)	Interventional	2018-10-01	Enrolling by invitation
Application of Iced Normal Saline Combined With Cocktail Perfusion in Total Knee Arthroplasty: Randomized Controlled Trial [NCT05204056]		60 participants (Actual)	Interventional	2018-03-02	Completed
A Phase I/II, Randomized, Double-blind, Comparator-controlled, Dose-escalation Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of TLC590 for Postsurgical Pain Management Following Inguinal Hernia Repair [NCT03591146]	Phase 1/Phase 2	65 participants (Actual)	Interventional	2018-07-31	Completed
Post Operative Analgesia After Pediatric Hip Surgery - PCA, Epidural or Lumbar Plexus Catheter: A Prospective Randomized Control Trial [NCT03435692]		42 participants (Actual)	Interventional	2011-07-15	Terminated(stopped due to Funding was exhausted prior to enrolling intended number of patients.)
Evaluation of the Efficacy of a Topical Analgesic Treatment With ROPIVACAINE in Children and Young Adults With Hereditary Epidermolysis Bullosa [NCT03730584]		10 participants (Actual)	Interventional	2017-02-27	Completed
Analgesic Efficacy of a Combined Saphenous Nerve Block and IPACK Block Versus Local Infiltration Analgesia After Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Double-blinded Trial. [NCT03680716]		60 participants (Actual)	Interventional	2018-11-01	Completed
A Phase 2b, Randomized, Double-Blind, Saline Placebo- and Active-Controlled, Multicenter Study of HTX-011 Via Infiltration for Postoperative Analgesia in Subjects Undergoing Total Knee Arthroplasty [NCT03015532]	Phase 2	285 participants (Actual)	Interventional	2017-01-13	Completed
Ultrasound-guided Transmuscular Quadratus Lumborum Catheters for Elective Caesarean Section. A Double Blind, Randomise, Placebo Controlled Trial. [NCT03663478]	Phase 4	32 participants (Actual)	Interventional	2018-09-04	Completed
Pre vs. Postoperative Adductor Canal Block for Total Knee Arthroplasty: Prospective Randomized Trial [NCT05974501]	Phase 4	84 participants (Anticipated)	Interventional	2023-09-29	Recruiting
A Randomized Controlled Trial (RCT) Comparing Presacral Nerve Block Versus Sham Block on Post-operative Pain in Women Undergoing Total Laparoscopic Hysterectomy. [NCT05953766]	Phase 2	60 participants (Anticipated)	Interventional	2023-08-02	Not yet recruiting
Effects of Preoperative Scalp Nerve Block on Postoperative Recovery Quality in Patients Undergoing Excision of Intracranial Meningioma [NCT03648034]		144 participants (Actual)	Interventional	2018-09-18	Completed
Postoperative Analgesic Efficacy of Continuous Wound Infusion With Local Anesthetics After Laparoscopy (PAIN): a Randomized, Double-blind, Placebo-controlled Trial [NCT03645304]		66 participants (Anticipated)	Interventional	2019-01-21	Recruiting
Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section [NCT02410317]	Phase 3	101 participants (Actual)	Interventional	2015-02-28	Completed
Comparison of the Effects of Adding Dexamethasone at 0.25% Ropivacaine With 0.5% Ropivacaine Alone in the Supraclavicular Brachial Plexus Block [NCT03572686]		90 participants (Anticipated)	Interventional	2018-04-13	Enrolling by invitation
Pain During Pars Plana Vitrectomy Comparing Peribulbar Anesthesia Versus Sub-tenon Injection Plus Topical Jelly Anesthesia [NCT03902925]	Phase 1/Phase 2	56 participants (Actual)	Interventional	2019-01-01	Completed
The Efficacy of Adductor-Canal-Block (ACB) in Patients After Knee Arthroscopy [NCT01254825]	Phase 4	72 participants (Actual)	Interventional	2010-11-30	Completed
The Randomised Epidural Analgesia in Term Delivering Women Trial [NCT01261689]		488 participants (Actual)	Interventional	2008-09-30	Completed
Double-blind Randomized Prospective Phase III Study of a Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment of the Postoperative Pain From Hospital to Home [NCT02525211]	Phase 3	59 participants (Actual)	Interventional	2012-10-31	Terminated(stopped due to Recruitment defect)
A Double-blind Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Per and Post Hepatectomy Infiltrations for Adult Pain Management [NCT01194843]		85 participants (Actual)	Interventional	2009-03-31	Completed
Pudendal Nerve Block in Patient Treated for Hemorrhoidectomy Under Spinal Anaesthesia: Prospective Randomized Double-blind Controlled Trial [NCT04251884]		49 participants (Actual)	Interventional	2018-01-01	Completed
Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block [NCT01334619]	Phase 4	30 participants (Actual)	Interventional	2010-03-31	Completed
Preoperative Versus Postoperative Ultrasound-guided Rectus Sheath Block for Improving Pain, Sleep Quality and Cytokine Levels of Patients With Open Midline Incisions Undergoing Transabdominal Gynaecological Operation [NCT02477098]	Phase 4	77 participants (Actual)	Interventional	2015-10-31	Completed
Evaluation of Trigeminal Nerve Blockade in the Pterygopalatine Fossa for Cleft Palate Repair: a Pilot Study [NCT03632044]	Early Phase 1	40 participants (Anticipated)	Interventional	2018-11-20	Enrolling by invitation
The Effects of Ultrasound-guided Transversus Abdominis Plane Block on Acute and Chronic Postsurgical Pain After Robotic Partial Nephrectomy. A Prospective, Randomized, Clinical Trial [NCT02460640]		96 participants (Actual)	Interventional	2015-05-31	Completed
Comparison Between Epidural and Patient Controlled Analgesia on Immunological and Inflammatory Systems Following Radical Retropubic Prostatectomy [NCT01367418]	Phase 3	26 participants (Actual)	Interventional	2010-09-30	Completed
Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section [NCT03695172]	Phase 4	12 participants (Actual)	Interventional	2019-09-12	Terminated(stopped due to Decline of eligible participants)
The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane [NCT03533452]	Phase 2/Phase 3	27 participants (Actual)	Interventional	2019-05-01	Completed
Efficacy of Regional Analgesia Techniques (Quadratus Lumborum Block and Transversus Abdominis Plane Block) in Acute and Chronic Pain Treatment in Patients After Cesarean Delivery [NCT03244540]	Phase 4	105 participants (Actual)	Interventional	2017-09-04	Completed
Epidural or Patient-controlled Analgesia for Colorectal Cancer Surgery. Long-term Outcomes. [NCT01318161]	Phase 3	221 participants (Actual)	Interventional	2011-03-31	Terminated(stopped due to Difficulty in recruiting)
Local Infiltration Analgesia in Total Knee Arthroplasty: A Randomized, Prospective, Placebo Controlled, Double Blinded Study. [NCT03206554]	Phase 2	40 participants (Actual)	Interventional	2015-09-30	Completed
The Effect of Intraperitoneal Local Anaesthetic on Functional Recovery Following Bowel Resection: A Prospective Randomised Blinded Trial [NCT02449720]	Phase 4	86 participants (Actual)	Interventional	2015-05-31	Completed
Ropivacaine Infusion to Alleviate Postoperative Pain After Cardiac Surgery [NCT02449486]	Phase 4	90 participants (Actual)	Interventional	2014-01-31	Completed
Can the Association of Dexamethasone and Local Anaesthetic in a Single-shot Femoral and Sciatic Nerve Block Improve Analgesia Postoperatively in Patients Submitted to Total Knee Arthroplasty [NCT02436694]		56 participants (Anticipated)	Interventional	2015-04-30	Recruiting
Intérêt du TFP (Transversalis Fascia Plane) Bloc échoguidé Pour l'analgésie du prélèvement Osseux de crête Iliaque [NCT02398474]	Phase 4	46 participants (Actual)	Interventional	2015-05-12	Completed
Interest of Parasternal Block to Limit the Doses of Anesthetics Necessary for the Maintenance of Arterial Blood Pressure and Heart Rate in the Recommended Values During Sternotomy in Patients Undergoing Coronary Artery Bypass Graft [NCT03734159]	Phase 4	35 participants (Actual)	Interventional	2018-12-13	Completed
Comparison of Programmed Intermittent Epidural Boluses With Continuous Epidural Infusion for Maintenance of Labor Analgesia [NCT02949271]	Phase 4	179 participants (Actual)	Interventional	2016-11-08	Completed
Clinical Assessment of the Treatment With Cardiac Sympathetic Blockade on Chronic Heart Failure [NCT02391142]		100 participants (Anticipated)	Interventional	2014-06-30	Recruiting
Efficacy of Parietal Continuous Infiltration of Local Anesthesic on Diaphragmatic Function After Upper Abdominal Surgery Through a Subcostal Incision [NCT02353702]	Phase 3	31 participants (Actual)	Interventional	2014-07-31	Completed
Effect of Nervus Cutaneous Femoris Lateralis-Blockade on Moderate Pain Responders After Total Hip Arthroplasty [NCT02344264]	Phase 4	60 participants (Actual)	Interventional	2015-01-31	Completed
A Randomized Controlled Trial Comparing Single Shot Fascia Iliaca Block With Femoral Nerve Block for Analgesia Following Surgical Fixation of Hip Fractures [NCT02330302]		30 participants (Actual)	Interventional	2014-08-31	Completed
The Effect of Pectoralis Block on Analgesia After Simple Mastectomy [NCT03143530]	Phase 4	0 participants (Actual)	Interventional	2017-12-31	Withdrawn(stopped due to Extensive protocol revisions initiated.)
Effectiveness of Preoperative iPACK on Postoperative Pain From Hamstring Autograft for ACL Repair [NCT05080348]		40 participants (Anticipated)	Interventional	2021-12-31	Not yet recruiting
Comparison of Ultrasound-guided PENG Block and Supra-inguinal Fascia Iliaca Compartment Block for Postoperative Opioids Consumption and Early Motor Recovery After Total Hip Arthroplasty: a Randomized Controlled Non-inferiority Clinical Trial. [NCT04690023]	Phase 4	82 participants (Anticipated)	Interventional	2022-01-01	Recruiting
A Randomized, Sham-procedure-controlled, Blinded Study to Evaluate the Effectiveness and Acceptability of Right-sided Stellate Ganglion Block for Treatment of Posttraumatic Stress Disorder Symptoms [NCT03077919]		113 participants (Actual)	Interventional	2016-05-25	Completed
A Comparison of Lidocaine Versus Ropivacaine for Bilateral Continuous Thoracic Paravertebral Nerve Blocks for Post-bowel Surgery Analgesia [NCT02849678]		68 participants (Actual)	Interventional	2008-01-31	Completed
Multimodal Anesthesia and Analgesia for Total Shoulder and Reverse Total Shoulder Arthroplasty: A Randomized Controlled Trial [NCT03586934]	Phase 3	0 participants (Actual)	Interventional	2018-06-01	Withdrawn(stopped due to Difficult to enroll patients for the study)
Sole Epidural Local Anesthetic Versus Opioid Plus Local Anesthetic in Epidural Labor Pain Control [NCT02036242]	Phase 4	500 participants (Actual)	Interventional	2013-09-30	Completed
Tranversus Abdominis Plane (TAP) Block vs. Systemic Lidocaine to Improve Quality of Recovery After Outpatient Laparoscopic Surgery: A Non-inferiority, Randomized, Double Blinded, Placebo Controlled Trial [NCT02053558]		0 participants (Actual)	Interventional	2014-11-03	Withdrawn(stopped due to Could not obtain dedicated ultrasound device.)
Health Related Quality of Life and Pain Managment Using Infiltration or Suprascapular Nerve Block Ultrasound Guided in Patients With Glenohumeral Arthirtis [NCT03794505]	Phase 3	40 participants (Actual)	Interventional	2018-04-01	Completed
THE TAP BLOCK TECHNIQUE VIA THE ANTERIOR APPROACH IN ELECTIVE SURGERY OF THE SPINE: Prospective, Randomised, Double Blind Trial, Comparing TAP BLOCK With Continuous Infiltration of Ropivacaine Versus Placebo [NCT02055664]	Phase 4	80 participants (Actual)	Interventional	2014-01-23	Completed
Determination of the Efficay of the Transversus Abdominis Plane (TAP) Block as Part of a Multimodal Regimen for Post-cesarean Delivery Analgesia: a Double Blinded Placebo-controlled Study. [NCT00573963]		100 participants (Actual)	Interventional	2007-12-31	Completed
Does Ultrasound-guided Erector Spinae Plane Block Improve Postoperative Quality of Recovery After Video-assisted Thoracic Surgery [NCT03756987]		76 participants (Actual)	Interventional	2018-12-28	Completed
Application of Combined Lumbar Plexus and Sciatic Nerve Block in Unilateral Knee Replacement [NCT02084368]	Phase 4	34 participants (Actual)	Interventional	2014-01-31	Completed
Intrathecal Plain Bupivacaine, Ropivacaine and Levo-bupivacaine With or Without Fentanyl for Elective c Section. [NCT01582607]	Phase 2/Phase 3	130 participants (Anticipated)	Interventional	2010-01-31	Recruiting
A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS [NCT02126332]	Phase 3	148 participants (Actual)	Interventional	2014-06-06	Completed
A Randomized Controlled Study of the Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy [NCT06145945]		72 participants (Anticipated)	Interventional	2023-11-25	Not yet recruiting
Pre-Operative and Post-Operative Paravertebral Block on Patients With Thoracic Outlet Syndrome. [NCT05544721]	Phase 4	50 participants (Anticipated)	Interventional	2022-10-05	Enrolling by invitation
Erector Spinae Plane Block for Reduction of Early Postoperative Pain Scores and Opioid Use in Lumbar Spinal Fusion Surgery, a Prospective Double-blinded Randomized Placebo-controlled Trial [NCT05345249]	Phase 4	76 participants (Anticipated)	Interventional	2022-06-01	Recruiting
Effect of Perineural Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Ankle Surgery [NCT03332316]	Phase 4	84 participants (Actual)	Interventional	2017-11-02	Completed
Improving Postoperative Pain Management With the Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Laparoscopic Hand-assisted Nephrectomy and Robot-assisted Partiel Nephrectomy: A Double Blind, Randomized, Placebo Controlled Trial [NCT03571490]	Phase 4	50 participants (Actual)	Interventional	2018-06-26	Completed
Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery [NCT02829944]	Phase 4	84 participants (Actual)	Interventional	2016-11-30	Completed
Local Infiltration Analgesia in Total Hip Arthroplasty - Efficacy of Multiple Bolus Injections With Ropivacaine and Ketorolac [NCT01344395]	Phase 4	80 participants (Actual)	Interventional	2010-03-31	Completed
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine vs. Ropivacaine for Relief of Postoperative Pain After Craniotomy in Adults [NCT03618264]	Phase 4	140 participants (Actual)	Interventional	2019-04-04	Completed
Adductor Canal Block Versus Femoral Nerve Block for Total Knee Arthroplasty [NCT03133481]	Phase 3	94 participants (Actual)	Interventional	2014-10-22	Completed
Does the Use of Ropivacaine Facilitates Cholecystectomy by Laparoscopy in Ambulatory Surgery? [NCT02085902]	Phase 4	120 participants (Actual)	Interventional	2014-03-31	Completed
The Transversus Abdominis Plane Block [NCT03634111]		60 participants (Actual)	Interventional	2017-07-10	Completed
Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial [NCT02680626]	Phase 4	86 participants (Actual)	Interventional	2016-01-31	Terminated(stopped due to Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients)
A Randomized Controlled Trial of Combined Spinal Epidural Versus Dural Puncture Epidural Techniques for Labor Analgesia [NCT05068661]	Phase 4	100 participants (Anticipated)	Interventional	2021-11-21	Recruiting
[NCT02163980]		80 participants (Actual)	Interventional	2011-05-31	Completed
Determination of the Minimal Effective Concentration (EC90) of Ropivacaine in Axillary Brachial Plexus Block With Intravenous Dexamethasone or Saline Injection [NCT03688269]	Phase 3	146 participants (Actual)	Interventional	2018-10-05	Completed
The Effect of Phrenic Nerve Blockade on Acute and Chronic Shoulder Pain in Patients for Lobectomy and Pneumonectomy. [NCT02173418]	Phase 4	76 participants (Actual)	Interventional	2012-11-30	Completed
The Efficacy of Ultrasound-guided Suprainguinal Fascia Iliaca Compartment Block on Early Post-operative Analgesia After Total Hip Arthroplasty [NCT03069183]	Phase 2/Phase 3	133 participants (Actual)	Interventional	2018-08-30	Completed
Does Regional Anesthesia Reduce Postoperative Opioid Consumption in Subjects Undergoing Fibula Free Flap Reconstruction of the Head and Neck: A Prospective Trial [NCT03906838]	Early Phase 1	0 participants (Actual)	Interventional	2020-01-01	Withdrawn(stopped due to funding not obtained)
Comparison of the Analgesic Effect of Femoral Nerve Block, Intraarticular Infiltration or a Combination of Both in the Control of Pain in Total Knee Arthroplasty [NCT01304212]	Phase 4	137 participants (Actual)	Interventional	2011-04-30	Completed
Effect of Local Anesthetic Continuous Preperitoneal Wound Infiltration on Incisional Hyperalgesia Following Colorectal Laparoscopic Surgery [NCT01077752]	Phase 3	95 participants (Actual)	Interventional	2010-02-28	Completed
Thoracic Paravertebral Block: a Comparative Study of Ropivacaine With Ropivacaine and Sufentanil for Treating Pain After Video-assisted Thoracic Surgery. [NCT01082744]	Phase 3	90 participants (Actual)	Interventional	2010-03-31	Completed
Effect of Adding Sufentanil to Epidural Ropivacaine on Perioperative Metabolic and Stress Responses in Combined General/Epidural Anaesthesia for Geriatric Radical Retropubic Prostatectomy [NCT01086956]		60 participants (Actual)	Interventional	2008-09-30	Completed
Optimal Effective Local Anesthetic Volume for Pain Relief Using Brachial Plexus Block Utilizing Continuous Reassessment Method for Arthroscopic Rotator Cuff Shoulder Surgery [NCT05868993]	Phase 4	150 participants (Anticipated)	Interventional	2023-02-17	Recruiting
Analgesic Effect of Bilateral Erector Spinae Plane Block With Ropivacaine After Sternotomy in Cardiac Surgery [NCT05160298]	Phase 2	84 participants (Actual)	Interventional	2021-10-20	Completed
Multimodal Periarticular Analgesic Injection With and Without Surgeon-Administered Adductor Canal Block During Total Knee Arthroplasty: A Randomized Controlled Trial [NCT04513145]	Phase 2/Phase 3	130 participants (Anticipated)	Interventional	2020-10-09	Enrolling by invitation
Effectiveness of Interscalene Brachial Plexus Block and Intra-articular Injection of Ropivacaine for Post-operative Analgesia in Arthroscopic Shoulder Stabilization Surgery [NCT01589354]		60 participants (Anticipated)	Interventional	2012-05-31	Not yet recruiting
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Laparoscopic Hysterectomy. A Double Blind, Randomized, Placebo Controlled Trial. [NCT03650998]	Phase 4	70 participants (Actual)	Interventional	2018-09-28	Completed
Improving Combined Spinal-epidural Anesthesia for Decreasing Hypotension in Pregnant Women Without Prophylactical Prehydration and Vasopressors [NCT03497364]		930 participants (Anticipated)	Interventional	2018-05-01	Recruiting
Stimulating Catheter for Lumbar Plexus Block: Better Postoperative Analgesia? [NCT02162121]	Phase 4	64 participants (Actual)	Interventional	2014-05-31	Completed
Magnetic Resonance Imaging of Local Anesthetic Distribution: A Comparison of 5 and 15 Milliliters of Ropivacaine 0,75% for Ultrasound Guided Interscalene Plexus Blockade [NCT02175069]	Phase 4	30 participants (Actual)	Interventional	2013-12-31	Completed
Minimum Effective Volume (MEV95%) of Ropivacaine 7.5 mg/ml to Block the Posterior and Lateral Cords of the Infraclavicular Brachial Plexus [NCT03329456]	Phase 4	23 participants (Actual)	Interventional	2017-10-30	Completed
Serratus Plain Block Versus Paravertebral Block Versus Serratus Plain Block and Paravertebral Block for Postoperative Pain Following Thoracoscopic Surgery [NCT04222010]		155 participants (Actual)	Interventional	2020-01-02	Completed
Evaluation of Magnesium as Adjuvant to Ropivacaine for Sciatic Block at Popliteal Level. [NCT02198547]		60 participants (Anticipated)	Interventional	2014-03-31	Enrolling by invitation
The Postoperative Analgesic Efficacy of Varied Concentrations of Ropivacaine Used for the Transverse Abdominis Plane (TAP) Block After Cesarean Delivery [NCT01170702]	Phase 4	120 participants (Actual)	Interventional	2010-01-31	Completed
Flurbiprofen Axetil as an Adjuvant to Pre-emptive Scalp Infiltration for Post-craniotomy Pain [NCT05624359]		216 participants (Anticipated)	Interventional	2023-11-01	Recruiting
Median Effective Concentration of Ropivacaine for Ultrasound-guided Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery [NCT04981067]		45 participants (Anticipated)	Interventional	2021-08-24	Recruiting
Efficacy of Liposomal Bupivacaine in Arthroscopic Rotator Cuff Repair [NCT03738696]	Phase 4	63 participants (Actual)	Interventional	2019-12-15	Completed
Postoperative Analgesic Effect of Morphine Added to Ropivacaine for Fascia Iliaca Compartment Block Following Femoral Fracture Surgeries [NCT03875274]	Phase 4	70 participants (Actual)	Interventional	2017-04-01	Completed
Effective Pain Management During Shoulder Replacement Surgery With Either Continuous Ropivacaine Interscalene Nerve Block or Local Infiltration With EXPAREL After Single Shot Injection Ropivacaine Interscalene Nerve Block [NCT03474510]	Phase 4	0 participants (Actual)	Interventional	2018-03-17	Withdrawn(stopped due to Investigator Decision)
Comparative Study Between Different Routes of Ropivacaïne Administration to Reduce Post-operative Pain in Gynecological Laparoscopy, a Double Blind Randomized Trial. [NCT04459026]	Phase 4	60 participants (Actual)	Interventional	2017-07-01	Completed
Effect of a Single Shot Sciatic Nerve Block (SNB) Combined With a Continuous Femoral Block (CFNB) on Pain Scores After Knee Arthroplasty. A Randomized Controlled Trial [NCT01337115]		50 participants (Actual)	Interventional	2011-04-30	Completed
Intercostobrachial Nerve Block (ICBN) for Tourniquet Pain: Is it Necessary? [NCT03797924]	Early Phase 1	46 participants (Actual)	Interventional	2019-04-25	Completed
The Effect of The Serratus Block on Analgesia After Breast Surgery A Randomized Controlled Double-Blinded Study [NCT02453516]	Phase 2/Phase 3	40 participants (Actual)	Interventional	2014-10-29	Completed
Postoperative Analgesic Effects of Ultrasound-guided Bilateral Rectus Sheath Block for Robotic Single-port Gynecologic Surgery [NCT02450084]		60 participants (Actual)	Interventional	2015-05-31	Completed
The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks Following Oromaxillofacial Reconstruction [NCT03118076]	Phase 4	40 participants (Anticipated)	Interventional	2017-04-20	Not yet recruiting
Efficacy of Continuous Infusion of Local Anesthesia After Radical Cystectomy: A Randomized, Double Blind, Placebo Controlled Study [NCT02438852]	Phase 3	0 participants (Actual)	Interventional	2019-02-25	Withdrawn(stopped due to No funding)
Comparing Efficacy and Safety of Three Regional Anesthesia Regimens in Total Hip and Knee Arthroplasty: A Double Blind Randomized Control Trial [NCT04257682]	Phase 4	135 participants (Anticipated)	Interventional	2022-09-30	Not yet recruiting
Ropivacaine For Post-POEM Pain Control [NCT03702647]		20 participants (Actual)	Interventional	2019-06-01	Completed
Continuous Infusion vs. Programmed Intermittent Bolus of Ropivacaine Through Peri-neural Femoral Nerve Catheter After Total Knee Arthroplasty: Impact on Analgesia Quality and Motor Block Frequency. [NCT03696095]	Phase 4	70 participants (Actual)	Interventional	2018-04-16	Completed
A Randomized Two-parallel Group Controlled Trial Comparing the Effects of 20mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Ultrasound-guided Supraclavicular Block for Upper Limb Surgery [NCT03480165]	Phase 3	86 participants (Actual)	Interventional	2016-06-20	Completed
Development of Variable Volume Automated Mandatory Boluses (VVAMB) for Patient-controlled Epidural Analgesia During Labour and Delivery [NCT04011150]	Phase 3	216 participants (Anticipated)	Interventional	2020-08-11	Recruiting
Effect of Local Infiltration Anesthesia With Ropivacaine on Pain After Primary Total Hip Arthroplasty [NCT02359136]		116 participants (Actual)	Interventional	2013-03-31	Completed
Extrafascial Injection Versus Subfascial Injection of Quadratus Lumborum Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy [NCT03421821]		80 participants (Actual)	Interventional	2018-02-25	Completed
Does Perineural Dexamethasone Prolong Duration of an Adductor Canal Block When Controlling for a Systemic Effect? A Paired, Randomized, Blinded, Study in Healthy Volunteers [NCT02351804]	Phase 2	20 participants (Actual)	Interventional	2015-02-28	Completed
A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Femoral Nerve Block for Analgesia Post Total Knee Arthroplasty [NCT02033603]		30 participants (Anticipated)	Interventional	2014-01-31	Recruiting
Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery [NCT04282239]		0 participants (Actual)	Interventional	2021-03-01	Withdrawn(stopped due to Did not have the staff to conduct the study)
Spinal Ropivacaine for Cesarean Delivery: A Comparison of Commonly Hyperbaric and Marginally Hyperbaric Solutions [NCT03142880]		120 participants (Anticipated)	Interventional	2017-05-31	Not yet recruiting
The Association Between Epidural Labor Analgesia and Pregnancy Outcomes [NCT03381495]		200 participants (Anticipated)	Interventional	2018-05-16	Recruiting
Comparison of the Effectiveness of the Use of Ropivacaine and Midazolam by Intraarticular vs Epidural Administration on Post-operative Analgesia After Isolated Arthroscopic ACL Reconstruction With Hamstring Autograft. [NCT05078372]	Phase 2	108 participants (Actual)	Interventional	2019-01-31	Completed
The Effect of Protracted Saphenous Nerve and Obturator Nerve Block Versus Saphenous Nerve Block Versus Local Infiltration Analgesia on Opioid Consumption, Pain, Block Duration of Action and Mobilization After Total Knee Arthroplasty. [NCT02067078]	Phase 4	75 participants (Actual)	Interventional	2014-02-28	Completed
The Analgesic Effect of Dexmedetomidine as an Adjunct to Local Anesthetics in Ultrasound-guided Interscalene Approach to Brachial Plexus Block for Shoulder Surgery: A Randomized Controlled Trial [NCT02225054]	Phase 2	99 participants (Actual)	Interventional	2013-05-31	Completed
Transversus Abdominis Plane Block During Kidney Transplant Surgery: Prospective Controlled Randomized Double-blind Trial Comparing Ropivacaine 0.2% With Placebo. [NCT02080728]	Phase 4	50 participants (Actual)	Interventional	2013-07-23	Completed
Comparison of Two Anesthetic Techniques in Blocking the Erector Plane of the Spine Bilateral in Cardiac Surgery: a Prospective Randomized Double-blinded Clinical Trial [NCT04313959]	Phase 3	40 participants (Anticipated)	Interventional	2022-01-20	Recruiting
Use of Tap Block in Patients After Hysterectomy [NCT02259374]		54 participants (Anticipated)	Interventional	2014-10-31	Not yet recruiting
Continuous Adductor Canal Block in Fast Track Total Knee Arthroplasty [NCT05962970]		40 participants (Anticipated)	Interventional	2023-10-04	Recruiting
Effect of the Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy [NCT05930405]		252 participants (Anticipated)	Interventional	2023-10-01	Recruiting
A Volunteer Study to Determine the Anatomical Distribution of Injectate, the Extent of Sensory Block, and the Pharmacokinetics of Ropivacaine Following Erector Spinae Plane (ESP) Blocks. [NCT03476642]	Phase 4	24 participants (Anticipated)	Interventional	2019-07-02	Recruiting
A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks vs Intrathecal Morphine for Post Cesarean Section Pain [NCT04368364]	Phase 4	3 participants (Actual)	Interventional	2020-05-22	Terminated(stopped due to Study was stopped early due to a conflicting study in the same patient population at the study location.)
Prospective Randomized Clinical Trial to Evaluate the Use of Caudal Nerve Blocks in Adult Penile Prosthesis Surgery [NCT02740127]	Phase 3	52 participants (Actual)	Interventional	2016-06-30	Completed
Comparison of Epidural Labor Analgesia With Dexmedetomidine or Sufentanil [NCT03622047]		1,800 participants (Anticipated)	Interventional	2018-08-15	Recruiting
Transverse Versus Longitudinal Technique of Ultrasound-Guided Transmuscular Quadratus Lumborum Block:A Randomized Controlled Study Comparing Dermatomal Spread [NCT05001802]		50 participants (Anticipated)	Interventional	2021-08-20	Recruiting
Quadratus Lumborum Block Versus Erector Spinal Block - Comparison of the Effectiveness of the Analgesic Effect in Patients After Abdominal Surgery [NCT05446727]		1,000 participants (Anticipated)	Interventional	2022-05-01	Recruiting
Prevention of Pro-inflammatory Cytokines-associated Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block [NCT02144766]	Phase 4	40 participants (Anticipated)	Interventional	2014-04-30	Recruiting
Is PECS Block Equivalent to Paravertebral Block in Preventing Postoperative Pain After Breast Surgery? A Randomized, Controlled, Double-blind, Multicenter Trial [NCT02645474]	Phase 4	86 participants (Anticipated)	Interventional	2018-01-01	Recruiting
Efficacy of the 8th Cervical Nerve Root Block During Interscalene Brachial Plexus Block for Arthroscopic Shoulder Surgery: Prospective Randomized Controlled Study [NCT03487874]		74 participants (Actual)	Interventional	2018-04-04	Completed
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section. A Double Blind, Randomized, Placebo Controlled Trial. [NCT03068260]	Phase 4	72 participants (Actual)	Interventional	2017-03-15	Completed
Ultrasound-guided Quadratus Lumborum Block for Postoperative Pain Control After Endoscopic Prostatectomy - Double Blinded, Placebo-controlled, Randomised Trial. [NCT03600129]		50 participants (Actual)	Interventional	2018-07-25	Completed
Peroperative Analgesia Following Cytoreductive Surgery. A Randomized, Double-blind, Comparison Between Intra-peritoneal Local Anesthesia and Placebo - Multicenter Study [NCT02256228]	Phase 3	40 participants (Actual)	Interventional	2014-10-31	Completed
The Effect of Tramadol on Interscalene Brachial Plexus Block With Ropivacaine in Shoulder Surgery. [NCT02182752]	Phase 2	80 participants (Actual)	Interventional	2013-04-30	Completed
Ropivacaine 0,2% Plus Dexamethasone Versus Ropivacaine 0,2% Plus Placebo in Modified Pectoral Block - a Randomized, Double-blind, Prospective Trial [NCT03700177]	Phase 4	60 participants (Anticipated)	Interventional	2019-02-01	Recruiting
0.25% Levobupivacaine Versus 0.375% Ropivacaine: a Comparative Study in Ultrasound-Guided Infraclavicular Brachial Plexus Block [NCT03679897]	Phase 4	46 participants (Actual)	Interventional	2018-09-18	Completed
Ultrasoundguided Transmuscular Quadratus Lumborum Block After Elective Laparoscopic Cholecystectomy. A Prospective, Randomized Clinical Trial. [NCT02225418]		0 participants (Actual)	Interventional	2014-11-30	Withdrawn(stopped due to Change of jobs)
The Use of Lumbar Erector Spinae Plane Block for Hip Arthroplasty at the L4 Interspace- a Randomized Controlled Study Comparing the 24-hour Opioid Requirements. [NCT03801863]		65 participants (Actual)	Observational	2019-03-01	Terminated(stopped due to "Study Administratively closed by Albert Einstein College of Medicine IRB as approval expired. PI no longer with institution. IRB approval expiry date used as Primary Completion date and Study Completion Date. Enrollment total derived from CTMS")
A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty [NCT02603900]	Phase 4	0 participants (Actual)	Interventional	2015-10-31	Withdrawn
Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis. [NCT03054610]	Phase 1	60 participants (Actual)	Interventional	2015-01-31	Completed
Fascia Iliaca Compartment Block Versus Fentanyl for Positioning Patients With Hip Fractures for Central Nervous Blockade: a Randomized Trial. [NCT02037633]		41 participants (Actual)	Interventional	2012-07-31	Completed
Randomized Study of the Effect of Initial Ropivacaine Dosage During Continuous Popliteal Nerve Blocks on Rebound Pain in Foot and Ankle Surgery [NCT04872322]	Phase 3	128 participants (Anticipated)	Interventional	2017-08-31	Enrolling by invitation
Adductor Canal Block: Single Injection vs Catheter for Pain Management of Total Knee Arthroplasty - A Randomized, Unblinded, Non-Inferiority Trial [NCT02798835]	Phase 4	180 participants (Actual)	Interventional	2016-07-31	Completed
Effect of the Sheath of Rectus Abdominis Block Combined With the Transverse Plane Block on the Condition in Laparoscopic Gynecological Surgery. [NCT04850404]		42 participants (Anticipated)	Interventional	2021-07-31	Not yet recruiting
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD: A Randomized Clinical Trial [NCT05889741]	Phase 2	140 participants (Anticipated)	Interventional	2024-01-31	Not yet recruiting
Blood Ropivacaine Concentrations Following Unilateral Chest Wall Nerve Block and Continuous Infusion in Infants and Toddlers Undergoing Thoracotomies [NCT02860091]		26 participants (Actual)	Observational	2018-10-01	Active, not recruiting
Effects of Intra-Operative Ropivaciane Epidural Injection on Post-Operative Outcomes Following Elective Lumbar Fusion [NCT03035656]	Phase 4	228 participants (Anticipated)	Interventional	2019-03-01	Not yet recruiting
Comparison of Local Anesthetic Infiltration, Trasversalis Fascia Block or Spinal Anesthesia for Inguinal Hernia Repair [NCT03128216]		48 participants (Anticipated)	Interventional	2017-04-30	Not yet recruiting
Comparison Between Femoral Nerve Block and Adductor Canal Block for Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Controlled Trial [NCT02604550]	Phase 4	115 participants (Actual)	Interventional	2015-11-30	Completed
[NCT02084589]		65 participants (Actual)	Interventional	2012-06-30	Completed
Comparison of Transversus Abdominis Plane Block Versus Patient-controlled Epidural Analgesia for Patients on Buprenorphine or Methadone, After Cesarean Section [NCT02091297]		0 participants (Actual)	Interventional	2014-04-30	Withdrawn(stopped due to two other institutions that were in the center thought they weren't going to be able to recruit enough patients)
A Prospective, Randomized, Double-blind, Multicenter Trial on the Effects of the Early Femoral Nerve Block in Elderly With Hip Fracture [NCT03092466]		600 participants (Anticipated)	Interventional	2017-02-26	Recruiting
Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial [NCT02094339]	Phase 4	45 participants (Anticipated)	Interventional	2014-03-31	Recruiting
Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial [NCT02114463]	Phase 4	36 participants (Anticipated)	Interventional	2014-03-31	Recruiting
Ultrasound Guided Fascia Iliaca Block for Postoperative Analgesia After Elective Total Hip Arthroplasty [NCT02108847]		42 participants (Actual)	Interventional	2014-04-30	Completed
Quadratus Lumborum Block (QLB) With and Without Dexamethasone: the Effect on Postoperative Pain and Recovery After Laparoscopic Nephrectomy [NCT03339284]	Phase 4	90 participants (Anticipated)	Interventional	2017-12-04	Recruiting
Effect of Local Infiltration Anesthesia in a Hip Arthroplasty Fast Track Program. [NCT03513276]	Phase 4	63 participants (Actual)	Interventional	2016-02-29	Completed
Ultrasound-guided Continuous Femoral Nerve Block: The Influence of Catheter Orifice Configuration (Six-hole Versus End-hole) on Post-operative Analgesia After Total Knee Arthroplasty. A Randomized Trial. [NCT03376178]		72 participants (Actual)	Interventional	2014-05-31	Completed
Pain After Total Knee Arthroplasty: a Comparison of Combined Continuous Adductor Canal Block With Infiltration of Local Anesthetic Between the Popliteal Artery and Capsule of the Knee Block Versus Continuous Adductor Canal Block Alone on Postoperative Ana [NCT03921034]	Phase 4	72 participants (Actual)	Interventional	2016-11-17	Completed
COMBINATION OF CONTINUOUS FEMORAL BLOCK AND INTRAVENOUS PARECOXIB FOR POSTOPERATIVE ANALGESIA AFTER TOTAL KNEE ARTHROPLASTY. A DOUBLE BLIND PROSPECTIVE STUDY. [NCT02185924]	Phase 2/Phase 3	90 participants (Actual)	Interventional	2009-01-31	Completed
Effective Pain Management of Continuous Versus Single Shot Injection Interscalene Block During Shoulder Replacement Surgery [NCT02267044]		76 participants (Actual)	Interventional	2014-08-31	Completed
The Influence of the Femoral Nerve Block on the Quadriceps Strength After Total Knee Replacement [NCT01111513]		135 participants (Actual)	Interventional	2007-11-30	Completed
Monocentric, Non-blinded, Prospective Randomized Parallel Group Phase IV Clinical Study to Evaluate the Efficacy of Ultrasound Guided Single Shot Block of Nervus Tibialis Posterior for Postoperative Pain Relief After Hallux Valgus Surgery. [NCT02282956]	Phase 4	60 participants (Anticipated)	Interventional	2014-10-31	Recruiting
Quadratus Lumborum Nerve Blocks in Laparoscopic Myomectomy Patients [NCT03935815]	Phase 1	26 participants (Actual)	Interventional	2019-05-01	Terminated(stopped due to Closed prior to completion secondary to surgeon leaving UCLA)
Reducing Posterior Knee Pain Following Total Knee Arthroplasty Using an Intraoperative Posterior Cruciate Ligament (Transcruciate) Injection [NCT01345604]	Phase 4	50 participants (Actual)	Interventional	2011-05-31	Completed
The Analgesic Effect of Transversus Abdominis Plane (TAP) Block Versus Wound Infiltration Versus Placebo Following Open Radical Prostatectomy, a Double Blinded, Randomized Clinical Trial [NCT01317368]		75 participants (Actual)	Interventional	2011-03-31	Completed
The Effects of Difference in Pupil Size Between Bilateral Eyes on Cardiac Sympathetic Nervous Activity Following Interscalene Brachial Plexus Block [NCT03514342]		48 participants (Actual)	Observational	2018-06-18	Completed
Respiratory Impact of Local Anaesthetic Volume for an Interscalene Brachial Plexus Block With an Extrafascial Approach. [NCT04726280]	Phase 4	60 participants (Actual)	Interventional	2021-02-01	Completed
Pre-emptive Scalp Infiltration With Dexamethasone Lipid Microsphere Plus Ropivacaine for Postoperative Pain After Craniotomy [NCT04488315]	Phase 4	130 participants (Actual)	Interventional	2022-10-01	Active, not recruiting
Comparison of Epidural Chloroprocaine 3% and Ropivacaine 0.75% for Unplanned Caesarean Section in Labouring Women Who Have an Epidural Catheter in Situ [NCT02919072]	Phase 3	16 participants (Actual)	Interventional	2016-10-31	Terminated(stopped due to The doctors involved in the study did not enroll any patients)
The Role of Nerve Blocks in Hip Arthroscopy [NCT03506620]	Phase 4	0 participants (Actual)	Interventional	2019-01-31	Withdrawn(stopped due to Unforeseen cost restrictions of the drug halted the execution of this study altogether.)
Ropivacaine Continuous Wound Infusion Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Delivery : A Randomized Controlled Trial [NCT03502642]	Phase 4	60 participants (Actual)	Interventional	2017-05-29	Completed
The Study of Ropivacaine Median Effective Concentration in Ultrasound-guided Supraclavicular Brachial Plexus Block [NCT02323282]	Phase 4	60 participants (Anticipated)	Interventional	2014-10-31	Recruiting
PEF-Block & Ribs Fractures Effect of Posterior Exo-thoracic Fascia Block in the Pain Management of Ribs Fractures: a Prospective, Randomized Study [NCT03396692]		90 participants (Actual)	Interventional	2018-06-18	Completed
The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty [NCT01261897]	Phase 4	40 participants (Anticipated)	Interventional	2011-01-31	Completed
Ropivacaine 0.75% Versus Levobupivacaine 0.5% for Conversion of Labour Epidural to Surgical Anaesthesia for Emergency Caesarean Section. [NCT01160965]	Phase 4	0 participants (Actual)	Interventional	2012-08-31	Withdrawn(stopped due to Not able provide staff for recruting at present)
Evaluation of the Postoperative Analgesic Efficacy of Bilateral Superficial Cervical Block for Thyroidectomy and Mini Incision Under General Balanced Anesthesia: a Randomized, Triple Masked, Placebo Controlled Trial. [NCT01171885]	Phase 4	120 participants (Anticipated)	Interventional	2009-07-31	Recruiting
Postoperative Analgesia After Cardiac Surgery: Effects of a Continuous Infusion of Ropivacaine Through Laterosternal Catheters [NCT01196767]	Phase 4	40 participants (Actual)	Interventional	2010-07-31	Completed
Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias [NCT05922605]	Phase 4	44 participants (Anticipated)	Interventional	2023-06-20	Recruiting
Effectiveness of Pericapsular Nerve Group (PENG) Block Combined to Lateral Femoral Cutaneous Nerve (LFCN) Block on the Quality of Recovery After Total Hip Replacement [NCT04245280]		74 participants (Anticipated)	Interventional	2021-05-04	Recruiting
Pain Control After Total Knee Arthroplasty: A Prospective, Double-blind Randomized Controlled Trial Examining the Benefit of a Combined Adductor-canal Nerve Block With Periarticular Infiltration Versus Periarticular Injection Alone [NCT02740192]	Early Phase 1	128 participants (Actual)	Interventional	2016-04-30	Completed
Postoperative Analgesia With Local Infiltration After Hip Fracture Of Intertrochanteric Type [NCT01119209]	Phase 4	74 participants (Actual)	Interventional	2008-02-29	Completed
Incidence of Urethrocutaneous Fistula Following Distal Hypospadias Repair With and Without Caudal Epidural Block - A Pilot Study [NCT03812731]		30 participants (Actual)	Interventional	2019-02-22	Completed
Lumbar Transversus Abdominal Plane (TAP) Block: Does Volume Make a Difference? [NCT01307215]		31 participants (Actual)	Interventional	2011-04-30	Completed
Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants? A Multi-center Prospective Randomized Trial. [NCT02861950]	Phase 4	490 participants (Anticipated)	Interventional	2017-05-24	Active, not recruiting
Extension of the Analgesia of an Interscalene Block of the Brachial Plexus by Combined Injection of Dexamethasone and Dexmedetomidine, After Arthroscopic Shoulder Surgery: Randomized, Controlled, Double-blind Trial [NCT04394481]	Phase 4	122 participants (Actual)	Interventional	2020-09-28	Completed
Does the Addition of Liposomal Bupivacaine to the Adductor Canal Block Impact Narcotic Use After Primary Total Knee Arthroplasty: a Prospective, Blind Randomized Control Trial [NCT04539730]	Phase 4	0 participants (Actual)	Interventional	2021-12-01	Withdrawn(stopped due to Did not acquire funding to pursue study)
Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver Resection [NCT02527577]		39 participants (Actual)	Interventional	2010-04-30	Terminated(stopped due to difficulties to recruit patients)
Influence of Intra-abdominal Ropivacaine 0.5% Spray on Postoperative Analgesia in Laparoscopic Surgery. [NCT05173090]		120 participants (Anticipated)	Interventional	2022-01-15	Not yet recruiting
SERRATHOR Trial : Analgesic Effect of Serratus Plane Block After Video-Assisted Thoracoscopic Surgery Lobectomy [NCT03867695]		130 participants (Anticipated)	Interventional	2019-07-31	Not yet recruiting
Comparison of Analgesic Efficacy of Local Wound Infiltration Plus Transversus Abdominis Plane Block and Local Wound Infiltration Only After Laparoscopic Colorectal Resection: a Randomized, Double-blind, Non-inferiority Trial [NCT03376048]		108 participants (Actual)	Interventional	2017-12-20	Completed
Catheter-based Peripheral Regional Anesthesia After Orthopedic Surgery to the Foot or Ankle: Comparison of Low Dose, Automated Periodic Infusions With Conventional High Dose, Continuous Infusion, and Patient-initiated Infusions Only [NCT03372304]	Phase 4	85 participants (Actual)	Interventional	2017-11-29	Completed
Analgesic Requirements for Post-operative Pain Control in Total Shoulder Replacement Patients: Comparison of Interscalene Single Shot Exparel (Bupivacaine Liposome) Injections to Cervical Paravertebral Catheter With Ropivacaine (0.2% Continuous Infusion) [NCT03739021]	Phase 2/Phase 3	60 participants (Anticipated)	Interventional	2019-11-30	Not yet recruiting
Is Postoperative Quality of Recovery After Unilateral Nephrectomy Related to the Type of Anesthesia and Analgesia? [NCT04521556]	Phase 4	80 participants (Actual)	Interventional	2019-04-01	Completed
The Effects of Clonidine on Postoperative Analgesia After Single Shot Femoral Nerve Block Following Arthroscopic Knee Surgery in Children [NCT01293149]	Phase 2	0 participants (Actual)	Interventional	2011-04-30	Withdrawn
The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Revision Knee Arthroplasty [NCT01191593]	Phase 4	36 participants (Actual)	Interventional	2010-09-30	Completed
Erector Spinae Plane Block for Video-assisted Thoracoscopic Surgery: a Randomized Controlled Trial [NCT03628040]	Phase 3	82 participants (Anticipated)	Interventional	2019-09-01	Not yet recruiting
Randomized Clinical Trial: Transverse Abdominis Plane Block Versus no Block in Laparoscopic Ventral Hernia Repair [NCT03342040]		90 participants (Actual)	Interventional	2017-10-15	Completed
Randomized Trials of Epidural Combined With General Anesthesia Versus General Anesthesia Alone to Evaluate the Changes of Blood Flow in Arterial Anastomosis of Free Flap Using Duplex Ultrasonography [NCT03330808]		52 participants (Actual)	Interventional	2017-10-28	Completed
WALANT Technique (Wide Awake Local Anesthesia No Tourniquet) in Association With Analgesic Troncular Blocks at the Wirst for Carpal Tunnel Release. [NCT04494100]		60 participants (Actual)	Interventional	2020-09-11	Completed
Comparison of Two Volumes of Local Anesthetics on the Efficiency and Safety of Stellate Ganglion Block for the Treatment of Complex Regional Pain Syndrome of the Arm [NCT03316066]		0 participants (Actual)	Interventional	2018-10-20	Withdrawn(stopped due to Not able to recruit enough patients)
Formulations of Liposomal Local Anesthetics for Dental Anesthesia [NCT01307969]	Phase 1	40 participants (Actual)	Interventional	2007-02-28	Completed
Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair [NCT03781505]	Phase 4	64 participants (Anticipated)	Interventional	2019-01-31	Recruiting
The Effect of Fascia Iliaca Compartment Block in Acute and Chronic Pain Management in Hip Fracture Patients [NCT02479828]		198 participants (Actual)	Interventional	2015-06-30	Completed
Pericapsular Nerve Group Block: An Imaging Study for Determination of the Spread of the Injectate Using 3-D CT Scan [NCT06062134]		10 participants (Actual)	Interventional	2023-05-15	Completed
Effect of Dexmedetomidine Plus Ropivacaine Versus Sufentanil Plus Ropivacaine for Epidural Labor Analgesia on Neonatal Outcomes: a Pilot Randomized Trial [NCT05698407]	Phase 4	200 participants (Anticipated)	Interventional	2023-03-16	Recruiting
Laparoscopic vs Ultrasound-Guided Transversus Abdominis Plane Block in Minimally Invasive Colon Surgery: A Randomized Controlled Multicentre Clinical Trial [NCT04311099]	Phase 4	360 participants (Anticipated)	Interventional	2021-01-14	Recruiting
Labor Analgesia With Ropivacaine Added to Clonidine. A Randomized Clinical Trial [NCT00626977]		32 participants (Actual)	Observational	2000-05-31	Completed
Efficacy of the Intralesional Infusion of Local Anesthetic and Steroids After Major Abdominal Surgery: a Randomized Double Blind Phase III Trial [NCT02002663]	Phase 3	120 participants (Actual)	Interventional	2013-08-31	Completed
Study of Ultrasound-guided Thoracic Paravertebral Block Using Ropivacaine With/Without Dexamethasone in Elective Thoracotomy [NCT02871193]		68 participants (Actual)	Interventional	2016-06-01	Completed
Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty: Quality Of Recovery Through Patient Reporting - a Multisite Study [NCT06054750]	Phase 4	226 participants (Anticipated)	Interventional	2024-01-01	Not yet recruiting
Efficacy of Pericapsular Nerve Group Block After Total Hip Arthroplasty Surgery [NCT04295408]		60 participants (Anticipated)	Interventional	2020-04-01	Recruiting
Spinal Analgesia Versus Epidural Analgesia in Minor Laparotomic Liver Surgery in an Enhanced Recovery Programme: A Randomized Controlled Trial [NCT02647047]		40 participants (Anticipated)	Interventional	2016-01-31	Not yet recruiting
A Randomized Controlled Trial Comparing Intrathecal Morphine With Quadratus Lumborum Block as Part of a Multimodal Analgesia Strategy for Post-cesarean Delivery Analgesia [NCT02871713]		76 participants (Anticipated)	Interventional	2017-05-30	Recruiting
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children [NCT04051723]	Phase 4	80 participants (Actual)	Interventional	2019-09-02	Completed
Transmuscular Quadratus Lumborum Block for Postoperative Pain After Total Abdominal Hysterectomy [NCT02586454]		64 participants (Actual)	Interventional	2015-11-30	Completed
The Use of Liposomal Bupivacaine Interscalene Brachial Plexus Block for Rotator Cuff Surgery: A Randomized, Double Blind, Clinical Trial [NCT04047745]		132 participants (Anticipated)	Interventional	2019-09-30	Not yet recruiting
Serratus Anterior Plane Block or Erector Spinae Plane Block Used as an Adjuvant for Hybrid Arrhythmia Ablation Surgery [NCT04868058]		132 participants (Anticipated)	Interventional	2019-11-01	Recruiting
Effects of Dexmedetomidine as an Adjunctive Analgesic Used in Continuous Thoracic Paravertebral Blocks for Post-thoracotomy Pain Syndrome [NCT02619513]	Phase 4	60 participants (Actual)	Interventional	2014-12-31	Completed
Postoperative Analgesia With Local Infiltration After Periacetabular Osteotomy For The Treatment Of Dysplasia [NCT00815503]	Phase 4	70 participants (Actual)	Interventional	2009-01-31	Completed
Intraoperative Use of Perineal Block for Hemorrhoidectomy [NCT04288349]		100 participants (Anticipated)	Interventional	2020-02-20	Recruiting
Efficacy and Safety of Periarticular Multimodal Drug Injections in Total Knee Arthroplasty [NCT00901628]	Phase 4	101 participants (Actual)	Interventional	2008-04-30	Completed
Randomized Clinical Trial to Evaluate the Efficacy of Levobupivacaine 0.125% vs Ropivacaine 0.2%, in Hemodynamic Alterations in Pregnant Women in Labor and Their Fetal Repercussions [NCT05877131]	Phase 4	40 participants (Anticipated)	Interventional	2023-06-01	Not yet recruiting
The Pharmacokinetic of Ropivacaine in Patients Undergoing Ultrasound-guided Continuous Thoracic Paravertebral Block [NCT03721406]		20 participants (Actual)	Interventional	2019-10-08	Completed
Comparative Study Between Systemic Analgesia and Continuous Sciatic Nerve Block in Patients With Chronic Obstructive Arterial Disease and Ischemic Pain in Lower Limbs [NCT02841488]	Phase 3	56 participants (Anticipated)	Interventional	2016-09-30	Not yet recruiting
Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia . [NCT03238430]	Phase 2/Phase 3	186 participants (Actual)	Interventional	2015-05-20	Completed
Local Analgesia in Laparoscopic Surgery [NCT02826876]		100 participants (Anticipated)	Interventional	2016-07-31	Not yet recruiting
Prospective, Two-center , Randomized, ITT , Parallel Group Evaluating the Interest of the Instillation of Saline Intraperitoneally (INSI ) Versus Instillation of Naropin the Surgical Site Versus Lung Recruitment Maneuvers ( PVM ) in the Management of Pain [NCT02819544]	Phase 3	0 participants (Actual)	Interventional	2016-09-30	Withdrawn(stopped due to investigator choice)
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Percutaneous Nephrolithotomy [NCT02818140]	Phase 4	60 participants (Actual)	Interventional	2016-07-31	Completed
Study of Caudal Ropivacaine With or Without Dexmedetomidine for Postoperative Analgesia in Pediatric Infra-umbilical Surgery: A Double-blinded Randomized Control Trial [NCT05979558]		62 participants (Actual)	Interventional	2020-06-16	Completed
[NCT00864409]	Phase 4	12 participants (Anticipated)	Interventional		Recruiting
The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks [NCT00616603]		43 participants (Actual)	Interventional	2007-08-31	Terminated(stopped due to PI is no longer here.)
Dexamethasone Compared With Dexmedetomidine as an Adjuvant to Ropivacaine for Supraclavicular Brachial Plexus Block [NCT02787018]	Phase 3	120 participants (Actual)	Interventional	2016-06-30	Completed
The Intertransverse Process Block - Single or Multiple Injection? A Randomised, Procedure Related, Blinded Crossover Trial in Healthy Volunteers [NCT05753397]	Phase 4	12 participants (Anticipated)	Interventional	2023-02-26	Recruiting
Effectiveness of TAP (Transversus Abdominis Plane) Block for Postoperative Pain Relief After Abdominal Aortic Surgery [NCT05860452]		40 participants (Anticipated)	Interventional	2023-06-01	Recruiting
Evaluation of the Analgesic Effect of Ropivacaine in Topical Use at the Thin Skin Graft Donor Site [NCT01999153]	Phase 3	88 participants (Anticipated)	Interventional	2013-12-31	Recruiting
Comparison of Intravascular Injection Rates During Cervical and Lumbar Medial Branch Block Using Touhy or Quincke Type Needle [NCT05031936]		67 participants (Actual)	Interventional	2021-08-12	Completed
A Multicenter Randomized Controlled Trial in Elderly Patients With Hip Fractures Comparing Continuous Fascia Iliaca Compartment Block to Systemic Opioids and Its Effect on Delirium Occurrence [NCT02689024]	Phase 4	239 participants (Actual)	Interventional	2016-05-31	Terminated(stopped due to recruitment too slow; intervention was standard care in patients who were not included; acute care pathways changed due to policy regarding hip fracture patients)
Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain [NCT05175001]	Phase 4	100 participants (Anticipated)	Interventional	2021-05-01	Recruiting
Improvement of Analgesia With Addition of Pectoral Nerve Block to Thoracic Paravertebral Blocks in Unilateral Total Simple Mastectomy [NCT01943240]	Phase 4	0 participants (Actual)	Interventional	2014-03-31	Withdrawn(stopped due to Insufficient population of eligible patients; none enrolled)
The Effect of Dexamethasone Used Together With Low Volume Ropivacaine in a Single Shot Interscalene Block on the Pain Free Time Experienced by the Patient [NCT02178449]	Phase 4	109 participants (Anticipated)	Interventional	2014-03-31	Recruiting
Erector Spinae Plane Block Versus Control for Pain Control Following Percutaneous Nephrolithotomy: A Randomized, Double-Blind, Placebo Controlled Study [NCT05024344]		128 participants (Anticipated)	Interventional	2021-08-09	Recruiting
The Influence of Different Doses of Local Anesthetic on the Distribution of Anesthesia of the Lateral Femoral Cutaneous Nerve - a Randomized, Blinded, Paired Study of Healthy Individuals [NCT03138668]	Phase 2	20 participants (Actual)	Interventional	2017-05-19	Completed
Ultrasound-guided Brachial Plexus Block With the Single-penetration Multiple-injection-technique for Upper Extremity Surgery [NCT01993290]		120 participants (Anticipated)	Interventional	2013-04-30	Completed
Comparative Evaluation of Newer Congeners i.e. Levobupivacaine and Ropivacaine With Bupivacaine, in Lumbar Epidural Anaesthesia for Hip Surgeries [NCT02513433]		90 participants (Actual)	Interventional	2012-12-31	Completed
Improving Perioperative Pain Management for Laparoscopic Surgery Due to Colon Cancer Using the Ultrasound-guided Transmuscular Quadratus Lumborum Block. A Double Blind, Randomized, Placebo Controlled Trial. [NCT03570541]	Phase 4	69 participants (Actual)	Interventional	2018-06-28	Completed
Peritoneal Nebulization of Ropivacaine for Postoperative Pain Control After Laparoscopic Cholecystectomy [NCT01143025]	Phase 3	165 participants (Anticipated)	Interventional	2010-03-31	Completed
Effects of Methylprednisolone Plus Ropivacaine Infiltration Before Wound Closure on Laminoplasty or Laminectomy [NCT04493463]	Phase 4	132 participants (Actual)	Interventional	2020-07-31	Completed
Does Perineural Dexmedetomidine Prolong the Duration of an Adductor Canal Block When Controlling for a Systemic Effect? - A Randomised Paired Trial in Healthy Volunteers. [NCT02488473]	Phase 2	21 participants (Actual)	Interventional	2015-08-31	Completed
Investigating Systemic Effects of Lidocaine Infusion for Transversus Abdominis Plane (TAP) Block Catheter [NCT03971708]		80 participants (Actual)	Interventional	2015-06-30	Completed
Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery: A Randomized, Double-Blinded, Controlled Trial [NCT05871073]	Phase 4	60 participants (Actual)	Interventional	2023-01-01	Completed
Efficacy of the Anterior Quadratus Lumborum Block Versus the Transversus Abdominis Plane Block for Elective Laparoscopic Inguinal Hernia Repair: A Randomized Controlled Trial [NCT03023462]		60 participants (Actual)	Interventional	2019-09-05	Completed
Total Knee Arthroplasty & Outcome: A Prospective Randomized Comparison Between Adductor Canal Block and Femoral Nerve Block [NCT02082067]	Phase 4	0 participants (Actual)	Interventional	2014-03-31	Withdrawn
Effectiveness of Ultrasound-guided Scalp Block for Supratentorial Craniotomy: a Randomised, Double-blind, Placebo-controlled Trial [NCT06127628]		60 participants (Anticipated)	Interventional	2023-12-31	Not yet recruiting
The Safety of Ropivacaine Transversus Abdominis Plane Block Combined With Intravenous Lidocaine in Patients Undergoing Colorectal Cancer Surgery: a Single Center, Open Label Dose Escalation Study [NCT06006026]		9 participants (Actual)	Interventional	2023-08-28	Completed
Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery [NCT05824338]	Early Phase 1	45 participants (Anticipated)	Interventional	2024-01-01	Not yet recruiting
Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty: A Single Institution, Single-blinded, Randomized Clinical Trial [NCT05188053]	Phase 4	98 participants (Anticipated)	Interventional	2022-02-07	Enrolling by invitation
Postoperative Analgesia With a Catheter Under the Erector Spinae Muscle for Videothoracoscopic Lung Surgery [NCT04665531]		50 participants (Actual)	Interventional	2020-02-19	Completed
Comparison of a Single Shot Femoral Nerve Block to Femoral Nerve Block Shot Plus Continuous Femoral Nerve Catheter for Total Knee Replacement Surgery; a Randomized, Blinded Controlled Trial. [NCT02106481]		99 participants (Actual)	Interventional	2014-04-30	Completed
Randomized Controlled Study: Comparison of Continuous Femoral Nerve Block and Adductor Canal Block After Total Knee Replacement Therapy Relating to Early Mobilization and Analgesia [NCT02125903]		44 participants (Actual)	Interventional	2013-05-31	Completed
Assessment of Subarachnoid Anesthesia With Low Dose of Pethidine and Combination of Ropivacaine With Fentanyl for Urologic Surgical Operations. [NCT03260283]	Phase 2/Phase 3	104 participants (Actual)	Interventional	2017-08-16	Completed
Comparison of Paracoracoid Subscapularis Plane Block to Interscalene Block for Arthroscopic Shoulder Surgery [NCT03073928]		120 participants (Anticipated)	Interventional	2017-06-15	Recruiting
Incidence of Transient Horner's Syndrome Following Thoracic Epidural Anesthesia for Mastectomy [NCT02130739]		450 participants (Actual)	Observational [Patient Registry]	2010-09-30	Completed
Evaluating Ropivacaine and Lidocaine in the Endotracheal Tube Cuff on Post-Operative Sore Throat Incidence and Severity - A Randomized Clinical Trial [NCT03563963]		63 participants (Actual)	Interventional	2018-08-01	Completed
Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures: A Randomized Controlled Trial [NCT02793947]	Phase 4	102 participants (Actual)	Interventional	2015-05-31	Completed
Up-down Sequential Allocation Study to Determine the Optimal Volume, Rate, and Interval of Bolus of Ropivacaine 0.2% in Interscalene Continuous Nerve Catheters for Shoulder Surgery [NCT02946268]	Phase 4	0 participants (Actual)	Interventional	2017-02-21	Withdrawn(stopped due to Insufficient staff)
Comparison of Long Acting vs. Short Acting Anesthetic Agents as a Tool for Improving Pain Management Post Ultrasound Guided Breast Biopsy [NCT02085239]	Phase 4	0 participants (Actual)	Interventional	2013-08-31	Withdrawn(stopped due to Study never got started; can't delete results)
A Comparison of Different Concentration Ropivacaine Combination With Fentanyl for Patient-controlled Epidural Analgesia After Cesarean Delivery [NCT03195309]	Phase 1/Phase 2	120 participants (Anticipated)	Interventional	2017-01-20	Active, not recruiting
Does Perineural Clonidine Prolong the Duration of an Adductor Canal Block When Controlling for a Systemic Effect? - A Randomised Paired Trial in Healthy Volunteers. [NCT02444559]	Phase 2	21 participants (Actual)	Interventional	2015-05-31	Completed
Effectiveness of Bilateral Erector Spinae Plane Block (ESPB) in Laparoscopic Colectomies -A Randomized, Controlled, Double Blind, Prospective Trial [NCT04879004]		40 participants (Anticipated)	Interventional	2021-01-01	Recruiting
Ultrasound Guided 0.25% Ropivacaine Transversus Abdominis Plane Block in Addition to Intrathecal Morphine and Multimodal Analgesia for the Management of Postoperative Pain Among Women Undergoing Cesarean Delivery. [NCT01261637]	Phase 4	86 participants (Actual)	Interventional	2009-07-31	Completed
Effect of Different Labour Analgesics on Maternal UtA, Fetal UA and MCA Blood Flow Index Observed by Doppler Ultrasonography：a Prospective Randomized Double-blinded Controlled Trial [NCT06099938]		90 participants (Actual)	Observational	2021-03-01	Completed
Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia [NCT03187899]	Phase 3	0 participants (Actual)	Interventional	2018-04-30	Withdrawn(stopped due to Principal investigator was unable to pursue research further due to time constraints.)
Ropivacaine Use in Interscalene Block; What is the Minimal Effective Analgesic Concentration (MEAC 90) [NCT04833296]	Phase 4	45 participants (Anticipated)	Interventional	2021-05-01	Not yet recruiting
Application of Transversus Thoracis Muscle Plane Block Plus Rectus Sheath Block in the Perioperative Pain Management of Cardiac Surgery : Study Protocol of a Randomized Double-blind Controlled Trial [NCT04838132]		80 participants (Anticipated)	Interventional	2021-03-16	Recruiting
Comparing the Analgesic Effects of Ultrasonography-guided and Direct-surgical Rectus Sheath Block in Single-port Access Laparoscopy Patients [NCT02431065]	Phase 2	30 participants (Anticipated)	Interventional	2015-05-31	Not yet recruiting
Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures: A Randomized Controlled Trial [NCT02967172]	Phase 4	100 participants (Actual)	Interventional	2016-10-31	Completed
Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Slit Intercostals Nerve Block for Chronic Post-thoracotomy Pain:A Single Blind Randomized Control Trial [NCT05556122]		100 participants (Anticipated)	Interventional	2022-07-04	Recruiting
Transversus Abdominis Plane Block With or Without Buprenorphine After Inguinal Hernia Surgery [NCT05549492]	Phase 1	64 participants (Actual)	Interventional	2021-01-01	Completed
Ultrasound Guided Thoracic Erector Spinae Plane Blocks Within an Enhanced Recovery Program Decreases Opioids Consumption and Improves Patient Postoperative Rehabilitation After Open Cardiac Surgery: A Controlled Before-After Study [NCT03541837]		40 participants (Actual)	Interventional	2017-10-20	Completed
Comparison of the Hemodynamic Effect Between the Paravertebral Block and Thoracic Epidural in Esophageal Surgery With Thoracotomy . [NCT03185403]		54 participants (Actual)	Interventional	2013-12-31	Completed
Effects of Thoracic Epidural Administered Ropivacaine Versus Bupivacaine on Lower Urinary Tract Function: A Randomized, Controlled Study [NCT02414373]	Phase 4	42 participants (Actual)	Interventional	2015-04-30	Completed
Comparison Between Single-shot Femoral Nerve Block and Epidural Techniques for Total Knee Arthroplasty: a Randomized Controlled Trial [NCT02164825]		60 participants (Actual)	Interventional	2014-01-31	Completed
Intraoperative Wound Infiltration With Local Anaesthetic in Surgical Patients; Is There Any Late Effect on the Postoperative Pain and the Requirements of Analgesia ? A Randomized Control Trial. [NCT02171299]		400 participants (Actual)	Interventional	2012-09-30	Completed
Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery: A Randomized Double-Blinded Controlled Trial Targeting Patients' Recovery and Satisfaction [NCT05696678]		96 participants (Anticipated)	Interventional	2023-02-28	Not yet recruiting
Postoperative Analgesia After Caesarean Section Under ALR: TAP Block Versus Catheter Scar Infiltration [NCT02184559]	Phase 3	60 participants (Anticipated)	Interventional	2012-02-29	Recruiting
Suprainguinal Fascia Iliaca (SIFI) Block Improves Analgesia Following Total Hip Arthroplasty [NCT02933671]	Phase 4	11 participants (Actual)	Interventional	2017-08-01	Terminated(stopped due to Study halted prematurely and will not resume; participants are no longer being examined or receiving any intervention.)
Interspace Between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) Block for Postoperative Rehabilitation in Total Knee Arthroplasty: a Randomized Control Trial [NCT06087562]	Phase 4	350 participants (Anticipated)	Interventional	2020-06-16	Active, not recruiting
Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO [NCT04481451]	Phase 4	156 participants (Anticipated)	Interventional	2020-12-01	Recruiting
Interpectoral and Pectoserratus Plane Block vs Local Anesthetic Infiltration for Partial Mastectomy - a Prospective Randomized Trial [NCT04824599]		60 participants (Actual)	Interventional	2021-02-19	Completed
The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty [NCT02576015]		380 participants (Anticipated)	Interventional	2016-03-31	Not yet recruiting
Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Triple-masked, Controlled Study [NCT02539628]	Phase 4	110 participants (Actual)	Interventional	2015-03-31	Completed
Interest of Continuous Ropivacaine Administration Through an Elastomeric Pump (Pain Buster ) for the Surgery of Latissimus Dorsi and Serratus Micro Anastomotic Flaps [NCT00724685]	Phase 4	34 participants (Actual)	Interventional	2008-01-31	Terminated
Postoperative Pain Management Following Total Hip Arthroplasty. A Comparison Between Local Infiltration Analgesia and Ultrasound Guided 3-in-1 Block [NCT02568995]	Phase 3	55 participants (Actual)	Interventional	2014-05-31	Completed
Trans-Abdominis Plane Block Efficacy for Post-Cesarean Section Pain: A Randomized Double-Blinded Case Control Trial [NCT00945620]		0 participants (Actual)	Interventional	2009-09-30	Withdrawn(stopped due to PI was unable to locate appropriate population)
New Truncal Nerve Blocks for Thoracoscopic Surgery and Open Heart Surgery. [NCT03704753]	Phase 4	200 participants (Anticipated)	Interventional	2019-01-25	Recruiting
Effect of the Injection of Local Analgesia With Epinephrine During Total Hip Arthroplasty on the Blood Losses Per and Operatively. [NCT00980616]	Phase 2	150 participants (Actual)	Interventional	2009-09-30	Completed
Postoperative Pain After Pediatric Umbilical Hernia Repair: a Randomized Clinical Trial of Ultrasound-guided Bilateral Rectus Sheath Blocks Versus Local Anesthetic Infiltration [NCT01015053]		53 participants (Actual)	Interventional	2009-11-30	Completed
Addition of Popliteal Plexus Block to Continuous Femoral Nerve Block for Total Knee Arthroplasty [NCT04048889]		66 participants (Anticipated)	Interventional	2019-07-22	Recruiting
Local Infiltration Analgesia With Ropivacaine, Ketorolac and Epinephrine Intra- and Postoperatively in Total Knee Arthroplasty [NCT00799175]		48 participants (Actual)	Interventional	2007-04-30	Completed
Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty [NCT00992082]		50 participants (Anticipated)	Interventional	2009-08-31	Recruiting
Continuous Thoracic Paravertebral Block for Open Hepatectomy [NCT03990922]		76 participants (Actual)	Interventional	2019-06-20	Completed
Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol - [NCT01052974]	Phase 4	60 participants (Actual)	Interventional	2009-03-26	Completed
Ideal Initial Bolus and Infusion Rate for Erector Spinae Plane Block Catheters [NCT03961048]	Phase 4	0 participants (Actual)	Interventional	2019-07-23	Withdrawn(stopped due to Change in hospital protocol)
Prospective Randomized Clinical Trial Comparing Infraclavicular Versus Axillary Approach to Brachial Plexus Block. [NCT02208245]		46 participants (Anticipated)	Interventional	2014-02-28	Active, not recruiting
Postoperative Pain Treatment in Total Hip Arthroplasty A Randomized Double-blinded Placebo-controlled Study to Assess the Effect of Local Analgesia [NCT00603083]	Phase 4	60 participants (Actual)	Interventional	2008-01-31	Completed
Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral [NCT00900913]	Phase 4	34 participants (Anticipated)	Interventional	2010-01-31	Completed
Phase 3 Prospective, Randomized, Controlled and Double-blinded Second Trial on Pain Relief by Continuous Intra-peritoneal Nebulization of Ropivacaine Under Remifentanil Anesthesia, During Gynecological Laparoscopic Surgery [NCT00927979]	Phase 3	40 participants (Actual)	Interventional	2009-06-30	Completed
[NCT02813018]		50 participants (Actual)	Interventional	2016-07-07	Completed
Intermittent Bolus Administration of Ropivacaine for Epidural Labor Analgesia : an Observational Study [NCT02809742]		500 participants (Actual)	Observational	2016-05-31	Completed
Effectiveness of Intraoperative Exparel, a Bupivacaine Liposome Injectable Suspension, for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study [NCT02808728]	Phase 4	100 participants (Actual)	Interventional	2014-05-31	Active, not recruiting
Erector Spinae Plane Block Versus Intrapleural Intercostal Plane Block for Post-thoracotomy Pain: a Randomized Trial [NCT04013815]		60 participants (Actual)	Interventional	2019-08-01	Completed
The Prevention of Hypotension After Epidural Analgesia After Major Surgery by Adding Epinephrine to Infusions to Counteract Sympathectomy: a Double- Blind, Controlled, Randomized, Prospective Dose-finding Study [NCT02722746]		66 participants (Actual)	Interventional	2016-11-15	Completed
Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty [NCT00562627]	Phase 4	102 participants (Actual)	Interventional	2007-11-30	Completed
EVALUATION OF ORAL USE OF DEXKETOPROFEN/TRAMADOL IN ACUTE POSTOPERATIVE PAIN IN PATIENTS UNDERGOING TOTAL HIP REPLACEMENT WITH A MINIMALLY INVASIVE ANTERIOR APPROACH (AMIS). [NCT04178109]	Phase 2	226 participants (Actual)	Interventional	2019-01-10	Completed
Comparison of the Sensitive Cutaneous Block Distribution Following Femoral Nerve Block Using an Ultrasound Plus Neurostimulator Technique Versus an Approach Based on the Localization of the Femoral Artery. [NCT02721290]		80 participants (Anticipated)	Interventional	2016-01-31	Recruiting
Comparing the Delivery of Local Anesthetic by Programmed Intermittent Bolus Versus Continuous Infusion Through a Popliteal Sciatic Nerve Catheter for Analgesia Following Major Ankle Surgery [NCT02707874]	Phase 4	60 participants (Anticipated)	Interventional	2014-10-31	Recruiting
Postoperative Analgesia After Thoracotomy Without Thoracic Epidural Analgesia : Paravertebral Analgesia With a Catheter Associated With Intravenous Morphine Patient-controlled-analgesia (Pca) [NCT00620490]	Phase 3	60 participants (Actual)	Interventional	2008-03-31	Completed
[NCT02848157]	Phase 4	40 participants (Actual)	Interventional	2016-06-17	Completed
Effects of the Pectoral Blocks in the Prosthetic Breast Expansion Surgery : Prospective, Randomized, Double Blind Study. [NCT02682186]	Phase 3	74 participants (Actual)	Interventional	2016-02-01	Completed
Serratus Plane Block for the Prevention of Chronic Pain After Breast Cancer Surgery [NCT02838173]		110 participants (Anticipated)	Interventional	2016-07-31	Not yet recruiting
The Effect of the Body Temperature 0.75% Ropivacaine on the Time to Convert Labour Epidural Analgesia to Anaesthesia for Surgical Delivery [NCT02838329]		90 participants (Anticipated)	Interventional	2016-07-31	Recruiting
Parturient Satisfaction With Epidural Analgesia During Parturient Controlled Pump [NCT06094946]		100 participants (Anticipated)	Observational	2023-12-31	Not yet recruiting
Liposomal Bupivacaine/Bupivacaine A Single-Dose Bilateral Rectus Sheath Blocks Vs. Ropivacaine in Bilateral RS Blocks And Catheters, Comparing Pain Scores And Opioid Use Following Open Abdominal Vascular Surgery [NCT05972018]	Phase 4	50 participants (Anticipated)	Interventional	2023-10-18	Recruiting
Erector Spinae Plane Block for Uncomplicated Renal Colic [NCT05625802]	Phase 2	60 participants (Anticipated)	Interventional	2023-02-08	Recruiting
Impact of Infiltration in the Region of the Palatine Ganglion Spheno by Ropivacaine on Postoperative Pain in the Setting of Endoscopic Sinonasal Surgery. [NCT02821169]	Phase 3	184 participants (Actual)	Interventional	2015-04-30	Completed
Comparison of Pudendal Nerve Block With Ropivacaine and Intravenous Tramadol for Prevention of Catheter-related Bladder Discomfort: a Randomized Controlled Trial [NCT02683070]		94 participants (Anticipated)	Interventional	2016-03-31	Not yet recruiting
Postoperative Pain in Children With Cerebral Palsy After Pelvic and Femoral Osteotomies. A Prospective, Randomized and Double-blinded Study [NCT00964639]	Phase 4	12 participants (Actual)	Interventional	2009-08-31	Completed
Evaluation of Dexketoprofen Given Intravenous or Intrathecal in Postoperative Pain in Patients Undergoing Total Knee Arthroplasty [NCT04161690]	Phase 2	120 participants (Anticipated)	Interventional	2019-11-06	Recruiting
Comparison of the Effect of Intra-articular Administration of 2% Ropivacaine vs. 7.5% Ropivacaine as an Analgesic in the Immediate Postoperative Period of Knee Arthroscopy in Acute Injuries at the ABC Medical Center [NCT05807945]	Phase 4	68 participants (Actual)	Interventional	2020-04-01	Completed
Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery [NCT04391855]	Phase 4	72 participants (Actual)	Interventional	2020-05-10	Completed
Application of Celiac Plexus Block in Postoperative Analgesia of Upper Abdominal Surgery [NCT05205720]	Phase 4	66 participants (Anticipated)	Interventional	2022-03-09	Recruiting
Surgical Anesthesia for Elective Hip Surgery - Hemodynamic Effect of Lumbosacral Plexus Blockade Compared to Spinal Anesthesia [NCT02544269]	Phase 4	8 participants (Actual)	Interventional	2016-06-01	Terminated(stopped due to After pilot study no difference in the primary end point was found between the two primary. Non-inferiority trial not deemed feasible.)
The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section. A Prospective, Observational and Non-inferiority Study Against Epidural Analgesia. [NCT05879536]		312 participants (Anticipated)	Observational	2023-05-23	Recruiting
Post-operative Pain Control With Sphenopalantine Ganglion Nerve Block in Septorhinoplasty Patients [NCT05667324]	Phase 4	120 participants (Anticipated)	Interventional	2023-04-12	Recruiting
Comparative Study on Postoperative Analgesia With Transversus Abdominis Plane Block to Local Anesthetic Infiltration With Ropivacaine in Laparoscopic Abdominal Surgery [NCT05995301]		100 participants (Actual)	Interventional	2022-03-12	Completed
Does the Addition of Epinephrine to Bilateral Ultrasound Guided Pterygopalatine Ganglion Block Reduce Bleeding During Functional Endoscopic Sinus Surgery (FESS)? A Pilot Study [NCT03970655]	Phase 1/Phase 2	80 participants (Anticipated)	Interventional	2019-09-25	Recruiting
A Single Center, Single-blind, Randomized, Dose-escalation, Parallel, Placebo and Active-controlled, Single Dose, Phase 1 Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GB-6002 Local Infiltration in Healthy M [NCT06095973]	Phase 1	30 participants (Anticipated)	Interventional	2023-10-24	Recruiting
Quadratus Lumborum Block for Perioperative Analgesia in Patients Treated With Abdominoplasty: A Randomised Controlled Trial [NCT02949778]	Phase 4	50 participants (Actual)	Interventional	2016-11-07	Completed
Continuous Erector Spinae Block Versus Continuous Paravertebral Block Following Thoracotomy: A Randomized, Controlled Non-Inferiority Study [NCT03768440]	Phase 3	100 participants (Anticipated)	Interventional	2019-04-16	Recruiting
Effects of Sono-guided Femoral Nerve Block in Arthroscopic Surgery for Anterior Cruciate Reconstruction Under Spinal Anesthesia: A Randomized Controlled Trial [NCT06048874]		100 participants (Anticipated)	Interventional	2023-09-18	Not yet recruiting
Effects of Sono-guided Femoral Nerve Block in Arthroscopic Surgery for Anterior Cruciate Reconstruction Under General Anesthesia: A Randomized Controlled Trial [NCT06048848]		100 participants (Anticipated)	Interventional	2023-09-18	Not yet recruiting
Effects of Sono-guided Femoral Nerve Block in Arthroscopic Surgery for Meniscal Tear Under Spinal Anesthesia: A Randomized Controlled Trial [NCT06048341]		100 participants (Anticipated)	Interventional	2023-09-18	Not yet recruiting
Effects of Sono-guided Femoral Nerve Block in Arthroscopic Surgery for Meniscal Tear Under General Anesthesia: A Randomized Controlled Trial [NCT06045884]		100 participants (Anticipated)	Interventional	2023-09-18	Not yet recruiting
Erector Spinae Plane Block for Pediatric Idiopathic Scoliosis Surgery. A Prospective, Randomized, Double-blinded Clinical Trial. [NCT05938959]	Phase 4	100 participants (Anticipated)	Interventional	2023-05-01	Recruiting
Thoracic Paravertebral Blocks in Open Nephrectomy. A Prospective, Randomized Study of Block Efficacy and Influence on Oxidative Stress and Patient Outcome. [NCT03428633]	Phase 2	60 participants (Actual)	Interventional	2018-03-09	Completed
The Effect of Local Anaesthetic Volume on Nerve Block Duration and Nerve Block Duration Variability. A Randomised, Blinded, Healthy Volunteer Study [NCT02829697]	Phase 4	120 participants (Actual)	Interventional	2016-07-31	Completed
The Volume-concentration Relationship of Analgesic Efficacy With Intra-capsular Local Anesthetic in Total Knee Arthroplasty: a Randomized, Double-blind, Cross-over Trial. [NCT01012232]	Phase 4	48 participants (Actual)	Interventional	2009-06-30	Completed
Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters [NCT00678314]	Phase 4	88 participants (Actual)	Interventional	2004-01-31	Completed
Efficacy of Local Anesthetic TAP Blocks in Providing Pain Relief Following Laparoscopic and Open Abdominal Surgery [NCT00682136]	Phase 1	206 participants (Anticipated)	Interventional	2008-04-30	Completed
A Randomized Trial Comparing the Efficacy on Post-operative Analgesia of Intra-articular Ropivacaine Added to a Femoral Block After Total Knee Replacement [NCT00910013]	Phase 1/Phase 2	80 participants (Actual)	Interventional	2006-04-30	Completed
A Randomised, Double-blind, Placebo-controlled Study to Assess the effectIveness of Pectoral Nerves Block (PECS) After Breast Surgery on Piritramide Consumption [NCT02655965]	Phase 3	54 participants (Actual)	Interventional	2016-05-31	Completed
Costoclavicular vs Paracoracoid Approach to Infraclavicular Brachial Plexus Block: a Feasibility Study [NCT02657291]		70 participants (Actual)	Interventional	2015-12-31	Completed
Sleep Quality After Stellate-ganglion Block of Patients Undergoing Breast Cancer Operation [NCT02651519]	Phase 4	105 participants (Actual)	Interventional	2016-01-31	Completed
Local Infiltration With Ropivacaine Improves Postoperative Pain Control in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Placebo Controlled, Double-blind Trial [NCT02649179]		140 participants (Actual)	Interventional	2016-08-31	Completed
Comparison of the Analgesic Duration of 0.5% Bupivacaine With 1:200,000 Epinephrine Versus 0.5% Ropivicaine Versus 1 % Ropivicaine for Low Volume Ultrasound-guided Interscalene Brachial Plexus Block [NCT02643563]		60 participants (Actual)	Interventional	2016-01-31	Completed
Ultrasound Guided Adductor Canal Block vs Intra-Operative Trans-Articular Saphenous Nerve Block: A Prospective Trial [NCT04155983]	Phase 4	140 participants (Anticipated)	Interventional	2020-03-11	Recruiting
Saphenous Nerve Block for Post-Op Pain Control After Tibial Plateau ORIF [NCT04314570]		50 participants (Anticipated)	Interventional	2023-12-31	Not yet recruiting
A Randomized, Blinded Study to Compare Exparel and Ropivacaine for Pain Relief Following Total Knee Arthroplasty [NCT02607579]		200 participants (Anticipated)	Interventional	2015-01-31	Active, not recruiting
Ultrasound-guided Subcostal Transversus Abdominis Plane Block in Gastric Cancer Patients Undergoing Laparoscopic Gastrectomy: A Randomized Controlled Double-blinded Study [NCT04138901]		112 participants (Actual)	Interventional	2019-11-04	Completed
Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Postoperative Pain Relief After Elective Supratentorial Craniotomy (PAINLESS) [NCT04141319]	Phase 4	100 participants (Anticipated)	Interventional	2021-12-31	Not yet recruiting
Lokal Infiltrations Analgesi Med Ropivakain 1 % Versus Placebo VED Vaginale Descensusoperationer: ET Prospektivt Randomiseret, Dobbeltblindet, Placebo- Kontrolleret Studie [NCT00769054]	Phase 4	48 participants (Anticipated)	Interventional	2008-10-31	Completed
Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain [NCT00768248]		2 participants (Actual)	Interventional	2008-10-31	Terminated(stopped due to No longer enrolling patients, not enough enrollment)
Effect of Laparoscopic-Guided Transversus Abdominus Plane (TAP) Block on Opioid Consumption Using Dual-Adjunct Therapy With Dexmedetomidine and Dexamethasone Versus Liposomal Bupivacaine (Exparel®) Following Minimally Invasive Colorectal Surgery: A Single [NCT05216055]	Phase 2	0 participants (Actual)	Interventional	2022-04-19	Withdrawn(stopped due to No Accrual. PI left Institution)
Location of Injection of Local Anesthetics in the Adductor Canal Block: A Randomized Controlled Trial of the Effect on Postoperative Analgesia and Motor Power [NCT02554864]		108 participants (Actual)	Interventional	2016-02-22	Completed
Epidural Anesthesia as an Alternative for Management in Acute Pancreatitis, a Randomised Clinical Trial [NCT02617199]	Phase 2/Phase 3	60 participants (Anticipated)	Interventional	2015-11-30	Recruiting
Does Magnesium Sulfate as a Supplement in Adductor Canal Blocks Improve Pain Control After Total Knee Arthroplasty? [NCT02581683]	Phase 4	130 participants (Actual)	Interventional	2015-09-30	Completed
Obturator Nerve Block in Total Hip Arthrosplasty. a Randomized Controlled Double Blind Study [NCT04085640]		60 participants (Actual)	Interventional	2020-01-14	Completed
Ultrasound Guidance or Electrical Nerve Stimulation for Interscalene Brachial Plexus Block: a Randomized, Controlled Trial [NCT00702416]	Phase 4	50 participants (Anticipated)	Interventional	2008-05-31	Completed
Study of Effectiveness of a Ropivacaïne Continuous Sternal Infusion to Reduce Postoperative Hyperalgesia Induced by Sternotomy After Cardiac Surgery [NCT00802048]	Phase 3	21 participants (Actual)	Interventional	2009-02-28	Terminated
Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery - a Randomized, Blinded, Placebo Controlled Study [NCT02576223]	Phase 4	40 participants (Anticipated)	Interventional	2015-10-31	Not yet recruiting
Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery: A Randomized, Double-blind, Placebo-controlled Trial Comparing Continuous Intraperitoneal Infusion of Ropivacaine Versus Saline for Post-operative Pain Control [NCT04118777]		0 participants (Actual)	Interventional	2020-05-01	Withdrawn(stopped due to Misregistered to wrong sponsor.)
Adductor Canal Block: Continuous Infusion Versus Automatic Intermittent Bolus For Postoperative Analgesia After Day-Case Anterior Cruciate Ligament Reconstruction [NCT02589288]		80 participants (Actual)	Interventional	2015-11-30	Completed
Pain Management and Functional Recovery After Adductor Canal Block Combined With iPACK Block for Total Knee Arthroplasty. A Prospective, Randomized, Double-blinded Clinical Trial. [NCT06086483]	Phase 4	361 participants (Actual)	Interventional	2020-06-18	Completed
Randomised Double Blind Trial to Investigate the Effects of Intraperitoneal Local Anaesthetic Following Colonic Surgery. [NCT00722709]	Phase 1	60 participants (Anticipated)	Interventional	2008-09-30	Completed
Onset Time of Brachial Plexus Anesthesia With the Axillary or Infraclavicular Approach Under Real-Time Ultrasound Guidance: a Randomized Controlled Trial [NCT00724035]	Phase 4	52 participants (Anticipated)	Interventional	2008-05-31	Completed
Comparison Of The Analgesia Obtained By Infiltration Of Lidocaïne 1% And Ropivacaïne 0,75% Versus Placebo For The Joinings Of Episiotomies Among Parturients Under Epidural Analgesia [NCT00727935]	Phase 4	165 participants (Actual)	Interventional	2006-10-31	Completed
Effects of Ultrasound-guided Adductor Canal Block Versus Femoral Nerve Block on Pain and Quadriceps Strength After Ambulatory Knee Arthroscopic Surgery [NCT05190120]	Phase 4	108 participants (Actual)	Interventional	2016-01-31	Completed
Efficacy of Continous Regional Anesthesia Using m. Erector Spinae Catheter After Video-assisted Thoracic Surgery Procedures [NCT04062045]		50 participants (Anticipated)	Interventional	2019-10-14	Recruiting
Minimum Effective Dose of Intrathecal Ropivacaine Required for Cesarean Delivery: A Prospective, Randomized Comparison Between L2-3 and L3-4 Approach [NCT02565303]		60 participants (Actual)	Interventional	2015-09-30	Completed
Comparison Between Ropivacaine/Dexamethasone and 10% Lignocaine Injection in Distal Glossopharyngeal Nerve Block for Intractable Cancer Pain- A Randomized Trial [NCT04085120]		60 participants (Anticipated)	Interventional	2019-08-23	Recruiting
The Effect of Epidural Steroid Use on Pain Relief in Patients With Continuous Epidural Nerve Block in Postherpetic Neuralgia Patients. [NCT03995563]	Phase 4	40 participants (Anticipated)	Interventional	2019-05-15	Recruiting
Volume Versus Concentration: a Prospective, Double Blind, Parallel Study to Compare the Clinical Effectiveness of Bilateral Quadratus Lumborum Blocks Using High Volume/Low Concentration or Low Volume/ High Concentration Local Anesthetic in Nephrectomies [NCT04077398]	Phase 4	0 participants (Actual)	Interventional	2020-01-22	Withdrawn(stopped due to covid interrupted initial start, then trainees involved finished program and no one took it on)
Continuous Lumbar Plexus Block for Postoperative Pain Control After Total Hip Arthroplasty [NCT00790179]		225 participants (Actual)	Interventional	2003-01-31	Completed
A Analgesic Study of Adductor Canal &IPACK Block With Liposomal Bupivacaine in Knee Arthroplasty ：A Randomized，Double-controlled，Parallel-controlled，Single-center Study [NCT06145165]	Phase 1	90 participants (Anticipated)	Interventional	2023-12-01	Recruiting
A Randomized Controlled Trial of Infraclavicular Nerve Blocks for Postoperative Pain Control in Operative Pediatric Lateral Condyle Fractures [NCT03796572]	Phase 4	90 participants (Anticipated)	Interventional	2019-09-16	Recruiting
Analgesic Efficacy of the Pectoral Nerve Block Type 1 for Breast Subpectoral Implant Surgery: A Randomized Controlled Study [NCT02849236]		56 participants (Actual)	Interventional	2016-10-16	Completed
A Dose-response Study of Spinally Administered Ropivacaine Combined With a Fix Dose of Fentanyl for Elective Caesarean Section in Tall Parturients Under Combined Spinal-epidural Anaesthesia [NCT03936790]		40 participants (Anticipated)	Interventional	2019-06-02	Enrolling by invitation
Effectiveness of Ultrasound Guided Supraclavicular Brachial Plexus Block With 20, 30, or 40 ml of Ropivacaine 0.5% [NCT00923494]		0 participants (Actual)	Interventional	2009-05-31	Withdrawn(stopped due to Unable to enroll. Change in patient population.)
Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries [NCT04016740]	Early Phase 1	22 participants (Actual)	Interventional	2019-08-20	Completed
Evaluation of the Effect of Intraperitoneal Nebulized Ropivacaine on Morphine Consumption After Laparoscopic Appendectomy in Children. A Prospective, Randomized Double Blind Clinical Trial [NCT02624089]	Phase 1/Phase 2	200 participants (Anticipated)	Interventional	2016-01-31	Recruiting
Comparison Between Ropivacaine and Liposomal Bupivacaine Periarticular Injections for Pain Relief After Total Knee Arthroplasty [NCT02616367]	Phase 2	0 participants (Actual)	Interventional	2015-12-31	Withdrawn(stopped due to Study never initiated)
Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain [NCT04034836]	Phase 4	132 participants (Anticipated)	Interventional	2019-10-12	Recruiting
Perineural Dexamethasone Administered in Femural Nerve Block After Anterior Cruciate Ligament Reconstruction [NCT02749162]	Phase 3	90 participants (Actual)	Interventional	2015-11-30	Completed
Effect of Infraorbital and Infratrochlear Nerve Block on Emergence Agitation in Patients Undergoing Septorhinoplasty: A Randomized Controlled Trial [NCT02751268]	Phase 4	66 participants (Actual)	Interventional	2016-04-30	Enrolling by invitation
Treatment of Rotator Cuff Syndrome With Injection of Autologous Platelet Rich Plasma [NCT01123889]		12 participants (Actual)	Interventional	2010-05-31	Completed
Ultrasound-guided Serratus Plane Block for the Quality of Recovery After Modified Radical Mastectomy [NCT02691195]	Phase 4	72 participants (Actual)	Interventional	2016-03-15	Completed
Combined Pericapsular Nerve Group (PENG) and Lateral Femoral Cutaneous Nerve (LFCN) Block for Total Hip Arthroplasty: A Randomized Controlled Trial [NCT04996290]		40 participants (Actual)	Interventional	2020-06-01	Completed
Efficacy of Ropivacaine Continuous Wound Instillation Versus Single Shot After Spine Fusion Surgery [NCT00823576]	Phase 4	60 participants (Actual)	Interventional	2008-12-31	Terminated
Efficacy of Erector Spinae Block With Ropivacaine and Dexmedetomidine on Opioid Consumption After Lumar Spine Surgeries - A Randomised Controlled Trial [NCT05664542]	Phase 4	42 participants (Anticipated)	Interventional	2022-12-15	Recruiting
Femoral or Sciatic Nerve Block to Provide Analgesia After Proximal Tibial Osteotomy [NCT05728294]		50 participants (Actual)	Interventional	2019-02-01	Completed
A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Group, Active and Placebo Controlled Study to Evaluate the Efficacy and Safety of Local Administration of HR18034 for Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy [NCT05769855]	Phase 3	294 participants (Actual)	Interventional	2023-03-21	Active, not recruiting
Double Blind Randomized Trial of Wound Infiltration With Ropivacaine After Breast Cancer Surgery [NCT01404377]	Phase 4	50 participants (Actual)	Interventional	2006-01-31	Completed
Wound Infiltration With Dexmedetomidine in Cesarean Section: Effect on Postoperative Analgesia [NCT03382938]		100 participants (Anticipated)	Interventional	2019-08-23	Recruiting
Ultrasound-guided Popliteal Sciatic Nerve Block: an Evaluation of the Intraneural [NCT02589041]		45 participants (Actual)	Interventional	2015-11-30	Completed
Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofrequency [NCT05519189]	Phase 4	134 participants (Anticipated)	Interventional	2023-01-10	Recruiting
Lokal Infiltrations Analgesi Med Ropivakain 0,5 % Versus Placebo VED Vaginal Hysterektomi: ET Prospektivt Randomiseret, Dobbeltblind ET, Placebo-kontrolleret Studie [NCT00768456]	Phase 4	48 participants (Anticipated)	Interventional	2008-10-31	Completed
Local Infiltration Analgesia in Bilateral Knee Arthroplasty - Efficacy of Subcutaneous Wound Infiltration With Local Anesthetic. [NCT00927225]	Phase 4	16 participants (Actual)	Interventional	2008-09-30	Completed
Evaluation of the Effect of Local Anesthetic Concentration on Rebound Pain After Interscalene Block for Shoulder Surgery [NCT04457557]		60 participants (Anticipated)	Interventional	2020-07-10	Recruiting
Ultrasound Guided Repeated Bilateral Transversus Thoracis Muscle Plane Block Via Catheter and Postoperative Pain in Cardiac Surgery [NCT04916418]	Phase 4	120 participants (Anticipated)	Interventional	2021-10-15	Recruiting
Randomised and Double-blind Clinical Trial on Post-operative Analgesic Efficacy in Colorectal Surgery and Hepatic Surgery With Continuous Infusion of Local Anesthesia vs Saline Serum in the Surgical Incision. [NCT01075646]	Phase 4	225 participants (Actual)	Interventional	2009-03-31	Completed
The MEC90 of Epidural Ropivacaine Blunting Hemodynamic Changes to Pneumoperitoneum in the Patients Undergoing Laparoscopic Gastrectomy [NCT04247373]		50 participants (Anticipated)	Interventional	2020-01-31	Not yet recruiting
Effect of Ultrasound-guided Transversus Abdominis Plane Block With Compound Lidocaine on Postoperative Pain in Patients Undergoing Gynecological Laparotomy：a Randomized Double-blind Controlled Trial [NCT04938882]		164 participants (Actual)	Interventional	2021-08-15	Completed
Dexamethasone as an Adjuvant to Ropivacaine for the Interscalene Brachial Plexus Block: a Dose-finding Study [NCT02818491]	Phase 4	75 participants (Actual)	Interventional	2017-11-01	Completed
[NCT02817321]		76 participants (Actual)	Interventional	2016-11-30	Completed
Intraartikulær Versus ekstraartikulær Bolus Injektion Med Ropivacain Ved Total knæalloplastik: et Prospektivt, Randomiseret, Dobbeltblindet, Kontrolleret Studie [NCT00632580]	Phase 4	60 participants (Anticipated)	Interventional	2008-01-31	Recruiting
The Analgesic Efficacy of Continuous Wound Instillation With Diclofenac or Ropivacaine Following Cesarean Section: a Randomized, Double-blind, Placebo Controlled Study [NCT00801528]	Phase 4	75 participants (Anticipated)	Interventional	2008-04-30	Completed
Postoperative Pain and Patient-controlled Epidural Analgesia Related Adverse Effects in Young and Elderly Patients [NCT02849730]		2,435 participants (Actual)	Observational	2016-07-31	Completed
A Single-Dose, Open-Label, Multi-Center Study to Evaluate the Safety, Pharmacokinetics and Preliminary Efficacy of PRF110 in Bunionectomy Surgery [NCT02784327]	Phase 2	15 participants (Anticipated)	Interventional	2016-08-31	Not yet recruiting
Chronic Pain and Functional Prognosis After Total Knee Replacement: Continuous Locoregional Analgesia by Catheter to the Femoral Triangle Versus Tissue Infiltration as Part of an Improved Rehabilitation After Surgery Approach [NCT03998813]		420 participants (Anticipated)	Interventional	2020-09-02	Active, not recruiting
Determining the Minimum Effective Ropivacaine Dose for Unilateral Hypobaric Spinal Anaesthesia During Traumatic Femoral Neck Surgery in the Aged Person: Prospective Comparative Randomized Study [NCT01005550]	Phase 4	64 participants (Actual)	Interventional	2009-04-30	Completed
Erector Spinae Plane Block Versus Paravertebral Block for Analgesic Outcomes After Cardiac Surgery (PEPS): a Prospective Randomized Comparative Study. [NCT04546113]		80 participants (Anticipated)	Interventional	2021-01-07	Recruiting
Intraneural Injection of Ropivacaine for Subgluteal Sciatic Nerve Block Leads to Faster Onset and Higher Success Rates: a Randomized, Controlled Trial [NCT01999647]		64 participants (Actual)	Interventional	2011-12-31	Completed
Effect of Local Infiltration Analgesia With Ropivacaine in Total Hip Arthroplasty: a Prospective, Randomized, Double-blind, Placebo-controlled Trail [NCT00968955]	Phase 4	120 participants (Actual)	Interventional	2009-09-30	Completed
The Effect of Continuous Administration of Ropivacaine by Bi-laterosternal Multiperforated Catheters Placed Before a Sternotomy for Cardiac Surgery [NCT04495504]	Phase 2	32 participants (Actual)	Interventional	2020-07-22	Completed
Sensory Distribution of Lateral Femoral Cutaneous Nerve Block - A Randomized, Blinded, Paired Trial in Healthy Volunteers [NCT02957903]	Phase 4	20 participants (Actual)	Interventional	2016-11-30	Completed
Influence of Epidural Analgesia in Elective Laparoscopic Colorectal Resections [NCT00512395]	Phase 4	75 participants (Actual)	Interventional	2004-11-30	Completed
Comparison Between Ropivacaine and Bupivacaine in Deep Topical Fornix Nerve Block Anesthesia in Patients Undergoing Cataract Surgery by Phacoemulsification. [NCT02925832]		100 participants (Actual)	Interventional	2016-10-31	Completed
A Single-center, Randomized, Placebo-controlled, Double-blind, Single-dose, Efficacy of PRF-108 4% and PRF-110 4% Versus Ropivacaine Solution 0.5% in an Experimental Pain Model [NCT00883194]	Phase 1/Phase 2	15 participants (Actual)	Interventional	2010-10-31	Completed
Ultrasound-guided Continous Quadratus Lumborum Block: Effect on Acute Pain and Quality of Recovery After Hepatic Surgery With Right Subcostal Incision [NCT02914015]		40 participants (Actual)	Interventional	2018-08-01	Terminated(stopped due to we change the study protocol)
Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study [NCT02541552]	Phase 3	26 participants (Actual)	Interventional	2015-04-30	Completed
Ultrasound Guided Quadratus Lumborum Block for Postoperative Pain in Abdominoplasty: A Randomized Controlled Study [NCT02932930]		40 participants (Actual)	Interventional	2016-10-31	Completed
Does it Worth to Reinforce With Additional Anesthesia to Improve Postoperative Course After Orthognathic Surgery? [NCT03974035]	Phase 2	52 participants (Actual)	Interventional	2018-01-10	Completed
Epidural Analgesia for Labor Pain and Infant Neurobehavior [NCT00987441]		1,200 participants (Actual)	Interventional	2009-09-30	Completed
Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty: a Single Center Randomized Controlled Trail (RCT) Study [NCT03977454]	Phase 2	192 participants (Actual)	Interventional	2019-11-11	Completed
Phase III Study of the Addition of Sufentanil to Interscalene Block in Shoulder Surgery [NCT01025102]	Phase 3	26 participants (Actual)	Interventional	2010-01-31	Completed
Assessment of Spread of Transversus Abdominis Plane Block After Administration of 20 ml Ropivacaine 0,5% Bilaterally [NCT01024868]		20 participants (Anticipated)	Observational	2009-12-31	Completed
New Approach for Brachial Plexus Block: Clinical Research of Retrograde Infraclavicular Brachial Plexus Blockade [NCT01075503]		90 participants (Actual)	Interventional	2008-03-31	Completed
Comparison of Two Multimodal Analgesia Regimens for Total Knee Arthroplasty : a Randomized Controlled Trial [NCT03990038]		2 participants (Actual)	Interventional	2019-08-01	Terminated(stopped due to Recruitment problems making the study completion unlikely)
Blood Levels of Local Anaesthetic in Knee Arthroplasty: A Pharmacological Study of Ropivacaine Blood Levels During the Caledonian Technique for Knee Arthroplasty [NCT01873313]		20 participants (Actual)	Observational	2012-08-31	Completed
Transversus Abdominis Plane (TAP) Block Versus Intrathecal Morphine for Caesarean Section - Randomised Controlled Trial [NCT01931215]	Phase 4	180 participants (Actual)	Interventional	2013-09-30	Completed
Comparative Study of the Effects of Two Local Anesthetics Administered Intrathecally: 0.5% Levobupivacaine and Ropivacaine 0.5% [NCT01935596]	Phase 4	50 participants (Actual)	Interventional	2013-05-31	Completed
Blood Levels of Local Anaesthetic in Knee Arthroplasty: A Pharmacological Study of Ropivacaine Blood Levels During the Caledonian Technique for Knee Arthroplasty [NCT01935648]		30 participants (Anticipated)	Observational	2013-09-30	Not yet recruiting
Adductor Canal Nerve Block Following Total Knee Arthroplasty: A Randomized, Prospective Study Comparing High vs. Low Volume Bolus of 0.33% Ropivacaine [NCT01939379]		0 participants (Actual)	Interventional	2013-09-30	Withdrawn(stopped due to PI left institution. Efforts made to contact PI unsuccessful. No study data available.)
Double Blinded Randomized Control Trial Comparing the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using Ropivacaine Versus Ropivacaine-Chloroprocaine Mixture [NCT01719237]	Phase 4	60 participants (Actual)	Interventional	2009-08-31	Completed
Multicentre Evaluation of a Novel Technique of Analgesia Following Open Liver Resection: Medial Open Transversus Abdominis Plane (MOTAP) Catheters [NCT01960049]	Phase 4	150 participants (Actual)	Interventional	2013-10-31	Completed
Prospective Randomised Double-blind Study to Compare Ropivacaine 10mg/mL Alone Versus Ropivacaine 10mg/mL Associated With Clonidine 1µg/kg for Peribulbar Anesthesia in Posterior Eye Surgery [NCT01963299]	Phase 2	60 participants (Actual)	Interventional	2013-08-16	Completed
Monocentric Prospective Study, in Order to Assess Analgesia Provided by Continuous Sciatic Nerve Block, in Patients With Hypertensive Leg Ulcer. [NCT01964911]	Phase 4	13 participants (Actual)	Interventional	2014-02-28	Completed
Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain [NCT01967524]	Phase 3	80 participants (Actual)	Interventional	2013-09-30	Completed
A Randomized Controlled Trial of Surgical TAP-block After Cesarean Delivery: a Cost-effective Alternative to the Conventional TAP-block [NCT02571439]	Phase 4	41 participants (Actual)	Interventional	2014-10-31	Completed
Adductor Canal Block and Effect of 10 Versus 30 ml Ropivacaine on Muscle Strength: a Randomized Study in Healthy Volunteers [NCT01981746]	Phase 4	26 participants (Actual)	Interventional	2013-11-30	Completed
Blocco Del Nervo Sciatico al Poplite, Intraneurale o Extraneurale? Confronto Prospettico, Randomizzato in Cieco Tra la modalità di Iniezione di Anestetico Locale Per il Blocco Eco Guidato Del Nervo Sciatico al Poplite Nella Chirurgia Dell'Alluce Valgo [NCT01987128]	Phase 4	88 participants (Actual)	Interventional	2013-11-30	Completed
Evaluate the Analgesic Effect of Intraperitoneal Infiltration of Ropivacaine in Children Undergoing Laparoscopic Surgery [NCT01997593]	Phase 2	70 participants (Actual)	Interventional	2013-11-30	Completed
Is Postoperative Quality of Recovery After Radical Prostatectomy Related to the Type of Anesthesia and Analgesia? [NCT04587505]	Phase 4	61 participants (Actual)	Interventional	2019-04-01	Completed
Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay [NCT02006355]	Phase 4	36 participants (Actual)	Interventional	2014-04-30	Terminated(stopped due to Recruitment difficulties)
Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach: Randomized, Double-blind Study [NCT05969457]	Phase 3	108 participants (Anticipated)	Interventional	2023-10-01	Not yet recruiting
A Three-Arm, Double-Blinded, Randomized Controlled Trial Comparing the Efficacy of Adductor Canal Pain Catheters Following Total Knee Arthroplasty [NCT05053087]	Phase 3	72 participants (Actual)	Interventional	2022-04-13	Completed
Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair: A Prospective, Randomized Study [NCT02341144]		61 participants (Actual)	Interventional	2014-12-31	Completed
Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy [NCT04429022]	Phase 3	68 participants (Actual)	Interventional	2020-11-24	Completed
Effect of Continuous Femoral Analgesia on Quadriceps Muscle Strength-0.2% Ropivacaine Continuous Infusion Versus Patient Controlled Femoral Analgesia [NCT02007850]		36 participants (Anticipated)	Interventional	2014-02-28	Recruiting
Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia [NCT05091905]	Phase 4	140 participants (Anticipated)	Interventional	2022-02-14	Enrolling by invitation
Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome. A Randomized Double Blind Placebo Study [NCT02857465]	Phase 3	0 participants (Actual)	Interventional	2017-01-31	Withdrawn(stopped due to French Agency for the Safety of Health Products refusal)
Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy [NCT02023684]		90 participants (Anticipated)	Interventional	2014-01-31	Not yet recruiting
The Effects of Various Concentrations of Ropivacaine on the Onset and Duration of Ankle Block - a Randomized, Triple-blinded, Parallel-group Interventional Study [NCT06185608]		126 participants (Anticipated)	Interventional	2024-03-01	Not yet recruiting
Effect of Brachial Plexus Block on Outcomes of Upper Extremity Arteries After Intracranial Aneurysm Interventional Surgery Via Transradial Access: A Randomized Clinical Trial [NCT06035692]		176 participants (Anticipated)	Interventional	2023-06-01	Recruiting
Ropivacaine 0.75% vs Ropivacaine 0.75% Plus Mepivacaine 1.5% for Subgluteal Sciatic Bloc: a Prospective Double Blind Randomized Controlled Study [NCT00567450]	Phase 4	30 participants (Anticipated)	Interventional	2007-09-30	Completed
Comparison of Quadratus Lumborum Block With Medical Management for Pain Control After Lumbar Spine Fusion Surgery [NCT04588389]	Phase 3	30 participants (Anticipated)	Interventional	2020-12-01	Recruiting
A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery [NCT00586976]	Phase 2/Phase 3	125 participants (Actual)	Interventional	2005-07-31	Terminated(stopped due to Stopped by DSMB due to increased wound infection rate.)
Comparison of Ropivacaine Plasma Concentration With or Without Epinephrine for Posterior Quadratus Lumborum Block in Cesarean Section [NCT04562103]		52 participants (Actual)	Interventional	2020-07-03	Completed
A Phase I Study to Evaluate the Safety, Pharmacokinetics and Efficacy of HR18034 for Pain Management After Inguinal Hernia Repair [NCT04551924]	Phase 1	64 participants (Anticipated)	Interventional	2020-10-01	Recruiting
Can Post-operative TAP Block Improve Quality of Recovery After C-sections in Patients on Methadone Maintenance Therapy for Opioid Abstinence? [NCT01644864]	Phase 4	0 participants (Actual)	Interventional	2012-07-31	Withdrawn(stopped due to No participants were enrolled. The PI left the institution.)
Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. [NCT02279628]	Phase 4	150 participants (Anticipated)	Interventional	2014-07-31	Recruiting
Epidural Analgesia and Troubles of Fetal Cardiaq Rythm : Effect of the Systemic Transfer of Ropivacaine and Sufentanil [NCT01686347]	Phase 4	40 participants (Actual)	Interventional	2012-06-30	Completed
Evaluation of a Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block for Postoperative Analgesia Following Ankle Surgery [NCT01167907]		32 participants (Actual)	Interventional	2010-07-31	Completed
The Effect of Pre-operative Transversus Abdominis Plane (TAP) Block in the Quality of Recovery of Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Randomized, Blinded Study [NCT01074229]		75 participants (Actual)	Interventional	2010-03-31	Completed
Lokal Infiltrations Analgesi Med Ropivakain 0,5 % Versus Placebo Ved Rygkirurgi for Spinalstenose: et Prospektivt Randomiseret, Dobbeltblindet, Placebo-kontrolleret Studie [NCT00771459]	Phase 4	48 participants (Anticipated)	Interventional	2008-10-31	Completed
Analgesic Efficacy of Ultrasound Guided Transversus Abdominis Plane Block After Cesarean Delivery in Patients With a BMI > 30 [NCT01217580]		0 participants (Actual)	Interventional	2010-10-31	Withdrawn(stopped due to The study was not feasible to perform at one institution with the amount of subjects that were needed to complete it.)
Postoperative Analgesia With Transversus Abdominis Plane Block or Quadratus Lumborum Block in Patients After Cesarian Delivery [NCT03404908]	Phase 4	105 participants (Actual)	Interventional	2018-02-07	Completed
Lokal Infiltrations Analgesi Med Ropivakain 0,5 % Versus Ropivakain 0,2 % Versus Placebo Efter Sectio Caesarea: et Prospektivt, Dobbeltblindet, Placebokontrolleret Studie. [NCT00891540]	Phase 4	90 participants (Anticipated)	Interventional	2009-07-31	Completed
Ultrasound Guided Motor Sparing Knee Blocks With or Without Dexmedetomidine for Postoperative Analgesia Following Knee Arthroplasty: a Randomized Double Blinded Study [NCT02540070]	Phase 3	135 participants (Anticipated)	Interventional	2014-08-31	Recruiting
Assessment of Efficacy and Safety of Continuous Wound Infiltration With Local Anesthesics Through a Parietal Paravertebral Catheter for Postoperative Analgesia After Posterior Lumbar Arthrodesis [NCT00825422]	Phase 3	50 participants (Actual)	Interventional	2009-01-31	Completed
Project Arthritis Recovering Quality of Life Through Education - Hip [NCT04018690]		48 participants (Anticipated)	Interventional	2019-09-01	Not yet recruiting
Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population [NCT04298099]	Phase 4	24 participants (Anticipated)	Interventional	2020-12-17	Recruiting
Comparative Evaluation of Lumbar Plexus and Suprainguinal Fascia Iliaca Compartment Blocks for Pain Management After Orthopedic Surgical Procedures Involving Hip and Femur in Pediatrics. [NCT03746951]	Phase 2/Phase 3	15 participants (Actual)	Interventional	2019-04-24	Completed
Evaluation of Postoperative Experience of Two WALANT-type Modes of Anesthesia (Lidocaine Alone or Combined With Ropivacaine) Used in Ambulatory Surgery of the Upper Limb. A Single-center Prospective Randomized, Single-blind Study [NCT05343299]	Phase 1	91 participants (Actual)	Interventional	2022-05-30	Completed
Effect of Scalp Nerve Block on the Quality of Recovery in Patients Undergoing Supratentorial Tumor Resection [NCT06157359]		84 participants (Anticipated)	Interventional	2023-11-27	Recruiting
Isobaric Ropivacaine 15 mg Versus Hyperbaric Bupivacaine 12.5 mg for Spinal Anesthesia in Geriatric Patients Undergoing Total Knee Arthroplasty [NCT02764723]		52 participants (Actual)	Interventional	2013-01-31	Completed
Use of Regional Anesthesia in Hip Arthroscopy [NCT02851888]	Phase 4	70 participants (Anticipated)	Interventional	2016-07-31	Recruiting
Pectoral Nerves Blocks and Their Effect on Chronic Pain After Breast Cancer Surgery [NCT02719795]	Early Phase 1	140 participants (Anticipated)	Interventional	2016-04-30	Recruiting
The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine for the Management of Pain After Surgical Correction of Ureteropelvic Junction Stenosis [NCT00930046]		15 participants (Actual)	Interventional	2009-04-24	Terminated(stopped due to The institution transitioned from open surgical procedure to Robotic procedure)
Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia [NCT02873091]		186 participants (Anticipated)	Interventional	2016-09-30	Recruiting
Double-blinded Randomised Controlled Trial (RCT) Comparing a High Ankle Block to Placebo in Patients Treated for Ankle Pathologies [NCT04292691]		60 participants (Anticipated)	Interventional	2020-04-01	Not yet recruiting
Triamcinolone Ketorolac (TriKe) Knee Trial Evaluating the Effectiveness and Possible Superiority of Ketorolac vs. Cortisone When Injected Intra-Articular in Subjects With Osteoarthrosis [NCT05336968]	Phase 4	150 participants (Anticipated)	Interventional	2022-09-15	Enrolling by invitation
Intravenous Dexamethasone Versus Placebo for Ultrasound Guided Axillary Brachial Plexus Block With Ropivacaine: Randomised, Controlled, Clinical Trial [NCT02862327]	Phase 3	99 participants (Actual)	Interventional	2016-12-01	Completed
[NCT02841982]		30 participants (Actual)	Interventional	2016-08-31	Completed
Intra-abdominal Infusions of Ropivacaine Following Laparoscopic Ventral Hernia Repair: a Randomised Double-blind Controlled Trial. [NCT02785276]		0 participants (Actual)	Interventional	2016-08-31	Withdrawn(stopped due to Study not initiated)
Analgesic Efficacy of Transversus Abdominis Plane (TAP) Block After Lumbar Spine Surgery Through Anterior Approach (Anterior Lumbar or Direct Lateral Interbody Fusion): a Prospective, Randomized, Double-blind Placebo-controlled Study [NCT02778178]	Phase 4	40 participants (Actual)	Interventional	2016-05-02	Completed
The Effect of Dexamedetomidine for Interscalene Brachial Plexus Block on Plasma Cortisol and IL-6 After Rotator Cuff Repair: a Prospective Randomized Study [NCT02766556]		50 participants (Actual)	Interventional	2014-08-31	Completed
Creation of Arteriovenous Ante-brachial Fistula Under Axillary Block Versus Local Anesthesia : Impact on Early Complications [NCT02722096]		78 participants (Actual)	Interventional	2014-03-31	Completed
Comparison of the Analgesic Effect of the Local Anesthetics Ropicacaine, Levobupivacaine, and Levobupivacaine + Epinephrin Via Interscalene Nerve Block in Patients Undergoing Shoulder Arthroscopy Under General Anesthesia [NCT02691442]	Phase 4	30 participants (Actual)	Interventional	2010-12-31	Completed
A Prospective Randomized Parallel Study to Compare Post-operative Pain Control With Addition of Sensory Posterior Articular Nerve Block to Adductor Canal Block (SPANK) and Intraoperative Periarticular Infiltration in Total Knee Arthroplasty. [NCT04290442]	Phase 4	0 participants (Actual)	Interventional	2021-01-01	Withdrawn(stopped due to initially cessation due to covid, then fellow doing the study graduated with no time to complete the study; will take up again if a current fellow takes on the project)
Evaluation of Non-invasive Monitor of Physiodoloris Pain in Patients With Complex Regional Pain Syndrome Treated by Nerve Block (Prospective Monocenter Study) [NCT02663284]		30 participants (Actual)	Interventional	2012-04-30	Completed
Intraperitoneal Ropivacaine Irrigation in Patients Undergoing Bariatric Surgery [NCT02641288]	Phase 3	110 participants (Actual)	Interventional	2015-01-31	Completed
Local Infiltration Analgesia (LIA) With Ropivacaine, Ketorolac and Epinephrine Intra- and Postoperatively in Unicompartmental Knee Arthroplasty [NCT00653926]		40 participants (Actual)	Interventional	2005-09-30	Completed
Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain [NCT00667264]		7 participants (Actual)	Interventional	2008-10-31	Completed
Patient Outcomes With Periarticular Liposomal Bupivacaine Injection vs Adductor Canal Block After Primary Total Knee Arthroplasty [NCT02863120]	Phase 4	63 participants (Actual)	Interventional	2016-07-31	Completed
A Double-blind Randomized Trial of Interpectoral Nerve Block (Pecs 1 and 2) With Ropivacaine Versus Placebo Before Breast Cancer Surgery: Effects on Acute Postoperative Pain. (MIRs 04) [NCT04327063]	Phase 3	182 participants (Actual)	Interventional	2020-08-04	Completed
Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Plexus Block, a Randomized Controlled Study [NCT02630290]	Phase 4	60 participants (Actual)	Interventional	2015-12-31	Completed
Continuous Wound Infiltration for Diminution of Post-surgery Pain After Caesarean Section (Dip-Caesar) [NCT02828059]		0 participants (Actual)	Observational	2016-08-31	Withdrawn(stopped due to changed drug approval)
Remifentanil-dexmedetomidine Anesthesia as an Alternative Anesthetic for Elective Pediatric Surgery: a Pilot Study. [NCT02799589]	Phase 4	0 participants (Actual)	Interventional	2016-07-31	Withdrawn(stopped due to Difficulty in recruitment)
Efficacy of Direct Versus Peripheral Low-Dose Adjuvant Dexamethasone on Duration and Rebound Pain in Regional Anesthesia for Distal Radius Fracture Fixation: A Prospective Randomized Controlled Blinded Study [NCT05274113]	Phase 3	50 participants (Anticipated)	Interventional	2022-03-10	Enrolling by invitation
Periarticular Injection and Hamstring Block Versus Placebo for Pain Control in Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial [NCT05248724]		44 participants (Actual)	Interventional	2017-08-01	Completed
A Comparison of Pulsed Electromagnetic Fields (PEMF) and Pectoral (PEC) Interfascial Blocks on Postoperative Pain Reduction in Patients Undergoing Mastectomy and Tissue Expander Reconstruction [NCT03360214]	Phase 4	60 participants (Actual)	Interventional	2017-07-05	Completed
The Evaluation of the Efficacy of Local Infiltration Analgesia and Infusion for Total Hip Arthroplasty [NCT01409278]		105 participants (Actual)	Interventional	2009-08-31	Completed
Effect of Transversus Abdominis Plane (TAP) Block as Postoperative Pain Management After Laparoscopic Colon Surgery [NCT01418144]	Phase 4	80 participants (Actual)	Interventional	2010-08-31	Completed
A Multicentric, Randomized, Controlled, Double Blinded, Phase III Clinical Trial; Comparing Peritoneal Nebulization of Ropivacaine 150 mg With Peritoneal Nebulization of Saline [NCT01432496]	Phase 3	130 participants (Anticipated)	Interventional	2011-09-30	Terminated(stopped due to There was insuficient recruitment in two centers)
The Effect of Phrenic Nerve Block on Postoperative Shoulder Pain in Patients for Liver Resection - a Double Blinded Randomised Controlled Trial. [NCT02903719]	Phase 4	30 participants (Anticipated)	Interventional	2016-09-30	Recruiting
Analgesic Efficacy of Adductor Canal Block (ACB) Before and After Primary Total Knee Arthroplasty (TKA): A Prospective Randomized Trial to Compare Postoperative Clinical Outcomes [NCT02908711]	Phase 4	50 participants (Actual)	Interventional	2016-10-31	Completed
Erector Spinae Plane Block Catheters: The Role in Acute Postoperative Pain After Hepatic Resection With Intrathecal Morphine [NCT04849455]	Phase 4	70 participants (Anticipated)	Interventional	2021-05-24	Recruiting
Influence of 0.75% Ropivacaine Topicalization on Emergence Agitation in Preschool-aged Children Undergoing Adenotonsillectomy [NCT02848287]		84 participants (Anticipated)	Interventional	2016-08-31	Not yet recruiting
Study of Posterior Lumbar Plexus Block for Pain Relief After Hip Surgery [NCT00150865]		60 participants	Interventional	2001-09-30	Completed
Effects of Local Anaesthetic Infusion Rates on Nerve Block Duration. A Randomised, Blinded, Healthy Volunteer Study [NCT02801799]	Phase 1	60 participants (Actual)	Interventional	2016-10-10	Terminated(stopped due to The trial was comprised of two parts. After the first part we could repudiate our hypothesis. Thus, no reason to carry on with the second part of the trial.)
[NCT02768493]		80 participants (Actual)	Interventional	2016-05-31	Completed
Administration of Ketamine to Branchial Plexus Block Using Axillary Approach : Comparative Study [NCT05297422]		81 participants (Anticipated)	Interventional	2022-01-20	Recruiting
Analgetic Efficiency of Single-shot Perineural Low Dose Dexamethasone Added to Infraclavicular Block Anesthesia for Upper Limb Surgery [NCT02698995]	Phase 3	180 participants (Actual)	Interventional	2015-11-30	Completed
Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty [NCT02585011]		123 participants (Actual)	Interventional	2015-12-31	Completed
Interscalene Block and Dysfunction Diaphragmatic: Effect of Low Volume of Ropivacaine 0,1%. A Randomised, Controlled Trial [NCT04173364]	Phase 3	60 participants (Actual)	Interventional	2019-10-29	Completed
ROPI Study: Evaluation of the Interest of Ropivacaine Streaming in Postoperative Pain After Mastectomy. [NCT01855529]	Phase 2	150 participants (Actual)	Interventional	2013-04-30	Completed
Pericapsular Nerve Group (PENG) Block for Arthroscopic Hip Surgery: A Randomized, Placebo-controlled Trial [NCT04508504]		70 participants (Actual)	Interventional	2020-12-01	Completed
Blood Levels of Local Anaesthetic in Hip Arthroplasty: A Pharmacological Study of Ropivacaine Blood Levels During the Caledonian Technique for Hip Arthroplasty [NCT01869946]		20 participants (Actual)	Observational	2012-08-31	Completed
Pain Treatment in Posterior Thoracolumbar Operation a Randomized Study to Assess the Effect of Local Analgesia After Operation [NCT01872494]	Phase 4	71 participants (Actual)	Interventional	2013-05-31	Completed
Superficial Cervical Plexus Block for Improved Outcomes in Pediatric Otolaryngologic Surgery [NCT06023329]	Phase 4	36 participants (Anticipated)	Interventional	2023-12-01	Not yet recruiting
Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery (VATS) - A Randomized Controlled Trial. [NCT03809442]	Phase 4	120 participants (Anticipated)	Interventional	2019-06-25	Recruiting
High Thoracic Epidural Anesthesia and Postoperative Analgesia With Ropivacaine or Levobupivacaine for Coronary Surgery: A Prospective Randomized Double-Blind Comparison [NCT00552864]	Phase 4	61 participants (Actual)	Interventional	2003-01-31	Completed
A Prospective Comparison of Pain and Analgesia in Patients With Continuous Peripheral Nerve Block Catheters Using Continuous Infusion or Scheduled Bolus Infusion [NCT03230565]	Phase 4	240 participants (Anticipated)	Interventional	2018-06-01	Enrolling by invitation
PENG Block vs. ESP Block for Pediatric Hip Surgery. A Randomized, Prospective Double-blinded Clinical Trial. [NCT06087549]	Phase 4	150 participants (Anticipated)	Interventional	2023-11-30	Not yet recruiting
Continuous Fascia Iliaca Block for Acute Hip Fractures: a Randomized Controlled Pilot Study [NCT03588689]	Phase 4	30 participants (Actual)	Interventional	2018-05-07	Completed
Transversus Abdominus Plane (TAP) Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery: A Prospective Randomized Control Trial [NCT03080142]	Phase 4	86 participants (Actual)	Interventional	2017-03-01	Completed
A Comparison of Ropivacaine Alone Versus Ropivacaine With Dexamethasone or Clonidine Versus a Combination of Ropivacaine, Dexamethasone, and Clonidine for Supraclavicular Brachial Plexus Block Using Ultrasound:A Prospective, Observer-blinded, Randomized S [NCT02151487]		97 participants (Actual)	Observational	2014-03-31	Completed
Evaluation of Intra-articular Continuous Infusion Pump With Ropivacaine in Addition to Local Infiltration Analgesia (LIA) in Total Knee Arthroplasty (TKA). A Placebo Controlled Randomised Trial. [NCT01726686]	Phase 4	200 participants (Actual)	Interventional	2010-02-28	Completed
Intermittent Bolus Versus Continuous Infusion Erector Spinae Catheters for Median Sternotomy Incisions: A Prospective Randomized Controlled Trial [NCT05642416]	Phase 4	240 participants (Anticipated)	Interventional	2022-10-15	Recruiting
Comparison of Intra-articular Infiltration and Gabapentin With Epidural Analgesia After Total Knee Replacement Surgery [NCT01489631]		81 participants (Actual)	Interventional	2013-03-31	Completed
Minimum Effective Volume of Ropivacaine 7.5 mg/ml for the Lateral and Sagittal Infraclavicular Brachial Plexus Block When Using Guidance by Both Ultrasound and Nerve Stimulation. [NCT01493986]	Phase 4	25 participants (Anticipated)	Interventional	2012-02-29	Completed
A Single Center, Randomized, Parallel Group Study to Evaluate the Efficacy of Ropivacaine Administered by Ultrasound-guided Erector Spinae Plane Block for Major Upper Abdominal Surgery [NCT04702685]	Phase 3	50 participants (Anticipated)	Interventional	2021-01-31	Not yet recruiting
Double Blind Randomized Phase III Controlled Trial Comparing the Effect of Intraperitoneal Nebulization of Ropivacaine With Intraperitoneal Instillation of Ropivacaine on Pain Control After Laparoscopic Cholecystectomy [NCT01248819]	Phase 3	60 participants (Actual)	Interventional	2008-04-30	Completed
Dexmedetomidine as Adjunct Medication to Local Infiltration Anesthesia (LIA) vs Ultrasound-Guided Regional Anesthesia (USRA) in Regard to Patients' Need for Opioids, Wellbeing, Satisfaction, and Knee Functionality in Knee-endoprosthetics [NCT04697537]	Phase 3	50 participants (Actual)	Interventional	2021-02-01	Completed
Analgesia For Positioning Patient With Femur Fracture For Spinal Anaesthesia : Ultrasound-Guided Fascia Iliaca Compartment Block Versus Intravenous Fentanyl [NCT02983344]		24 participants (Actual)	Interventional	2015-10-31	Completed
Preventive Effect of Stellate Ganglion Block on Cerebral Vasospasm in Patients Undergoing Aneurysm Surgery [NCT02275247]		40 participants (Anticipated)	Interventional	2014-08-31	Enrolling by invitation
Postoperative Analgesia With Local Infiltration After Femoral Neck Fracture vs. Traditional Treatment of Pain With Opioids [NCT00529425]	Phase 4	50 participants (Actual)	Interventional	2008-01-31	Completed
[NCT00523289]	Phase 4	48 participants (Anticipated)	Interventional	2007-10-31	Active, not recruiting
Abdominal Wall Nerve Blockade: A Comparison With Local Port Site Injection as Well as Between the Use of Ultrasound and Laparoscopy to Guide Placement [NCT02945696]		0 participants (Actual)	Interventional	2016-10-31	Withdrawn(stopped due to Funding issues)
The Effect of 3 Ropivacaine Suprascapular Nerve Blocks in Subacute Adhesive Capsulitis: a Randomized Controlled Trial [NCT02944526]	Phase 4	36 participants (Actual)	Interventional	2016-11-30	Completed
Intercostal Cryoneurolysis Following Traumatic Rib Fractures [NCT04198662]	Phase 4	20 participants (Actual)	Interventional	2020-04-03	Active, not recruiting
A Randomized, Double-Blind, Placebo- and Active-Controlled, Dose Escalation and Optional Dose Expansion Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CPL-01 in Postoperative Pain After Open Inguinal Herniorrhaphy [NCT05080959]	Phase 2	105 participants (Actual)	Interventional	2021-07-28	Completed
Paravertebral Block, an Adjunct to General Anaesthesia for Breast Surgery? [NCT00547989]	Phase 3	46 participants (Actual)	Interventional	2006-10-31	Completed
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management [NCT04567407]	Phase 4	45 participants (Actual)	Interventional	2020-09-22	Completed
Caudal vs. Pudendal Block for Early Postoperative Pain Control in a Pediatric Population Undergoing Lower Genitourinary Surgery [NCT05708989]	Phase 4	138 participants (Anticipated)	Interventional	2023-03-06	Suspended(stopped due to Transitioning to new clinic)
Ropivacaine for Ultrasound-guided Interscalene Block: 3mL Provide Similar Analgesia to 5mL With Less Diaphragmatic Paralysis in Shoulder Arthroscopy Surgeries [NCT04317235]		60 participants (Actual)	Interventional	2016-01-10	Completed
Effect of Scalp Nerve Block Combined With Intercostal Nerve Block on Quality of Recovery After Deep Brain Stimulation in Patients With Parkinson's Disease [NCT05353764]		88 participants (Anticipated)	Interventional	2022-04-20	Recruiting
The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block on Plasma Cortisol and Pain-related Cytokines After Arthroscopic Rotator Cuff Repair: a Randomized Controlled Trial [NCT04398589]	Phase 4	46 participants (Actual)	Interventional	2015-05-20	Completed
Optimizing Local Anesthetic Concentration for Continuous Lumbar Plexus Nerve Blocks [NCT00912873]	Phase 4	50 participants (Actual)	Interventional	2008-05-31	Completed
The Impact of a Preoperative Nerve Block in Foot and Ankle Surgery on the Consumption of Sevoflurane [NCT04022057]	Phase 2/Phase 3	100 participants (Anticipated)	Interventional	2019-08-01	Recruiting
[NCT00956709]	Phase 4	35 participants (Actual)	Interventional	2008-12-31	Terminated
Preemptive Co-infiltration of Dexamethasone Palmitate Emulsion With Ropivacaine for Postoperative Pain in Patients Undergoing Major Spinal Surgery [NCT05693467]	Phase 4	124 participants (Anticipated)	Interventional	2023-03-01	Recruiting
Clinical Outcome Following Arthroscopic Knee Surgery (COFAKS)-Addendum [NCT03704376]	Phase 4	125 participants (Actual)	Interventional	2016-02-01	Completed
Comparison Between Single Shot Versus Continuous Infraclavicular Brachial Plexus Block for Postoperative Analgesia After Distal Radius Fracture: A Prospective Randomized Open Label Study [NCT02744352]		8 participants (Actual)	Interventional	2016-10-31	Terminated(stopped due to prior to its planned completion as anticipated by the protocol due to lack of resources)
Erector Spine Block in Patients Undergoing Back Surgery, Observational Feasibility Trial of the Effect on Postoperative Pain-scores and Opioid Consumption [NCT03214536]		15 participants (Actual)	Interventional	2017-06-25	Completed
Effect of Dexmedetomidine as Adjuvant to Ropivacaine for Brachial Plexus Block [NCT05767827]		40 participants (Anticipated)	Interventional	2023-02-01	Recruiting
Ultrasound Guided Nerve Block Combinations for Anterior Cruciate Ligament Reconstruction; Femoral, Saphenous and Obturator (Posterior Branch)Nerves. [NCT01840800]		82 participants (Actual)	Interventional	2013-02-28	Completed
Application of Ultrasound-Guided Thoracic Paravertebral Block in Pulmonary Ablation Surgery [NCT05437718]		30 participants (Actual)	Interventional	2021-12-01	Completed
Outcomes of Perioperative Epidural Analgesia in Gynecologic Oncology Patients: A Parallel Prospective Cohort and Randomized Clinical Study [NCT00295945]		240 participants (Actual)	Observational	2005-03-31	Completed
Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block [NCT04209504]		60 participants (Anticipated)	Observational	2021-10-12	Recruiting
Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults [NCT03901612]	Phase 4	0 participants (Actual)	Interventional	2019-01-05	Withdrawn(stopped due to covid and surgeon left)
Impact of Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Nausea and Vomiting and Early Outcome After Laparoscopic Bariatric Surgery: a Randomized Double-Blinded Controlled Trial [NCT05016180]	Phase 2	120 participants (Anticipated)	Interventional	2020-09-25	Recruiting
Surgeon Performed Saphenous Nerve Block at the Medial Femoral Condyle for Arthroscopic Partial Meniscectomy and Meniscus Repair: A Randomized Control Trial [NCT04717609]	Phase 3	160 participants (Actual)	Interventional	2021-01-25	Enrolling by invitation
Paravertebral Block vs no Block in Open Pancreaticoduodenectomy: Prospective Randomized Controlled Trial [NCT05820997]	Phase 4	40 participants (Anticipated)	Interventional	2023-04-24	Recruiting
Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block for Pain Management in Pediatric Patients With Developmental Dysplasia Sia of the Hip Joint, Randomized Controlled Trial [NCT05543109]		85 participants (Anticipated)	Interventional	2022-09-29	Enrolling by invitation
Pre-operative Paravertebral Blocks to Decrease Post-operative Pain Following Mastectomy With Immediate Tissue Expander Reconstruction [NCT02161705]	Phase 3	18 participants (Actual)	Interventional	2014-07-31	Terminated(stopped due to Poor accrual due to change in standard of care procedure.)
Ultrasound-guided Intermediate Cervical Block Versus Superficial Cervical Block for Carotid : a Randomised Controlled Trial [NCT01742845]		86 participants (Actual)	Interventional	2011-04-30	Completed
Double Blind Randomized Phase III Controlled Trial Comparing the Effect of Preoperative and Postoperative Nebulization of Ropivacaine on Pain Control After Laparoscopic Cholecystectomy [NCT01247857]	Phase 3	90 participants (Actual)	Interventional	2008-04-30	Completed
Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery [NCT04516174]		180 participants (Anticipated)	Interventional	2020-09-01	Not yet recruiting
Early and Late Postoperative Analgesia and Recovery Effects of Programmed Intermittent Bolus Infusion of Thoracic Paravertebral Block for Hepatectomy: A Prospective, Randomized, Double-blinded, Controlled Study [NCT04304274]		76 participants (Actual)	Interventional	2020-03-10	Completed
Pain Management of Anterior Cruciate Ligament Reconstruction: Evaluation of Adductor Canal Block Versus Oral Pain Regimen [NCT03365908]		60 participants (Anticipated)	Interventional	2017-10-09	Enrolling by invitation
Choose Between Two Different Concentration of Ropivacaine on TAP Block for Children Submitted of Open Appendectomy [NCT03005808]	Phase 4	40 participants (Actual)	Interventional	2015-01-31	Completed
A Double Blind, Multi-center, Randomized, Placebo-Controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Ropivacaine 0.2% Pre-Filled Dispenser for the Treatment of Postsurgical Pain in Patients Undergoing Cesarean Delivery [NCT02959476]	Phase 3	132 participants (Actual)	Interventional	2017-03-13	Completed
The Effect of Thoracolumbar Paravertebral Block or Intravenous Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain After Inguinal Herniorrhaphy [NCT00720330]		12 participants (Actual)	Interventional	2008-07-31	Terminated(stopped due to Enrollment challenges prohibited study progression.)
The Effect of Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine or Bupivacaine [NCT00801138]		218 participants (Actual)	Interventional	2008-11-30	Terminated(stopped due to A strong primary outcome crosses the efficacy boundary at the interim analysis)
Ultrasound Guided Supraclavicular Nerve Block: Comparison Between a Mixture of Mepivacaine and Ropivacaine, and Sequential Injection of Mepivacaine Followed by Ropivacaine [NCT00825786]	Phase 3	103 participants (Actual)	Interventional	2008-09-30	Completed
Post Operative Analgesia Using the Transverse Abdominal Plan (TAP) Block in Patients Undergoing a Radical Retropubic Prostatectomy (RRP) [NCT00913068]		110 participants (Actual)	Interventional	2009-07-31	Completed
Comparison of Temporomandibular Joint Arthrocentesis With Infiltration of PRP + Ropivacaine Versus PRP: Does It Reduce Postoperative Pain? [NCT05817162]	Phase 4	30 participants (Anticipated)	Interventional	2023-04-01	Enrolling by invitation
Local Infiltration Analgesia for Postoperative Pain After Caesarean Section. A Prospective, Randomised, Controlled Trial [NCT01094106]	Phase 4	70 participants (Actual)	Interventional	2010-04-30	Completed
Prospective Randomized Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Postoperative Pain After Total Knee Replacement. [NCT01163214]	Phase 4	160 participants (Actual)	Interventional	2010-07-31	Completed
Perioperative Ropivacaine Wound Infusion in Laparoscopic Cholecystectomy. A Randomized Controlled Double-blind Trial [NCT01388946]		110 participants (Actual)	Interventional	2010-05-31	Completed
Minimum Effective Anesthetic Concentration of Supraclavicular Block, Infraclavicular Block, Femoral Nerve Block and Sciatic Nerve Block Via the Popliteal and Parasacral Approach [NCT01452126]	Phase 2	49 participants (Actual)	Interventional	2011-06-30	Terminated(stopped due to Departure of principal investigator)
Randomized Trial of Transversus Abdominal Plane (TAP) Block at Total Laparoscopic Hysterectomy: Effect of Regional Analgesia on Quality of Recovery [NCT01479270]		56 participants (Actual)	Interventional	2011-05-31	Completed
Comparing Intrathecal Morphine and Erector Spinae Plane Regional Anesthesia Against Intrathecal Morphine Alone for Post-Cesarean Section Pain [NCT06114121]	Phase 4	100 participants (Anticipated)	Interventional	2024-01-10	Not yet recruiting
A Comparison of 0.1 and 0.2% Ropivacaine in Lumbar Plexus Catheters After Primary Total Hip Arthroplasty: a Comparison of Postoperative Analgesia and Motor Function. [NCT01556724]		41 participants (Actual)	Interventional	2010-01-31	Completed
Interventional Study of Antalgic Efficacy of the CycloMesh™ Implant Soaked in Ropivacaine Hydrochloride 10 mg/mL in the Treatment of Uncomplicated Inguinal Hernia. Randomized Comparative Study Versus CycloMesh™ Soaked in Physiological Saline Solution NaCl [NCT04033055]		304 participants (Actual)	Interventional	2019-10-31	Completed
Impact of Individualized Timing of Analgesia on the Effectiveness of Labor Analgesia: a Randomized Controlled Trial [NCT02920489]		200 participants (Actual)	Interventional	2016-08-31	Completed
Effects of Scalp Nerve Blocks on Systemic Inflammation After Meningeoma Resection Surgery：a Prospective Randomized Controlled Trial [NCT02939833]		160 participants (Anticipated)	Interventional	2017-01-31	Not yet recruiting
Antepartum Chronic Epidural Therapy (ACET) Using Ropivacaine to Improve Uteroplacental Blood Flow in Pre-Eclampsia and Intrauterine Growth Restriction [NCT00197340]	Phase 3	20 participants (Anticipated)	Interventional	2003-08-31	Completed
Randomized Trial to Evaluate the Analgesic Efficacy of Inter Pleural Ropivacaine Road in Post Thoracotomy Pain for Oncologic Surgery [NCT00210132]	Phase 2	90 participants (Actual)	Interventional	2003-10-31	Completed
Pain Relief by Continuous Intra-Peritoneal Nebulization of Ropivacaine During Gynecological Laparoscopic Surgery [NCT00433316]	Phase 3	40 participants (Actual)	Interventional	2007-02-28	Completed
Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty: A Randomized Controlled Trial [NCT02954484]	Phase 3	116 participants (Actual)	Interventional	2015-04-30	Completed
Impact of Intraperitonael Nebulization of Local Anesthetic on Postoperative Pain Associated With Laparoscopic Surgery [NCT01512914]	Phase 3	120 participants (Actual)	Interventional	2008-05-31	Completed
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair [NCT03041935]		90 participants (Actual)	Interventional	2015-09-01	Completed
A Prospective, Randomized, Single-Blind Study to Evaluate the Efficacy of Transversus Abdominis Plane Versus Paravertebral Regional Blockade in Patients Undergoing Laparoscopic Colectomy [NCT02164929]		17 participants (Actual)	Interventional	2013-12-31	Terminated(stopped due to Poor recruitment)
Postoperative Analgesia in Third Molar Surgery Under General Anesthesia: Ropivacaine Versus Placebo [NCT01541059]	Phase 4	100 participants (Actual)	Interventional	2012-06-30	Completed
Low Dose IV Dexamethasone in Prolonging Caudal Anesthesia in Children Undergoing Genitourinary Surgery [NCT02436265]	Phase 4	8 participants (Actual)	Interventional	2015-02-28	Terminated(stopped due to Lack of enrollment/lack of potential subjects fitting criteria)
The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function After Robot-assisted Prostatectomy [NCT01547416]	Phase 4	50 participants (Actual)	Interventional	2011-11-30	Completed
Effect of Adductor-Canal-Blockade on High Pain Responders the 1. or 2. Postoperative Day After Total Knee Arthroplasty [NCT01549704]	Phase 4	50 participants (Actual)	Interventional	2012-02-29	Completed
Analgesic Efficiency of the Type 3 Quadratum Lumborum Block in Patients Undergoing Total Hip Arthroplasty : a Randomized Double Blinded Trial [NCT04555291]		60 participants (Anticipated)	Interventional	2022-01-05	Recruiting
Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients [NCT02909322]	Phase 4	50 participants (Anticipated)	Interventional	2016-04-30	Recruiting
Comparative, Randomized Trial of SPI-directed Intravenous Analgesia Using Metamizole With Tramadol Versus Preemptive Wound Infiltration Using 0,2 % Ropivacaine With Fentanyl or 0,2 % Bupivacaine With Fentanyl for Lumbar Discectomy [NCT02971540]		132 participants (Actual)	Interventional	2016-02-29	Completed
" Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Brachial Plexus Block in Patients Receiving a Large Multimodal Analgesia: a Randomized Controlled Trial " [NCT04394130]		60 participants (Actual)	Interventional	2020-05-12	Completed
Comparison Between Infraclavicular Brachial Plexus Block Versus Local Infiltration for Postoperative Analgesia After Wrist Arthroscopy, a Prospective Randomized Open Label Study [NCT02970097]		0 participants (Actual)	Interventional	2016-09-30	Withdrawn(stopped due to lack of resources)
Examination of the LIA (Local Infiltration) Versus Regional Blockade as Pain Management for Open-wedge High Tibial Osteotomy [NCT01537146]	Phase 4	60 participants (Actual)	Interventional	2010-04-30	Completed
A Prospective, Randomised, Non-inferiority Study of Chloroprocaine 2% and the Active Control Ropivacaine 0.75% (AstraZeneca) in Ultrasound-guided Axillary Nerve Block for Short-duration Distal Upper Limb Surgery [NCT02385097]	Phase 3	211 participants (Actual)	Interventional	2015-04-30	Completed
A Randomized Comparison of a Continuous Posterior Tibial Nerve Block and Single Injection Posterior Tibial Nerve Block in Patients Undergoing Forefoot Surgery [NCT01555216]		0 participants (Actual)	Interventional	2011-10-31	Withdrawn(stopped due to Lack of participant recruitment)
Optimal Pain Control After Prothetic Knee Surgery Either by Selective Tibial Nerve Block Versus Local Infiltration Analgesia [NCT03698006]		60 participants (Actual)	Interventional	2021-02-12	Completed
Autologous Blood Transfusion After Local Infiltration Analgesia With Ropivacaine in Total Knee and Hip Arthroplasty [NCT01576263]		52 participants (Actual)	Observational	2010-03-31	Completed
A Phase Ⅱ Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Single Injection Intercostal Nerve Block With HR18034 for Postoperative Pain Management [NCT05744674]	Phase 2	96 participants (Anticipated)	Interventional	2023-02-21	Recruiting
Ultrasound-guided Lumbar Plexus Combined With Quadratus Lumborum Block Using Single-needle Technique With Shamrock Method for Hip Arthroplasty [NCT04266236]		84 participants (Anticipated)	Interventional	2020-07-09	Recruiting
Study on the Efficacy of Infiltration of Upper Cluneal Nerves in Chronic Pain Related to Cluneal Syndrome [NCT05423132]		0 participants (Actual)	Interventional	2022-06-30	Withdrawn(stopped due to Investigator left the team)
Role of Ropivacaine Postincisional Infiltration With Intraperitoneal Instillation Analgesia in Postoperative Pain Relief in Patients Undergoing Non Descent Vaginal Hysterectomy: Randomized Controlled Trial [NCT03099720]	Phase 4	48 participants (Actual)	Interventional	2017-04-04	Completed
Axillary Block in Association With Analgesic Truncal Blocks of the Median and Radial Nerves at the Elbow for Wrist Surgery. [NCT04046744]		150 participants (Actual)	Interventional	2019-10-07	Completed
Effect of Ultrasound-guided Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Postoperative Pain in Patients Undergoing Colorectal Surgery: a Randomized Double-blind Controlled Trial [NCT05964985]		160 participants (Anticipated)	Interventional	2023-08-06	Not yet recruiting
Can Erector Spinae Plane (ESP) Block Better Relieve Acute Renal Colic Pain Than Standard of Care [NCT05323175]	Phase 4	24 participants (Anticipated)	Interventional	2022-04-25	Recruiting
The Evaluation of Erector Spinae Plane Block for the Pain Control of Thoracic Postherpetic Neuralgia [NCT03595046]		0 participants (Actual)	Interventional	2018-07-31	Withdrawn(stopped due to It was difficult to recruit subjects.)
Paravertebral Catheter Use for Postoperative Pain Control in Patients After Lung Transplant Surgery: A Prospective Observational Study [NCT02380417]		33 participants (Actual)	Observational	2013-10-31	Completed
The Minimal Effective Volume (MEV90) of Ropivacaine 0.75% for Ultrasound-guided Transmuscular Quadratus Lumborum Block for Unilateral Percutaneous Nephrolitotomy: a Study Protocol for a Dose Finding Trial [NCT04196270]	Phase 4	40 participants (Anticipated)	Interventional	2020-01-05	Not yet recruiting
Fascia Iliaca Block for Post-Operative Pain Control After Total Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study [NCT02299271]	Phase 4	72 participants (Actual)	Interventional	2014-06-30	Terminated(stopped due to Preliminary analysis showed no difference between groups.)
Incidence Of Hemidiaphragmatic Paralysis With Patient Controlled Infusion Of Low Volume Of Ropivacaine After Usg Guided Low Dose Interscalene Brachial Plexus Block [NCT03081728]		56 participants (Actual)	Interventional	2017-04-01	Completed
The Effect of Ultrasound Guided Blockade of the Femoral Nerve, the Anterior Division of the Obturator Nerve, and the Lateral Femoral Cutaneous Nerve on Postoperative Pain, Morphine Consumption, and Mobilization After Total Hip Arthroplasty. [NCT01276925]		81 participants (Anticipated)	Interventional	2011-08-31	Recruiting
Effects of Thoracic Epidural Anesthesia With Different Local Anesthetics on Propofol Induction [NCT02000973]	Phase 4	80 participants (Actual)	Interventional	2013-11-30	Completed
Efficacy of Hematoma Block on Postoperative Pain After Femoral Intramedullary Rodding: A Randomized Trial [NCT04860856]	Phase 4	88 participants (Actual)	Interventional	2019-08-17	Completed
A Pilot Study to Assess the Feasibility of a Future Randomized, Double-Blinded, Placebo-Controlled Trial to Investigate the Role of Intra-Peritoneal Ropivacaine in Gastric Bypass Surgery: INOPAIN Trial [NCT02154763]	Phase 3	120 participants (Actual)	Interventional	2014-07-31	Completed
Decision Support for Intraoperative Low Blood Pressure [NCT02726620]		22,435 participants (Actual)	Interventional	2017-01-05	Completed
Trans-incisional Rectus Sheath Block Versus Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy: A Prospective, Randomized Study [NCT02494336]		48 participants (Actual)	Interventional	2015-06-30	Completed
Efficacy of Infiltration of Chlorhydrate of Ropivacaine in the Prevention of Chronic Breast Pain After Surgery for Breast Cancer. [NCT00370240]	Phase 4	260 participants (Actual)	Interventional	2006-09-30	Completed
Proximal Lower Limb Intramuscular Block : Effects on Hemiparetic Gait [NCT05519592]		30 participants (Anticipated)	Interventional	2022-09-09	Not yet recruiting
Efficacy of Multimodal Perioperative Analgesia Protocol With Periarticular Drug Injection in Total Knee Arthroplasty: A Randomized, Double Blind Study [NCT01042093]		160 participants (Actual)	Interventional	2010-01-31	Completed
Ultrasound Guided Distal Sciatic Nerve Block - a Randomised Comparison With Nerve Stimulator Technique [NCT01643616]		250 participants (Actual)	Interventional	2010-11-30	Completed
Does Single Injection Adductor Canal Block Improve Postoperative Analgesia in Patients Receiving Periarticular Local Anesthesia Injections for Total Knee Arthroplasty? [NCT02276495]		55 participants (Actual)	Interventional	2014-09-26	Active, not recruiting
Analgesic Efficacy of Perineural Dexamethasone Added to Ropivacaine 0.5% With 1:400,000 Epinephrine During Single-injection Supraclavicular Block for Outpatient Hand Surgery [NCT02154048]	Phase 2	5 participants (Actual)	Interventional	2012-04-30	Terminated
Analgesic Efficacy of Transversus Abdominis Plane Block Versus Local Injection in Postoperative Pain Management Following Minimally Invasive Gynecological Surgery [NCT02314104]		220 participants (Actual)	Interventional	2011-05-31	Completed
Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks Versus Placebo for Pain Control After Arthroscopic Rotator Cuff Repair [NCT02462382]	Phase 4	51 participants (Actual)	Interventional	2013-09-01	Completed
Impact of Peripheral Pain Perception on Central Sensitization and Movement Strategies in Patients With Chronic Achilles Tendinopathy [NCT03316378]	Phase 2/Phase 3	46 participants (Actual)	Interventional	2016-01-28	Completed
Comparative Study of Ropivacaine and Ropivacaine With Dexmeditomedine in Transversus Abdominis Plane (TAP) Block for Post-operative Analgesia in Patients Undergoing Cesarean Sections [NCT02472522]		100 participants (Actual)	Interventional	2015-05-31	Completed
Liposomal Bupivacaine Versus Interscalene Nerve Block for Pain Control After Shoulder Arthroplasty: A Prospective Randomized Trial [NCT02570022]	Phase 4	57 participants (Actual)	Interventional	2014-10-31	Completed
Optimal Postoperative Pain Management by Ultrasound-guided Abdominal Wall Nerve Blockade in Laparoscopic Surgery for Acute Appendicitis - a Randomised Controlled Trial. [NCT01825863]		56 participants (Actual)	Interventional	2013-06-30	Completed
Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration for Pain Management After Total Hip Arthroplasty: A Randomized Controlled Trial [NCT02658240]		60 participants (Actual)	Interventional	2016-04-05	Completed
Erector Spinae Plane Block (ESPB) vs. Iliopsoas Plane Block for Pain Management and Stress Response in Patients Undergoing Total Hip Arthroplasty. A Prospective, Randomized Trial. [NCT06083428]	Phase 4	60 participants (Anticipated)	Interventional	2023-11-01	Not yet recruiting
A Single-dose, Open-Label, Multi-center Study to Assess the Safety and Preliminary Efficacy of PRF 110 (Formerly LNP) in Open Herniorrhaphy Surgery [NCT01681966]	Phase 2	15 participants (Actual)	Interventional	2012-09-30	Completed
Postoperative Analgesia After Total Hip Arthroplasty. A Comparison of Continuous Epidural Infusion and Wound Infiltration With Intraarticular Bolus Injection. [NCT00289419]	Phase 4	80 participants (Actual)	Interventional	2005-02-28	Completed
Safety and Efficacy of Cocktail Periarticular Injection for Pain Management in Simultaneous Bilateral Total Knee Arthroplasty- A Prospective, Randomized Trial [NCT02270437]	Phase 4	55 participants (Actual)	Interventional	2014-06-30	Completed
Prevention of Systemic Toxicity Induced by Levobupivacaine and Ropivacaine by Intralipid® [NCT01602250]	Phase 2	16 participants (Actual)	Interventional	2011-01-31	Completed
The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients [NCT03805360]	Phase 1	4 participants (Actual)	Interventional	2019-05-24	Terminated(stopped due to Insufficient enrollment)
Rotator Cuff Repair Under Isolated Loco-regional Anesthesia Versus General Anesthesia Combined With Loco-regional Anesthesia: Randomized Controlled Trial of Superiority. [NCT05848375]		80 participants (Anticipated)	Interventional	2023-11-13	Recruiting
A Phase 2/3, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TLC590 for Postsurgical Pain Management Following Inguinal Hernia Repair [NCT05161637]	Phase 2/Phase 3	415 participants (Anticipated)	Interventional	2023-11-30	Not yet recruiting
[NCT01495624]		16 participants (Actual)	Interventional	2011-12-31	Terminated(stopped due to Accrual insufficient to complete study in a feasible time frame)
Effekt of Transversus Abdominis Plane (TAP) Block After Robot-assisted Laparocopic Hysterectomy [NCT01504386]	Phase 4	70 participants (Actual)	Interventional	2011-12-31	Terminated(stopped due to Due to local restructering, further recruting was not possible)
Effect of Dexamethasone on Duration of Analgesia After Ultrasound-Guided Femoral, Obturator, and Popliteal Blocks With Ropivacaine in Total Knee Arthroplasty [NCT01511211]	Phase 4	0 participants (Actual)	Interventional	2012-09-30	Withdrawn(stopped due to Other researchers have published results on a similar trial)
Intraperitoneal Atomization of Ropivacaine During Gynecologic Laparoscopic Surgery: Impact on Pain, Opioid Use and Length of Recovery Room Stay [NCT01623635]	Phase 3	200 participants (Anticipated)	Interventional	2012-02-29	Recruiting
Whether Opioids Are Factor That Induced Postoperative Delirium? [NCT05596071]		130 participants (Actual)	Interventional	2016-06-25	Completed
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Arthroplasty: A Prospective, Blinded, Randomized Controlled Study [NCT03119038]	Phase 4	0 participants (Actual)	Interventional	2016-04-30	Withdrawn(stopped due to Investigator no longer actively pursuing this study.)
Duration of Interscalene Nerve Blocks With Ropivacaine Alone, Ropivacaine Mixed With Dexamethasone, and Ropivacaine Alone Combined With Systemic Dexamethasone [NCT00519584]		218 participants (Actual)	Interventional	2007-07-31	Terminated(stopped due to Collected study data was not usable due to process miscommunications)
Continuous Right Thoracic Paravertebral Block on Postoperative Pain After Right Lobe Hepatectomy [NCT01691937]	Phase 2	48 participants (Actual)	Interventional	2012-09-30	Completed
Evaluation of Ropivacaine and Ropivacaine Plus Magnesium Sulphate Infiltration for Postoperative Analgesia in Patients Undergoing Thyroidectomy [NCT05294393]	Phase 4	64 participants (Anticipated)	Interventional	2022-01-21	Enrolling by invitation
The Effect of Preoperative Stellate Ganglion Block on Postoperative Atrial Fibrillation After Video-assisted Thoracoscopic Surgeries: A Randomized Controlled Trial [NCT05753644]		480 participants (Anticipated)	Interventional	2023-03-27	Recruiting
Postoperative Analgesia After Thoracotomy Without Thoracic Epidural Analgesia: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine Patient-Controlled-Analgesia (PCA) [NCT01698203]	Phase 4	92 participants (Actual)	Interventional	2012-10-14	Completed
Pilot Study: A Non-Inferiority Trial of the Analgesic Effect of Paravertebral Analgesia to Epidural Analgesia for the Management of Post-Operative Pain After Thoracotomy [NCT01700491]	Phase 3	21 participants (Actual)	Interventional	2012-10-31	Terminated(stopped due to Difficulty in recruiting and maintenance of blinding necessary for the trial)
Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia [NCT01703130]	Phase 4	60 participants (Anticipated)	Interventional	2012-10-31	Recruiting
[NCT01703351]	Phase 2	79 participants (Actual)	Interventional	2012-10-04	Completed
Comparison of Subgluteal Sciatic Nerve Block Duration in Type-2 Diabetic and Non Diabetic Patients [NCT01704612]	Phase 4	70 participants (Actual)	Interventional	2011-07-31	Completed
Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty Within an Enhanced Recovery Programme - a Randomised Controlled Trial [NCT02478372]		242 participants (Actual)	Interventional	2010-04-30	Completed
Interscalene Block on Ventilatory Function After Shoulder Surgery : Evaluation of Single or Continuous Injection [NCT01740453]	Phase 4	70 participants (Actual)	Interventional	2012-01-31	Completed
Ultrasound Guided Transversus Abdominis Plane Block With Ropivacaine vs Placebo for Abdominal Hysterectomy: a Double-blinded, Randomized Clinical Trial [NCT01743378]		48 participants (Actual)	Interventional	2011-02-28	Completed
Efficacy of Continuous Wound Infusion in Major Lumbar and Thoracic Spine Surgery : A Randomised, Double-blinded, Placebo-controlled Study [NCT01743794]	Phase 2/Phase 3	60 participants (Actual)	Interventional	2011-01-31	Completed
Comparison of Posterior Lumbar Plexus Block Plus Sciatic Nerve Block With Sciatic Plus Femoral Plus Obturator Nerve Block for Total Knee Replacement (TKR) [NCT01755117]		100 participants (Anticipated)	Interventional	2012-12-31	Recruiting
Safety and Feasibility Study of an Enhanced Recovery After Surgery Protocol in Patients Undergoing Elective Pancreaticoduodenectomy. [NCT01759706]		123 participants (Actual)	Interventional	2010-10-31	Completed
Influence of the Concentration of the Local Anesthetic Ropivacaine on the Quality of a Ultrasound Guided Block of the Regio Collis Lateralis for Carotid Endarterectomy: a Prospective, Randomized and Controlled Trail [NCT01759940]	Phase 4	46 participants (Actual)	Interventional	2012-11-30	Completed
A Randomised, Double-blind Study to Evaluate the Effect of Bilateral Dual Transversus Abdominis Plane Block on Postoperative Pain and Plasma Concentration of Ropivacaine After Robotic Assisted Laparoscopic Surgery [NCT01760161]		80 participants (Anticipated)	Interventional	2014-04-30	Terminated(stopped due to No signal on pain-score)
A Randomized Double Blind Trial Comparing the Effect of Transversus Abdominal Plane-catheter and Epidural Catheter on Postoperative Pain After Open Gynecologic Surgery [NCT01760174]		0 participants (Actual)	Interventional	2016-01-31	Withdrawn(stopped due to Because of logistic and practical reasons.)
Use of Pre-operative Nerve Blocks in Older Patients With Hip Fracture: A Pilot Study [NCT02450045]		73 participants (Actual)	Interventional	2015-06-30	Terminated(stopped due to PI no longer at institution)
Local Infiltration Analgesia After Abdominal Hysterectomy [NCT01782781]	Phase 3	60 participants (Actual)	Interventional	2012-11-30	Completed
Regional Haemodynamic Changes in Radial Artery Assessment With Continuous Pulsed-wave Doppler Ultrasound in Patients Undergoing Video-assisted Thoracic Surgery With Different Kinds of Anaesthesia Management [NCT03302221]	Phase 4	0 participants (Actual)	Interventional	2017-10-15	Withdrawn(stopped due to No participants enrolled)
Onset Time of Brachial Plexus Block Using Local Anaesthetic Diluted With 0.9% Saline vs 5% Dextrose [NCT01815944]		55 participants (Actual)	Interventional	2011-12-31	Completed
Postoperative Rehabilitation After Cardiac Surgery in Patients at Risk of Respiratory Complications. Effects of a Continuous Bi-laterosternal Infusion of Ropivacaine Through Multihole Catheters. [NCT01828788]	Phase 2	120 participants (Actual)	Interventional	2013-04-27	Completed
Continuous Versus Intermittent Sciatic Block Combined With a Continuous Femoral Block for Patients Undergoing Total Knee Arthroplasty: a Prospective, Randomized Trial. [NCT01843153]	Phase 4	140 participants (Actual)	Interventional	2013-04-30	Completed
Comparison of a Pain Pump Versus Injectable Medication for Analgesia in Knee Arthroscopy [NCT01242644]	Phase 2	48 participants (Actual)	Interventional	2006-10-31	Completed
Prospective Blinded Study Looking at PO/IV Analgesia Alone Versus PO/IV Analgesia With Superior Hypogastric Nerve Block for Uterine Artery Embolization Pain Management [NCT02270255]	Phase 2	44 participants (Actual)	Interventional	2015-04-30	Completed
Regional Scalp Block Versus IV Parecoxib for Post-operative Cranioplasty Surgery Pain: A Comparison of Pain Score. [NCT05442411]	Phase 1	58 participants (Actual)	Interventional	2021-03-09	Completed
The Effect of Sono-Guided Interscalene Brachial Plexus Block Combined With Arthroscopy-Guided Suprascapular Nerve Block in Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial [NCT02424630]		52 participants (Actual)	Interventional	2013-08-31	Completed
UCSF Sphenopalatine Ganglion Block Study- a Randomized Double Blind Placebo Controlled Trial to Compare Nasal Anesthetics for Migraine Prevention in Adults. [NCT03666663]	Phase 4	10 participants (Actual)	Interventional	2019-02-01	Completed
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management: A Pilot Study [NCT03936387]	Phase 3	10 participants (Actual)	Interventional	2019-07-01	Completed
The Ultrasound-guided Multiple-injection Costotransverse Block for Mastectomy and Primary Reconstructive Surgery. A Double Blind, Randomised, Placebo Controlled Trial. [NCT04248179]	Phase 4	36 participants (Actual)	Interventional	2019-11-29	Completed
Postoperative Analgesia After Total Knee Arthroplasty. A Comparison of Continuous Epidural Infusion and Wound Infiltration With Continuous Intraarticular Infusion [NCT00421967]	Phase 4	80 participants (Actual)	Interventional	2007-01-31	Terminated(stopped due to Interim analysis)
A Randomized Comparison of Single Injection vs. Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block in Postoperative Pain Treatment After Major Ankle Surgery: Clinical Outcome and Cost Analysis [NCT01445210]		50 participants (Actual)	Interventional	2011-09-30	Completed
Selective Block of the Axillary Nerve in Postoperative Pain Management, a Randomised, Blinded, Placebo-controlled Trial [NCT01463865]		60 participants (Actual)	Interventional	2011-11-30	Completed
Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia: A Randomized Controlled Quadruple Blinded Non-Inferiority Trial (CLASSIER Trial) [NCT05487196]	Phase 2	88 participants (Actual)	Interventional	2022-09-28	Completed
A Safety Study of Ropivacaine Concentrations During Continuous Erector Spinae Plane Block for Thoracic Surgery [NCT04807504]		20 participants (Actual)	Observational	2021-03-26	Active, not recruiting
Evaluation of Post-operative Biochemical Recurrence in Patients Submitted to Radical Prostatectomy Under General Opioid-free Anesthesia Compared to Conventional General Anesthesia [NCT03212456]		146 participants (Actual)	Interventional	2017-01-12	Active, not recruiting
TAP) Block in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study [NCT01075087]		19 participants (Actual)	Interventional	2010-03-31	Completed
A Randomised Single Blind Study Comparing the Molar Median Effective Dose of Levobupivacaine and Molar Median Effective Dose of Ropivacaine When Administered as a Femoral Perineural Infusion for Pain Relief After Total Knee Replacement [NCT01172197]	Phase 4	14 participants (Actual)	Interventional	2009-01-31	Terminated(stopped due to Terminated prior to its planned completion as anticipated by the protocol).)
Rebound Pain at Block Resolution After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block [NCT03011905]	Phase 3	53 participants (Actual)	Interventional	2017-01-31	Completed
The Optimal Dosage of Ropivacaine for Arthroscopic Knee Surgery [NCT04759742]	Early Phase 1	115 participants (Actual)	Interventional	2021-03-01	Completed
Transverse Abdominal Plane Blocks for Bariatric Surgery Patients: A Single Blinded Randomized Controlled Study [NCT04051684]	Phase 1/Phase 2	23 participants (Actual)	Interventional	2013-04-30	Completed
PATHOS Study Pain Assessment in Thoracic Oncologic Surgery: a Prospective Randomized Trial on Pain Management After Video Assisted Major Lung Resections. [NCT03134729]		90 participants (Actual)	Interventional	2017-05-04	Completed
Prospective Randomized Clinical Trial to Evaluate the Use of Paravertebral Blocks in Reconstructive Breast Surgery [NCT00542542]	Phase 3	89 participants (Actual)	Interventional	2007-09-30	Completed
Dexmedetomidine Added to Ropivacaine Single Shot vs Continuous Interscalene Nerve Block for Elective Arthroscopic Shoulder Surgery: a Prospective Randomized Control Trial [NCT05775861]		96 participants (Anticipated)	Interventional	2022-08-23	Recruiting
A Phase 2, Multicenter, Randomized, Double-Blind, Parallel-Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Local Administration of HR18034 for Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy [NCT05376904]	Phase 2	86 participants (Actual)	Interventional	2022-06-13	Completed
Efficacy of Liposomal Bupivacaine Versus Standard Analgesia in Pain Management of Total Joint Arthroplasty [NCT02197273]		211 participants (Actual)	Interventional	2014-07-31	Completed
Comparison Ropivacaine and Bupivacaine in Sphenopalatine Ganglion Block for Postoperative Analgesia After Functional Endoscopic Sinus Surgery: A Randomized Controlled Trial [NCT03013361]	Phase 3	60 participants (Actual)	Interventional	2013-07-31	Completed
Evaluation of Plasma Concentrations of Intravenous Lidocaine and Epidural Ropivacaine When Used in Combination in Major Abdominal Surgery [NCT05368753]	Phase 4	50 participants (Anticipated)	Interventional	2022-03-09	Recruiting
Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study) [NCT05345639]	Phase 3	280 participants (Anticipated)	Interventional	2022-07-01	Not yet recruiting
Single Shot Liposomal Bupivacaine (EXPAREL®)/Bupivicaine) Versus Continuous Erector Spinae Plane Block Catheter in Patients Undergoing Video Assisted Thoracoscopic (VAT) Surgery; Single Center, Non Inferiority, Open Label, Randomized Trial [NCT04559347]	Phase 2	74 participants (Anticipated)	Interventional	2020-12-10	Suspended(stopped due to Reviewing randomization process)
The Effect of Combined Popliteal and Saphenous Block in Addition to General Anesthesia in Surgical Fixation of Ankle Fractures: a Prospective Randomized Study [NCT01923623]	Phase 4	0 participants (Actual)	Interventional	2013-07-01	Withdrawn(stopped due to Study was redesigned and taken over by a ph.D-student)
The Dose Dependent Effect of Ropivacaine Transversus Abdominis Plane Blocks on Postoperative Analgesia After Cesarean Section [NCT02893423]		51 participants (Actual)	Interventional	2013-01-01	Terminated(stopped due to A better study with a better drug was started and thus this study was terminated)
Effect of the Transmuscular Quadratus Lumborum Block on Duration of Stay in Recovery: a Single-centre, Retrospective, Observational Study Based on Five Selected Randomised Controlled Trials [NCT04951752]		307 participants (Actual)	Observational	2021-04-14	Active, not recruiting
Perioperative Pain Management for Total Shoulder Arthroplasty: A Pilot Non-Inferiority Trial [NCT05908851]		80 participants (Anticipated)	Interventional	2023-11-01	Not yet recruiting
A Randomized Case Control Study of Pre-emptive Caudal Epidural Analgesia With Ropivacaine With and Without Dexamethasone for Lumbosacral Spine Surgery [NCT05904275]		60 participants (Anticipated)	Interventional	2023-08-01	Not yet recruiting
Transverse Abdominis Plane Block for Anterior Approach Spine Surgery: A Prospective Randomized Study [NCT02884440]	Phase 2	43 participants (Actual)	Interventional	2016-11-07	Completed
Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries [NCT02980835]	Phase 4	36 participants (Actual)	Interventional	2016-09-28	Completed
Minimum Effective Volume of 0.5% Ropivacaine for Ultrasound-Guided Infraclavicular Block [NCT03824717]		55 participants (Anticipated)	Interventional	2019-01-31	Not yet recruiting
Pudendal Block Versus Penian Block For Circumcision In Children: A Double Blind Randomised Controlled Trial [NCT03046290]		60 participants (Anticipated)	Interventional	2017-01-31	Recruiting
Impact of Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block on Postoperative Delirium and Long-term Oucomes in Elderly Patients After Single Knee Arthroplasty [NCT03629483]	Phase 4	736 participants (Anticipated)	Interventional	2018-12-10	Suspended(stopped due to Trial stopped by the sponsor because of no funding.)
Surgical Pain Control With Ropivacaine by Atomized Delivery [NCT01480089]	Phase 4	56 participants (Actual)	Interventional	2011-11-30	Completed
Does Administration of the Transmuscular Quadratus Lumborum Block Cause Quadriceps Muscle Weakness: A Randomised, Double-blinded Volunteer Study [NCT05023343]	Phase 4	20 participants (Actual)	Interventional	2021-10-02	Completed
Randomized and Controlled Phase IV Clinical Trial on the Analgesic Effectiveness of the Combined Blockade (Peng - Pericapsular Nerve Group- and the Femoral Lateral Cutaneous Nerve) in the Hip Fractures of the Elderly: Comparative Study Between Levobupivac [NCT04773301]	Phase 4	108 participants (Anticipated)	Interventional	2021-02-13	Recruiting
Erector Spinae Plane Block for Minimally Invasive Mitral Surgery [NCT04770961]		50 participants (Anticipated)	Interventional	2021-04-01	Not yet recruiting
Comparison of Modified Programmed Intermittent Bolus (MPIB), Computer-integrated Patient Controlled Epidural Analgesia (CIPCEA) and Conventional Patient Controlled Epidural Analgesia (PCEA) During Labour [NCT02278601]	Phase 3	839 participants (Actual)	Interventional	2015-01-28	Active, not recruiting
Ropivacaine Use in Femoral Nerve Block; What is the Minimal Effective Analgesic Concentration (MEAC 90) [NCT04834440]	Phase 4	45 participants (Anticipated)	Interventional	2021-05-01	Not yet recruiting
Transversus Abdominis Plane Catheter Following Kidney Transplantation [NCT04786470]	Phase 3	120 participants (Anticipated)	Interventional	2021-05-31	Not yet recruiting
Combined Erector Muscle Spinae Plane Block and General Anaesthesia Versus General Anaesthesia Alone - Effect on Perioperative Opioid Consumption in Open Heart Surgery [NCT04338984]	Phase 4	86 participants (Actual)	Interventional	2019-12-01	Completed
Regional Anesthesia for Breast Cancer Surgery, Effects on Postoperative Wellbeing and Disease Recurrence. [NCT03117894]		200 participants (Actual)	Interventional	2017-05-23	Completed
Randomized Controlled Trial Evaluating Postoperative Analgesia and Muscle Strength Between Single Versus Continuous Adductor Canal Block for Ambulatory ACL Reconstruction. [NCT02584452]		59 participants (Actual)	Interventional	2015-11-03	Completed
Assessment of Knee Pain in Patients Receiving Continuous Femoral Nerve Block Combined With Either Ultrasound Guided Posterior Capsular Injection or Selective Tibial Nerve Block Following Total Knee Arthroplasty [NCT02701296]		80 participants (Actual)	Interventional	2011-11-07	Completed
Double Blinded Randomized Controlled Study Evaluating the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block in Patients Undergoing Ambulatory Shoulder Surgery [NCT02653144]	Phase 4	105 participants (Actual)	Interventional	2016-03-31	Completed
The Effect of Bilateral Infraorbital and Infratrochlear Nerve Block on Perioperative Analgesia After Endoscopic Binostril Transnasal Transsphenoidal Resection of Pituitary: a Prospective, Randomized Study [NCT05555147]		120 participants (Anticipated)	Interventional	2022-09-01	Active, not recruiting
Comparison of Intraoperative Intravenous Lidocaine Infusion and Transversus Abdominis Plane (TAP) Block for Post-operative Analgesia Following Laproscopic Cholecystectomy [NCT05231941]		90 participants (Anticipated)	Interventional	2022-01-17	Recruiting
Does Continuous Adductor Canal Nerve Block Improve the Quality of Recovery for Outpatient Total Knee Arthroplasty Patients? [NCT03038425]		81 participants (Actual)	Interventional	2017-05-02	Completed
The Efficacy of Pecto-intercostal Fascial Plane Catheters for Reduction of Sternal Pain in Cardiac Surgery Patients With Complete Median Sternotomy: A Randomized, Placebo-controlled Trial [NCT05054179]	Phase 2/Phase 3	80 participants (Anticipated)	Interventional	2022-09-07	Recruiting
Multimodal Post-Cesarean Analgesia With Spinal Morphine and Continuous Wound Infiltration of Ropivacaine Using the OnQ® Elastomeric Pump: A Dose-Ranging Study Using a High-Volume, Low-Dose Protocol [NCT02579629]	Phase 4	64 participants (Actual)	Interventional	2015-07-31	Completed
Augmenting Massed Prolonged Exposure With a Stellate Ganglion Block to Treat Posttraumatic Stress Disorder (PTSD) in Active Duty or Retired Service Members: A Pilot Study [NCT04302181]	Early Phase 1	12 participants (Actual)	Interventional	2020-10-05	Completed
The Benefit of Adding Ultrasound-guided ESP Block to PCA vs. PCA Alone for Postoperative Analgesia After Laparoscopic Nephrectomy Surgeries: a Pilot, Randomized Controlled Trial [NCT04085237]		22 participants (Anticipated)	Interventional	2020-01-04	Recruiting
Pain Management After Total Shoulder Arthroplasty: Continuous Interscalene Block Versus Local Tissue Infiltration With Liposomal Bupivacaine [NCT03219983]	Phase 4	22 participants (Actual)	Interventional	2016-11-30	Terminated
A Phase 2, Randomized, Double-blind, Comparator- and Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of TLC590 for Postsurgical Pain Management Following Bunionectomy [NCT03838133]	Phase 2	150 participants (Actual)	Interventional	2019-03-05	Completed
Effect of Adductor Canal Block vs. Placebo on Muscle Strength, Mobilisation and Pain on the First Post-operative Day After Total Knee Arthroplasty [NCT02242591]	Phase 4	64 participants (Actual)	Interventional	2014-08-31	Completed
Propofol EC50 for Inducing Loss of Consciousness in Gastrectomy: Combined General and Epidural Anesthesia Versus General Anesthesia [NCT05124704]		60 participants (Actual)	Interventional	2021-07-01	Completed
Assessment of Sensory and Motor Block After Intrathecal Administration of Bupivacaine, Ropivacaine and Levo-bupivacaine Combined With Small Doses of Fentanyl, Followed by Administration of Normal Saline Epidurally:a Clinical Trial in Parturients Scheduled [NCT01558713]	Phase 2/Phase 3	120 participants (Anticipated)	Interventional	2010-01-31	Recruiting
Effects of Epidurally Administered Ropivacaine Concentration on the Hemodynamic Parameters [NCT01559285]	Phase 4	120 participants (Actual)	Interventional	2011-11-16	Completed
Method Study of Bilateral Transversus Abdominis Plane (TAP) Block With 24 Hours Infusion. Extent of Sensory Block, Analgetic Effect and Lung Function in Healthy Volunteers [NCT01577940]	Phase 4	8 participants (Actual)	Interventional	2011-01-31	Completed
Effectiveness of Adding Transverse Abdominus Plane (TAP) Catheter Blocks to Patient-controlled Analgesia (PCA) in Laparoscopic Colon Resections: a Prospective, Randomized Controlled Study [NCT01592630]	Phase 3	0 participants (Actual)	Interventional	2012-05-31	Withdrawn(stopped due to Investigator Left Institution)
[NCT01593319]	Phase 4	37 participants (Actual)	Interventional	2012-01-31	Terminated
Ultrasound Guided Intermediate Cervical Plexus Block -Randomized Evaluation Concerning the Significance of Additional Perivascular Local Anesthetic Infiltration [NCT02336958]		40 participants (Actual)	Interventional	2013-09-30	Completed
The Analgesic Efficacy of Continuous Infusion of Ketorolac and Ropivacaine at the Wound Site Using ON-Q Pump for Postoperative Pain Management [NCT00638508]	Phase 4	67 participants (Actual)	Interventional	2007-06-30	Completed
Continuous Preperitoneal Infusion of Ropivacaine After Open Liver Resection: Effect on Post-operative Recovery and Morbidity [NCT01890408]	Phase 2	5 participants (Actual)	Interventional	2013-11-30	Terminated(stopped due to promoter decision)
The Efficacy and Safety of Multimodal Analgesia in Children and Adolescents After the Ravitch Procedure and Thoracotomy - a Prospective Randomized Study [NCT03444636]	Phase 4	94 participants (Actual)	Interventional	2015-03-02	Completed
[NCT01726205]	Phase 4	45 participants (Actual)	Interventional	2008-10-31	Completed
Continuous Popliteal Sciatic Nerve Block Interest in Postoperative Pain Management for Patients With Leg Amputation [NCT00427947]	Phase 3	6 participants (Actual)	Interventional	2006-12-31	Terminated(stopped due to lack of patients)
Laparoscopic- Vs Ultrasound-guided Transversus Abdominis Plane Block in Laparoscopic Colectomy: a Prospective Randomized Controlled Trial [NCT04575233]		116 participants (Actual)	Interventional	2018-01-15	Completed
Effectiveness of Transversus Abdominis Plane Block in Reducing Immediate Postoperative Pain in Obese Women After Laparoscopic or Robotic Gynecologic Procedures [NCT01866917]	Phase 1/Phase 2	35 participants (Actual)	Interventional	2013-04-30	Terminated(stopped due to Pharmacy stopped dispensing study medication)
Comparison of Analgesic Efficacy of Quadratus Lumborum Block With Local Anesthesia and Quadratus Lumborum Block With Placebo Only After Ileostomy Repair: a Randomized, Double-blind, Non-inferiority Trial [NCT03411096]		60 participants (Anticipated)	Interventional	2020-03-30	Recruiting
The Post-Operative Pain Management of Pediatric Supracondylar Elbow Fractures [NCT01328782]		124 participants (Actual)	Interventional	2008-06-30	Completed
A Prospective, Randomized, Double-blinded, Active-comparator, Non-inferiority Study to Observe Relative Efficacy of Ultrasound-guided Transmuscular Quadratus Lumborum Block Versus Class Lumbar Plexus Block in Managing Post-operative Pain Following Total H [NCT03801265]	Phase 4	46 participants (Actual)	Interventional	2019-03-19	Completed
Quadratus Lumborum Block Reduced Postpartum Uterine Pain After Virginal Childbirth [NCT05371015]		66 participants (Actual)	Interventional	2022-03-01	Completed
Comparison of Postoperative Analgesic Efficacy of Adductor Canal Block With IPACK Versus Adductor Canal and Popliteal Sciatic Nerve Block in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction [NCT03983941]	Phase 3	7 participants (Actual)	Interventional	2019-08-30	Terminated(stopped due to PI leaving the institution, no subjects enrolled since 2019, and no other PI interested in taking it over.)
A Phase Ⅱ Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Single Injection Adductor Canal Block With HR18034 for Postoperative Pain Management [NCT05561309]	Phase 2	96 participants (Anticipated)	Interventional	2022-10-20	Recruiting
Exparel Pericapsular Injection: A Prospective Evaluation of Postoperative Pain in Bunion Surgery, First Metatarsophalangeal Joint Fusion, and Cheilectomy [NCT02499575]		2 participants (Actual)	Interventional	2015-07-31	Terminated(stopped due to Logistical issues prevent efficient enrollment)
Is Continuous Wound Infusion With Ropivacaine Better Than Intrathecal Morphine for Post-caesarean Analgesia? A Prospective, Randomized, Controlled, Double Blinded Study [NCT02264821]	Phase 3	192 participants (Actual)	Interventional	2012-02-29	Completed
Are Preemptive Femoral and Lateral Femoral Cutaneous Nerve Blocks Given Immediately Prior to Hip Arthroscopy(THA) Effective for Acute Postoperative Pain Management? [NCT01997567]		3 participants (Actual)	Interventional	2013-07-31	Terminated(stopped due to Subject recruitment is too difficult and we foresee that this will not improve)
Preemptive Analgesia in Children Using Caudal Epidural Ropivacaine: A Prospective, Randomized, Double-blinded, Controlled Study [NCT00616577]		26 participants (Actual)	Interventional	2007-10-31	Terminated(stopped due to PI is no longer here.)
Lateral Femoral Cutaneous Nerve and Pericapsular Nerve Group (PENG) Blocks Versus Suprainguinal Fascia Iliaca Block in Postoperative Analgesia of Hip Fractures: a Prospective, Controlled, Randomized and Double Blind Study [NCT05749367]		66 participants (Anticipated)	Interventional	2023-03-06	Not yet recruiting
Dexamethasone as an Adjuvant to Ropivacaine for Femoral Nerve Blocks in Children Undergoing Knee Arthroscopy [NCT01971645]	Phase 3	77 participants (Actual)	Interventional	2014-07-31	Completed
A Retrospective Investigation of Safety and Efficacy From Increasing Concentrations of Local Anesthetic in Pediatric Femoral Nerve Blocks [NCT02501135]		281 participants (Actual)	Observational	2015-06-30	Completed
ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study [NCT02439281]		50 participants (Actual)	Interventional	2015-05-31	Terminated(stopped due to The patients were discharged on the day of the surgery.)
Does Anesthetic Contribute to Symptomatic Relief in Corticosteroid Injections for Knee Osteoarthritis? A Double-Blind Randomized Trial Comparing Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections [NCT02576249]	Phase 4	29 participants (Actual)	Interventional	2015-10-31	Completed
Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks [NCT01898689]	Phase 4	24 participants (Actual)	Interventional	2013-07-31	Completed
Correlation Between Perioperative Pain and Delirium in Geriatric Patients With Hip Fracture [NCT04404959]		80 participants (Anticipated)	Interventional	2019-05-10	Recruiting
Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques? [NCT02788019]	Phase 4	52 participants (Actual)	Interventional	2016-05-26	Terminated(stopped due to Unable to complete the sample size needed for 80% power due to changes in surgical approach to adductor block usage.)
The Effect of Continuous Interscalene Brachial Plexus Block With 0.125% Bupivacaine Versus 0.2% Ropivacaine on Diaphragmatic Motility and Ventilatory Function [NCT02059070]		39 participants (Actual)	Interventional	2012-06-30	Completed
the Safety and Effectiveness of the Effects on the Perioperative Pain Control Comparing Between the Thoracic Paravertebral Nerve Block Using the Camera Guided and the Intrathoracic Intercostals Nerve Block for the Management of Nonintubated Local Regional [NCT03086213]		48 participants (Actual)	Interventional	2017-03-01	Completed
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies - the PATHFINDER II Study [NCT05279898]		70 participants (Anticipated)	Interventional	2023-02-28	Recruiting
Periarticular Infusion With Liposomal Bupivacaine or a Ropivacaine Cocktail Versus Continuous Femoral Nerve Catheters for Multimodal Pain Management Following Primary TKA: A Randomized Controlled Trial [NCT02369523]	Early Phase 1	84 participants (Actual)	Interventional	2014-09-30	Terminated(stopped due to Adequate enrollment was not reached for this study.)
A Randomised, Double-Blind, Multi-Centre, Parallel Group Study Comparing Efficacy and Safety of 5 mg/ml Ropivacaine and 5 mg/ml Bupivacaine for Spinal Anaesthesia in Patients Undergoing Unilateral Lower Limb Surgery [NCT00358280]	Phase 3	220 participants	Interventional	2006-04-30	Completed
Supraclavicular Brachial Plexus Block Using Ropivacaine Alone or Combined With Dexmedetomidine for Upper Limb Surgery: A Prospective, Randomized, Double-blinded, Comparative Study [NCT02393677]		80 participants (Actual)	Interventional	2011-07-31	Completed
Analgesia After Total Shoulder Arthroplasty [NCT01782872]	Phase 4	80 participants (Actual)	Interventional	2012-10-31	Completed
Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks [NCT02523235]	Phase 4	117 participants (Actual)	Interventional	2015-08-31	Completed
Dorsal Penile Nerve Block for Rigid Cystoscopy in Men: a Single-center, Randomized, Double-blind and Placebo-controlled Study [NCT02502487]		258 participants (Actual)	Interventional	2015-06-30	Completed
A Comparative Study Between Levobupivacaine 0.5% and Ropivacaine 0.75% in Patients Undergoing Spinal Anaesthesia for Lower Limb Orthopaedic Surgery. [NCT02201784]	Phase 4	60 participants (Actual)	Interventional	2012-12-31	Completed
Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair: a Prospective Randomized Trial [NCT04737980]	Phase 4	92 participants (Actual)	Interventional	2019-07-18	Completed
The Effectiveness of Bilateral Erector Spinae Plane Block (ESPB) in Laparoscopic Cholecystectomies. A Randomized, Controlled, Double Blind, Prospective, Trial [NCT04587973]		60 participants (Actual)	Interventional	2020-06-01	Completed
Comparison of Programmed Intermittent Bolus Infusions of Spinae Plane Block Versus Paravertebral Block for Analgesia in Minimally Invasive Direct Coronary Artery Bypass Grafting [NCT05320718]		140 participants (Anticipated)	Interventional	2022-04-15	Recruiting
Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients [NCT02949674]	Phase 3	93 participants (Actual)	Interventional	2016-09-30	Completed
A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block [NCT03117140]	Phase 4	160 participants (Actual)	Interventional	2013-12-31	Completed
Serratus Anterior Plane Block: Sub-Serratus vs Supra-Serratus Plane Block for Pain Control in Patients Undergoing Mastectomy [NCT03154658]	Phase 4	66 participants (Actual)	Interventional	2017-04-01	Completed
Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section: A Prospective Randomized Double-Blinded Clinical Study [NCT03098420]	Phase 2/Phase 3	29 participants (Actual)	Interventional	2016-07-31	Terminated(stopped due to Low enrollment; recruitment challenges due to competing studies in women and infant center)
Surgical Treatment of Proximal Femoral Fractures Under Peripheral Regional Anesthesia. A Prospective Pilot Study [NCT04005404]		80 participants (Actual)	Interventional	2019-08-05	Completed
Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures: a Randomized, Active Comparator-controlled, Blinded Trial [NCT02679560]	Phase 2	3 participants (Actual)	Interventional	2017-10-01	Terminated(stopped due to Poor recruitment)
The Effect of Saphenous Nerve and Obturator Nerve Block Combined With Systemic High Dose Glucocorticoid Versus Local Infiltration Analgesia Combined With a Systemic High Dose Glucocorticoid on Opioid Consumption and Pain After Total Knee Arthroplasty [NCT02374008]	Phase 4	74 participants (Anticipated)	Interventional	2015-03-31	Completed
An Open Label Pilot Study of Feasibility of a Dexmedetomidine-Remifentanil-Caudal Anaesthetic for Infant Lower Abdominal/Lower Extremity Surgery: The TREX Pilot Study [NCT02353182]	Phase 4	60 participants (Actual)	Interventional	2015-05-31	Completed
Femoral Nerve Block in Patient With Total Knee Arthroplasty; Analgesic Effect of Perineural Fentanyl Additive to Local Anesthetics [NCT02331576]		100 participants (Anticipated)	Interventional	2015-01-31	Recruiting
A Randomised Controlled Trial Comparing Ultrasound-guided Supraclavicular Brachial Plexus Block With Combined Supraclavicular and Pecs II Block in Patients Undergoing Arteriovenous Grafting Surgery [NCT02331030]		36 participants (Actual)	Interventional	2014-12-31	Completed
Perineural Versus Systemic Dexamethasone as an Analgesic Adjunct to Ultrasound-Guided Ropivacaine Interscalene Blockade in Arthroscopic Rotator Cuff Repair [NCT01450007]	Phase 4	130 participants (Actual)	Interventional	2012-05-31	Completed
Local Anesthetic Concentration and Nerve Block Duration: A Randomized, Blinded Study in Healthy Volunteers [NCT03326609]	Phase 4	60 participants (Actual)	Interventional	2017-10-04	Completed
A Randomized Controlled Trial of Continuous Gastrocnemius Plane Block and Intravenous Analgesia After Foot and Ankle Surgery [NCT05463809]	Phase 3	60 participants (Anticipated)	Interventional	2022-07-14	Not yet recruiting
Ultrasound-guided Selective Supraclavicular Nerve Block for Postoperative Pain Control in Pediatric Patients Receiving Hickman Catheter, Chemoport or Perm Cath Insertion : a Randomized Controlled Trial [NCT05015907]		50 participants (Actual)	Interventional	2021-10-22	Completed
The Correlation Between the Diffusion Length of Local Anesthetics in the Subparaneural Space and Duration of Analgesia for Patients Receiving Sciatic Block [NCT05437835]		90 participants (Anticipated)	Interventional	2022-07-30	Not yet recruiting
QORVATS Study. A Randomized Controlled, Triple Blinded to Compare the Quality of Recovery (QoR 40) Between Intercostal Block and a Combination of Intercostal Nerve Block With Serratus Plane Catheter for Patient's Undergoing VATS Procedures. [NCT04990713]	Phase 3	200 participants (Anticipated)	Interventional	2021-08-01	Not yet recruiting
Postoperative Analgesic Effects of Ultrasound-guided Bilateral Rectus Sheath Block for Laparoscopic Gynecologic Surgery [NCT02476799]		60 participants (Actual)	Interventional	2014-11-30	Completed
Randomized Controlled Study of Intraincisional Infiltration Versus Intraperitoneal Instillation of Standardized Dose of Ropivacaine 0.2% in Post-laparoscopic Cholecystectomy Pain [NCT03265223]	Phase 4	353 participants (Actual)	Interventional	2014-04-01	Completed
Addition of Clonidine to Ropivacaine in Adductor Canal Block for Postoperative Pain Relief in Total Knee Arthroplasty: A Prospective Randomized Double Blind Placebo Controlled Trial [NCT03057015]	Phase 4	80 participants (Anticipated)	Interventional	2017-05-22	Recruiting
A Comparison of Postoperative Outcomes Provided by a Continuous Preperitoneal Infusion Versus Ultrasound Guided Transversus Abdominis Plane Block for Abdominoplasty [NCT03228797]		60 participants (Actual)	Interventional	2015-02-11	Completed
Regional Blockade for Knee Prothesis Surgery: Comparison Between Femoral, Sciatic and Adductor Canal Block [NCT02451605]		40 participants (Anticipated)	Interventional	2015-06-30	Not yet recruiting
Does Perineural Dexmedetomidine Prolong the Duration of an Ulnar Nerve Block When Controlling for Possible Systemic Effects? [NCT03222323]	Phase 2	22 participants (Anticipated)	Interventional	2017-07-17	Recruiting
The Comparison Between Epidural and Intravenous Patient-controlled Analgesia for Laparoscopic Gastrectomy [NCT02444897]	Phase 3	60 participants (Actual)	Interventional	2013-09-30	Completed
The Effect of Scalp Nerve Block on the Emergence Agitation in Children Undergoing Nevus Surgery During Sevoflurane Anesthesia [NCT02428283]	Phase 4	44 participants (Actual)	Interventional	2015-05-31	Completed
The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance [NCT02139982]	Phase 1	110 participants (Actual)	Interventional	2011-01-31	Completed
MIRs03: A Double-blind Randomized Trial of Paravertebral Block With Ropivacaine Before Breast Cancer Surgery: Effects on Chronic Postoperative Pain [NCT02408393]	Phase 3	380 participants (Actual)	Interventional	2015-03-27	Completed
Single-center, Double-blind, Placebo-controlled Study Evaluating the Efficacy of Pre-incisional Local Analgesia With Ropivacaine and Dexamethasone for Pain Management After Tonsillectomy [NCT05504967]	Phase 2	104 participants (Anticipated)	Interventional	2020-12-22	Recruiting
A Randomized Comparison of Ultrasound Guided Supraclavicular Block(UGSB) and General Anesthesia (GA) to IV Narcotics and General Anesthesia for Postoperative Pain Relief in Children With Supracondylar Fractures. [NCT02056288]	Phase 4	78 participants (Actual)	Interventional	2011-03-10	Terminated(stopped due to Enrollment was suspended due to the duration of the study and poor follow-up response by participants.)
Prospective Comparison Between Continuous Femoral Nerve Block and the Association of Adductor Canal Block and Sciatic Nerve Block in Total Knee Arthroplasty. [NCT02387021]		80 participants (Anticipated)	Interventional	2015-03-31	Not yet recruiting
A Randomized Controlled Non-inferiority Trial Between the Intra-articular Local Anesthetic Infiltration With Catheter and Interscalene Block With Catheter in Postoperative Analgesia After Shoulder Prosthesis [NCT02365181]	Phase 4	98 participants (Actual)	Interventional	2014-09-30	Completed
Two-arm, Double-blind Randomized Study Comparing Exparel and Exparel Plus an Adductor Canal Block in Total Knee Arthroplasty [NCT02365727]	Phase 4	0 participants (Actual)	Interventional	2015-04-30	Withdrawn(stopped due to Protocol not feasible as written)
A Randomized Controlled Trial to Determine if Pre- and Post- Operative Regional Pain Control (Transversus Abdominis Plane Block) With Ropivacaine Versus Placebo Leads to Lower Anesthetic and Narcotic Dosing, and Alters Pain Scores [NCT03149783]	Phase 2	80 participants (Anticipated)	Interventional	2018-02-13	Recruiting
[NCT02326727]		30 participants (Anticipated)	Interventional	2015-04-30	Not yet recruiting
Assessment of Sensory and Motor Blockade of the Adductor Canal Blockade Performed for Surgery of Arthroscopic Anterior Cruciate Ligament Repair [NCT02419261]		40 participants (Anticipated)	Interventional	2014-10-31	Recruiting
Adductor Canal Block and Functional Recovery After Total Knee Arthroplasty. A Double-Blind, Randomized Controlled Trial [NCT02411149]	Phase 4	200 participants (Actual)	Interventional	2014-04-30	Completed
Intraperitoneal Local Anesthetic in Bariatric Surgery: A Double Blind-randomized Controlled Pilot Trial [NCT03175081]		54 participants (Actual)	Interventional	2017-04-27	Completed
Psoas Compartment Block Versus Periarticular Local Anesthetic Infiltration for Pain Management for Total Hip Arthroplasty: A Prospective, Randomized Study [NCT02658149]	Phase 4	100 participants (Actual)	Interventional	2016-05-31	Completed
[NCT02396563]		100 participants (Anticipated)	Observational	2016-06-30	Not yet recruiting
Liposomal Bupivacaine Versus Femoral Nerve Block for Pain Control After Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Trial [NCT02606448]	Phase 4	84 participants (Actual)	Interventional	2014-08-31	Completed
Continuous Erector Spinae Plane Blocks for Analgesia and Improving Incentive Spirometry Following Traumatic Rib Fractures [NCT04558281]	Phase 4	4 participants (Actual)	Interventional	2021-05-23	Terminated(stopped due to Could only enroll 4 subjects in nearly 2 years)
[NCT02375191]		58 participants (Actual)	Interventional	2015-01-31	Completed
Ultrasound Guided Paravertebral Catheter Versus Patient Controlled Analgesia for Postoperative Pain Control in Video Assisted Thoracoscopic Surgery: A Prospective Outcomes Study [NCT02361775]	Early Phase 1	50 participants (Actual)	Interventional	2012-07-31	Completed
Effects of Continuous Erector Spinae Plane Blocks on Recovery, Pain and Opioid Consumption After Multilevel Spine Surgery: A Prospective Randomized Clinical Trial [NCT05494125]		44 participants (Anticipated)	Interventional	2022-09-14	Recruiting
Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block for Postoperative Pain Control in Laparoscopic Cholecystectomy: Prospective Randomized Controlled Trial in Pediatric Patients [NCT02712151]	Phase 3	80 participants (Anticipated)	Interventional	2024-03-01	Not yet recruiting
Evaluation of the PENG Block vs Placebo for Preoperative Pain Control in Hip Fractures in the Elderly - a Double-blinded Randomised Controlled Trial [NCT04996979]		60 participants (Anticipated)	Interventional	2021-05-24	Recruiting
A Comparison Between Scalp Nerve Block and Scalp Infiltration on the Circulatory and Stress Response for Aneurysm Clipping Using an Enhanced Recovery After Surgery Programme [NCT03073889]		45 participants (Anticipated)	Interventional	2016-06-30	Recruiting
Is Paraspinal Intramuscular Ropivacaine Injection an Effective Treatment for Headache in a Pediatric Emergency Department? [NCT00680823]		150 participants (Actual)	Interventional	2009-01-31	Completed
Analgesic Effect of Blind Fascia Iliaca Compartment Block Compared to an Ultrasound-guided Femoral Nerve Block in Patients With Hip Fractures [NCT05365555]		100 participants (Anticipated)	Observational	2022-05-01	Recruiting
The Treatment of Acute Gastrointestinal Injury Via Ultrasound-guided Erector Spinae Plane Block - a Prospective, Single-center, Randomized, Controlled Trial [NCT04934904]		100 participants (Actual)	Interventional	2019-08-01	Completed
Postoperative Knee Strength Following Total Knee Replacement: A Double-Blinded Randomized Comparison Study [NCT01620047]		60 participants (Actual)	Interventional	2011-03-31	Completed
The Effect and Safety of the Four Points Transversus Abdominis Plane Block Under the Ultrasound Guidance in Postoperative Analgesia to the Hepatectomy [NCT03598192]		30 participants (Actual)	Interventional	2018-08-15	Completed
Dexamethasone and Dexmedetomidine as Adjuvants to Ropivacaine in Ultrasound-guided Multilevel Thoracic Paravertebral Block for Lobectomy: A Prospective, Randomized, Triple-blind Study [NCT04763434]	Phase 4	90 participants (Anticipated)	Interventional	2021-03-20	Not yet recruiting
A Prospective, Randomized Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty [NCT02543801]	Phase 4	239 participants (Actual)	Interventional	2016-01-25	Completed
Erector Spinae Plane Block Versus Paravertebral Block in Patients Undergoing Elective Breast Surgery. A Randomized Controlled Trial Comparing Dermatomal Spread. [NCT03471442]		48 participants (Actual)	Interventional	2018-05-29	Completed
Transversus Abdominis Plane Block: A Placebo-controlled Study in Healthy Volunteers [NCT01679392]		16 participants (Actual)	Interventional	2012-08-31	Completed
Ultrasound-guided Peripheral Nerve Block for Non-intubated Uniportal Video-assisted Thoracoscopic Surgery [NCT03083080]		30 participants (Anticipated)	Interventional	2017-03-27	Not yet recruiting
Pain Control With Regional Anesthesia Following Pediatric Cardiac Surgery: A Randomized Double-Blinded Pilot Study [NCT05688670]	Phase 4	42 participants (Anticipated)	Interventional	2023-03-29	Recruiting
Effect of Adductor Canal Blockade vs Femoral Nerve Blockade on Muscle Strength, Mobility and Pain in Patients With Severe Pain After Total Knee Arthroplasty [NCT01922596]	Phase 4	50 participants (Actual)	Interventional	2013-01-31	Completed
The Effect of Pectoral Blocks on Perioperative Pain in Simple Mastectomy and Breast Reduction in Gender Affirmation Surgery [NCT04474366]	Phase 4	50 participants (Actual)	Interventional	2020-06-16	Completed
A Randomized Controlled Trial Comparing Continuous Sciatic Nerve Block to Single Shot Sciatic Nerve Block [NCT01615939]	Phase 4	17 participants (Actual)	Interventional	2012-06-30	Terminated(stopped due to The study has been terminiated due to minimal subject recruitment)
Ropivacaine Pharmacokinetics After Erector Spinae Block in Children Undergoing Posterior Spinal Fusion [NCT05755334]	Phase 4	46 participants (Anticipated)	Interventional	2023-06-01	Not yet recruiting
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty. [NCT03353233]	Phase 4	50 participants (Actual)	Interventional	2018-05-03	Completed
A Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study to Evaluate the Efficacy and Safety of CPL-01 in the Management of Postoperative Pain After Unilateral Distal First Metatarsal Bunionectomy With Osteotomy [NCT05831449]	Phase 3	574 participants (Anticipated)	Interventional	2023-05-22	Recruiting
Single Transversus Abdominis Laparoscopy-guided Plane Block Combined With Local Trocar Site Ropivacaine Infiltration (STALL) vs Sole Local Wound Infiltration in LCC (Laparoscopic CholeCystectomy) - Double-blinded Randomized Controlled Trial. [NCT06123117]		850 participants (Anticipated)	Interventional	2024-01-31	Not yet recruiting
Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery [NCT05767749]	Phase 4	75 participants (Actual)	Interventional	2023-03-14	Completed
Phase 3 Study of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy [NCT02112370]	Phase 3	148 participants (Actual)	Interventional	2014-05-31	Completed
Comparison of Ropivacaine With or Without Fentanyl in Spinal Anaesthesia for Lower Limb Surgeries [NCT04199013]	Phase 4	74 participants (Anticipated)	Interventional	2020-01-10	Recruiting
The Effect of the Ultrasound-guided Serratus Anterior Plane Block in Combinaison With Thoracic Paravertebral cathéter Versus Thoracic Paravertebral Cather for Perioperative Analgesia in Thoracic Surgery [NCT04024683]		159 participants (Actual)	Observational	2018-03-01	Completed
A Prospective, Randomized, Controlled Trial of Post Operative Pain Control Using Ropivacaine and the ON-Q System in the Adult Pectus Excavatum Patient After Minimally Invasive Repair [NCT01816477]		85 participants (Actual)	Interventional	2013-04-30	Completed
The Effect Of Initial Local Anesthetic Dose With Continuous Interscalene Analgesia On Postoperative Pain And Diaphragmatic Function In Arthroscopic Shoulder Surgery Patients: A Double-Blind, Randomized, Parallel Group, Dose-Ranging Study [NCT00672100]		36 participants (Actual)	Interventional	2009-01-31	Completed
Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain Relief After Elective Supratentorial Craniotomy (PAINLESS): a Randomized Controlled Pilot Trial [NCT04380298]	Phase 4	40 participants (Anticipated)	Interventional	2020-12-01	Not yet recruiting
Comparison of Ultrasound Hydrolocalization Technique Versus Neurostimulation for Placement of Continuous Femoral Catheters. [NCT01726192]		50 participants (Anticipated)	Interventional	2012-08-31	Recruiting
The Significance of Peripheral Input in Patients With Post Surgery Neuropathic Pain: Evaluation of Trigger Point Anesthesia. A Double-blind, Randomized, Controlled Exploratory Study [NCT04764045]		12 participants (Anticipated)	Interventional	2019-11-20	Recruiting
Study of the Analgesic Effect of the Perineal Infiltration of Ropivacaine 0.75% Versus Placebo in Post-episiotomy Perineal Pain: a Randomized, Double-blind Study [NCT03084549]	Phase 3	272 participants (Actual)	Interventional	2017-10-24	Completed
The Effects of Thoracic Nerve Blocks on Postoperative Pain, Respiratory Function and Recovery in Patients Undergoing Thoracoscopic Surgery [NCT04400721]	Phase 3	120 participants (Anticipated)	Interventional	2020-07-01	Not yet recruiting
The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery [NCT04021264]	Phase 2/Phase 3	0 participants (Actual)	Interventional	2019-08-01	Withdrawn(stopped due to Inability to enroll participants.)
Erector Spinae Plane Block (ESPB): A New Technique for Perioperative Pain Control in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision. [NCT03691935]	Phase 4	40 participants (Anticipated)	Interventional	2018-09-28	Enrolling by invitation
Efficacy of Dexmedetomidine on Postoperative Analgesia After Radical Mastectomy: Randomized Controlled Trial [NCT05110339]		28 participants (Actual)	Interventional	2019-11-01	Completed
Fast-track Rehabilitation Protocol for Total Knee Arthroplasty: A Randomized Controlled Trial Comparing Local Infiltration Analgesia With Femoral Nerve Block [NCT01966263]	Phase 4	80 participants (Actual)	Interventional	2013-11-30	Completed
Adductor Canal Blocks Using Exparel for Pain Control After Total Knee Arthroplasty [NCT04910165]	Phase 3	100 participants (Actual)	Interventional	2020-06-01	Completed
The Minimum Effective Volume (MEV) of 0.5% Ropivacaine in Ultrasound-guided Supra-anterior Superior Iliac Spine Fascia Iliaca Compartment Block (SASIS-FICB) [NCT05012137]		54 participants (Anticipated)	Interventional	2021-08-25	Not yet recruiting
Transversus Abdominis Plane (TAP) Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine: A Prospective Randomized Control Trial for Pain Control After Renal Transplant Surgery [NCT03737604]	Phase 4	200 participants (Anticipated)	Interventional	2018-10-04	Recruiting
Effect of Epidural Hydromorphone Combined With Ropivacaine in Labor Analgesia [NCT05901441]	Phase 2	240 participants (Actual)	Interventional	2022-06-01	Completed
Efficacy of a Peri-Operative Surgical-Site, Multimodal Drug Injection in Pediatric Patients With Cerebral Palsy Undergoing Hip Surgery: A Randomized Controlled Trial [NCT04074265]	Phase 4	34 participants (Actual)	Interventional	2019-12-01	Completed
Impact of Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Nausea and Vomiting and Early Outcome After Laparoscopic Bariatric Surgery: a Randomized Double-Blinded Controlled Trial [NCT05286008]		90 participants (Anticipated)	Interventional	2022-03-18	Not yet recruiting
the Effect of Dexmedetomidine in Coracoid Approach Brachial Plexus Block [NCT02961361]	Phase 4	60 participants (Actual)	Interventional	2016-11-12	Completed
Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery [NCT01986751]	Phase 1/Phase 2	14 participants (Actual)	Interventional	2014-01-31	Terminated(stopped due to failure to enroll)
Continuous Infusion of Lidocaine Versus Blockade of the Erector Spinae Plane Block - Comparison of Analgesic Efficacy in Patients After Bariatric Surgery [NCT05700214]		100 participants (Anticipated)	Interventional	2023-01-16	Recruiting
Randomized, Double-Blinded, Placebo-Controlled Trial to Investigate the Role of Laparoscopic Transversus Abdominis Plane Block in Gastric Bypass Surgery (LapTAP Trial) [NCT03367728]	Phase 4	150 participants (Anticipated)	Interventional	2018-11-27	Recruiting
Prospective, Randomized, Controlled Trial Comparing Continuous Femoral and Single Injection Sciatic Peripheral Nerve Blocks vs Periarticular Injection With Ropivacaine or Liposomal Bupivacaine (Exparel) on Patients Undergoing Total Knee Arthroplasty [NCT02223364]	Phase 4	165 participants (Actual)	Interventional	2014-07-31	Completed
Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia: a Randomized Controlled Trial [NCT06036797]	Phase 2	240 participants (Anticipated)	Interventional	2023-09-17	Recruiting
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve Block [NCT05897307]		90 participants (Anticipated)	Interventional	2023-08-01	Recruiting
A Prospective, Randomized, Active-Comparator, Open-Label, Non-Inferiority Study of the Efficacy of Continuous Nerve Block vs Single Block Plus Intravenous Lidocaine for Postoperative Pain. [NCT04208516]	Phase 4	17 participants (Actual)	Interventional	2021-05-26	Terminated(stopped due to Recruitment was unable to be obtained in a timely fashion, so the study was stopped.)
The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery: a Randomized, Double-blind, Controlled Study [NCT05825378]		260 participants (Anticipated)	Interventional	2023-05-01	Not yet recruiting
Evaluation of Influence of Thoracic Paravertebral Block on Cardiac Repolarization [NCT05822076]		60 participants (Anticipated)	Observational	2023-02-02	Enrolling by invitation
Single-Shot Versus Continuous Regional Anesthesia for Treating Acute Postoperative Pain in Pediatric Orthopaedic Surgery: A Prospective Randomized Trial [NCT04669145]	Phase 2/Phase 3	88 participants (Anticipated)	Interventional	2021-06-24	Recruiting
Opioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee [NCT03294174]		48 participants (Actual)	Observational		Terminated(stopped due to Responsible Investigator left institution)
Inflammatory Mediators, Neural Tissue Injury Markers and the Markers of Oxidative Stress in the CSF of Patients Undergoing Spinal Anesthesia With Ropivacaine and Bupivacaine [NCT03293472]	Phase 4	60 participants (Anticipated)	Interventional	2017-12-01	Recruiting
A Phase 3, Randomized, Double-Blind, Saline Placebo- and Active-Controlled, Multicenter Study to Evaluate the Analgesic Efficacy and Safety of Intra-operative Administration of PRF-110 Following Unilateral Bunionectomy [NCT05773846]	Phase 3	415 participants (Anticipated)	Interventional	2023-03-13	Recruiting
Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically [NCT02355093]	Phase 4	40 participants (Anticipated)	Interventional	2014-07-31	Enrolling by invitation
Effect of a Lateral Nerve of the Thigh Block on Postoperative Pain After Total Hip Replacement Surgery: a Clinical Randomized Trial [NCT02289937]	Phase 4	100 participants (Actual)	Interventional	2014-03-31	Completed
Ultrasound-Guided Obturator Nerve Block for Ambulatory Hip Arthroscopy: A Prospective, Randomized Controlled Trial [NCT02346357]		70 participants (Anticipated)	Interventional	2014-05-31	Recruiting
Investigational Plan for the Clinical Evaluation of the ReLeaf Analgesic Infusion Catheter & Wound Drain [NCT02293525]		0 participants (Actual)	Interventional		Withdrawn(stopped due to No subjects were enrolled and the sponsor suspended support at this time)
Erector Spine Plane (ESP) Block for Analgesia in Pediatric Scoliosis Surgery [NCT05944393]		50 participants (Anticipated)	Interventional	2022-09-08	Recruiting
Periarticular Nerve Group (PENG) Block for Postoperative Rehabilitation in Total Hip Arthroplasty: a Randomized Controlled Trial [NCT05944380]	Phase 4	556 participants (Actual)	Interventional	2020-06-16	Completed
[NCT02311517]		90 participants (Actual)	Interventional	2014-01-28	Completed
Pre-emptive Scalp Infiltration With Ropivacaine Plus Methylprednisolone vs Ropivacaine Alone for Relief of Postoperative Pain After Craniotomy in Children (RP/MP vs RP) [NCT03636165]	Phase 4	90 participants (Anticipated)	Interventional	2022-09-01	Not yet recruiting
Single Dose Adductor Canal Block With SPANK (Sensory Posterior Articular Nerves of the Knee) Block Compared to Single Dose Adductor Canal Block and Pain Control After Total Knee Arthroplasty [NCT03502889]		128 participants (Anticipated)	Interventional	2019-06-30	Not yet recruiting
Evaluation of Regional Distribution of Ventilation in Spontaneous Breathing Patients During Labor With or Without Epidural Analgesia Using EIT (Electrical Impedance Tomography) [NCT02523755]	Phase 4	40 participants (Actual)	Interventional	2015-09-30	Completed
Minimum Effective Local Anesthetic Dose for Adductor Canal Block for Knee Analgesia - a Preliminary Study [NCT03427385]		60 participants (Actual)	Interventional	2012-09-30	Completed
Influence of Local Anesthetic Administration on the Cancer Recurrence Rate After Pancreatic Oncologic Surgery [NCT04449289]	Phase 2	100 participants (Anticipated)	Interventional	2020-07-01	Not yet recruiting
Influence of SPI-guided Analgesia With Preventive Different Peribulbar Blocks (PBB) on the Presence of OCR, Postoperative Pain, PONV in Patients Undergoing VRS Under General Anaesthesia: a Randomised, Controlled Trial [NCT03413371]		175 participants (Anticipated)	Interventional	2018-04-26	Recruiting
Intrathecal Morphine Compared to Intravenous Tramadol and Transversus Abdominal Plane Block for Catheter Related Bladder Discomfort Syndrome [NCT04814745]		33 participants (Actual)	Interventional	2020-07-07	Completed
A Randomized, Prospective, Double Blind Clinical Trial to Investigate the Increase in Duration of Analgesia With Addition of 0.25mcg/kg of Dexmedetomidine (DEX) to 25 ml of 0.5%Ropivacaine in Supraclavicular Brachial Plexus Block. [NCT03385967]	Phase 4	0 participants (Actual)	Interventional	2019-04-30	Withdrawn(stopped due to PI is leaving the University of Florida)
Catheter-based Peripheral Regional Anesthesia After Total Knee Arthroplasty: Comparison of Low Dose, Automated Periodic Infusions With Conventional High Dose, Continuous Infusion and Patient-initiated Infusions Only [NCT03372265]	Phase 4	111 participants (Actual)	Interventional	2017-12-06	Completed
A Randomized Double Blind, Multicenter Trial to Assess Time-interval Between Cytoreductive Surgery and Adjuvant Chemotherapy After Administration of Local Anesthetic Intraperitoneally/Perioperatively in Advanced Epithelial Ovarian Cancer [NCT04065009]	Phase 3	220 participants (Anticipated)	Interventional	2020-08-26	Recruiting
Impact of Adding iPACK Block With Dexamethasone to Existing APS Multimodal Analgesia Protocol for Patients Undergoing Total Knee Arthroplasty [NCT04917055]	Phase 4	14 participants (Actual)	Interventional	2021-06-07	Terminated(stopped due to staffing)
The Impact of the Continuous Infusion of Intraperitoneal Analgesics on Postoperative Pain After Minimally Invasive Hysterectomy: a Randomized Controlled Trial [NCT04130464]	Phase 4	120 participants (Anticipated)	Interventional	2019-09-30	Recruiting
A Dose Response Study for Duration of Analgesia Using Bupivacaine and Ropivacaine for Infragluteal Parabiceps Sciatic Block [NCT01272921]	Phase 4	142 participants (Actual)	Interventional	2010-11-30	Completed
The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane in Total Shoulder Arthroplasty [NCT04020601]	Phase 2/Phase 3	50 participants (Anticipated)	Interventional	2019-08-01	Recruiting
Effect of Ultrasound-guided Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Postoperative Pain in Patients Undergoing Colorectal Cancer Surgery: a Randomized Double-blind Controlled Trial [NCT05122338]		160 participants (Anticipated)	Interventional	2021-12-01	Not yet recruiting
Do Intraoperative Periarticular Injections Improve Postoperative Pain Control in Patients Receiving Duramorph (Preservative Free) During Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial [NCT02570503]	Phase 4	64 participants (Actual)	Interventional	2015-10-31	Terminated(stopped due to Study's primary aims are no longer clinically impactful, as intrathecal morphine has fallen out of favor and replaced with different agents so that outpatient/23 hr surgery is more predictably achievable.)
A Double-blind Randomized Non-inferiority Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery: Effects on Acute Postoperative Pain. [NCT04827030]	Phase 4	292 participants (Anticipated)	Interventional	2021-06-28	Recruiting
Transversus Abdominis Plane (TAP) Block Study for Postoperative Pain Control [NCT02652156]	Phase 3	14 participants (Actual)	Interventional	2015-11-01	Terminated(stopped due to Operational barriers at the site.)
Efficacy of Peri-Incisional Multimodal Drug Injection in Reducing Post-Operative Pain Following Lumbar Spine Surgery [NCT03513445]	Phase 3	0 participants (Actual)	Interventional	2018-06-01	Withdrawn(stopped due to No participants enrolled)
The Efficacy of Continuous Intercostal Nerve Blocks in the Treatment of Patients With Multiple Rib Fractures [NCT05642026]	Phase 4	180 participants (Anticipated)	Interventional	2023-12-01	Not yet recruiting
Prospective Randomized Double-Blind Study of Pain Control With Hepatic Hilum Nerve Block Versus Sham Procedure For Hepatic Chemoembolization or Radiofrequency Ablation [NCT04769713]	Phase 4	80 participants (Anticipated)	Interventional	2021-11-23	Recruiting
The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block [NCT02512471]		114 participants (Actual)	Interventional	2015-05-31	Completed
Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP): Modifying an Existing Technique for Ease of Administration and Increased Accuracy [NCT02506855]	Phase 3	0 participants (Actual)	Interventional	2015-06-30	Withdrawn(stopped due to The investigator decided not to continue the study.)
Transversus Abdominis Plane (TAP) Block for Laparoscopic Appendicectomy in Children: Opioid Saving and Alternative in the Curarization [NCT02505841]		240 participants (Anticipated)	Interventional	2015-05-31	Active, not recruiting
Analgesic Effect of Ropivacaine Plus Fentanyl vs Ropivacaine for Continuous 3-in-1 FNB After Total Knee Arthroplasty [NCT02501863]		40 participants (Actual)	Interventional	2015-10-31	Completed
Effect of 0.5µg/ml Sufentanil and Ropivacaine Towards Pregnant Women and Fetus in Analgesia Labor [NCT02488291]		120 participants (Actual)	Interventional	2014-04-30	Completed
[NCT02483923]		40 participants (Actual)	Interventional	2015-06-16	Completed
Erector Spinae Plane Block for Rib Fractures: A Pilot Study [NCT04916691]	Early Phase 1	40 participants (Actual)	Interventional	2021-05-15	Completed
Effect of Tramadol in Prevention of Postpartum Depression [NCT03309163]	Phase 4	1,230 participants (Actual)	Interventional	2017-10-09	Completed
The Double-blind, Randomized Controlled Trial: Comparison of Levobupivacaine and Ropivacaine for Postoperative Analgesia TAP-block After Caesarean Section [NCT03302689]		50 participants (Actual)	Interventional	2017-09-25	Active, not recruiting
Selective Blocks for Total Knee Arthroplasty [NCT02465827]	Phase 4	75 participants (Actual)	Interventional	2014-01-31	Completed
A Randomized Comparison of Minimum Effective Volume With 0.5% Ropivacaine Between Costoclavicular and Paracoracoid Ultrasound-guided Infraclavicular Block for Forearm Surgery [NCT03279679]		50 participants (Anticipated)	Interventional	2017-10-31	Not yet recruiting
Pilot Study on the Thermal Effects of Local Anesthetics [NCT04761887]	Phase 1	0 participants (Actual)	Interventional	2022-12-31	Withdrawn(stopped due to Study withdrawn prior to enrollment (insufficient funds and reduced access to patients related to COVID protocols))
Paravertebral Block to Reduce the Incidence of New Onset Atrial Fibrillation After Cardiac Surgery: A Prospective Randomized Controlled Pilot Trial [NCT04472299]	Phase 4	30 participants (Anticipated)	Interventional	2021-04-09	Recruiting
Comparison of the Role of Epidural Analgesia Versus Non-epidural Analgesia in Postnatal Depression and Persistent Pain Development: a Randomized Controlled Trial [NCT03167905]	Phase 2/Phase 3	881 participants (Actual)	Interventional	2017-06-15	Active, not recruiting
Contribution Of Anesthesia Technique For Post-operative Mortality Reduction After Proximal Femur Fractures Surgical Treatment - A Randomized Clinical Trial [NCT02406300]		57 participants (Actual)	Interventional	2015-04-01	Terminated(stopped due to Organizational changes made recruitment no longer possible)
Prospective, Randomized Controlled Trial Comparing Continuous Posterior Lumbar Plexus Nerve Block vs Periarticular Injection With Ropivacaine or Liposomal Bupivacaine (Exparel®) on Patients Undergoing Total Hip Arthroplasty [NCT02242201]	Phase 4	165 participants (Actual)	Interventional	2014-09-30	Completed
Continuous Wound Infiltration After Hallux Valgus Surgery A Prospective, Randomized, Double-blind and Placebo-controlled Single-center Trial [NCT02182999]	Phase 4	50 participants (Actual)	Interventional	2014-05-31	Completed
Peripheral Nerve Blocks in Pediatric Orthopedic Patients: Are There Any Post Recovery Benefits? [NCT02236130]		49 participants (Actual)	Interventional	2014-06-30	Terminated(stopped due to Poor response rate on follow up of patients)
A Prospective, Double Blinded, Randomized Comparison of Transversus Abdominis Plane Block Versus Local Anesthetic Infiltration for Laparoscopic Appendectomy in the Pediatric Population [NCT01575028]	Phase 2	3 participants (Actual)	Interventional	2012-10-31	Terminated(stopped due to The study was allowed to expire due to changes in standard care for the patient population within the NCH institution.)
Effect of Local Anesthetic Concentration (0.2% Ropivacaine vs 0.1% Ropivacaine) on Phrenic Nerve Function, Pulmonary Function, and Analgesia After Ultrasound-guided Interscalene Brachial Plexus Block for Shoulder Arthroscopy [NCT02181296]		50 participants (Actual)	Interventional	2014-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Trial	Outcome
NCT00519584 (4) [back to overview]	Time to a Significant Increase in Shoulder Discomfort
NCT00519584 (4) [back to overview]	Maximum VRS Pain Scores at Rest
NCT00519584 (4) [back to overview]	the Duration of Analgesia
NCT00519584 (4) [back to overview]	Total Opioid Consumption
NCT00562627 (3) [back to overview]	Time to Readiness for Discharge
NCT00562627 (3) [back to overview]	Opioid Use
NCT00562627 (3) [back to overview]	Pain at Rest (VAS)
NCT00638508 (20) [back to overview]	Pain Score at Rest
NCT00638508 (20) [back to overview]	Pain Score on Coughing
NCT00638508 (20) [back to overview]	Pain Scores at Rest
NCT00638508 (20) [back to overview]	Pain Scores at Rest
NCT00638508 (20) [back to overview]	Pain Scores on Movement
NCT00638508 (20) [back to overview]	Pain Scores on Coughing
NCT00638508 (20) [back to overview]	NAUSEA
NCT00638508 (20) [back to overview]	Pain on Movement
NCT00638508 (20) [back to overview]	VOMITING
NCT00638508 (20) [back to overview]	VOMITING
NCT00638508 (20) [back to overview]	PATIENT SATISFACTION
NCT00638508 (20) [back to overview]	PATIENT SATISFACTION
NCT00638508 (20) [back to overview]	DROWSINESS
NCT00638508 (20) [back to overview]	DROWSINESS
NCT00638508 (20) [back to overview]	Pain on Movement
NCT00638508 (20) [back to overview]	Morphine Equivalents
NCT00638508 (20) [back to overview]	Morphine Equivalents
NCT00638508 (20) [back to overview]	Morphine Equivalents Utilization
NCT00638508 (20) [back to overview]	Pain Scores on Coughing
NCT00638508 (20) [back to overview]	NAUSEA
NCT00672100 (4) [back to overview]	Change in Diaphragmatic Displacement From Baseline to Post-surgery
NCT00672100 (4) [back to overview]	"Percentage of Participants Who Considered the Analgesic Technique Helpful or Extremely Helpful"
NCT00672100 (4) [back to overview]	Functional Outcome - Simple Shoulder Test (SST)
NCT00672100 (4) [back to overview]	Pain Measurements Via Numeric Pain Rating Scales (NRS)
NCT00680823 (3) [back to overview]	The Primary Outcome Will be Pain Relief Sufficient for Discharge From the Emergency Department.
NCT00680823 (3) [back to overview]	Re-presentation to the Emergency Department With Headache Within 72 Hours of Participating in the Study
NCT00680823 (3) [back to overview]	Number and Percent of Patients Admitted to the Hospital for Additional Therapy in Each Treatment Arm Based Upon Treating Clinicians Decision
NCT00720330 (5) [back to overview]	Postoperative Opioid Consumption in Oral Oxycodone Equivalents
NCT00720330 (5) [back to overview]	Pre- and Intra-operative Opioid Consumption in Fentanyl Equivalents
NCT00720330 (5) [back to overview]	Postoperative Nausea
NCT00720330 (5) [back to overview]	Time From the End of Surgery to Readiness for Hospital Discharge.
NCT00720330 (5) [back to overview]	Pain Scores on Numerical Rating Scale
NCT00801138 (4) [back to overview]	Time to First Report of Pain
NCT00801138 (4) [back to overview]	Total Three-day Opioid Consumption in Oral Oxycodone Equivalent
NCT00801138 (4) [back to overview]	Median Maximum VAS Pain Scores at Rest
NCT00801138 (4) [back to overview]	The Duration of the Interscalene Nerve Block Which is Time to First Administration of Pain Medication After Block
NCT00825786 (7) [back to overview]	Duration of Analgesia.
NCT00825786 (7) [back to overview]	Maximum Verbal Response Score (VRS) With Rest
NCT00825786 (7) [back to overview]	Time to Complete Motor Block
NCT00825786 (7) [back to overview]	Time to Onset of First Sensory Block
NCT00825786 (7) [back to overview]	Total Opioid Consumption
NCT00825786 (7) [back to overview]	Duration of Analgesia
NCT00825786 (7) [back to overview]	Maximum Verbal Response Score (VRS) With Movement
NCT00901628 (6) [back to overview]	the Proportion of Patients Who Were Satisfied With the Pain Management
NCT00901628 (6) [back to overview]	Pain( Visual Analog Scale )
NCT00901628 (6) [back to overview]	Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery
NCT00901628 (6) [back to overview]	The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended
NCT00901628 (6) [back to overview]	Intravenous Patient Controlled Analgesia(PCA) Consumption During 24 Hours After Surgery
NCT00901628 (6) [back to overview]	Maximal Flexion Angle Degree on Postoperative 7 Day
NCT00912873 (7) [back to overview]	Percent Change From Baseline in Quadriceps Femoris Maximum Voluntary Isometric Contraction (MVIC)
NCT00912873 (7) [back to overview]	Total Ambulation
NCT00912873 (7) [back to overview]	Ambulation 100-foot Walking Test
NCT00912873 (7) [back to overview]	Average Dynamic Pain
NCT00912873 (7) [back to overview]	Worst Dynamic Pain
NCT00912873 (7) [back to overview]	Percent Change From Baseline in Hip Flexion
NCT00912873 (7) [back to overview]	Mean Resting Pain
NCT00913068 (1) [back to overview]	Total Milligrams of Opiates
NCT00930046 (2) [back to overview]	Morphine
NCT00930046 (2) [back to overview]	FLACC Pain Intensity [Faces Legs Activity Cry Consolability] 0-10 Points
NCT00956709 (3) [back to overview]	Compare the Onset of Action of Ropivacaine 0.5% and levobupivacaïne 0.5 % for Sciatic Nerve Block Guided in Major Surgery of the Foot
NCT00956709 (3) [back to overview]	Duration of Sensory Sciatic Block (h)
NCT00956709 (3) [back to overview]	Duration of Motor Sciatic Block (h)
NCT01042093 (3) [back to overview]	Knee Society Pain Scores at 6 Week Follow-up Appointment
NCT01042093 (3) [back to overview]	Numerical Rating Scale (NRS) Pain Scores During Hospitalization.
NCT01042093 (3) [back to overview]	Narcotic Consumption During Hospitalization
NCT01074229 (2) [back to overview]	QoR40 on the Day After Surgery
NCT01074229 (2) [back to overview]	24 Total Morphine Consumption
NCT01075087 (2) [back to overview]	24 Hour Total Opioid Consumption.
NCT01075087 (2) [back to overview]	Quality of Recovery 40 Score
NCT01075646 (6) [back to overview]	Mg of Morphine Consumption During 48 Hours Administered by Patient Controlled Analgesia System
NCT01075646 (6) [back to overview]	Contamination of the Catheter (Microbiologist Analysis)
NCT01075646 (6) [back to overview]	Intensity of Pain Measured by Verbal Pain Scale.
NCT01075646 (6) [back to overview]	Local Reaction in the Wound and Insertion Point of the Catheter (Inflammation Signs and Infection)
NCT01075646 (6) [back to overview]	Time Spent Sitting in a Chair, Deambulation, Solid Ingestion.
NCT01075646 (6) [back to overview]	Secondary Effects Due to Morphine: Nausea and Vomiting
NCT01094106 (3) [back to overview]	Postoperative Nausea and Vomiting (PONV)
NCT01094106 (3) [back to overview]	Strength of Pain on Numerical Rating Scale (NRS)
NCT01094106 (3) [back to overview]	The Demand of Rescue Analgesics (Oxycodone)
NCT01123889 (3) [back to overview]	Pain and Disability of the Shoulder Through Validated Questionnaires
NCT01123889 (3) [back to overview]	Pain and Disability of the Shoulder Through Validated Questionnaires
NCT01123889 (3) [back to overview]	Pain and Disability of the Shoulder Through Validated Questionnaires
NCT01163214 (6) [back to overview]	Pain Scores in the Per-protocol Subset (Participants Who Received the Allocated Treatment)
NCT01163214 (6) [back to overview]	Number of Subjects Who Experienced Neurological Changes Postoperatively
NCT01163214 (6) [back to overview]	Straight-leg Raise
NCT01163214 (6) [back to overview]	Narcotic Use
NCT01163214 (6) [back to overview]	Post-Operative Pain
NCT01163214 (6) [back to overview]	Length of Stay in Hospital
NCT01167907 (6) [back to overview]	Nausea
NCT01167907 (6) [back to overview]	Vomiting
NCT01167907 (6) [back to overview]	Verbal Pain Scores
NCT01167907 (6) [back to overview]	Sleep Disturbance
NCT01167907 (6) [back to overview]	Opioid Use
NCT01167907 (6) [back to overview]	Reduction of Quadriceps Strength
NCT01170702 (8) [back to overview]	Morphine Equivalents 0-24 Hours (Mgs)
NCT01170702 (8) [back to overview]	Morphine Equivalents 24-72 Hours (Mgs)
NCT01170702 (8) [back to overview]	Morphine Equivalents Total (Mgs)
NCT01170702 (8) [back to overview]	Pain Burden With Movement
NCT01170702 (8) [back to overview]	Time to First PCA Request
NCT01170702 (8) [back to overview]	Pain Scores at Rest
NCT01170702 (8) [back to overview]	Pain Scores With Movement
NCT01170702 (8) [back to overview]	Pain Burden at Rest
NCT01172197 (1) [back to overview]	Pain
NCT01242644 (8) [back to overview]	Number of Narcotic Pills and Morphine Sulfate Used
NCT01242644 (8) [back to overview]	Pain Scale
NCT01242644 (8) [back to overview]	Number of Narcotic Pills and Morphine Sulfate Used
NCT01242644 (8) [back to overview]	Pain Scale
NCT01242644 (8) [back to overview]	Pain Scale
NCT01242644 (8) [back to overview]	Number of Narcotic Pills and Morphine Sulfate Used
NCT01242644 (8) [back to overview]	Pain Score 8 Hours Post-operativley
NCT01242644 (8) [back to overview]	Number of Narcotic Pills and Morphine Sulfate Used
NCT01272921 (2) [back to overview]	Cumulative Probabilities for Needle Positioning Above and Below CIEL.
NCT01272921 (2) [back to overview]	Duration of Motor and Sensory Block of the Sciatic With 0.5% Bupivacaine and Ropivacaine After Ultrasound-guided Nerve-stimulator-Assisted Needle Positioning Beneath the CIEL
NCT01328782 (5) [back to overview]	Need for IV Morphine of Fentanyl
NCT01328782 (5) [back to overview]	The Faces Pain Scale-Revised (FSP-R) Scores (Scored 0-10).
NCT01328782 (5) [back to overview]	Time (in Minutes) to First Narcotic Administration
NCT01328782 (5) [back to overview]	Total Quality Pain Management Survey (TQPM) Scores for Questions # 16: Child's Current Level of Pain, Question # 17: Child's Worst Level of Pain When Moving Around After Surgery and Question # 18: Child's Worst Level of Pain While Resting
NCT01328782 (5) [back to overview]	Total Dosage in Morphine Equivalents (mg/kg) of All Analgesics Received in Prior to Discharge
NCT01337115 (4) [back to overview]	Visual Analogue Scores (VAS) - Pain Scores Measured in mm (0-100)
NCT01337115 (4) [back to overview]	VAS Results - Pain Scores Measured in mm (0-100)
NCT01337115 (4) [back to overview]	VAS Results - Pain Measured in mm (0-100)
NCT01337115 (4) [back to overview]	Satisfaction With Anesthesia Technique in Each Arm of the Study
NCT01388946 (14) [back to overview]	Chronic Pain
NCT01388946 (14) [back to overview]	Chronic Pain
NCT01388946 (14) [back to overview]	Pain Scores at Rest 2 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores at Rest 24 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores at Rest 4 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores at Rest 8 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores During Cough 2 h Postoperatively
NCT01388946 (14) [back to overview]	VAS Score Changes ( Cough) During 24 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores in the Postoperative Care Unit (PACU) at Rest
NCT01388946 (14) [back to overview]	Pain Scores During Cough in the PACU
NCT01388946 (14) [back to overview]	Pain Scores During Cough 8 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores During Cough 48 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores During Cough 4 h Postoperatively
NCT01388946 (14) [back to overview]	Pain Scores at Rest 48 h Postoperatively
NCT01450007 (4) [back to overview]	Duration of Sensory Blockade
NCT01450007 (4) [back to overview]	Post Operative Opioid Dose at 24 Hours
NCT01450007 (4) [back to overview]	Time Until First Dose of Analgesic
NCT01450007 (4) [back to overview]	Patient Satisfaction With Pain Control
NCT01452126 (2) [back to overview]	Number of Patients With Complications
NCT01452126 (2) [back to overview]	Effective Concentration of Ropivacaine to Produce Surgical Anesthesia in 50% of Population
NCT01479270 (4) [back to overview]	Intraoperative Time
NCT01479270 (4) [back to overview]	Narcotic Use
NCT01479270 (4) [back to overview]	Visual Analog Scale (VAS) for Pain
NCT01479270 (4) [back to overview]	Quality of Recovery Questionnaire (QoR-40) on Postop Day #1 or #2
NCT01480089 (2) [back to overview]	Post-op Pain With Atomized Intraperitoneal Ropivacaine (AIR)
NCT01480089 (2) [back to overview]	Post-op Pain With Atomized Intraperitoneal Ropivacaine (AIR)
NCT01556724 (5) [back to overview]	Number of Participants With Increased Infusion Rates
NCT01556724 (5) [back to overview]	Numeric Rating Scale Pain Score With Movement at 24 Hours
NCT01556724 (5) [back to overview]	Patient Satisfaction With Pain Control
NCT01556724 (5) [back to overview]	Opiate Consumption Postoperatively
NCT01556724 (5) [back to overview]	Number of Participants With Decreased Infusion Rates
NCT01615939 (3) [back to overview]	Temporary Neurologic Symptoms Between Groups
NCT01615939 (3) [back to overview]	Participant Satisfaction With Anesthesia
NCT01615939 (3) [back to overview]	Pain Control
NCT01620047 (1) [back to overview]	Comparison of Postoperative Strength (Extension)
NCT01643616 (3) [back to overview]	Time Until Readiness for Surgery (Minutes)
NCT01643616 (3) [back to overview]	Success Rate Without Supplementation
NCT01643616 (3) [back to overview]	Success Rate With Supplementation
NCT01719237 (2) [back to overview]	Onset of Surgical Anesthesia
NCT01719237 (2) [back to overview]	Duration of Analgesia
NCT01782872 (4) [back to overview]	Duration of Analgesia From Interscalene Nerve Block
NCT01782872 (4) [back to overview]	Middle Deltoid
NCT01782872 (4) [back to overview]	Numeric Rating Scale (NRS) Pain Score With Movement
NCT01782872 (4) [back to overview]	Numeric Rating Scale (NRS) Pain Scores at Rest
NCT01816477 (3) [back to overview]	Hospital Length of Stay
NCT01816477 (3) [back to overview]	Use of Analgesic Narcotic
NCT01816477 (3) [back to overview]	Mean Daily Pain Score
NCT01866917 (2) [back to overview]	Postoperative Numeric Pain Rating Score (NPRS) 0-10 Scale; (0 is Equivalent to no Pain; 10 is Equivalent to the Worst Pain Imaginable)
NCT01866917 (2) [back to overview]	Postoperative Numeric Pain Score (NPS) 0-10 Scale; (0 is Equivalent to no Pain; 10 is Equivalent to the Worst Pain Imaginable)
NCT01898689 (3) [back to overview]	Maximum Tolerance to Transcutaneous Electrical Stimulation
NCT01898689 (3) [back to overview]	Maximum Tolerance to Transcutaneous Electrical Stimulation
NCT01898689 (3) [back to overview]	Percent of Maximum Voluntary Isometric Contraction Baseline (Quadriceps Femoris)
NCT01966263 (3) [back to overview]	Timed Up and Go Test (TUG)
NCT01966263 (3) [back to overview]	Stair Climbing Task (SCT)
NCT01966263 (3) [back to overview]	Six Minute Walking Test (6MWT)
NCT01971645 (2) [back to overview]	Intra-operative and Post-operative Opioid Consumption
NCT01971645 (2) [back to overview]	Post-operative Pain Scores
NCT02000973 (4) [back to overview]	Mean Arterial Pressure
NCT02000973 (4) [back to overview]	Heart Rate
NCT02000973 (4) [back to overview]	Bispectral Index Score
NCT02000973 (4) [back to overview]	Propofol Effect-site Concentration
NCT02056288 (6) [back to overview]	Patient and Parent Satisfaction
NCT02056288 (6) [back to overview]	Opioid Consumption
NCT02056288 (6) [back to overview]	Incidence of Side Effects
NCT02056288 (6) [back to overview]	Time of First Analgesia Request
NCT02056288 (6) [back to overview]	Time of Achieving Discharge Readiness
NCT02056288 (6) [back to overview]	The Mean Pain Score in the Postoperative Period
NCT02059070 (4) [back to overview]	Ultrasonographic Evaluation of Diaphragmatic Excursion- Operative Side Sigh Test
NCT02059070 (4) [back to overview]	Forced Expiratory Volume at 1 Second (% Change From Baseline)
NCT02059070 (4) [back to overview]	Post-operative Oxycodone Use (mg)
NCT02059070 (4) [back to overview]	Highest Patient Pain Level
NCT02112370 (8) [back to overview]	Maximum of Measured Systolic Blood Pressures
NCT02112370 (8) [back to overview]	NRS Pain Scores for the First 12 Hours
NCT02112370 (8) [back to overview]	Pain Killer Dose
NCT02112370 (8) [back to overview]	Operation Time
NCT02112370 (8) [back to overview]	Maximum of Measured Heart Rates
NCT02112370 (8) [back to overview]	Maximum of Measured Diastolic Blood Pressures
NCT02112370 (8) [back to overview]	Blood Loss Amount
NCT02112370 (8) [back to overview]	NRS Change
NCT02139982 (6) [back to overview]	Changes in Skin Temperature From Baseline to 30min After Brachial Plexus Block(Phase 2)
NCT02139982 (6) [back to overview]	Changes in Hemodynamic Parameters of Brachial Artery From Baseline to 30min After Brachial Plexus Block(Phase 2)
NCT02139982 (6) [back to overview]	Changes in Skin Temperature From Baseline to 30 Min After Specific Nerve Block Followed by 30 Min After Brachial Plexus Block(Phase 1)
NCT02139982 (6) [back to overview]	Changes in Hemodynamic Parameters of Radial/Ulnar Artery From Baseline to 30min After Specific Nerve Block Followed by 30min After Brachial Plexus Block(Phase 1)
NCT02139982 (6) [back to overview]	Changes in Cross-sectional Area of Radial/Ulnar Artery From Baseline to 30min After Specific Nerve Block Followed by 30min After Brachial Plexus Block(Phase 1)
NCT02139982 (6) [back to overview]	Success of Brachial Plexus Block ( Phase 2)
NCT02151487 (2) [back to overview]	Duration of the Sensorial Supraclavicular Block
NCT02151487 (2) [back to overview]	Postoperative Analgesia
NCT02154048 (1) [back to overview]	Time to First Analgesic Dose
NCT02154763 (54) [back to overview]	24-48 h Postoperative Tylenol Consumption
NCT02154763 (54) [back to overview]	24-48 h Postoperative Tramadol Consumption
NCT02154763 (54) [back to overview]	24-48 h Postoperative Ketorolac Consumption
NCT02154763 (54) [back to overview]	24-48 h Postoperative Dilaudid Consumption
NCT02154763 (54) [back to overview]	24-32 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	20h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	20-24 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	2-4 h Postoperative Tylenol Consumption
NCT02154763 (54) [back to overview]	2-4 h Postoperative Tramadol Consumption
NCT02154763 (54) [back to overview]	2-4 h Postoperative Ketorolac Consumption
NCT02154763 (54) [back to overview]	2-4 h Postoperative Fentanyl Consumption
NCT02154763 (54) [back to overview]	2-4 h Postoperative Dilaudid Consumption
NCT02154763 (54) [back to overview]	1h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	24h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	2h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	32-40 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	32h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	4-12 h Postoperative Dilaudid Consumption
NCT02154763 (54) [back to overview]	4-12 h Postoperative Ketorolac Consumption
NCT02154763 (54) [back to overview]	4-12 h Postoperative Tylenol Consumption
NCT02154763 (54) [back to overview]	4-8 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	2-4 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	16h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	16-20 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	12h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	12-24 h Postoperative Tylenol Consumption
NCT02154763 (54) [back to overview]	12-24 h Postoperative Tramadol Consumption
NCT02154763 (54) [back to overview]	40-48 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	12-24 h Postoperative Ketorolac Consumption
NCT02154763 (54) [back to overview]	12-24 h Postoperative Dilaudid Consumption
NCT02154763 (54) [back to overview]	12-16 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	1-2 h Postoperative Tylenol Consumption
NCT02154763 (54) [back to overview]	40h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	48h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	4h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	6 Minute Walking Distance Post Operative Day 1 (POD1)
NCT02154763 (54) [back to overview]	6 Minute Walking Distance Post Operative Day 2 (POD2)
NCT02154763 (54) [back to overview]	6 Minute Walking Distance Post Operative Day 7-10 (POD 7-10)
NCT02154763 (54) [back to overview]	8-12 Hours Post Operative Pain Level
NCT02154763 (54) [back to overview]	4-12 h Postoperative Tramadol Consumption
NCT02154763 (54) [back to overview]	Postoperative Day 1 Quality of Recovery Questionnaire (QR-40)
NCT02154763 (54) [back to overview]	Postoperative Day 7-10 Quality of Recovery Questionnaire (QR-40)
NCT02154763 (54) [back to overview]	1-2 h Postoperative Tramadol Consumption
NCT02154763 (54) [back to overview]	1-2 h Postoperative Pain Level
NCT02154763 (54) [back to overview]	1-2 h Postoperative Ketorolac Consumption
NCT02154763 (54) [back to overview]	1-2 h Postoperative Fentanyl Consumption
NCT02154763 (54) [back to overview]	1-2 h Postoperative Dilaudid Consumption
NCT02154763 (54) [back to overview]	8h Peak Expiratory Flow (PEF) Score
NCT02154763 (54) [back to overview]	0-1 h Postoperative Tramadol Consumption
NCT02154763 (54) [back to overview]	0-1 h Postoperative Pain Level
NCT02154763 (54) [back to overview]	0-1 h Postoperative Ketorolac Consumption
NCT02154763 (54) [back to overview]	0-1 h Postoperative Fentanyl Consumption
NCT02154763 (54) [back to overview]	0-1 h Postoperative Dilaudid Consumption
NCT02154763 (54) [back to overview]	0-1 h Postoperative Tylenol Consumption
NCT02161705 (1) [back to overview]	Postoperative Static Pain Score
NCT02164929 (8) [back to overview]	Pain Scores
NCT02164929 (8) [back to overview]	Opioid Related Side Effects
NCT02164929 (8) [back to overview]	Length of Stay
NCT02164929 (8) [back to overview]	Time to First Ingestion of Solid Food
NCT02164929 (8) [back to overview]	Time to First Bowel Movement
NCT02164929 (8) [back to overview]	Quality of Recovery
NCT02164929 (8) [back to overview]	Postoperative Opioid Consumption
NCT02164929 (8) [back to overview]	Number of Epidural-related Side Effects
NCT02181296 (4) [back to overview]	Percentage Change in Forced Expired Volume in First Second (FEV1) After the Block
NCT02181296 (4) [back to overview]	Percentage Change of Forced Vital Capacity (FVC) From Pre-block Value to Value Measures in PACU
NCT02181296 (4) [back to overview]	Number of Patients With Paradoxical Diaphragmatic Movement
NCT02181296 (4) [back to overview]	Opioid Requirements for 72 Hours After Surgery
NCT02182999 (5) [back to overview]	Average Postoperative Numeric Rating Scale (NRS) for Pain
NCT02182999 (5) [back to overview]	Peak Postoperative Numeric Rating Scale (NRS) for Pain
NCT02182999 (5) [back to overview]	American Orthopaedic Foot and Ankle Society Score (AOFAS)
NCT02182999 (5) [back to overview]	Patient's Overall Satisfaction With Surgery
NCT02182999 (5) [back to overview]	Patient's Overall Satisfaction With Pain Management
NCT02197273 (3) [back to overview]	Time to Post-operative Rescue Opioids (Hours)
NCT02197273 (3) [back to overview]	Readmission or Emergency Department (ED) Visit Due to Pain Control Within 30 Days
NCT02197273 (3) [back to overview]	Length of Stay in Hospital (Days)
NCT02201784 (5) [back to overview]	Onset of Sensory Block at T10
NCT02201784 (5) [back to overview]	Duration of Motor Block
NCT02201784 (5) [back to overview]	Duration of Analgesia
NCT02201784 (5) [back to overview]	Onset of Motor Block to Bromage3
NCT02201784 (5) [back to overview]	Time to Maximum Cephalic Spread of Sensory Block
NCT02223364 (15) [back to overview]	Balance Testing on Operative Leg Using Unipedal Stance Time
NCT02223364 (15) [back to overview]	POD 2 Opioid Use
NCT02223364 (15) [back to overview]	POD 1 Opioid Use
NCT02223364 (15) [back to overview]	POD 0 Post-PACU Opioid Use
NCT02223364 (15) [back to overview]	PACU Opioid Use
NCT02223364 (15) [back to overview]	Maximum Pain Post-PACU
NCT02223364 (15) [back to overview]	Maximum Pain POD 2 (24 Hours)
NCT02223364 (15) [back to overview]	Maximum Pain POD 1 (24 Hours)
NCT02223364 (15) [back to overview]	Intraoperative Opioid Use
NCT02223364 (15) [back to overview]	Hospital Length of Stay
NCT02223364 (15) [back to overview]	Average Pain Post-Postanesthesia Care Unit (PACU)
NCT02223364 (15) [back to overview]	Average Pain POD 2 (24 Hours)
NCT02223364 (15) [back to overview]	Preoperative Daily Opioid Use
NCT02223364 (15) [back to overview]	Average Pain POD 1 (24 Hours)
NCT02223364 (15) [back to overview]	Maximum Pain Post-Operative Day (POD) 1 (Morning)
NCT02236130 (2) [back to overview]	Patient/Family Satisfaction With Pain Management
NCT02236130 (2) [back to overview]	Total Hydrocodone Dose (mg/kg)
NCT02242201 (9) [back to overview]	Total Opioid Consumption During Hospitalization
NCT02242201 (9) [back to overview]	Change in Short Form-36 (SF-36) Quality of Life Physical Component
NCT02242201 (9) [back to overview]	Post-Operative Pain Score
NCT02242201 (9) [back to overview]	Change in Short Form-36 (SF-36) Quality of Life Mental Component
NCT02242201 (9) [back to overview]	Hospital Length of Stay
NCT02242201 (9) [back to overview]	Number of Participants Reporting Complications Since Surgery
NCT02242201 (9) [back to overview]	Number of Participants Reporting a NRS Pain Score Greater Than 3
NCT02242201 (9) [back to overview]	Change in Unipedal Stance Time
NCT02242201 (9) [back to overview]	Maximum Postoperative Pain Score
NCT02264821 (2) [back to overview]	Morphine Consumption
NCT02264821 (2) [back to overview]	Duration of Effective Analgesia
NCT02270255 (2) [back to overview]	Number of Patients With Serious Adverse Reactions From Superior Hypogastric Nerve Block
NCT02270255 (2) [back to overview]	mg Equivalent Morphine Used Until Discharge From Recovery Room to Control Pain Level Below 4/10 (VAS)
NCT02314104 (5) [back to overview]	Postoperative Pain on a Visual Analogue Pain Scale at One Hour Postoperatively
NCT02314104 (5) [back to overview]	Postoperative Pain on a Visual Analogue Pain Scale at Six Hours Postoperatively
NCT02314104 (5) [back to overview]	Postoperative Pain on a Visual Analogue Pain Scale at Twenty-four Hours Postoperatively
NCT02314104 (5) [back to overview]	Time Until First Request for Pain Medication
NCT02314104 (5) [back to overview]	Total Narcotic Usage in Morphine Equivalents
NCT02336958 (2) [back to overview]	Amount (ml) of Local Anesthetic Supplemented by Surgeon
NCT02336958 (2) [back to overview]	Number of Patients With Required Supplementation of Local Anesthetic by Surgeon
NCT02341144 (5) [back to overview]	PACU Length of Stay (LOS)
NCT02341144 (5) [back to overview]	PACU Morphine Equivalents
NCT02341144 (5) [back to overview]	Time to First Narcotic
NCT02341144 (5) [back to overview]	Pain Score of Zero
NCT02341144 (5) [back to overview]	Post Operative Pain Rating
NCT02385097 (14) [back to overview]	Neurological Symptoms
NCT02385097 (14) [back to overview]	Time to Regression of Motor Block
NCT02385097 (14) [back to overview]	Time to Regression of Sensory Block
NCT02385097 (14) [back to overview]	Blood Pressure
NCT02385097 (14) [back to overview]	Heart Rate
NCT02385097 (14) [back to overview]	SpO2
NCT02385097 (14) [back to overview]	Time to Onset of Motor Block
NCT02385097 (14) [back to overview]	Percentage of Participants With Successful Block for Distal Upper Limb Surgeries
NCT02385097 (14) [back to overview]	Partecipants Received Rescue Anaesthesia or Rescue Analgesia
NCT02385097 (14) [back to overview]	Number of Subjects Who Received Post-operative Analgesia
NCT02385097 (14) [back to overview]	Number of Participants With Normal Electrocardiogram (ECG) Parameters
NCT02385097 (14) [back to overview]	Number of Participants With Treatment-emergent Adverse Events (TEAEs)
NCT02385097 (14) [back to overview]	Time to Onset of Sensory Block (Corresponding to Readiness for Surgery)
NCT02385097 (14) [back to overview]	Time to Eligibility for Home Discharge
NCT02393677 (1) [back to overview]	Duration of Analgesia
NCT02424630 (2) [back to overview]	Patient Satisfaction (SAT) Score
NCT02424630 (2) [back to overview]	Visual Analog Scale (VAS) Pain Score
NCT02439281 (7) [back to overview]	Complications Rate
NCT02439281 (7) [back to overview]	Duration of Analgesia at Umbilicus Instrument Site-How Many Minutes Passed From the Time When the Blocks Where Performed Until Patient Reported Pain at Umbilicus
NCT02439281 (7) [back to overview]	Duration of Sensory Block (Paresthesia)
NCT02439281 (7) [back to overview]	Medication Consumption
NCT02439281 (7) [back to overview]	Satisfaction With Pain Control From Patient
NCT02439281 (7) [back to overview]	Average Pain Severity at the Umbilicus Laparoscopic Site
NCT02439281 (7) [back to overview]	Change in Anxiety Scores
NCT02462382 (4) [back to overview]	Oxycodone Consumption
NCT02462382 (4) [back to overview]	Oxycodone Consumption After the First Two Postoperative Days.
NCT02462382 (4) [back to overview]	Mean Visual Analog Scale
NCT02462382 (4) [back to overview]	Mean Visual Analog Scale Score
NCT02472522 (13) [back to overview]	Duration of Sensory Loss at T10 Level
NCT02472522 (13) [back to overview]	Percentage of Patients Needing Rescue Analgesic
NCT02472522 (13) [back to overview]	Visual Analogue Scale on Coughing (VAS-C)
NCT02472522 (13) [back to overview]	Short Assessment of Patient Satisfaction Score (SAPS)
NCT02472522 (13) [back to overview]	The Time After the TAP Block When Rescue Analgesia Was First Sought
NCT02472522 (13) [back to overview]	Time to Complete Disappearance of Motor Block
NCT02472522 (13) [back to overview]	Total Dose of Required Morphine in 24 Hours Postoperatively
NCT02472522 (13) [back to overview]	Visual Analogue Scale at Rest (VAS-R)
NCT02472522 (13) [back to overview]	Mean Arterial Pressure (MAP): Postoperative Period
NCT02472522 (13) [back to overview]	Mean Arterial Pressure (MAP): Intraoperative Period
NCT02472522 (13) [back to overview]	Heart Rate: Postoperative
NCT02472522 (13) [back to overview]	Heart Rate: Intraoperative Period
NCT02472522 (13) [back to overview]	Adverse Effects Like Pruritus, Nausea and Vomiting
NCT02478372 (9) [back to overview]	Verbal Rating Score (VRS) Pain Scores
NCT02478372 (9) [back to overview]	Patient Reported Outcome Measure - Oxford Knee Score
NCT02478372 (9) [back to overview]	Average Post-operative Length of Stay
NCT02478372 (9) [back to overview]	Maximal Flexion Angle of the Operative Knee at Discharge From Rehabilitation
NCT02478372 (9) [back to overview]	Post-operative Nausea and Vomiting Scores
NCT02478372 (9) [back to overview]	Post-operative Urinary Catheterisation Rates
NCT02478372 (9) [back to overview]	Proportion of Patients Discharged From Rehabilitation by Day Four
NCT02478372 (9) [back to overview]	Day of Ambulation
NCT02478372 (9) [back to overview]	Total Number of Reported Participants With Complications and/or Adverse Events
NCT02494336 (7) [back to overview]	Use of Post-operative Intravenous/Oral Opioid and Non-opioid
NCT02494336 (7) [back to overview]	Number of Participants With Complications
NCT02494336 (7) [back to overview]	Number of Participants With Side Effects
NCT02494336 (7) [back to overview]	Operative Time
NCT02494336 (7) [back to overview]	Post Operative Pain Rating
NCT02494336 (7) [back to overview]	Time to First Rescue Analgesic
NCT02494336 (7) [back to overview]	Total Number of Complications
NCT02499575 (3) [back to overview]	Opioid Use as Measured by Questionnaire
NCT02499575 (3) [back to overview]	Total Opioid Use as Measured by Questionnaire
NCT02499575 (3) [back to overview]	Pain Relief Measured by Defense and Veterans Pain Scale
NCT02501135 (7) [back to overview]	Post-operative Pain Scale Using VAS
NCT02501135 (7) [back to overview]	Time to Discharge From PACU
NCT02501135 (7) [back to overview]	Concentration of Local Anesthetic Injected for Femoral Nerve Block
NCT02501135 (7) [back to overview]	Intraoperative Tylenol Administered
NCT02501135 (7) [back to overview]	Total mg of Local Anesthetic Injected for Femoral Nerve Block
NCT02501135 (7) [back to overview]	Post-operative Pain Scale Using FLACC
NCT02501135 (7) [back to overview]	Post-operative Opioids Administered
NCT02502487 (21) [back to overview]	Visual Analog Scale (VAS) for Pain
NCT02502487 (21) [back to overview]	Heart Rate at Cystoscopic Inspection of External Sphincter
NCT02502487 (21) [back to overview]	Heart Rate After Withdrawal of Cystoscope
NCT02502487 (21) [back to overview]	Breath Rate After Withdrawal of Cystoscope
NCT02502487 (21) [back to overview]	Breath Rate at Cystoscopic Inspection of External Sphincter
NCT02502487 (21) [back to overview]	Breath Rate at Cystoscopic Inspection of Penile and Bulbar Urthra
NCT02502487 (21) [back to overview]	Breath Rate Before Gel Administration
NCT02502487 (21) [back to overview]	Visual Analog Scale (VAS) for Pain
NCT02502487 (21) [back to overview]	Visual Analog Scale (VAS) for Pain
NCT02502487 (21) [back to overview]	Visual Analog Scale (VAS) for Pain
NCT02502487 (21) [back to overview]	Visual Analog Scale (VAS) for Pain
NCT02502487 (21) [back to overview]	Oxygen Saturation by Pulse Before Gel Administration
NCT02502487 (21) [back to overview]	Oxygen Saturation by Pulse at Cystoscopic Inspection of Penile and Bulbar Urthra
NCT02502487 (21) [back to overview]	Oxygen Saturation by Pulse at Cystoscopic Inspection of External Sphincter
NCT02502487 (21) [back to overview]	Oxygen Saturation by Pulse After Withdrawal of Cystoscope
NCT02502487 (21) [back to overview]	Mean Arterial Pressure Before Gel Administration
NCT02502487 (21) [back to overview]	Mean Arterial Pressure at Cystoscopic Inspection of Penile and Bulbar Urthra
NCT02502487 (21) [back to overview]	Mean Arterial Pressure at Cystoscopic Inspection of External Sphincter
NCT02502487 (21) [back to overview]	Mean Arterial Pressure After Withdrawal of Cystoscope
NCT02502487 (21) [back to overview]	Heart Rate Before Gel Administration
NCT02502487 (21) [back to overview]	Heart Rate at Cystoscopic Inspection of Penile and Bulbar Urthra
NCT02523235 (8) [back to overview]	Pain (Average): Numeric Rating Scale for Pain
NCT02523235 (8) [back to overview]	Pain (Worst) :Numeric Rating Scale for Pain
NCT02523235 (8) [back to overview]	Pain During Afternoon Physical Therapy Session
NCT02523235 (8) [back to overview]	Toe/Foot Numbness (Insensate) :0-10 Scale
NCT02523235 (8) [back to overview]	Total Local Anesthetic Infused (Adductor Only) : mL
NCT02523235 (8) [back to overview]	Ambulation: Distance in Meters
NCT02523235 (8) [back to overview]	Analgesic Use: IV Morphine Equivalents
NCT02523235 (8) [back to overview]	Number of Participants That Had Fluid Leakage Reported at Catheter Site.
NCT02543801 (3) [back to overview]	Length of Stay
NCT02543801 (3) [back to overview]	Narcotic Consumption
NCT02543801 (3) [back to overview]	Pain Score
NCT02570022 (2) [back to overview]	Pain Levels
NCT02570022 (2) [back to overview]	Morphine Equivalents
NCT02570503 (1) [back to overview]	Narcotic Use During Hospitalization
NCT02571439 (10) [back to overview]	Itching.
NCT02571439 (10) [back to overview]	Number of Participants With Postoperative Nausea/Vomiting
NCT02571439 (10) [back to overview]	Sedation
NCT02571439 (10) [back to overview]	Severity of Postoperative Pain at Rest
NCT02571439 (10) [back to overview]	Severity of Postoperative Pain at Rest
NCT02571439 (10) [back to overview]	Severity of Postoperative Pain at Rest
NCT02571439 (10) [back to overview]	Total Narcotic Consumption
NCT02571439 (10) [back to overview]	Time Taken to Perform the Block
NCT02571439 (10) [back to overview]	Time From Delivery of Neonate to Ready to Exit Operating Room
NCT02571439 (10) [back to overview]	Severity of Postoperative Pain at Rest
NCT02576249 (3) [back to overview]	Tegner Activity Level Scale
NCT02576249 (3) [back to overview]	The Knee Osteoarthritis Outcome Score (KOOS) Pain Subscale
NCT02576249 (3) [back to overview]	Pain Scale Score
NCT02579629 (14) [back to overview]	Amount of Opioid Use
NCT02579629 (14) [back to overview]	Change in Intensity of Pain: VAPS From Baseline
NCT02579629 (14) [back to overview]	Change in Time From Baseline to First Dose of Rescue Medications
NCT02579629 (14) [back to overview]	Change in McGill Pain Questionnaire Score From Baseline
NCT02579629 (14) [back to overview]	Change in Pain Scores at Rest From Baseline
NCT02579629 (14) [back to overview]	Patient Satisfaction at 72 Hours Post Intervention
NCT02579629 (14) [back to overview]	Cost Analysis
NCT02579629 (14) [back to overview]	Change in Intensity of Pain: Numerical Pain Scale (NPS) From Baseline
NCT02579629 (14) [back to overview]	Breastfeeding Success
NCT02579629 (14) [back to overview]	Number of Patients With Wound Dysesthesia, Infection, Dehiscence and Keloid Formation at 6 Weeks and 3 Months Post-intervention
NCT02579629 (14) [back to overview]	Number of Participants With Catheter or Infiltrate-related Issues at 24, 48 and 72 Hours Post-intervention
NCT02579629 (14) [back to overview]	Dosing Amount of Non-steroidal Anti-inflammatory Drugs
NCT02579629 (14) [back to overview]	Change in Pain Scores During Cough From Baseline
NCT02579629 (14) [back to overview]	Change in Pain Scores During 20°Straight Leg Raise
NCT02584452 (4) [back to overview]	Quadriceps Strength of on POD 1 of Preoperative Femoral Nerve Block Plus Postoperative Continuous Adductor Canal Nerve Catheter Compared to Preoperative Femoral Nerve Block Plus Postoperative Saphenous Nerve Block at 48 Hours After Discharge From PACU
NCT02584452 (4) [back to overview]	Subjective Postoperative Pain Score at Post Operative Week 6 of Preoperative Femoral Nerve Block Plus Postoperative Continuous Adductor Canal Nerve Catheter Compared to Preoperative Femoral Nerve Block Plus Postoperative Saphenous Nerve Block
NCT02584452 (4) [back to overview]	Total Postop Opioid Consumption of Patients Receiving (1) Preoperative Femoral Nerve Block Plus Postoperative Continuous Adductor Canal Nerve Catheter Compared to (2) Preoperative Femoral Nerve Block Plus Postoperative Saphenous Nerve Block.
NCT02584452 (4) [back to overview]	Quadriceps Strength on POD Week 6- Pts Receiving (1) Long-acting Single Bolus Adductor Canal Nerve Block Comparied to (2) Continuous Adductor Canal Nerve Catheter.
NCT02604550 (10) [back to overview]	"Percent of Patients Rating Their Satisfaction as Excellent or Good"
NCT02604550 (10) [back to overview]	Patient-Reported Vomiting
NCT02604550 (10) [back to overview]	Pain Score
NCT02604550 (10) [back to overview]	Number of Percocet Tablets Consumed
NCT02604550 (10) [back to overview]	Total Hours of Sleep
NCT02604550 (10) [back to overview]	Time to Straight Less Raise
NCT02604550 (10) [back to overview]	Patient-Reported Sedation
NCT02604550 (10) [back to overview]	Patient-Reported Nausea
NCT02604550 (10) [back to overview]	Patient-Reported Itching
NCT02604550 (10) [back to overview]	Patient-Reported Constipation
NCT02652156 (7) [back to overview]	Patient Reported Pain by VAS Scale
NCT02652156 (7) [back to overview]	Patient Reported Pain by VAS Scale
NCT02652156 (7) [back to overview]	Patient Reported Pain by VAS Scale
NCT02652156 (7) [back to overview]	Postoperative Vomiting (Events)
NCT02652156 (7) [back to overview]	Total Dosage of Narcotic
NCT02652156 (7) [back to overview]	Number of Days Required for a Patient to Walk Unassisted
NCT02652156 (7) [back to overview]	Number of Days Required for a Patient to Get Out of Bed
NCT02653144 (4) [back to overview]	Opioid Requirements (Morphine Equivalents)
NCT02653144 (4) [back to overview]	Opioid Requirements (Morphine Equivalents)
NCT02653144 (4) [back to overview]	Time to Discharge From PACU to First Opioid Consumption
NCT02653144 (4) [back to overview]	Return of Motor and Sensory Function
NCT02658149 (5) [back to overview]	Opioid Usage In-hospital at 24 Hours
NCT02658149 (5) [back to overview]	Pain Score at 3-24 Hours
NCT02658149 (5) [back to overview]	Pain Score at 3 Hours
NCT02658149 (5) [back to overview]	Pain Score at 24-48 Hours
NCT02658149 (5) [back to overview]	Opioid Usage In-hospital at 48 Hours
NCT02658240 (4) [back to overview]	Postoperative Pain Score With Movement
NCT02658240 (4) [back to overview]	Postoperative Pain Score at Resting
NCT02658240 (4) [back to overview]	The Time to Ambulation
NCT02658240 (4) [back to overview]	Oral Morphine Equivalents of Postoperative Opioid Requirements for 48 Hours
NCT02701296 (6) [back to overview]	Sensation in the Peroneal Nerve Distribution
NCT02701296 (6) [back to overview]	Plantar Flexion in the Tibial Nerve Distribution
NCT02701296 (6) [back to overview]	Pain Intensity
NCT02701296 (6) [back to overview]	Cold Sensation in the Tibial Nerve Distribution
NCT02701296 (6) [back to overview]	Dorsiflexion in the Peroneal Nerve Distribution
NCT02701296 (6) [back to overview]	Opioid Consumption
NCT02726620 (43) [back to overview]	Usage Frequency of Cardiovascular Drugs: Ephedrine
NCT02726620 (43) [back to overview]	Usage Frequency of Cardiovascular Drugs: Ephinephrine
NCT02726620 (43) [back to overview]	In-hospital Mortality
NCT02726620 (43) [back to overview]	Estimated Intraoperative Blood Loss
NCT02726620 (43) [back to overview]	Depth and Duration of Intraoperative Hypotension - Threshold MAP 75 mmHg
NCT02726620 (43) [back to overview]	Depth and Duration of Intraoperative Hypotension - Threshold MAP 70 mmHg
NCT02726620 (43) [back to overview]	Depth and Duration of Intraoperative Hypotension - Threshold MAP 65 mmHg
NCT02726620 (43) [back to overview]	Depth and Duration of Intraoperative Hypotension - Threshold MAP 60 mmHg
NCT02726620 (43) [back to overview]	Depth and Duration of Intraoperative Hypotension - Threshold MAP 55 mmHg
NCT02726620 (43) [back to overview]	Incidence of a MAP < 50 mmHg
NCT02726620 (43) [back to overview]	Depth and Duration of Intraoperative Hypotension - Threshold MAP 50 mmHg
NCT02726620 (43) [back to overview]	Average Use of Cardiovascular Drugs: Phenylephrine
NCT02726620 (43) [back to overview]	Average Use of Cardiovascular Drugs: Norepinephrine
NCT02726620 (43) [back to overview]	Incidence of a MAP < 55 mmHg for > 20 Minutes
NCT02726620 (43) [back to overview]	Incidence of a MAP < 60 mmHg
NCT02726620 (43) [back to overview]	Incidence of a MAP < 60 mmHg for > 10 Minutes
NCT02726620 (43) [back to overview]	Incidence of a MAP < 60 mmHg for > 20 Minutes
NCT02726620 (43) [back to overview]	Intraoperative Administration of Intravenous Fluids
NCT02726620 (43) [back to overview]	Intravenous Anesthetic Drug Use During Intraoperative Hypotension: MAP < 50 mmHg
NCT02726620 (43) [back to overview]	Average Use of Cardiovascular Drugs: Glycopyrrolate
NCT02726620 (43) [back to overview]	Average Use of Cardiovascular Drugs: Epinephrine
NCT02726620 (43) [back to overview]	Inhaled Anesthetic Drug Use During Intraoperative Hypotension: MAP < 65 mmHg
NCT02726620 (43) [back to overview]	Inhaled Anesthetic Drug Use During Intraoperative Hypotension: MAP < 60 mmHg
NCT02726620 (43) [back to overview]	Inhaled Anesthetic Drug Use During Intraoperative Hypotension: MAP < 55 mmHg
NCT02726620 (43) [back to overview]	Intravenous Anesthetic Drug Use During Intraoperative Hypotension: MAP < 60 mmHg
NCT02726620 (43) [back to overview]	Intravenous Anesthetic Drug Use During Intraoperative Hypotension: MAP < 55 mmHg
NCT02726620 (43) [back to overview]	Inhaled Anesthetic Drug Use During Intraoperative Hypotension: MAP < 50 mmHg
NCT02726620 (43) [back to overview]	Usage Frequency of Cardiovascular Drugs: Phenylephrine
NCT02726620 (43) [back to overview]	Usage Frequency of Cardiovascular Drugs: Norepinephrine
NCT02726620 (43) [back to overview]	Usage Frequency of Cardiovascular Drugs: Glycopyrrolate
NCT02726620 (43) [back to overview]	Incidence of a MAP < 55 mmHg for > 10 Minutes
NCT02726620 (43) [back to overview]	Incidence of a MAP < 55 mmHg
NCT02726620 (43) [back to overview]	Incidence of a MAP < 50 mmHg for > 20 Minutes
NCT02726620 (43) [back to overview]	Incidence of a MAP < 50 mmHg for > 10 Minutes
NCT02726620 (43) [back to overview]	30-day Mortality
NCT02726620 (43) [back to overview]	Average Use of Cardiovascular Drugs: Ephedrine
NCT02726620 (43) [back to overview]	Time to Discharge Readiness at the Postanesthesia Care Unit (PACU)
NCT02726620 (43) [back to overview]	Timing of Cardiovascular Drugs for MAP < 50 mmHg
NCT02726620 (43) [back to overview]	Timing of Cardiovascular Drugs for MAP < 55 mmHg
NCT02726620 (43) [back to overview]	Timing of Cardiovascular Drugs for MAP < 60 mmHg
NCT02726620 (43) [back to overview]	Timing of Cardiovascular Drugs for MAP < 65 mmHg
NCT02726620 (43) [back to overview]	Intravenous Anesthetic Drug Use During Intraoperative Hypotension: MAP < 65 mmHg
NCT02726620 (43) [back to overview]	Postoperative Rise in Creatinine Levels
NCT02740127 (3) [back to overview]	Length of Hospital Stay
NCT02740127 (3) [back to overview]	Post-Operative Pain Medication Usage in Post Anesthesia Care Unit (PACU)
NCT02740127 (3) [back to overview]	Post-operative Pain the First 24hrs
NCT02788019 (1) [back to overview]	Number of Grid Points With Change of Sensation to Pinprick After Blockade
NCT02793947 (3) [back to overview]	Visual Analog Scale Pain Assessment
NCT02793947 (3) [back to overview]	Number of Participants With Medication-related Side Effects
NCT02793947 (3) [back to overview]	Total Narcotic Consumption
NCT02798835 (10) [back to overview]	Length of Stay
NCT02798835 (10) [back to overview]	Pain Score
NCT02798835 (10) [back to overview]	Time to First Use of PCA
NCT02798835 (10) [back to overview]	Cumulative 48 Hour Oral Morphine Equivalent Consumption
NCT02798835 (10) [back to overview]	Cumulative 24 Hour Oral Morphine Equivalent Consumption
NCT02798835 (10) [back to overview]	Nerve Block Complications
NCT02798835 (10) [back to overview]	Quality of Recovery (QoR-40)
NCT02798835 (10) [back to overview]	Cumulative 12 Hour Oral Morphine Equivalent Consumption
NCT02798835 (10) [back to overview]	Adductor Canal Block Complications
NCT02798835 (10) [back to overview]	Incidence of Participants With Nausea/Vomiting Requiring Anti-emetics
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Nausea
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Nausea
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Nausea
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Pruritus
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Pruritus
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Vomiting
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Vomiting
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Vomiting
NCT02829944 (23) [back to overview]	Number of Subjects With Chronic Pain
NCT02829944 (23) [back to overview]	Number of Subjects With Chronic Pain
NCT02829944 (23) [back to overview]	Opioid Consumption
NCT02829944 (23) [back to overview]	Opioid Consumption
NCT02829944 (23) [back to overview]	Opioid Consumption
NCT02829944 (23) [back to overview]	Pain Score on Movement
NCT02829944 (23) [back to overview]	Pain Score on Movement (Sitting in Bed From a Supine Position)
NCT02829944 (23) [back to overview]	Pain Scores at Rest
NCT02829944 (23) [back to overview]	Pain Scores at Rest
NCT02829944 (23) [back to overview]	Pain Scores at Rest
NCT02829944 (23) [back to overview]	Patient Satisfaction With Postoperative Analgesia on a 0-10 Scale
NCT02829944 (23) [back to overview]	Postpartum Depression, as Measured by the Edinburgh Postnatal Depression Scale
NCT02829944 (23) [back to overview]	Postpartum Depression, as Measured by the Edinburgh Postnatal Depression Scale
NCT02829944 (23) [back to overview]	Time to First Rescue Analgesic
NCT02829944 (23) [back to overview]	Number of Subjects Experiencing Pruritus
NCT02849678 (7) [back to overview]	Postoperative Opioid Consumption (Milligrams of Dilaudid or Equivalent)
NCT02849678 (7) [back to overview]	Time to First Flatus/Defecation
NCT02849678 (7) [back to overview]	Number of Patients With Complications (Including But Not Limited to Pneumonia, Atelectasis, Hypotension, Motor Weakness, Etc.)
NCT02849678 (7) [back to overview]	Time to First Ambulation(Walking Greater Than 15 Feet)
NCT02849678 (7) [back to overview]	Consumption of Nerve Block Boluses Will Also be Recorded Daily
NCT02849678 (7) [back to overview]	Hospital Length of Stay.
NCT02849678 (7) [back to overview]	11-point Verbal Numerical Rating Scale (NRS) Pain Assessment
NCT02893423 (1) [back to overview]	POSTOPERATIVE PAIN
NCT02919072 (3) [back to overview]	Time to the Onset of Anaesthesia
NCT02919072 (3) [back to overview]	Time From T0 to Loss Light Touch Sensation
NCT02919072 (3) [back to overview]	Quality of the Block
NCT02924324 (1) [back to overview]	Number of Participants Requiring Post-procedural Opioid Analgesia Per Study Arm
NCT02933671 (5) [back to overview]	Numeric Pain Score at 4 Hours Postoperatively, as Measured by Numerical Rating Scale (NRS) 11
NCT02933671 (5) [back to overview]	Cumulative Opioid Consumption
NCT02933671 (5) [back to overview]	Numeric Pain Score at 24 Hours, as Measured by NRS 11
NCT02933671 (5) [back to overview]	Motor Strength, as Measured by Dynamometry
NCT02933671 (5) [back to overview]	Ambulation, as Measured by Distanced Walked
NCT02949271 (10) [back to overview]	Total Number of Subjects Experiencing Each Mode of Delivery
NCT02949271 (10) [back to overview]	Degree of Motor Blockade Measured as Lowest Recorded Modified Bromage Score
NCT02949271 (10) [back to overview]	Number of Subjects Who Were Satisfied With Procedure
NCT02949271 (10) [back to overview]	Maximum Reported Labor Pain Score
NCT02949271 (10) [back to overview]	Number of Patient Controlled Epidural Analgesia (PCEA) Attempts
NCT02949271 (10) [back to overview]	Number of Subjects Experiencing Hypotension Requiring Vasopressor Treatment
NCT02949271 (10) [back to overview]	Ratio of Patient Controlled Epidural Analgesia (PCEA) Successful Attempts to Unsuccessful Attempts
NCT02949271 (10) [back to overview]	Volume of Local Anesthetic Received Through Patient Controlled Epidural Analgesia (PCEA) Per Hour
NCT02949271 (10) [back to overview]	Volume of Local Anesthetic Required Per Hour
NCT02949271 (10) [back to overview]	Duration of Second Stage of Labor
NCT02949674 (1) [back to overview]	VAS
NCT02950558 (4) [back to overview]	Pain Score at 2 Weeks - Experimental Group vs. Control Group
NCT02950558 (4) [back to overview]	Pain Score at 3 Months - Experimental Group vs. Control Group
NCT02950558 (4) [back to overview]	Pain Score at 12 Months - Experimental Group vs. Control Group
NCT02950558 (4) [back to overview]	Pain Score at 6 Months - Experimental Group vs. Control Group
NCT02967172 (4) [back to overview]	Post-operative Length of Stay
NCT02967172 (4) [back to overview]	Patients Returning Home Following Surgery
NCT02967172 (4) [back to overview]	Opioid Use in First 24 Hours Post-surgery
NCT02967172 (4) [back to overview]	Change in Post-operative Visual Analog Pain Scores (VAS)
NCT03015532 (3) [back to overview]	Mean Area Under the Curve (AUC) of the NRS-R (Windowed Worst Observation Carried Forward) Pain Intensity Scores
NCT03015532 (3) [back to overview]	Mean Area Under the Curve (AUC) of the NRS-R (Windowed Worst Observation Carried Forward) Pain Intensity Scores
NCT03015532 (3) [back to overview]	Mean Total Postoperative Opioid Consumption (in Morphine Equivalents)
NCT03077919 (12) [back to overview]	Clinician Administered PTSD Score (CAPS-5) TSSS
NCT03077919 (12) [back to overview]	Current Medications
NCT03077919 (12) [back to overview]	Generalized Anxiety Disorder 7-item Survey (GAD-7)
NCT03077919 (12) [back to overview]	Kessler Psychiatric Distress Scale (K6)
NCT03077919 (12) [back to overview]	PTSD Checklist (PCL-5)
NCT03077919 (12) [back to overview]	PTSD Checklist Civilian (PCL-C)
NCT03077919 (12) [back to overview]	Short Pain Scale
NCT03077919 (12) [back to overview]	12 Item Short Form Survey (SF-12) of Mental Functioning
NCT03077919 (12) [back to overview]	The Patient Health Questionnaire (PHQ-9)
NCT03077919 (12) [back to overview]	12-item Short Form Survey (SF-12) of Physical Functioning
NCT03077919 (12) [back to overview]	Alcohol Use Disorders Identification Test (AUDIT/AUDIT-C)
NCT03077919 (12) [back to overview]	Mini-International Neuropsychiatric Interview (M.I.N.I.-Plus) Suicidality Items
NCT03080142 (1) [back to overview]	Mean Opioid Consumption in Morphine Opioid Equivalents in mg
NCT03086213 (6) [back to overview]	Comparing the Inflammatory Markers During the Operation After the Intervention of the Each Group
NCT03086213 (6) [back to overview]	Comparing the Hemodynamics of the Intervention of the Each Group During the Operation
NCT03086213 (6) [back to overview]	Comparing the Hemodynamics of the Intervention of the Each Group During the Operation
NCT03086213 (6) [back to overview]	Number of Participants With Puncture Related Complications
NCT03086213 (6) [back to overview]	Comparing the Blood Gas Analysis After the Intervention of the Each Group
NCT03086213 (6) [back to overview]	Concentration of Cortisol at Different Point During the Operation
NCT03098420 (3) [back to overview]	Average Pain Score
NCT03098420 (3) [back to overview]	Average Opioid Consumption
NCT03098420 (3) [back to overview]	First Post-Operative Opioid Administration
NCT03117140 (15) [back to overview]	Sensory Duration of Block
NCT03117140 (15) [back to overview]	Patient Reporting Vomiting at Home
NCT03117140 (15) [back to overview]	Block Set up Time
NCT03117140 (15) [back to overview]	Pain Score Reported by Patients at First Phone Call
NCT03117140 (15) [back to overview]	Surgical Length
NCT03117140 (15) [back to overview]	Surgical Position
NCT03117140 (15) [back to overview]	Motor Duration of Block
NCT03117140 (15) [back to overview]	Number of Patients With Blood Pressure (BP) Changes in the PACU
NCT03117140 (15) [back to overview]	Duration of Analgesia
NCT03117140 (15) [back to overview]	Number of Patients Reporting Itching at Home
NCT03117140 (15) [back to overview]	Number of Patient With Blood Pressure Changes in the Second Stage Recovery Area
NCT03117140 (15) [back to overview]	Number of Patients Reporting Itching in the PACU
NCT03117140 (15) [back to overview]	Number of Patients Reporting Nausea at Home
NCT03117140 (15) [back to overview]	Number of Patients Reporting Nausea in the PACU
NCT03117140 (15) [back to overview]	Number of Patients Vomiting in the PACU (Post-Anesthesia Care Unit)
NCT03133481 (12) [back to overview]	Mean Distance Ambulated at 48 Hours Post Operatively
NCT03133481 (12) [back to overview]	Mean Distance Ambulated at 24 Hours Post Operatively
NCT03133481 (12) [back to overview]	Mean Pain Scores at 24 Hours
NCT03133481 (12) [back to overview]	Mean Pain Scores 48 Hours Postoperatively
NCT03133481 (12) [back to overview]	Mean Opioid Consumption as Measured in Oral Morphine Milligram Equivalents
NCT03133481 (12) [back to overview]	Mean Opioid Consumption as Measured in Oral Morphine Milligram Equivalents
NCT03133481 (12) [back to overview]	Mean Opioid Consumption as Measured in Oral Morphine Equivalents
NCT03133481 (12) [back to overview]	Mean Opioid Consumption as Measured by Oral Morphine Milligram Equivalents
NCT03133481 (12) [back to overview]	Mean Hours to Discharge
NCT03133481 (12) [back to overview]	Patient Satisfaction at 48 Hours Post Operatively
NCT03133481 (12) [back to overview]	Mean Pain Scores in PACU
NCT03133481 (12) [back to overview]	Mean Pain Scores Immediately Preoperatively
NCT03154658 (7) [back to overview]	Maximum Post-operative Pain Score
NCT03154658 (7) [back to overview]	Length of Stay
NCT03154658 (7) [back to overview]	Block Performance Time
NCT03154658 (7) [back to overview]	Opioid Consumption
NCT03154658 (7) [back to overview]	Patient Satisfaction Scale
NCT03154658 (7) [back to overview]	Sleep Duration Night of Postoperative Day 0
NCT03154658 (7) [back to overview]	Number of Participants With Nausea/Vomiting
NCT03316378 (3) [back to overview]	Pain Psychology
NCT03316378 (3) [back to overview]	Central Sensitization
NCT03316378 (3) [back to overview]	Movement System
NCT03353233 (4) [back to overview]	Ambulation as Measured by Distance Walked After Surgery
NCT03353233 (4) [back to overview]	Cumulative Opioid Consumption
NCT03353233 (4) [back to overview]	Number of Participants Able to Hyperextend the Knee After Surgery
NCT03353233 (4) [back to overview]	Pain as Measure by Numerical Rating Scale (NRS) 11
NCT03435692 (6) [back to overview]	Hospital Length of Stay
NCT03435692 (6) [back to overview]	Itching
NCT03435692 (6) [back to overview]	Maximum Pain Score
NCT03435692 (6) [back to overview]	Total Perioperative Morphine Equivalents
NCT03435692 (6) [back to overview]	Muscle Spasm
NCT03435692 (6) [back to overview]	Nausea
NCT03591146 (1) [back to overview]	Safety and Tolerability: Event of SAE and Treatment-related Severe AE
NCT03666663 (1) [back to overview]	Number of Participants With a Reduction in Headache Days From Baseline to Month 8 of Treatment
NCT03695172 (16) [back to overview]	Postoperative Pain Scores
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antiemetics
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antiemetics
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antiemetics
NCT03695172 (16) [back to overview]	Postoperative Pain Scores
NCT03695172 (16) [back to overview]	Postoperative Pain Scores
NCT03695172 (16) [back to overview]	Postoperative Opioid Consumption
NCT03695172 (16) [back to overview]	Postoperative Opioid Consumption
NCT03695172 (16) [back to overview]	Postoperative Opioid Consumption
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antipruritics
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antipruritics
NCT03695172 (16) [back to overview]	Postoperative Pain Scores
NCT03695172 (16) [back to overview]	Postoperative Opioid Consumption
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antipruritics
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antipruritics
NCT03695172 (16) [back to overview]	Number of Participants Requiring Antiemetics
NCT03704376 (17) [back to overview]	Number of Successful Repetitions With Straight Leg Raise Test
NCT03704376 (17) [back to overview]	Number of Successful Repetitions With Straight Leg Raise Test
NCT03704376 (17) [back to overview]	Number of Successful Repetitions With Straight Leg Raise Test
NCT03704376 (17) [back to overview]	Narcotics Use as Assessed by Morphine Equivalents Consumed
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Quadriceps Muscle Activation as Assessed by Surface Electromyography (sEMG)
NCT03704376 (17) [back to overview]	Quadriceps Muscle Activation as Assessed by Surface Electromyography (EMG)
NCT03704376 (17) [back to overview]	Quadriceps Muscle Activation as Assessed by Surface Electromyography (EMG)
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03704376 (17) [back to overview]	Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale
NCT03746951 (3) [back to overview]	Opioid Consumption in the PACU
NCT03746951 (3) [back to overview]	Post-op Pain Scores
NCT03746951 (3) [back to overview]	Total Time to Perform the Regional Anesthesia Technique
NCT03801265 (19) [back to overview]	Pain With Movement After Surgery
NCT03801265 (19) [back to overview]	Patients With Postoperative Quadriceps Weakness
NCT03801265 (19) [back to overview]	Postoperative Time to Accomplish Walking 100 Feet
NCT03801265 (19) [back to overview]	Total Acetaminophen Consumption During 24 Hours After Surgery
NCT03801265 (19) [back to overview]	Total Celecoxib Consumption During 24 Hours After Surgery
NCT03801265 (19) [back to overview]	Total Gabapentin Consumption During 24 Hours After Surgery
NCT03801265 (19) [back to overview]	Total Ketorolac Consumption During 24 Hours After Surgery
NCT03801265 (19) [back to overview]	Total Opioid Consumption During 24 Hours After Surgery
NCT03801265 (19) [back to overview]	Total Oral Ketamine Consumption During 24 Hours After Surgery
NCT03801265 (19) [back to overview]	Pain at Rest After Surgery
NCT03801265 (19) [back to overview]	Pain During Physical Therapy
NCT03801265 (19) [back to overview]	Pain With Movement After Surgery
NCT03801265 (19) [back to overview]	Pain With Movement After Surgery
NCT03801265 (19) [back to overview]	Block Procedure Duration
NCT03801265 (19) [back to overview]	Opioid Consumption During 0-6 Hours After Surgery
NCT03801265 (19) [back to overview]	Opioid Consumption During 12-24 Hours After Surgery
NCT03801265 (19) [back to overview]	Opioid Consumption During 6-12 Hours After Surgery
NCT03801265 (19) [back to overview]	Pain at Rest After Surgery
NCT03801265 (19) [back to overview]	Pain at Rest After Surgery
NCT03875274 (1) [back to overview]	Duration of Analgesia
NCT03936387 (2) [back to overview]	Number of Participants Who Completed a Successful Intervention With No Major Adverse Events
NCT03936387 (2) [back to overview]	Number of Participants Who Completed a Successful Intervention With a Full Data Set
NCT03977454 (4) [back to overview]	Brief Pain Inventory: Interference
NCT03977454 (4) [back to overview]	Length of Stay
NCT03977454 (4) [back to overview]	Daily Opioid Consumption
NCT03977454 (4) [back to overview]	Change in Pain Intensity While in Hospital
NCT03983941 (2) [back to overview]	Number of Opioid Doses Administered
NCT03983941 (2) [back to overview]	Average Post-operative Pain Score
NCT04005404 (3) [back to overview]	Success Rate (Conversion to General Anesthesia)
NCT04005404 (3) [back to overview]	Success Rate (Supplemental Medication)
NCT04005404 (3) [back to overview]	Circulation Stability
NCT04051684 (4) [back to overview]	Post Operative Opioid Usage
NCT04051684 (4) [back to overview]	Nausea: The Number of Participants Experiencing Nausea Will be Assessed by Chart Review
NCT04051684 (4) [back to overview]	Pain Score Assessed With Visual Analog Score (VAS)
NCT04051684 (4) [back to overview]	Vomiting: The Number of Participants Experiencing Vomiting Will be Assessed by Chart Review
NCT04080739 (2) [back to overview]	Opioid Medication Use
NCT04080739 (2) [back to overview]	Opioid Utilization Measured in Oral Morphine Equivalent (OME)
NCT04208516 (17) [back to overview]	Local Anesthetic Consumption After Surgery
NCT04208516 (17) [back to overview]	Serum Lidocaine Level
NCT04208516 (17) [back to overview]	Serum Lidocaine Level
NCT04208516 (17) [back to overview]	Total Hospital Length of Stay
NCT04208516 (17) [back to overview]	Pain After Surgery
NCT04208516 (17) [back to overview]	Pain After Surgery
NCT04208516 (17) [back to overview]	Local Anesthetic Consumption After Surgery
NCT04208516 (17) [back to overview]	Pain After Surgery
NCT04208516 (17) [back to overview]	Pain After Surgery
NCT04208516 (17) [back to overview]	Pain After Surgery
NCT04208516 (17) [back to overview]	Opioid Consumption After Surgery
NCT04208516 (17) [back to overview]	Serum Lidocaine Level
NCT04208516 (17) [back to overview]	Opioid Consumption After Surgery
NCT04208516 (17) [back to overview]	Opioid Consumption After Surgery
NCT04208516 (17) [back to overview]	Incidence of Adverse Events
NCT04208516 (17) [back to overview]	Local Anesthetic Consumption After Surgery
NCT04208516 (17) [back to overview]	Local Anesthetic Consumption After Surgery
NCT04251884 (5) [back to overview]	Opioids Consumption
NCT04251884 (5) [back to overview]	Lenght of Hospital Stay
NCT04251884 (5) [back to overview]	Postoperative Pain on the Visual Analogue Scale (VAS)
NCT04251884 (5) [back to overview]	Complications Related to the Pudendal Nerve Block
NCT04251884 (5) [back to overview]	Postoperative Pain on the Visual Analogue Scale (VAS)
NCT04368364 (12) [back to overview]	Severity of Vomiting as Assessed by a Scale
NCT04368364 (12) [back to overview]	Time to First Analgesic Request
NCT04368364 (12) [back to overview]	Total Narcotic Consumption in Morphine Equivalents (in Milligrams)
NCT04368364 (12) [back to overview]	Static Pain as Measured by the Numerical Pain Score (NPS)
NCT04368364 (12) [back to overview]	Severity of Sedation as Assessed by a Scale
NCT04368364 (12) [back to overview]	Patient Satisfaction as Assessed by Likert Scale
NCT04368364 (12) [back to overview]	Severity of Nausea as Assessed by a Scale
NCT04368364 (12) [back to overview]	Patient Satisfaction as Assessed by Likert Scale
NCT04368364 (12) [back to overview]	Patient Satisfaction as Assessed by Likert Scale
NCT04368364 (12) [back to overview]	Dynamic Pain as Measured by the Numerical Pain Score (NPS)
NCT04368364 (12) [back to overview]	Severity of Pruritus as Assessed by a Scale
NCT04368364 (12) [back to overview]	Total Narcotic Consumption in Morphine Equivalents (in Milligrams)
NCT04429022 (8) [back to overview]	Number of Patients With Return to the Clinic, Emergency Department Due to Post Operative Pain Within a 2 Week Period
NCT04429022 (8) [back to overview]	Length of Stay in Hours
NCT04429022 (8) [back to overview]	Total Opioid Pain Medications Required Through 3-24h Post op in MME
NCT04429022 (8) [back to overview]	Pain Scores
NCT04429022 (8) [back to overview]	Total Opioid Pain Medications Required 0-3h Post op in Morphine Milligram Equivalents (MME)
NCT04429022 (8) [back to overview]	Estimated Blood Loss
NCT04429022 (8) [back to overview]	Pain Scores
NCT04429022 (8) [back to overview]	Operative Time
NCT04474366 (3) [back to overview]	Comparison of Intra Operative Narcotic Requirements
NCT04474366 (3) [back to overview]	Comparison of Post Operative Narcotic Requirements
NCT04474366 (3) [back to overview]	Comparison of Post Operative Pain Scores
NCT04558281 (13) [back to overview]	Maximal Inspired Volume - Percentage Change From Baseline Prior to Intervention
NCT04558281 (13) [back to overview]	Rib Fracture Pain When Using an Incentive Spirometer
NCT04558281 (13) [back to overview]	Sleep Disturbances Due to Rib Fracture Pain
NCT04558281 (13) [back to overview]	Opioid Consumption
NCT04558281 (13) [back to overview]	Maximal Inspired Volume - Absolute
NCT04558281 (13) [back to overview]	AVERAGE Rib Fracture Pain in Previous 24 Hours
NCT04558281 (13) [back to overview]	Maximal Inspired Volume - Percentage Change From Baseline Prior to Intervention
NCT04558281 (13) [back to overview]	Brief Pain Inventory (Short Form, Interference Subscale)
NCT04558281 (13) [back to overview]	CURRENT Rib Fracture Pain in Previous 24 Hours
NCT04558281 (13) [back to overview]	LEAST Rib Fracture Pain in Previous 24 Hours
NCT04558281 (13) [back to overview]	Maximal Inspired Volume - Absolute
NCT04558281 (13) [back to overview]	Maximal Inspired Volume - Absolute
NCT04558281 (13) [back to overview]	WORST Rib Fracture Pain in Previous 24 Hours
NCT04567407 (11) [back to overview]	Analgesic Requirement
NCT04567407 (11) [back to overview]	Time to First Mobilization
NCT04567407 (11) [back to overview]	Duration of Mechanical Ventilation/Intubation
NCT04567407 (11) [back to overview]	Length of Hospital Stay
NCT04567407 (11) [back to overview]	Length of Postoperative ICU Stay
NCT04567407 (11) [back to overview]	Median Pain Scores
NCT04567407 (11) [back to overview]	Median Pain Scores
NCT04567407 (11) [back to overview]	Median Pain Scores
NCT04567407 (11) [back to overview]	Median Pain Scores
NCT04567407 (11) [back to overview]	Analgesic Requirement
NCT04567407 (11) [back to overview]	Analgesic Requirement
NCT04910165 (7) [back to overview]	Numeric Rating Scale (NRS) Pain Score Improvement
NCT04910165 (7) [back to overview]	WOMAC Score
NCT04910165 (7) [back to overview]	Hospital Length of Stay
NCT04910165 (7) [back to overview]	Number of Participants Needing to be Admitted to an Inpatient Rehabilitation Facility Post-Operatively
NCT04910165 (7) [back to overview]	Number of Participants Needing to be Readmitted to the Hospital Secondary to Inadequate Pain Control Post-operatively
NCT04910165 (7) [back to overview]	Inpatient Opioid Use
NCT04910165 (7) [back to overview]	Outpatient Opioid Use

Time to a Significant Increase in Shoulder Discomfort

the length of time until the patients' first report of surgical site pain. (NCT00519584)
Timeframe: during postoperative day 1 to 3

Intervention	hours (Median)
Ropivacaine/Saline	22.3
Ropivacaine/Dex	11.9
Bupivacaine/Dex	14.7
Bupivacaine/Saline	25.7

Intervention	units on a scale (Median)
	POD#1	POD#2	POD#3
Bupivacaine/Dex	3	4.1	4
Bupivacaine/Saline	4.9	4.1	1.8
Ropivacaine/Dex	3.9	3	2.9
Ropivacaine/Saline	5	3	1.9

Intervention	hours (Median)
Ropivacaine/Saline	22.2
Ropivacaine/Dex	11.8
Bupivacaine/Dex	14.8
Bupivacaine/Saline	22.4

Intervention	days (Mean)
LIA IV (Local Infiltration Analgesia, Intravenous)	4
LIA IA, (Local Infiltration Analgesia, Intra-articular)	3.5
Epidural	5.5

Intervention	percent change (Mean)
	% change in diaphragm displacement ipsilateral	% change in diaphragm displacement contralateral
Ropivacaine 10 mL	60	-56
Ropivacaine 20 mL	65	-39
Ropivacaine 5 mL	66	-28

Intervention	percentage of participants (Number)
	Percentage of participants at 24 hours	Percentage of participants at 48 hours
Ropivacaine 10 mL	83	75
Ropivacaine 20 mL	92	85
Ropivacaine 5 mL	83	83

Intervention	units on a scale (Mean)
	SST at Baseline (n=36)	SST at 12 weeks (n=35)
All Study Participants	6.3	8.2

Intervention	units on a scale (Mean)
	NRS at Discharge	NRS at 24 hours post discharge	NRS at 48 hours post discharge	NRS at 12 weeks post discharge (n=11, 12, 12)
Ropivacaine 10 mL	1.58	3.33	2.08	2.42
Ropivacaine 20 mL	0.62	2.54	2.15	1.15
Ropivacaine 5 mL	2.67	3.67	2.67	1.5

Intervention	Participants (Count of Participants)
Ropivacaine Injections	16
Normal Saline Injections	14
Observation	2

Intervention	units on a scale (Mean)
	PACU	POD1	POD2
Lidocaine/Ketamine	2.0	3.3	2.8
Placebo	6.3	3.7	2
Ropivacaine	0.8	4.6	2.6

Intervention	meters (Mean)
	morning	afternoon
0.1% Ropivicaine	136	223
0.4% Ropivicaine	119	214

Intervention	scores on a scale 0-10 (Mean)
	Vas Pain Scale - 1 Hour Post Op	Vas Pain Scale - 8 Hour Post Op	Vas Pain Scale - 16 Hour Post Op	Vas Pain Scale - 24 Hour Post Op	Vas Pain Scale - 32 Hour Post Op	Vas Pain Scale - 40 Hour Post Op	Vas Pain Scale - 48 Hour Post Op	Vas Pain Scale Preoperatively
ROP/EPI	1.60	2.82	2.41	2.96	3.13	2.80	2.11	2.13
ROP/EPI/CLO	2.67	3.93	2.75	3.63	3.62	3.28	2.56	2.43
ROP/EPI/TOR	1.90	1.52	2.22	2.56	2.66	2.35	1.97	2.47
ROP/EPI/TOR/CLO	1.06	1.52	1.85	2.33	2.18	2.54	2.41	1.93

Intervention	mg (Mean)
	Morphine Equivalent Day of Surgery	Morphine Equivalent Post Operative Day 1	Morphine Equivalent Post Operative Day 2	Morphine Equivalent Post Operative Day 3
ROP/EPI	52.50	51.08	36.76	15.54
ROP/EPI/CLO	55.20	64.61	50.07	21.97
ROP/EPI/TOR	43.09	47.95	42.69	18.72
ROP/EPI/TOR/CLO	46.92	46.54	40.71	20.45

Intervention	units on a scale (Median)
PLACEBO	152
20 cc of 0.5% Ropivacaine	180
20 cc of 0.25% Ropivacaine	180

Intervention	miligrams of morphine (Mean)
Placebo	22.75
20 cc of 0.5% Ropivacaine	12.5
20 cc of 0.25% Ropivacaine	17.5

Intervention	mg (Median)
Ropivacaine Colorectal Surgery	23
Saline Solution Colorectal Surgery	52
Ropivacaine Hepatic Surgery	24.63
Saline Solution Hepatic Surgery	26.78

Intervention	units on a scale (Median)
	Verbal numeric scale 0h after surgery	Verbal numeric scale 6h after surgery	Verbal numeric scale 12h after surgery	Verbal numeric scale 24h after surgery	Verbal numeric scale 48h after surgery
Ropivacaine Colorectal Surgery	1	2	2	2	2
Ropivacaine Hepatic Surgery	2.75	1.72	1.45	1.64	1.62
Saline Solution Colorectal Surgery	2.5	3	2	2	2
Saline Solution Hepatic Surgery	2.5	2.38	1.8	2	2.14

Intervention	hours (Median)
	Sitting in the chair	Deambulation	Solid food intake
Ropivacaine Colorectal Surgery	46	72	96
Ropivacaine Hepatic Surgery	51.75	81.2	88
Saline Solution Colorectal Surgery	48	72	120
Saline Solution Hepatic Surgery	43.2	87.37	79.79

Intervention	units on a scale (Median)
	Highest recorded pain scores at rest, 0-6 h	Highest recorded pain scores at rest, 6-12 h	Highest recorded pain scores at rest, 12-24 h	Highest recorded pain scores at rest, 24-36 h	Highest recorded pain scores at rest, 36-48 h	Highest recorded pain scores when moving, 0-6 h	Highest recorded pain scores when moving, 6-12 h	Highest recorded pain scores when moving, 12-24 h	Highest recorded pain scores when moving, 24-36 h	Highest recorded pain scores when moving, 36-48 h
NaCl 0,9%	6	3.75	3	3	2	7	6	5.75	5	4
Ropivacaine 0,75%	5	3	3	2.25	1	6.5	5	5	4.25	3

Intervention	participants (Number)
	Femoral nerve (nerve block n=77)	Common peroneal nerve (nerve block n=78)	Tibial nerve (nerve block n=78)	Femoral, peroneal, or tibial (nerve block n=77)
Nerve Block	1	6	2	9
Periarticular Injection	0	0	1	1

Intervention	participants (Number)
	Day 1 AM (Nerve Block=78, Injection=80)	Day 1 PM (Nerve Block=76, Injection=78)	Day 2 AM (Nerve Block=78, Injection=79)	Day 2 PM (Nerve Block=69, Injection=51)
Nerve Block	19	21	52	57
Periarticular Injection	63	63	69	42

ropivacaine

Description

Cross-References

Synonyms (127)

Research Excerpts

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Bioavailability

Dosage Studied

Roles (1)

Drug Classes (3)

Pathways (1)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Biological Processes (33)

Molecular Functions (14)

Ceullar Components (13)

Bioassays (85)

Research

Studies (3,457)

Study Types

Clinical Trials (962)

Trial Overview

Trial Outcomes

Time to a Significant Increase in Shoulder Discomfort

Maximum VRS Pain Scores at Rest

the Duration of Analgesia

Total Opioid Consumption

Time to Readiness for Discharge

Opioid Use

Pain at Rest (VAS)

Pain Score at Rest

Pain Score on Coughing

Pain Scores at Rest

Pain Scores at Rest

Pain Scores on Movement

Pain Scores on Coughing

NAUSEA

Pain on Movement

VOMITING

VOMITING

PATIENT SATISFACTION

PATIENT SATISFACTION

DROWSINESS

DROWSINESS

Pain on Movement

Morphine Equivalents

Morphine Equivalents

Morphine Equivalents Utilization

Pain Scores on Coughing

NAUSEA

Change in Diaphragmatic Displacement From Baseline to Post-surgery

"Percentage of Participants Who Considered the Analgesic Technique Helpful or Extremely Helpful"

Functional Outcome - Simple Shoulder Test (SST)

Pain Measurements Via Numeric Pain Rating Scales (NRS)

The Primary Outcome Will be Pain Relief Sufficient for Discharge From the Emergency Department.

Re-presentation to the Emergency Department With Headache Within 72 Hours of Participating in the Study

Number and Percent of Patients Admitted to the Hospital for Additional Therapy in Each Treatment Arm Based Upon Treating Clinicians Decision

Postoperative Opioid Consumption in Oral Oxycodone Equivalents

Pre- and Intra-operative Opioid Consumption in Fentanyl Equivalents

Postoperative Nausea

Time From the End of Surgery to Readiness for Hospital Discharge.

Pain Scores on Numerical Rating Scale

Time to First Report of Pain

Total Three-day Opioid Consumption in Oral Oxycodone Equivalent

Median Maximum VAS Pain Scores at Rest

The Duration of the Interscalene Nerve Block Which is Time to First Administration of Pain Medication After Block

Duration of Analgesia.

Maximum Verbal Response Score (VRS) With Rest

Time to Complete Motor Block

Time to Onset of First Sensory Block

Total Opioid Consumption

Duration of Analgesia

Maximum Verbal Response Score (VRS) With Movement

the Proportion of Patients Who Were Satisfied With the Pain Management

Pain( Visual Analog Scale )

Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery

The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended

Intervention	mg (Mean)
	Intraoperative	Day of Surgery	Post-Operative Day 1	Post-Operative Day 2
Nerve Block	17.4	4.6	43.0	33.0
Periarticular Injection	23.6	11.7	49.0	30.0

Intervention	units on a scale (Median)
	At first PCA request	2 hous after first PCA request	6 hours after first PCA request	24 hours after first PCA request	72 hours after first PCA reqest
Group 1	3	3	3	2	1
Group 2	3	1	2	1	.5
Group 3	2	0	2	1	1
Group 4	2	2	2	3	1

Intervention	Number of pills (Mean)
Pain Pump , Injectable Medication	3.41
Saline Pain Pump , Injectable Medication	3.8
Injectable Medication Only	3.8

Intervention	units on a scale (Mean)
Pain Pump , Injectable Medication	1.75
Saline Pain Pump , Injectable Medication	3.23
Injectable Medication Only	3.06

Intervention	units on a scale (Mean)
Pain Pump , Injectable Medication	3.3
Saline Pain Pump , Injectable Medication	4.05
Injectable Medication Only	3.13

Intervention	units on a scale (Mean)
Pain Pump , Injectable Medication	1.81
Saline Pain Pump , Injectable Medication	3.17
Injectable Medication Only	2.26

Intervention	Hours (Median)
	Motor: < 10ml	Motor: >/= 10ml	Sensory: <10ml	Sensory: >/= 10ml
Bupivacaine	10	21	9	20
Ropivacaine	7	15	8	14

Intervention	Scores on a scale (Mean)
Oral Narcotic Group	4.14
Bupivacaine Group	2.73
Ropivacaine Group	3.66

Intervention	Minutes (Median)
Oral Narcotic Group	30
Bupivacaine Group	50.5
Ropivacaine Group	34

Intervention	Scores on a scale (Mean)
Oral Narcotic Group	4.58
Bupivacaine Group	2.73
Ropivacaine Group	4.32