potassium profile

liver regeneration factor 1: a leucine-zipper protein that is rapidly & highly induced in regenerating liver; MW 21 kDa; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

potassium(1+) : A monoatomic monocation obtained from potassium. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Products

ID Source	ID
PubMed CID	813
CHEBI ID	29103
MeSH ID	M0017374

Synonym
k(+)
CHEBI:29103 ,
potassium ion(+)
potassium(+)
potassium monocation
potassium (k+)
potassium ion(1+)
k1+
potassium (1+)
potassium ion (k+)
potassium, ion (k1+) (8ci,9ci)
C00238
potassium ion
potassium(i)
K+ ,
potassium(1+)
24203-36-9
potassium cation
potassium(i) cation
potassium (ion)
DB01345
potassium(1+) ion
nabumeton a (tn)
D08403
125352-08-1
295o53k152 ,
unii-295o53k152
potassium, ion (k1+)
138363-30-1
liver regeneration factor 1
DTXSID9042671 ,
potassium ion (k1+)
Q15901933
potassium+
runny nose warts
colds dry cough
skin affections
headache nervousness
dtxcid7022671
sore throat 911
nasel congestion

Product Category	Products
Productos a base de carne, Carnes, Embutidos, Jamón, en:cured-ham, Jamones secos, fr:Jambons ibériques, Jamón ibérico de bellota, en:raw-cured-ham	1
Other	111
Meals, Soups	1
Viandes et dérivés, Viandes, Volailles, Dinde et dérivés, Dindes	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Pâtes alimentaires, Pâtes sèches	1
Plant-based foods and beverages, Plant-based foods, Fruits and vegetables based foods, Fruits based foods	1
Smaakmakers, Sauzen, Pestosauzen, Groene pesto	1
en:olive-oils	1
Dietary supplements	1
Produits laitiers, Produits fermentés, Produits laitiers fermentés, Fromages, en:cooked-pressed-cheeses, Fromages de France	1
Snacks, Sweet snacks, Biscuits and cakes, Biscuits	2
Plant-based foods and beverages, Beverages, Hot beverages, Plant-based beverages, Teas, Tea bags	2
Cibi e bevande a base vegetale, Cibi a base vegetale, Cereali e patate, Pani, Focacce, Piadina	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Aliments à base de fruits et de légumes, Légumes et dérivés, Légumes, Frais, Aliments à base de plantes frais, Légumes frais, Mélanges de légumes, Mélanges de légumes frais	1
Aliments et boissons à base de végétaux, Boissons, Boissons à base de végétaux	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Condiments, Epices, Mélanges d'herbes et d'épices, Ras el hanout, en:groceries	1
Chocolate covered nuts	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale	2
Viandes et dérivés, Viandes, Charcuteries, Terrines, Terrines de campagne	1
Zuivelproducten,Gefermenteerde levensmiddelen,Gefermenteerde zuivelproducten,Kazen,Koemelkkazen,Onverhitte geperste kazen,Nederlandse kazen,Gouda,Jonge Goudas	1
Seafood, Canned foods, Fishes, Fatty fishes, Canned fishes, Tunas, Canned tunas, Tunas in oil, Tuna in olive oil	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Graines	1
Lácteos, Comidas fermentadas, Productos fermentados de la leche, Quesos, Quesos de vaca, Quesos daneses, Havarti	1
Pain bretzel	1
Condiments, Sauces, Sauces tomate, Sauces tomates frites, en:groceries	1
Plant-based foods and beverages, Plant-based foods, Fruits and vegetables based foods, Fruits based foods, Fruits, Tropical fruits, Bananas	1
Plant-based foods,Fats,Vegetable fats,Olive tree products,Vegetable oils,Olive oils,Extra-virgin olive oils,Virgin olive oils	1
Productos a base de carne, Embutidos, Jamón, en:cured-ham, Jamones secos, Productos cárnicos españoles, Jamón Serrano	1
en:pork	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Céréales et pommes de terre, Graines, Céréales et dérivés, Céréales en grains, Riz, Riz parfumés, Riz de variété indica, Riz long grain, Riz Basmati	1
Condiments, Sauces, Sauces salades, Vinaigrettes, Vinaigrettes allégées en matières grasses, en:groceries	1
Snack, Snack dolci	1
Produits de la mer, Poissons et dérivés, Poissons, Préparations de poisson, Surimi, Bâtonnets de surimi	1
Snacks, Petit-déjeuners, Snacks sucrés, Biscuits et gâteaux, Biscuits, Biscuits au chocolat, Biscuits aux céréales, Biscuits petits-déjeuners	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Aliments à base de fruits et de légumes, Conserves, Légumes et dérivés, Aliments à base de plantes en conserve, Légumes, Légumes en conserve, Légumes tiges, Artichauts, Artichauts en co	1
Snacks, Desserts, Snacks sucrés, Biscuits et gâteaux, Gâteaux, Cakes aux fruits	1
Snacks, Snacks sucrés, Confiseries, Calissons, Calissons d'Aix	1
Produits de la mer, Crustacés, Crevettes, Crevettes cuites	1
Beverages, Dried products, Dried products to be rehydrated, Dehydrated beverages	1
Produits laitiers, Produits fermentés, Desserts, Produits laitiers fermentés, Desserts lactés, Desserts lactés fermentés, Frais, Yaourts, Desserts lactés fermentés aromatisés, Yaourts sucrés, Yaourts au Bifidus, Yaourts au bifidus aromatisés, Yaourts arom	1
Snacks, Snacks sucrés, Biscuits et gâteaux, Gâteaux, Donuts	1
en:Alimentos de origen vegetal, en:Alimentos y bebidas de origen vegetal, en:Confituras de albaricoque, en:Desayunos, en:Mermeladas, en:Mermeladas y confituras, en:Preparaciones a base de frutas y verduras, en:Untables, en:Untables dulces, en:Untables veg	1
Snacks, Sweet snacks, Confectioneries	1
Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Breads	1
Desserts	1
en:Dairies,en:Fermented foods,en:Fermented milk products,en:Cheeses	1
Petit-déjeuners, Produits à tartiner, Produits à tartiner sucrés, Pâtes à tartiner, Pâtes à tartiner aux noisettes, Pâtes à tartiner au chocolat, Pâtes à tartiner aux noisettes et au cacao	1
Meats and their products,Meats,Prepared meats,fr:Charcuteries diverses,fr:Allumettes de porc,Lardons	1
Viandes et dérivés, Viandes, Charcuteries, Jambons, Jambons blancs	2
Meats and their products, Meats, Prepared meats, Sausages, en:cured-sausages	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Aliments à base de fruits et de légumes, Conserves, Desserts, Aliments à base de plantes en conserve, Fruits et produits dérivés, Fruits en conserve, Fruits au sirop, Pêches au sirop, F	1
Plant-based foods and beverages, Plant-based foods, Snacks, Fruits and vegetables based foods, Fruits based foods, Fruits, Dates, Deglet Noor dates	1
Naposteltavat, Makeat naposteltavat, Sokerileipomotuotteet, en:Halva, en:Sesame halva	1
Condiments, Groceries	1
Aliments et boissons à base de végétaux, Boissons, Surgelés, Boissons à base de végétaux, Smoothies, Smoothies aux fruits	1
Bevande	1
en:yogurts	1
Snacks, Snacks sucrés, Confiseries, Calissons	2
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Petit-déjeuners, Céréales et pommes de terre, Céréales et dérivés, Surgelés, Céréales pour petit-déjeuner, Céréales au chocolat, Mueslis, Mueslis au chocolat	1
Plats préparés	1
Plant-based foods and beverages, Plant-based foods, Breakfasts, Cereals and potatoes, Cereals and their products, Breakfast cereals, Mueslis, en:mueslis-with-chocolate	1
Aliments festifs, Aliments et boissons de Noël, Calendriers de l'avent	1
Desserts, Frozen foods, Frozen desserts, Mochi ice cream	1
Decorticated lentils	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Céréales et pommes de terre, Céréales et dérivés, Plats préparés, Plats à base de pâtes, Pâtes alimentaires, Pâtes farcies, Pâtes fraîches	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Petit-déjeuners, Aliments à base de fruits et de légumes, Produits à tartiner, Fruits et produits dérivés, Pâtes à tartiner végétales, Produits à tartiner sucrés, Confitures et marmelad	1
Condiments, Sauces, Moutardes, Moutardes à l'ancienne	1
Viandes et dérivés, Viandes, Volailles, Dinde et dérivés, Dindes, Escalopes de dinde	2
en:Condiments, en:Sauces, Hořčice, en:Groceries	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Céréales et pommes de terre, Céréales et dérivés	1
Aliments et boissons à base de végétaux,Aliments d'origine végétale,Céréales et pommes de terre,Graines,Céréales et dérivés,Plats préparés,Céréales en grains,Plats préparés d'origine végétale,Couscous	1
Snacks, Snacks sucrés	1
Tomate ronde	1
Plant-based foods and beverages, Plant-based foods, Breakfasts, Spreads, Plant-based spreads, Sweet spreads, Fruit and vegetable preserves, Jams, Berry jams, Raspberry jams	1
Préparation dessert	1
en:oils	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Céréales et pommes de terre, Céréales et dérivés, Semoules de céréales, Semoules de blé	1
Snack, Snack dolci, Biscotti e torte, Biscotti	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Aliments à base de fruits et de légumes, Plats préparés, Aliments et boissons à base de légumes, Soupes, Soupes de légumes	1
Seafood, Fishes, Fatty fishes, Salmons	1
Plant-based foods and beverages, Beverages, Plant-based beverages, Fruit-based beverages, Still fruit soft drinks	1
en:open-beauty-facts	1
Lanches comida, Petiscos salgados, Aperitivos, en:Chips and fries, en:Crisps	1
Grickalice	1
Plant-based foods and beverages, Plant-based foods, Snacks, Sweet snacks, Nuts and their products, Bars, Nut bars	1
Aliments et boissons à base de végétaux, Boissons, Boissons chaudes, Boissons à base de végétaux, Thés, Boissons au thé, Thés glacés	1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Produits à tartiner, Pâtes à tartiner végétales, Produits à tartiner salés, Caviars d'aubergine	1
Meats and their products, Frozen foods, Meats, Frozen meats	1
herbal teas	1
Beverages, Coffee drinks	1
Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Cereals and their products, Pie dough	1
хлопья,злаки	1
th:เครื่องจิ้ม-เครื่องปรุง	1
en:Plant-based foods and beverages, เครื่องดื่ม, ผลิตภัณฑ์จากพืชทั้งหมด, ธัญพืชและมันฝรั่ง, en:Dairy substitutes, ผลิตภัณฑ์จากผักและผลไม้, ผลิตภัณฑ์จากธัญพืช, en:Milk substitutes, เครื่องดื่มจากพืช, ผลิตภัณฑ์จากพืช, en:Plant-based milk alternatives, en:Ce	1

Product	Brand	Category	Compounds Matched from Ingredients	Date Retrieved
Dry mix noodle soup		Meals, Soups	riboflavin,niacin	2024-02-12
jumbo battered haddock fishcakes		Other	niacin	2024-02-14
Nabisco ritz crackers cheese 1x45.000 oz		Snacks, Sweet snacks, Biscuits and cakes, Biscuits	niacin	2024-02-11
fig bars	Benton's	Other	riboflavin,niacin	2024-02-13
Soft & Delicious Frosted Sugar Cookies	Create A Treat	Snacks, Sweet snacks, Biscuits and cakes, Biscuits	riboflavin,niacin	2024-02-09
Drink mix - watermelon	Crush	Beverages, Dried products, Dried products to be rehydrated, Dehydrated beverages	ACESULFAME POTASSIUM	2024-02-13
Licorice Allsorts	Dutch Valley Food Distributors	Snacks, Sweet snacks, Confectioneries	glycerol,curcumin	2024-02-09
Gluten Free Seeds & Grains Bread	Eating Right For Gluten Free	Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Breads	niacin,riboflavin	2024-08-22
Sausage Patties	Smoky Farms	Meats and their products, Frozen foods, Meats, Frozen meats	propyl gallate	2024-02-09
Cinnamon Rolls With Icing	Wal-Mart Stores Inc.	Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Cereals and their products, Pie dough	niacin	2024-02-09

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
cofactor	An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
monoatomic monocation
alkali metal cation
elemental potassium
monovalent inorganic cation	An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Glycolysis	61	32
Transport of small molecules	392	95
ABC-family proteins mediated transport	77	11
SLC-mediated transmembrane transport	135	67
Transport of inorganic cations/anions and amino acids/oligopeptides	54	27
Sodium/Calcium exchangers	4	4
Cation-coupled Chloride cotransporters	1	3
Ion channel transport	45	16
Ion transport by P-type ATPases	13	12
Reproduction	86	8
Fertilization	15	4
Sperm Motility And Taxes	2	4
Metabolism	1496	1108
Carbohydrate metabolism	173	120
Glucose metabolism	76	42
Fructose metabolism	7	21
Fructose catabolism	5	15
Biological oxidations	150	276
Phase II - Conjugation of compounds	73	122
Methylation	13	38
Visual phototransduction	62	41
The phototransduction cascade	26	21
Activation of the phototransduction cascade	10	8
Muscle contraction	77	21
Cardiac conduction	52	12
Phase 4 - resting membrane potential	15	1
Phase 1 - inactivation of fast Na+ channels	0	1
Phase 2 - plateau phase	4	2
Phase 3 - rapid repolarisation	4	1
Ion homeostasis	18	10
Neuronal System	166	50
Transmission across Electrical Synapses	5	1
Electric Transmission Across Gap Junctions	5	1
Transmission across Chemical Synapses	122	50
Presynaptic depolarization and calcium channel opening	7	2
Neurotransmitter release cycle	31	33
Glutamate Neurotransmitter Release Cycle	15	8
Neurotransmitter receptors and postsynaptic signal transmission	78	20
GABA receptor activation	8	8
GABA B receptor activation	7	7
Activation of GABAB receptors	7	7
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	6	2
Potassium Channels	24	4
Ca activated K+ channels	2	1
HCN channels	4	2
Inwardly rectifying K+ channels	9	3
G protein gated Potassium channels	6	2
Activation of G protein gated Potassium channels	6	2
Potassium transport channels	3	1
ATP sensitive Potassium channels	2	2
Classical Kir channels	0	1
Voltage gated Potassium channels	0	1
Tandem pore domain potassium channels	9	1
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	3	1
TWIK related potassium channel (TREK)	0	1
TWIK-releated acid-sensitive K+ channel (TASK)	2	1
TWIK-related alkaline pH activated K+ channel (TALK)	2	1
TWIK-related spinal cord K+ channel (TRESK)	1	1
Tandem pore domain halothane-inhibited K+ channel (THIK)	1	1
Kidney Function	34	9
Lactose Degradation	12	9
Trehalose Degradation	13	10
Lactose Intolerance	12	9
Glucose Transporter Defect (SGLT2)	31	8
Hartnup Disorder	31	8
Iminoglycinuria	31	8
Lysinuric Protein Intolerance	31	8
Esomeprazole Action Pathway	10	13
Omeprazole Action Pathway	10	14
Lansoprazole Action Pathway	10	12
Pantoprazole Action Pathway	10	13
Rabeprazole Action Pathway	10	13
Ranitidine Action Pathway	10	12
Famotidine Action Pathway	10	12
Cimetidine Action Pathway	10	12
Nizatidine Action Pathway	10	12
Pirenzepine Action Pathway	10	12
Chlorothiazide Action Pathway	31	9
Polythiazide Action Pathway	31	9
Methyclothiazide Action Pathway	31	9
Bumetanide Action Pathway	31	9
Bendroflumethiazide Action Pathway	31	9
Quinethazone Action Pathway	31	9
Ethacrynic Acid Action Pathway	31	9
Hydrochlorothiazide Action Pathway	31	9
Cyclothiazide Action Pathway	31	9
Metolazone Action Pathway	31	9
Hydroflumethiazide Action Pathway	31	9
Indapamide Action Pathway	31	9
Furosemide Action Pathway	31	9
Torsemide Action Pathway	31	9
Trichlormethiazide Action Pathway	31	9
Chlorthalidone Action Pathway	31	9
Triamterene Action Pathway	31	9
Amiloride Action Pathway	31	9
Spironolactone Action Pathway	31	9
Eplerenone Action Pathway	31	9
Acebutolol Action Pathway	47	8
Alprenolol Action Pathway	47	8
Atenolol Action Pathway	47	8
Betaxolol Action Pathway	47	8
Bisoprolol Action Pathway	47	8
Esmolol Action Pathway	47	8
Metoprolol Action Pathway	47	8
Nadolol Action Pathway	47	8
Oxprenolol Action Pathway	47	8
Penbutolol Action Pathway	47	8
Pindolol Action Pathway	47	8
Propranolol Action Pathway	47	8
Quinidine Action Pathway	47	8
Procainamide (Antiarrhythmic) Action Pathway	47	8
Disopyramide Action Pathway	47	8
Fosphenytoin (Antiarrhythmic) Action Pathway	47	9
Phenytoin (Antiarrhythmic) Action Pathway	69	23
Lidocaine (Antiarrhythmic) Action Pathway	49	22
Mexiletine Action Pathway	47	8
Tocainide Action Pathway	47	8
Flecainide Action Pathway	47	8
Ibutilide Action Pathway	47	8
Diltiazem Action Pathway	47	8
Nebivolol Action Pathway	47	8
Carvedilol Action Pathway	48	8
Labetalol Action Pathway	48	8
Verapamil Action Pathway	47	8
Amlodipine Action Pathway	47	8
Felodipine Action Pathway	47	8
Isradipine Action Pathway	47	8
Nifedipine Action Pathway	47	8
Nimodipine Action Pathway	47	8
Nisoldipine Action Pathway	47	8
Nitrendipine Action Pathway	47	8
Benzocaine Action Pathway	31	11
Bupivacaine Action Pathway	31	11
Chloroprocaine Action Pathway	31	11
Cocaine Action Pathway	31	11
Dibucaine Action Pathway	31	11
Levobupivacaine Action Pathway	31	11
Lidocaine (Local Anaesthetic) Action Pathway	33	25
Mepivacaine Action Pathway	31	11
Oxybuprocaine Action Pathway	31	11
Prilocaine Action Pathway	31	11
Procaine Action Pathway	31	11
Proparacaine Action Pathway	31	11
Ropivacaine Action Pathway	31	11
Codeine Action Pathway	34	20
Morphine Action Pathway	47	16
Methadone Action Pathway	37	17
Oxycodone Action Pathway	31	11
Hydromorphone Action Pathway	31	11
Hydrocodone Action Pathway	31	11
Oxymorphone Action Pathway	31	11
Alfentanil Action Pathway	31	11
Carfentanil Action Pathway	31	11
Fentanyl Action Pathway	31	11
Remifentanil Action Pathway	31	11
Sufentanil Action Pathway	31	11
Imipramine Action Pathway	35	21
Desipramine Action Pathway	32	17
Citalopram Action Pathway	37	24
Escitalopram Action Pathway	31	11
Fluoxetine Action Pathway	36	18
Nicotine Action Pathway	38	32
Nateglinide Action Pathway	6	5
Repaglinide Action Pathway	6	5
Glibenclamide Action Pathway	6	5
Gliclazide Action Pathway	6	5
Blue Diaper Syndrome	31	8
Lysinuric Protein Intolerance (LPI)	31	8
Striated Muscle Contraction	47	7
Gastric Acid Production	10	11
Pancreas Function	6	4
Bopindolol Action Pathway	47	8
Carteolol Action Pathway	47	8
Timolol Action Pathway	47	8
Sotalol Action Pathway	47	8
Epinephrine Action Pathway	47	8
Dobutamine Action Pathway	47	8
Isoprenaline Action Pathway	47	8
Arbutamine Action Pathway	47	8
Amiodarone Action Pathway	57	11
Levobunolol Action Pathway	47	8
Metipranolol Action Pathway	47	8
Bevantolol Action Pathway	47	8
Practolol Action Pathway	47	8
Bupranolol Action Pathway	47	8
Tramadol Action Action Pathway	31	11
Propoxyphene Action Pathway	31	11
Levorphanol Action Pathway	31	11
Anileridine Action Pathway	31	11
Diphenoxylate Action Pathway	31	11
Dezocine Action Pathway	31	11
Levomethadyl Acetate Action Action Pathway	31	11
Methadyl Acetate Action Pathway	31	11
3-Methylthiofentanyl Action Pathway	31	11
Dimethylthiambutene Action Pathway	31	11
Ethylmorphine Action Pathway	31	11
Levallorphan Action Pathway	31	11
Buprenorphine Action Pathway	31	11
Alvimopan Action Pathway	31	11
Pentazocine Action Pathway	31	11
Naltrexone Action Pathway	31	11
Naloxone Action Pathway	31	11
Dihydromorphine Action Pathway	31	11
Ketobemidone Action Pathway	31	11
Nalbuphine Action Pathway	32	11
Cystinuria	31	8
Roxatidine Acetate Action Pathway	10	12
Metiamide Action Pathway	10	12
Betazole Action Pathway	10	12
Disease	1278	231
Disorders of transmembrane transporters	102	43
ABC transporter disorders	57	10
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	1	1
Defective ABCC8 can cause hypo- and hyper-glycemias	1	2
SLC transporter disorders	45	37
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	0	3
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	0	2
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	0	3
Defective SLC1A3 causes episodic ataxia 6 (EA6)	0	3
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	1	3
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)	0	3
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)	0	3
Infectious disease	895	79
Lafutidine H2-Antihistamine Action	10	12
Immune System	914	82
Innate Immune System	414	75
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	33	5
Inflammasomes	16	3
The NLRP3 inflammasome	13	2
glycolysis IV (plant cytosol)	13	47
methyl indole-3-acetate interconversion	2	12
guanine and guanosine salvage III	0	10
purine nucleosides salvage II (plant)	4	19
hyperxanthone E biosynthesis	1	24
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle	28	56
S-adenosyl-L-methionine cycle II	4	27
farnesene biosynthesis	7	5
glycolysis I (from glucose 6-phosphate)	12	20
sucrose degradation III (sucrose invertase)	9	10
polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)	2	31
glycolysis II (from fructose 6-phosphate)	13	20
superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)	2	34
Rubisco shunt	6	32
superpathway of anaerobic sucrose degradation	33	60
sucrose degradation II (sucrose synthase)	17	22
Distal convoluted tubule 1 (DCT1) cell	9	3
Vitamin D-sensitive calcium signaling in depression	2	13
Type I collagen synthesis in the context of osteogenesis imperfecta	0	2
Neuron Function	31	10
Muscle/Heart Contraction	30	10
Kidney Function - Ascending Limb of The Loop of Henle	13	6
Kidney Function - Collecting Duct	20	11
Kidney Function - Distal Convoluted Tubule	18	10
Pancreas Function - Beta Cell	19	10
Pancreas Function - Alpha Cell	10	5
Pancreas Function - Delta Cell	6	4
SARS-CoV Infections	282	29
SARS-CoV-1 Infection	114	22
SARS-CoV-2 coagulation pathway (COVID-19 Disease Map)	1	4
Nanomaterial-induced inflammasome activation	6	1
Proximal tubule transport	0	21
SARS-CoV-2 Infection	195	27
Sensory Perception	215	68
Sensory processing of sound	36	7
Sensory processing of sound by inner hair cells of the cochlea	30	6
Sensory processing of sound by outer hair cells of the cochlea	17	6
Acetylcholine inhibits contraction of outer hair cells	5	3
Sensory perception of taste	40	12
Sensory perception of sour taste	2	2
Dravet syndrome	28	4
SARS-CoV-2-host interactions	155	9
SARS-CoV-2 activates/modulates innate and adaptive immune responses	85	8
Hippocampal synaptogenesis and neurogenesis	1	6
Genetic causes of porto-sinusoidal vascular disease	0	9
SARS-CoV-1 activates/modulates innate immune responses	41	4
Chronic hyperglycemia impairment of neuron function	4	3
Dravet syndrome: Scn1a-A1783V point mutation model	78	9
Amino acid transport defects (IEMs)	9	25
Carnosine metabolism of glial cells	0	9
Lactate shuttle in glial cells	18	18
Viral Infection Pathways	727	39
4p16.3 copy number variation	0	8
10q22q23 copy number variation	0	14
Respiratory Syncytial Virus Infection Pathway	89	15
RSV-host interactions	69	4
mevalonate pathway	10	25
isoleucine degradation	12	17
tryptophan degradation	13	45
superpathway of tryptophan utilization	42	92
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)	5	13
superpathway NAD/NADP - NADH/NADPH interconversion (yeast)	10	31
polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)	2	38
(S)-propane-1,2-diol degradation	6	18
pyrimidine ribonucleosides degradation	5	13
superpathway of glycol metabolism and degradation	10	35
chitin biosynthesis	16	40
L-homoserine biosynthesis	6	27
superpathway of 5-aminoimidazole ribonucleotide biosynthesis	6	36
5-aminoimidazole ribonucleotide biosynthesis I	12	38
5-aminoimidazole ribonucleotide biosynthesis II	6	32
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)	17	38
L-glutamate degradation VII (to butanoate)	10	36
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle	24	59
glyoxylate cycle	13	36
NADH repair	3	10
superpathway of glycolysis and the Entner-Doudoroff pathway	23	58
Rubisco shunt	8	32
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass	39	89
superpathay of heme b biosynthesis from glutamate	20	47
superpathway of b heme biosynthesis from glycine	10	46
farnesene biosynthesis	7	9
phosphopantothenate biosynthesis I	13	29
enterobacterial common antigen biosynthesis	11	33
anhydromuropeptides recycling I	13	48
L-lysine biosynthesis II	6	35
L-lysine biosynthesis I	16	63
pyruvate fermentation to acetate I	3	17
CDP-archaeol biosynthesis	7	16
archaetidylinositol biosynthesis	7	24
thiamine salvage I	2	16
archaetidylserine and archaetidylethanolamine biosynthesis	8	23
methyl indole-3-acetate interconversion	0	13
acetone degradation II (to acetoacetate)	3	16
TCA cycle I (prokaryotic)	17	41
L-tryptophan degradation II (via pyruvate)	2	11
photosynthetic 3-hydroxybutanoate biosynthesis (engineered)	63	73
pyrimidine deoxyribonucleotides de novo biosynthesis II	10	30
pyrimidine deoxyribonucleotides de novo biosynthesis I	30	34
NADH to cytochrome bo oxidase electron transfer I	17	34
NADH to cytochrome bd oxidase electron transfer I	16	27
pyrimidine deoxyribonucleotide phosphorylation	15	15
superpathway of C1 compounds oxidation to CO2	22	32
diacylglycerol and triacylglycerol biosynthesis	14	13
UMP biosynthesis I	12	34
preQ0 biosynthesis	7	23
superpathway of L-lysine degradation	33	112
L-lysine degradation IV	0	39
superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation	18	55
superpathway of Clostridium acetobutylicum acidogenic fermentation	10	32
purine nucleotides degradation II (aerobic)	22	46
inosine 5'-phosphate degradation	13	24
L-asparagine degradation I	4	25
flavin biosynthesis II (archaea)	8	28
superpathway of purine nucleotides de novo biosynthesis I	36	49
superpathway of guanosine nucleotides de novo biosynthesis I	24	36
trehalose degradation II (cytosolic)	6	21
acetate and ATP formation from acetyl-CoA I	12	23
L-lysine fermentation to acetate and butanoate	8	57
4-hydroxymandelate degradation	6	38
hexitol fermentation to lactate, formate, ethanol and acetate	7	36
4-amino-3-hydroxybenzoate degradation	2	40
anaerobic energy metabolism (invertebrates, mitochondrial)	13	42
superpathway of aromatic compound degradation via 2-hydroxypentadienoate	50	95
mixed acid fermentation	32	76
superpathway of anaerobic energy metabolism (invertebrates)	16	60
superpathway of aromatic compound degradation via 3-oxoadipate	36	81
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I	6	26
tetrahydrofolate biosynthesis	7	42
superpathway of tetrahydrofolate biosynthesis	19	65
glutaryl-CoA degradation	3	14
folate polyglutamylation	4	20
superpathway of tetrahydrofolate biosynthesis and salvage	13	70
N10-formyl-tetrahydrofolate biosynthesis	12	56
D-malate degradation	1	7
glycine betaine biosynthesis II (Gram-positive bacteria)	2	10
glycine betaine biosynthesis I (Gram-negative bacteria)	2	21
peptidoglycan biosynthesis III (mycobacteria)	12	36
superpathway of N-acetylneuraminate degradation	39	79
superpathway of coenzyme A biosynthesis I (bacteria)	9	42
peptidoglycan biosynthesis I (meso-diaminopimelate containing)	11	42
ectoine biosynthesis	5	20
superpathway of arginine and polyamine biosynthesis	18	101
tetrahydromonapterin biosynthesis	3	22
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)	36	33
1,3-propanediol biosynthesis (engineered)	15	35
S-adenosyl-L-methionine biosynthesis	5	19
factor 420 polyglutamylation	1	11
u03B3-glutamyl cycle	12	19
guanosine ribonucleotides de novo biosynthesis	15	35
guanine and guanosine salvage III	1	15
superpathway of guanine and guanosine salvage	6	21
folate transformations I	22	41
L-phenylalanine degradation IV (mammalian, via side chain)	6	39
L-threonine biosynthesis	4	17
superpathway of L-methionine biosynthesis (transsulfuration)	9	59
L-methionine biosynthesis II (plants)	3	21
superpathway of L-homoserine and L-methionine biosynthesis	6	49
superpathway of L-methionine biosynthesis (by sulfhydrylation)	19	55
formaldehyde assimilation I (serine pathway)	9	44
mevalonate pathway I	24	31
ketogenesis	6	14
ketolysis	4	12
gluconeogenesis I	28	62
superpathway of hexitol degradation (bacteria)	29	60
L-methionine salvage cycle I (bacteria and plants)	19	38
adenine and adenosine salvage V	4	17
lactose and galactose degradation I	5	21
L-arginine biosynthesis I (via L-ornithine)	11	53
L-arginine biosynthesis II (acetyl cycle)	1	37
L-isoleucine degradation I	15	20
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I	19	94
glycolate and glyoxylate degradation I	7	26
superpathway of cholesterol biosynthesis	21	78
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II	8	35
Methanobacterium thermoautotrophicum biosynthetic metabolism	22	79
chorismate biosynthesis I	15	59
chorismate biosynthesis from 3-dehydroquinate	10	37
formaldehyde oxidation VI (H4MPT pathway)	8	10
tRNA processing	7	6
glycolysis II (from fructose 6-phosphate)	21	49
glycolysis I (from glucose 6-phosphate)	37	51
glycolysis IV (plant cytosol)	7	47
L-rhamnose degradation I	8	22
superpathway of bacteriochlorophyll a biosynthesis	22	70
superpathway of L-threonine biosynthesis	7	41
L-selenocysteine biosynthesis I (bacteria)	3	14
thiamine salvage II	9	28
superpathway of chorismate metabolism	56	186
L-glutamate degradation VI (to pyruvate)	2	14
superpathway of pyrimidine ribonucleotides de novo biosynthesis	23	45
UDP-N-acetyl-u03B1-D-mannosaminouronate biosynthesis	3	10
Entner-Doudoroff pathway I	16	39
superpathway of fucose and rhamnose degradation	11	41
Entner-Doudoroff pathway III (semi-phosphorylative)	2	28
UDP-2,3-diacetamido-2,3-dideoxy-u03B1-D-mannuronate biosynthesis	5	16
L-tryptophan degradation III (eukaryotic)	17	45
glycerol degradation V	4	16
aspartate superpathway	25	122
thiamine diphosphate biosynthesis I (E. coli)	2	18
superpathway of S-adenosyl-L-methionine biosynthesis	9	61
creatinine degradation II	3	27
pyridoxal 5'-phosphate salvage I	5	19
ppGpp biosynthesis	5	23
superpathway of anaerobic sucrose degradation	26	61
gibberellin inactivation II (methylation)	2	16
superpathway of glyoxylate bypass and TCA	18	55
ribose phosphorylation	2	10
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage	9	37
superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis	24	61
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis	46	62
trehalose biosynthesis I	7	19
tetrapyrrole biosynthesis I (from glutamate)	12	37
tetrapyrrole biosynthesis II (from glycine)	7	30
L-methionine degradation I (to L-homocysteine)	8	18
pyruvate fermentation to ethanol II	9	11
superpathway of L-isoleucine biosynthesis I	17	55
methanogenesis from acetate	5	26
L-isoleucine biosynthesis II	14	30
S-adenosyl-L-methionine cycle I	4	17
NAD salvage pathway I (PNC VI cycle)	4	20
trans-cinnamoyl-CoA biosynthesis	4	12
NAD salvage pathway II (PNC IV cycle)	3	14
NAD de novo biosynthesis I (from aspartate)	7	34
superpathway of polymethylated quercetin/quercetagetin glucoside biosynthesis (Chrysosplenium)	2	46
salvage pathways of pyrimidine ribonucleotides	9	36
methionine degradation I (to homocysteine)	3	17
superpathway NAD/NADP - NADH/NADPH interconversion	11	29
NAD/NADP-NADH/NADPH mitochondrial interconversion	7	13
Thick ascending limb transporters	0	9
Calcium regulation in cardiac cell	0	9
Vascular smooth muscle contraction	0	13
Nicotine activity on dopaminergic neurons	0	9
Hydrochloric acid secretion in parietal cells	0	3
Iron uptake and transport	0	30
Nicotine activity on chromaffin cells	0	5
Nicotine effect on dopaminergic neurons	0	9
Nicotine effect on chromaffin cells	0	5
Endothelin pathways	0	13
Secretion of hydrochloric acid in parietal cells	0	3
NO/cGMP/PKG mediated neuroprotection	0	16
Calcium regulation in cardiac cells	0	9

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	8 (53.33)	18.2507
2000's	5 (33.33)	29.6817
2010's	2 (13.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-acetylaminofluorene 2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.	1.99	1	2-acetamidofluorenes	antimitotic; carcinogenic agent; epitope; mutagen
pyrazolanthrone pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source. anthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.	2.05	1	anthrapyrazole; aromatic ketone; cyclic ketone	antineoplastic agent; c-Jun N-terminal kinase inhibitor; geroprotector
galactosamine 2-amino-2-deoxy-D-galactopyranose : The pyranose form of D-galactosamine.. D-galactosamine : The D-stereoisomer of galactosamine.	1.97	1	D-galactosamine; primary amino compound	toxin
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.05	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
u 73122 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione: structure given in first source. U-73122 : An aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C.	2.05	1	aromatic ether; aza-steroid; maleimides	EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
lysophosphatidylcholines lysophosphatidylcholine : An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.	2.01	1	1-O-acyl-sn-glycero-3-phosphocholine
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	2.05	1
glucagon Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.	1.97	1	peptide hormone
epidermal growth factor Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	1.98	1
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2	1
metallothionein Metallothionein: A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.	1.98	1

Condition	Relationship Strength	Studies
Germinoblastoma [description not available]	2.02	1
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	2.02	1
Disease Exacerbation [description not available]	1.99	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.99	1
Experimental Hepatoma [description not available]	1.99	1
Cancer of Lung [description not available]	1.99	1
B16 Melanoma [description not available]	1.99	1
Metastase [description not available]	1.99	1
Lung Neoplasms Tumors or cancer of the LUNG.	1.99	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	1.99	1
Blood Poisoning [description not available]	2	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2	1
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	2	1
Arteriosclerosis Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	2.01	1
Acute Liver Injury, Drug-Induced [description not available]	1.97	1
Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	1.97	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.97	1

potassium

Description

Cross-References

Synonyms (41)

Occurs in Manufacturing (210 Product(s))

Product Categories

Products

Roles (2)

Drug Classes (4)

Pathways (460)

Research

Studies (15)

Market Indicators

Research Demand Index: 117.80

Study Types

potassium

Description

Cross-References

Synonyms (41)

Occurs in Manufacturing (210 Product(s))

Product Categories

Products

Roles (2)

Drug Classes (4)

Pathways (460)

Research

Studies (15)

Market Indicators

Research Demand Index: 117.80

Study Types

Related Drugs (11)

Related Conditions (17)