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Mineralocorticoid receptor
A mineralocorticoid receptor that is encoded in the genome of rat. [OMA:P22199, PRO:DNx]
Synonyms
MR;
Nuclear receptor subfamily 3 group C member 2
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (18)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bicalutamide | Rattus norvegicus (Norway rat) | IC50 | 680.0000 | 2 | 2 |
| aldosterone | Rattus norvegicus (Norway rat) | IC50 | 0.0430 | 2 | 2 |
| dihydrotestosterone | Rattus norvegicus (Norway rat) | IC50 | 2.1000 | 2 | 2 |
| eplerenone | Rattus norvegicus (Norway rat) | IC50 | 0.0398 | 1 | 1 |
| eplerenone | Rattus norvegicus (Norway rat) | Ki | 0.0444 | 1 | 1 |
Drugs with Activation Measurements
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs).Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs).Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs).Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist.Journal of medicinal chemistry, , 06-23, Volume: 65, Issue:12, 2022
[no title available]Journal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019