precocene i profile

Precocene I is a naturally occurring insect growth regulator found in plants like Vitex agnus-castus. It interferes with the biosynthesis of juvenile hormone in insects, leading to developmental abnormalities and reproductive failure. This compound has been extensively studied for its potential use in pest control. Precocene I has shown promise in controlling various insect species, including moths, beetles, and flies, without harming beneficial insects. Its mechanism of action, specificity, and environmental safety make it a promising alternative to traditional insecticides. Research continues to explore the potential of precocene I and its analogs for sustainable pest management.'

precocene I: cpd not in Chemline 7/20/83; structure; inhibits juvenille hormones [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

precocene I : A member of the class of chromenes that is 2H-chromene substituted by a methoxy group at position 7 and two methyl groups at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	28619
CHEMBL ID	451866
CHEBI ID	8368
SCHEMBL ID	118080
MeSH ID	M0072053

Synonym
7-methoxy-2,2-dimethyl-2h-chromene
7-methoxy-2,2-dimethylchromene
2,2-dimethyl-7-methoxy-2h-1-benzopyran
CHEBI:8368 ,
2,2-dimethyl-2h-chromen-7-yl methyl ether
6-demethoxyageratochromene
pricocene i
nsc318791
nsc-318791
brn 0133917
ai3-36846
nsc 318791
einecs 241-566-0
2h-1-benzopyran, 2,2-dimethyl-7-methoxy-
demethoxyageratochromene
2h-1-benzopyran, 7-methoxy-2,2-dimethyl-
inchi=1/c12h14o2/c1-12(2)7-6-9-4-5-10(13-3)8-11(9)14-12/h4-8h,1-3h
17598-02-6
precocene 1
precocene i
C09017
precocene i, 99%
prococene i
CHEMBL451866
BMSE000754
unii-25hlf91dgr
25hlf91dgr ,
AKOS006229098
FT-0637570
7-methoxy-2,2-dimethyl-2h-1-benzopyran
SCHEMBL118080
2,2-dimethyl-2h-chromen-7-yl methyl ether #
7-methoxy-2,2-dimethyl-3-chromene
DTXSID2037261
AS-42606
mfcd00006818
Q27108062
SB67357
dibutylchlorendate

Excerpt	Reference	Relevance
"Precocene I is a juvenile hormone antagonist that needs to be activated via oxidative biotransformation catalyzed by cytochrome P450 (CYP). "	( NADPH-cytochrome P450 reductase knockdown decreases the response to precocene I in the migratory locust Locusta migratoria. Li, H; Liu, X; Wu, H; Yuan, S; Zhang, J; Zhang, Y, 2023)	2.59

Excerpt	Reference	Relevance
"Precocene is known to inhibit JH biosynthesis in several non-social insects, but has been poorly studied in social insects."	( Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers. Amsalem, E; Grozinger, CM; Hefetz, A; Teal, P, 2014)	1.12

Excerpt	Reference	Relevance
" Precocene II was significantly more toxic to hepatocytes cultured from PB-treated, compared with untreated, gerbils."	( Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures. Fentem, JH; Fry, JR; Hammond, AH, 1991)	1.19
" Treatment of rats with cysteamine prior to treatment with precocene I protected the animals against the toxic effects."	( Metabolism and hepatotoxicity of the naturally occurring benzo[b]pyran precocene I. El-Naggar, SF; Halpin, RA; Jerina, DM; Vyas, KP, 1984)	0.74

Role	Description
precocenes	null
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
chromenes
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (23)

Assay ID	Title	Year	Journal	Article
AID1090246	Antifeeding activity against Sitophilus granarius (granary weevil) adults in compound treated wheat wafer disk assessed as absolute coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090254	Antifeeding activity against Trogoderma granarium (khapra beetle ) larvaes in compound treated wheat wafer disk assessed as absolute coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090257	Antifeeding activity against Tribolium confusum (confused flour beetle) larvaes in compound treated wheat wafer disk assessed as total coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090243	Antifeeding activity against Aphididae (aphids) in compound treated chinese cabbage leaves assessed as settled aphids measured up to 24 hr	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1080536	Inhibition of deoxynivalenol production by Fusarium graminearum in compound-pretreated rice solid culture medium at 152 ppm at 26.5 degC after 7 days by LC/MS analysis	2009	Journal of agricultural and food chemistry, Feb-11, Volume: 57, Issue:3	Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.
AID1090249	Antifeeding activity against Leptinotarsa decemlineata larvaes in compound treated wheat wafer disk assessed as relative coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090258	Antifeeding activity against Tribolium confusum (confused flour beetle) adults in compound treated wheat wafer disk assessed as absolute coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090252	Antifeeding activity against Trogoderma granarium (khapra beetle) larvaes in compound treated wheat wafer disk assessed as total coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090255	Antifeeding activity against Tribolium confusum (confused flour beetle) adults in compound treated wheat wafer disk assessed as total coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090242	Antifeeding activity against Leptinotarsa decemlineata adults in compound treated wheat wafer disk assessed as absolute coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1080540	Inhibition of 3-acetyldeoxynivalenol production by Fusarium graminearum in liquid culture at 26.5 degC after 7 days by thin layer chromatography	2009	Journal of agricultural and food chemistry, Feb-11, Volume: 57, Issue:3	Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.
AID1090256	Antifeeding activity against Tribolium confusum (confused flour beetle) adults in compound treated wheat wafer disk assessed as relative coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090251	Antifeeding activity against Sitophilus granarius (granary weevil) adults in compound treated wheat wafer disk assessed as total coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090259	Antifeeding activity against Tribolium confusum (confused flour beetle) larvaes in compound treated wheat wafer disk assessed as relative coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090248	Antifeeding activity against Leptinotarsa decemlineata larvaes in compound treated wheat wafer disk assessed as absolute coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090245	Antifeeding activity against Leptinotarsa decemlineata adults in compound treated wheat wafer disk assessed as relative coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090247	Antifeeding activity against Leptinotarsa decemlineata larvaes in compound treated wheat wafer disk assessed as total coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090244	Antifeeding activity against Leptinotarsa decemlineata adults in compound treated wheat wafer disk assessed as total coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1080538	Inhibition of 3-acetyldeoxynivalenol production by Fusarium graminearum in compound-pretreated rice solid culture medium at 26.5 degC after 7 days by LC/MS analysis	2009	Journal of agricultural and food chemistry, Feb-11, Volume: 57, Issue:3	Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.
AID1090250	Antifeeding activity against Sitophilus granarius (granary weevil) adults in compound treated wheat wafer disk assessed as relative coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090253	Antifeeding activity against Trogoderma granarium (khapra beetle) larvaes in compound treated wheat wafer disk assessed as relative coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1090260	Antifeeding activity against Tribolium confusum (confused flour beetle) larvaes in compound treated wheat wafer disk assessed as absolute coefficient of deterrence by feeding deterrent activity test	2005	Journal of agricultural and food chemistry, Jul-27, Volume: 53, Issue:15	Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.
AID1080537	Inhibition of deoxynivalenol production by Fusarium graminearum in compound-pretreated rice solid culture medium at 5.7 ppm at 26.5 degC after 7 days by LC/MS analysis	2009	Journal of agricultural and food chemistry, Feb-11, Volume: 57, Issue:3	Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	9 (29.03)	18.7374
1990's	6 (19.35)	18.2507
2000's	6 (19.35)	29.6817
2010's	8 (25.81)	24.3611
2020's	2 (6.45)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.86%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	34 (97.14%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.38	2	coumarins	fluorescent dye; human metabolite; plant metabolite
1-propanol 1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.	1.98	1	propan-1-ols; short-chain primary fatty alcohol	metabolite; protic solvent
1-aminobenzotriazole [no description available]	2.06	1
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	1.96	1	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
acetaminophen Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	2.02	1	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.06	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
midazolam Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.. midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.	2.02	1	imidazobenzodiazepine; monofluorobenzenes; organochlorine compound	anticonvulsant; antineoplastic agent; anxiolytic drug; apoptosis inducer; central nervous system depressant; GABAA receptor agonist; general anaesthetic; muscle relaxant; sedative
quinone benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.. 1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.. quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).	2.02	1	1,4-benzoquinones	cofactor; human xenobiotic metabolite; mouse metabolite
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.37	2	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
sulfaphenazole Sulfaphenazole: A sulfonilamide anti-infective agent.. sulfaphenazole : A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.	2.06	1	primary amino compound; pyrazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial drug; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor; P450 inhibitor
piperonyl butoxide [no description available]	1.97	1	benzodioxoles	pesticide synergist
piperitone piperitone: from Mentha longifolia var. chorodictya Rech F; structure in first source. piperitone : A p-menthane monoterpenoid that is cyclohex-2-en-1-one substituted by a methyl group at position 3 and an isopropyl group at position 6.	2.05	1	cyclic terpene ketone; p-menthane monoterpenoid	plant metabolite; volatile oil component
allyl alcohol allyl alcohol: structure. allylic alcohol : An alcohol where the hydroxy group is attached to a saturated carbon atom adjacent to a double bond (R groups may be H, organyl, etc.).. allyl alcohol : A propenol in which the C=C bond connects C-2 and C-3. It is has been found in garlic (Allium sativum). Formerly used as a herbicide for the control of various grass and weed seeds.	1.98	1	primary allylic alcohol; propenol	antibacterial agent; fungicide; herbicide; insecticide; plant metabolite
ditiocarb Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.	2.06	1	dithiocarbamic acids	chelator; copper chelator
precocene ii precocene II: has antibacterial, antifungal, insecticidal, and antioxidant activities; from plants of genus Ageratum; an antiallotropin compound capable of inhibiting juvenile hormone biosynthesis	4.95	12	chromenes	precocenes
tranylcypromine Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311). tranylcypromine : A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).. (1R,2S)-tranylcypromine : A 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine.	2.06	1	2-phenylcyclopropan-1-amine
deoxynivalenol deoxynivalenol : A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.	2.05	1	cyclic ketone; enone; primary alcohol; secondary alpha-hydroxy ketone; trichothecene; triol	mycotoxin
fenoxycarb fenoxycarb: used against mosquitoes (Diptera:Culicidae); structure given in first source. fenoxycarb : A carbamate ester that is the O-ethyl carbamate of 2-(4-phenoxyphenoxy)ethylamine.	2.21	1	aromatic ether; carbamate ester	environmental contaminant; insecticide; juvenile hormone mimic; xenobiotic
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.06	1	1,2,3-triazole
thionium [no description available]	2.01	1
phenazopyridine lapachenole: photoaffinity label	2.02	1	benzochromene
flavin-adenine dinucleotide Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)	2.6	1	flavin adenine dinucleotide; vitamin B2	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; prosthetic group
sesquiterpenes [no description available]	2.7	3
nadp [no description available]	7.6	1
caryophyllene caryophyllene: RN given refers to cpd without isomeric designation; structure given in first source	2.06	1
methoprene Methoprene: Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.	2.41	2	isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate; isopropyl ester	juvenile hormone mimic
ecdysterone Ecdysterone: A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.. 20-hydroxyecdysone : An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20.	2.72	3	14alpha-hydroxy steroid; 20-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; ecdysteroid; phytoecdysteroid	animal metabolite; plant metabolite
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.38	2	benzenes; hydroxycoumarin; methyl ketone

Condition	Relationship Strength	Studies
Sterility, Female [description not available]	2.1	1
Aggression Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.	2.1	1
Infertility, Female Diminished or absent ability of a female to achieve conception.	2.1	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.06	1
American Trypanosomiasis [description not available]	1.95	1
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	1.95	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2	1

precocene i

Description

Cross-References

Synonyms (39)

Research Excerpts

Overview

Actions

Toxicity

Roles (2)

Drug Classes (2)

Bioassays (23)

Research

Studies (31)

Market Indicators

Research Demand Index: 20.36

Study Types

precocene i

Description

Cross-References

Synonyms (39)

Research Excerpts

Overview

Actions

Toxicity

Roles (2)

Drug Classes (2)

Bioassays (23)

Research

Studies (31)

Market Indicators

Research Demand Index: 20.36

Study Types

Related Drugs (28)

Related Conditions (7)