A thromboxane-A synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24557]
TXA synthase;
TXS;
EC 5.3.99.5;
Cytochrome P450 5A1;
Hydroperoxy icosatetraenoate dehydratase;
4.2.1.152
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 11 (28.21) | 18.7374 |
| 1990's | 17 (43.59) | 18.2507 |
| 2000's | 9 (23.08) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| imidazole | Homo sapiens (human) | IC50 | 670.0000 | 1 | 1 |
| aminoglutethimide | Homo sapiens (human) | IC50 | 18.5000 | 2 | 3 |
| bithionol | Homo sapiens (human) | IC50 | 1.8400 | 1 | 0 |
| candesartan | Homo sapiens (human) | IC50 | 3.0594 | 1 | 0 |
| clotrimazole | Homo sapiens (human) | IC50 | 0.0140 | 1 | 0 |
| econazole | Homo sapiens (human) | IC50 | 0.0290 | 1 | 0 |
| hexachlorophene | Homo sapiens (human) | IC50 | 3.0870 | 1 | 0 |
| indomethacin | Homo sapiens (human) | IC50 | 50.0500 | 2 | 2 |
| ketoconazole | Homo sapiens (human) | IC50 | 2.1650 | 1 | 0 |
| miconazole | Homo sapiens (human) | IC50 | 0.2630 | 1 | 0 |
| nifedipine | Homo sapiens (human) | IC50 | 18.5940 | 1 | 0 |
| nitrendipine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| imatinib | Homo sapiens (human) | IC50 | 0.1980 | 1 | 0 |
| sulconazole | Homo sapiens (human) | IC50 | 0.1830 | 1 | 0 |
| sulfasalazine | Homo sapiens (human) | IC50 | 19.6390 | 1 | 0 |
| troglitazone | Homo sapiens (human) | IC50 | 2.9660 | 1 | 0 |
| ici 204,219 | Homo sapiens (human) | IC50 | 3.8100 | 1 | 0 |
| ergotamine | Homo sapiens (human) | IC50 | 3.0640 | 1 | 0 |
| sterogenol | Homo sapiens (human) | IC50 | 6.4520 | 1 | 0 |
| alpha-naphthoflavone | Homo sapiens (human) | IC50 | 6.7608 | 1 | 0 |
| vinblastine | Homo sapiens (human) | IC50 | 1.8700 | 1 | 0 |
| 3,3',4',5-tetrachlorosalicylanilide | Homo sapiens (human) | IC50 | 4.9270 | 1 | 0 |
| 4-octylphenol | Homo sapiens (human) | IC50 | 66.0490 | 1 | 0 |
| closantel | Homo sapiens (human) | IC50 | 0.0640 | 1 | 0 |
| sulotroban | Homo sapiens (human) | IC50 | 94.1000 | 1 | 1 |
| dazoxiben hydrochloride | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| dazoxiben | Homo sapiens (human) | IC50 | 0.5985 | 15 | 16 |
| dazmegrel | Homo sapiens (human) | IC50 | 0.0280 | 2 | 2 |
| pirmagrel | Homo sapiens (human) | IC50 | 0.0032 | 1 | 1 |
| ablukast | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| trovafloxacin | Homo sapiens (human) | IC50 | 4.0230 | 1 | 0 |
| nelfinavir | Homo sapiens (human) | IC50 | 21.1100 | 1 | 0 |
| amprenavir | Homo sapiens (human) | IC50 | 6.7270 | 1 | 0 |
| ergocornine | Homo sapiens (human) | IC50 | 1.9930 | 1 | 0 |
| 1-benzylimidazole | Homo sapiens (human) | IC50 | 0.6020 | 1 | 0 |
| rosiglitazone | Homo sapiens (human) | IC50 | 3.5600 | 1 | 0 |
| cv 6504 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| fpl 55712 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid | Homo sapiens (human) | IC50 | 0.0120 | 1 | 1 |
| cyclohexylaminoglutethimide | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| cgs 22652 | Homo sapiens (human) | IC50 | 0.0060 | 4 | 6 |
| 1-(2,3-bis((4-methoxyphenyl)methoxy)propyl)-1h-imidazole | Homo sapiens (human) | IC50 | 9.9000 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | IC50 | 0.4940 | 1 | 0 |
| uk 34787 | Homo sapiens (human) | IC50 | 0.0150 | 2 | 2 |
| ritonavir | Homo sapiens (human) | IC50 | 0.0760 | 1 | 0 |
| saquinavir | Homo sapiens (human) | IC50 | 2.1820 | 1 | 0 |
| e 3040 | Homo sapiens (human) | IC50 | 0.0495 | 2 | 2 |
| diethylstilbestrol | Homo sapiens (human) | IC50 | 4.3590 | 1 | 0 |
| tamoxifen | Homo sapiens (human) | IC50 | 0.9160 | 1 | 0 |
| sitagliptin | Homo sapiens (human) | IC50 | 0.0194 | 1 | 1 |
| alprostadil | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| genistein | Homo sapiens (human) | IC50 | 7.7200 | 1 | 0 |
| montelukast | Homo sapiens (human) | IC50 | 1.5250 | 1 | 0 |
| ozagrel | Homo sapiens (human) | IC50 | 0.0864 | 5 | 5 |
| isbogrel | Homo sapiens (human) | IC50 | 0.0202 | 7 | 7 |
| lacidipine | Homo sapiens (human) | IC50 | 1.6940 | 1 | 0 |
| oxiconazole | Homo sapiens (human) | IC50 | 0.6174 | 1 | 0 |
| ridogrel | Homo sapiens (human) | IC50 | 0.0062 | 6 | 7 |
| indinavir sulfate | Homo sapiens (human) | IC50 | 1.8510 | 1 | 0 |
| 6-(4-(2-(((4-chlorophenyl)sulfonyl)amino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid | Homo sapiens (human) | IC50 | 0.0040 | 3 | 3 |
| ozagrel, monohydrochloride, (e)-isomer | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| terbogrel | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| gw 1929 | Homo sapiens (human) | IC50 | 2.9530 | 1 | 0 |
| isbogrel | Homo sapiens (human) | IC50 | 0.0222 | 3 | 4 |
| mf63 compound | Homo sapiens (human) | IC50 | 3.0000 | 2 | 2 |
| tannins | Homo sapiens (human) | IC50 | 0.3250 | 1 | 0 |
| pf 9184 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| monooxygenase activity | molecular function | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732] |
| thromboxane-A synthase activity | molecular function | Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). [EC:5.3.99.5, RHEA:17137] |
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. [GOC:mah] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| 12-hydroxyheptadecatrienoic acid synthase activity | molecular function | Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA). [GOC:mw, PMID:11297515] |
| hydroperoxy icosatetraenoate dehydratase activity | molecular function | A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O. [PMID:12881489, RHEA:55556] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| prostaglandin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. [GOC:ai] |
| icosanoid metabolic process | biological process | The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. [GOC:ma] |
| cyclooxygenase pathway | biological process | The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. [PMID:19854273] |
| intracellular chloride ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell. [GOC:mah] |
| response to ethanol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators] |
| positive regulation of vasoconstriction | biological process | Any process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators] |
| response to fatty acid | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:lp] |