Proteins > Nociceptin receptor
Page last updated: 2024-08-07 16:37:31

Nociceptin receptor

A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146]

Synonyms

Kappa-type 3 opioid receptor;
KOR-3;
Orphanin FQ receptor

Research

Bioassay Publications (48)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (4.17)18.2507
2000's29 (60.42)29.6817
2010's15 (31.25)24.3611
2020's2 (4.17)2.80

Compounds (21)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fluspirileneHomo sapiens (human)Ki0.500022
loperamideHomo sapiens (human)Ki10.000011
atomoxetineHomo sapiens (human)IC505.000011
u 69593Homo sapiens (human)Ki10.000011
j 113397Homo sapiens (human)IC500.002855
j 113397Homo sapiens (human)Ki0.001422
n-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamideHomo sapiens (human)IC500.030011
n-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamideHomo sapiens (human)Ki0.008222
naltrexoneHomo sapiens (human)Ki10.000011
enkephalin, ala(2)-mephe(4)-gly(5)-Homo sapiens (human)Ki10.000011
norbinaltorphimineHomo sapiens (human)Ki0.047011
dermorphinHomo sapiens (human)IC5010.000011
pmx 53Homo sapiens (human)IC502.200011
camostatHomo sapiens (human)IC505.000011
ro 64-6198Homo sapiens (human)Ki0.001111
sr 14150Homo sapiens (human)Ki0.001444
sb-612111Homo sapiens (human)Ki0.000333
naluzotanHomo sapiens (human)Ki2.000011
cebranopadolHomo sapiens (human)Ki0.000911
a 803467Homo sapiens (human)IC5010.000011
nociceptinHomo sapiens (human)IC500.00101011
nociceptinHomo sapiens (human)Ki0.00021515
1-(1-(1-methylcyclooctyl)-4-piperidinyl)-2-((3r)-3-piperidinyl)-1h-benzimidazoleHomo sapiens (human)Ki0.000111

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
j 113397Homo sapiens (human)EC5010.000022
naltrindoleHomo sapiens (human)EC500.003911
ro 64-6198Homo sapiens (human)EC500.021011
sr 14150Homo sapiens (human)EC500.020633
cebranopadolHomo sapiens (human)EC500.013011
nociceptinHomo sapiens (human)EC500.00691718
nociceptinHomo sapiens (human)Kd0.000122
1-(1-(1-methylcyclooctyl)-4-piperidinyl)-2-((3r)-3-piperidinyl)-1h-benzimidazoleHomo sapiens (human)EC500.000411

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
j 113397Homo sapiens (human)Kb0.000611
j 113397Homo sapiens (human)Ke0.000811
sb-612111Homo sapiens (human)Kb0.001833
nociceptinHomo sapiens (human)Kb0.002611

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
nociceptin receptor activitymolecular functionCombining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:18670432]
G protein-coupled receptor activitymolecular functionCombining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
neuropeptide bindingmolecular functionInteracting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cytoplasmic vesiclecellular componentA vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
phospholipase C-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
sensory perceptionbiological processThe series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai, GOC:dph]
sensory perception of painbiological processThe series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]
response to estradiolbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
positive regulation of urine volumebiological processAny process that increases the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]
G protein-coupled opioid receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bf, PMID:20494127]
eating behaviorbiological processThe specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967]
negative regulation of cAMP-mediated signalingbiological processAny process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling. [GOC:jl]
estrous cyclebiological processA type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. [GOC:jl, Wikipedia:Estrous_cycle]
negative regulation of blood pressurebiological processAny process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]
regulation of locomotor rhythmbiological processAny process that modulates the frequency, rate or extent of locomotor rhythm. [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
conditioned place preferencebiological processThe associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug. [PMID:21549821]
neuropeptide signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]