Proteins > UDP-glucuronosyltransferase 2B10

Page last updated: 2024-08-07 13:15:38

UDP-glucuronosyltransferase 2B10

A UDP-glucuronosyltransferase 2B10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36537]

Synonyms

UDPGT 2B10;
EC 2.4.1.17

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Compounds (18)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
coumarin	Homo sapiens (human)	IC50	300.0000	1	5
bupropion	Homo sapiens (human)	IC50	228.0000	1	5
chlorzoxazone	Homo sapiens (human)	IC50	300.0000	1	5
diclofenac	Homo sapiens (human)	IC50	131.0000	1	3
furafylline	Homo sapiens (human)	IC50	300.0000	1	6
midazolam	Homo sapiens (human)	IC50	75.5000	1	4
omeprazole	Homo sapiens (human)	IC50	228.2000	1	5
phenacetin	Homo sapiens (human)	IC50	300.0000	1	7
sulfaphenazole	Homo sapiens (human)	IC50	300.0000	1	6
tolbutamide	Homo sapiens (human)	IC50	296.2000	1	5
chlormethiazole	Homo sapiens (human)	IC50	300.0000	1	5
alpha-naphthoflavone	Homo sapiens (human)	IC50	115.4000	1	5
paclitaxel	Homo sapiens (human)	IC50	139.7800	1	5
oleandomycin	Homo sapiens (human)	IC50	154.0000	1	7
(S)-Mephenytoin	Homo sapiens (human)	IC50	300.0000	1	5
quinidine	Homo sapiens (human)	IC50	273.2000	1	5
cyclosporine	Homo sapiens (human)	IC50	211.8333	1	6

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezogabine	Homo sapiens (human)	EC50	3.9000	1	1

Enables

This protein enables 1 target(s):

Target	Category	Definition
UDP-glycosyltransferase activity	molecular function	Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. [InterPro:IPR004224, PMID:11846783]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Involved In

This protein is involved in 3 target(s):

Target	Category	Definition
lipid metabolic process	biological process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
cellular glucuronidation	biological process	The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]
estrogen metabolic process	biological process	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]