Proteins > cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Page last updated: 2024-08-07 17:02:22

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

A 3,5-cyclic-AMP phosphodiesterase 4B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07343]

Synonyms

EC 3.1.4.53;
DPDE4;
PDE32

Research

Bioassay Publications (155)

TimeframeStudies on this Protein(%)All Drugs %
pre-19907 (4.52)18.7374
1990's28 (18.06)18.2507
2000's50 (32.26)29.6817
2010's57 (36.77)24.3611
2020's13 (8.39)2.80

Compounds (79)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
theophyllineHomo sapiens (human)IC50527.750044
theophyllineHomo sapiens (human)Ki530.000011
denbufyllineHomo sapiens (human)IC500.085122
dipyridamoleHomo sapiens (human)IC500.500011
fluoxetineHomo sapiens (human)Ki1.560011
ibudilastHomo sapiens (human)IC501.710033
amrinoneHomo sapiens (human)IC50113.600045
1-methyl-3-isobutylxanthineHomo sapiens (human)IC5023.570033
losartanHomo sapiens (human)IC5026.000011
milrinoneHomo sapiens (human)IC506.000011
pentoxifyllineHomo sapiens (human)IC5090.000011
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinoneHomo sapiens (human)IC5018.933323
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinoneHomo sapiens (human)Ki1.930011
rolipramHomo sapiens (human)IC5017.00128999
rolipramHomo sapiens (human)Ki1.25771418
streptonigrinHomo sapiens (human)IC501.870011
thalidomideHomo sapiens (human)IC50500.000011
trequinsinHomo sapiens (human)IC500.400011
zardaverineHomo sapiens (human)IC5071.4748514
1-hydroxyphthalazineHomo sapiens (human)IC500.520011
9-benzyladenineHomo sapiens (human)IC50160.000011
8-bromo cyclic adenosine monophosphateHomo sapiens (human)IC5018.466723
cartazolateHomo sapiens (human)IC500.199511
enoximoneHomo sapiens (human)IC5052.633333
imazodanHomo sapiens (human)IC506.000011
nitraquazoneHomo sapiens (human)IC500.050011
cipamfyllineHomo sapiens (human)IC501.900011
cipamfyllineHomo sapiens (human)Ki21.000011
ethyl 3-amino-1h-pyrazole-4-carboxylateHomo sapiens (human)IC50200.000012
8-((4-chlorophenyl)thio)cyclic-3',5'-ampHomo sapiens (human)IC5081.333323
8-thio-benzyl cyclic ampHomo sapiens (human)IC5029.000023
8-chloro-cyclic adenosine monophosphateHomo sapiens (human)IC5034.333323
tadalafilHomo sapiens (human)IC5066.9007616
4-phenylpyrrolidone-2Homo sapiens (human)IC501,000.000012
cdp 840Homo sapiens (human)IC500.102867
7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridineHomo sapiens (human)IC500.016011
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)Ki200.000011
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)IC5016.000011
cilomilastHomo sapiens (human)IC5014.36752639
cilomilastHomo sapiens (human)Ki0.038022
rp 73401Homo sapiens (human)IC5011.49842132
rp 73401Homo sapiens (human)Ki0.001166
moracin cHomo sapiens (human)IC5018.100011
(+)-rolipramHomo sapiens (human)IC501.350022
n(6)-benzyl-cyclic adenosine 5'-monophosphateHomo sapiens (human)IC5068.000023
betulinan aHomo sapiens (human)IC5044.000011
moracin mHomo sapiens (human)IC504.500011
mesembrenoneHomo sapiens (human)IC500.470011
cocaineHomo sapiens (human)Ki1.115011
rolipramHomo sapiens (human)IC500.36661111
mesopramHomo sapiens (human)IC500.420022
roflumilastHomo sapiens (human)IC5031.86603039
roflumilastHomo sapiens (human)Ki0.000411
cyclic nucleotide phosphodiesterases, type 4Homo sapiens (human)IC500.029023
hc 030031Homo sapiens (human)IC50200.000011
3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzeneHomo sapiens (human)IC50117.266733
4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2h)-pyridazinoneHomo sapiens (human)Ki50.000026
tetomilastHomo sapiens (human)IC500.074011
indolidanHomo sapiens (human)IC500.150011
fosbretabulinHomo sapiens (human)IC5010.000011
sch 351591Homo sapiens (human)IC500.060033
rs 14203Homo sapiens (human)IC500.005022
gsk 256066Homo sapiens (human)IC500.000044
ci 1044Homo sapiens (human)IC500.270011
l-454,560Homo sapiens (human)IC500.000867
t 1032Homo sapiens (human)IC503.300011
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chlorideHomo sapiens (human)Ki1.000011
8-(methylthio)cyclic 3',5'-adenosine monophosphateHomo sapiens (human)IC5039.000023
apremilastHomo sapiens (human)IC500.059077
f-amidineHomo sapiens (human)IC50110.800022
8-benzylthio-n(6)-n-butyladenosine cyclic-3,5'-monophosphateHomo sapiens (human)IC5040.000023
3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineHomo sapiens (human)IC503.361833
n-alpha-benzoyl-n5-(2-chloro-1-iminoethyl)-l-ornithine amideHomo sapiens (human)IC505.900011
an2728Homo sapiens (human)IC5010.179677
bms-911543Homo sapiens (human)IC505.600011
gsk1210151aHomo sapiens (human)IC503.981111
chf6001Homo sapiens (human)IC500.000033
sildenafilHomo sapiens (human)IC5023.52511120
zaprinastHomo sapiens (human)IC5024.333333
zaprinastHomo sapiens (human)Ki43.126726
vardenafilHomo sapiens (human)IC506.6668312
ImidazosagatriazinoneHomo sapiens (human)IC500.500011
pelrinoneHomo sapiens (human)IC504.000011
lixazinoneHomo sapiens (human)IC500.006011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
rolipramHomo sapiens (human)EC500.660022

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
resveratrolHomo sapiens (human)AC50100.000011
pterostilbeneHomo sapiens (human)AC5045.000011
3,4',5-trimethoxystilbeneHomo sapiens (human)AC5025.000011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
3',5'-cyclic-AMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]
calcium channel regulator activitymolecular functionModulates the activity of a calcium channel. [GOC:mah]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
cAMP bindingmolecular functionBinding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]
gamma-tubulin bindingmolecular functionBinding to the microtubule constituent protein gamma-tubulin. [GOC:jl]
transmembrane transporter bindingmolecular functionBinding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
3',5'-cyclic-GMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957]

Located In

This protein is located in 7 target(s):

TargetCategoryDefinition
centrosomecellular componentA structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
synaptic vesiclecellular componentA secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. [PMID:10099709, PMID:12563290]
postsynaptic densitycellular componentAn electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
Z disccellular componentPlatelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]
dendritic spinecellular componentA small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
excitatory synapsecellular componentA synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
perinuclear region of cytoplasmcellular componentCytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
gamma-tubulin complexcellular componentA multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. [GOC:clt, PMID:12134075]
voltage-gated calcium channel complexcellular componentA protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
neutrophil homeostasisbiological processThe process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]
cAMP catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [ISBN:0198506732]
neutrophil chemotaxisbiological processThe directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]
positive regulation of type II interferon productionbiological processAny process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-2 productionbiological processAny process that activates or increases the frequency, rate, or extent of interleukin-2 production. [GOC:mah]
T cell receptor signaling pathwaybiological processThe series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add]
leukocyte migrationbiological processThe movement of a leukocyte within or between different tissues and organs of the body. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
cellular response to xenobiotic stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:krc, GOC:mah]
cellular response to epinephrine stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah]
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah]
regulation of cardiac muscle cell contractionbiological processAny process that modulates the frequency, rate or extent of cardiac muscle cell contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
negative regulation of relaxation of cardiac musclebiological processAny process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelbiological processAny process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]
cAMP-mediated signalingbiological processAn intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]