Page last updated: 2024-08-07 16:06:26
D
A D(1A) dopamine receptor that is encoded in the genome of rat. [OMA:P18901, PRO:DNx]
Synonyms
Dopamine D1 receptor
Research
Bioassay Publications (106)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 35 (33.02) | 18.7374 |
| 1990's | 46 (43.40) | 18.2507 |
| 2000's | 21 (19.81) | 29.6817 |
| 2010's | 4 (3.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (125)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sk&f 82958 | Rattus norvegicus (Norway rat) | IC50 | 0.0051 | 1 | 4 |
| octoclothepine | Rattus norvegicus (Norway rat) | IC50 | 0.0028 | 2 | 4 |
| octoclothepine | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 2 | 2 |
| sk&f 77434 | Rattus norvegicus (Norway rat) | IC50 | 0.0197 | 1 | 4 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 0.1900 | 1 | 4 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | Ki | 0.0640 | 1 | 2 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| bmy 7378 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 2 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 2 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 0.1414 | 9 | 14 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0337 | 3 | 4 |
| cisapride | Rattus norvegicus (Norway rat) | IC50 | 0.0065 | 1 | 1 |
| cisapride | Rattus norvegicus (Norway rat) | Ki | 1.7000 | 1 | 1 |
| clonidine | Rattus norvegicus (Norway rat) | Ki | 4.0000 | 1 | 2 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| adtn | Rattus norvegicus (Norway rat) | IC50 | 0.0024 | 2 | 2 |
| fenoldopam | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 1 | 1 |
| granisetron | Rattus norvegicus (Norway rat) | IC50 | 3.8019 | 1 | 1 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 0.0091 | 1 | 2 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.1103 | 7 | 9 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.1550 | 17 | 23 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 2.0992 | 2 | 2 |
| jl 18 | Rattus norvegicus (Norway rat) | Ki | 0.3980 | 1 | 1 |
| ketanserin | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| methiothepin | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| metoclopramide | Rattus norvegicus (Norway rat) | Ki | 0.2291 | 1 | 2 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 1.4200 | 1 | 1 |
| mirtazapine | Rattus norvegicus (Norway rat) | Ki | 4.1670 | 1 | 1 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| nomifensine | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 3 |
| perhexiline | Rattus norvegicus (Norway rat) | IC50 | 7.7625 | 1 | 1 |
| phenoxybenzamine | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 1 | 2 |
| prazosin | Rattus norvegicus (Norway rat) | Ki | 5.6000 | 1 | 3 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 1.0400 | 1 | 2 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 2 |
| 3-allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine | Rattus norvegicus (Norway rat) | IC50 | 0.0101 | 1 | 4 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.0602 | 3 | 4 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 1.5010 | 2 | 2 |
| sulpiride | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| terfenadine | Rattus norvegicus (Norway rat) | IC50 | 0.1288 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.3046 | 4 | 5 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.4744 | 12 | 12 |
| apomorphine | Rattus norvegicus (Norway rat) | Ki | 0.3862 | 8 | 8 |
| caramiphen | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 2 |
| phenylpiperazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| yohimbine | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| apomorphine hydrochloride, anhydrous | Rattus norvegicus (Norway rat) | Ki | 0.1218 | 2 | 2 |
| liriodenine | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| boldine | Rattus norvegicus (Norway rat) | IC50 | 0.4000 | 1 | 1 |
| boldine | Rattus norvegicus (Norway rat) | Ki | 0.2900 | 1 | 1 |
| triethylenephosphoramide | Rattus norvegicus (Norway rat) | IC50 | 0.4300 | 1 | 1 |
| bulbocapnine | Rattus norvegicus (Norway rat) | IC50 | 0.7395 | 2 | 2 |
| apocodeine | Rattus norvegicus (Norway rat) | IC50 | 8.5667 | 3 | 3 |
| 11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.2000 | 1 | 2 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 2 | 3 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0211 | 2 | 4 |
| clothiapine | Rattus norvegicus (Norway rat) | Ki | 0.0141 | 1 | 2 |
| pimozide | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 4 |
| glaucine | Rattus norvegicus (Norway rat) | Ki | 2.9000 | 1 | 1 |
| laurolitsine | Rattus norvegicus (Norway rat) | IC50 | 2.5000 | 1 | 1 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| penfluridol | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0053 | 2 | 3 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 2 | 2 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 2 | 3 |
| fluperlapine | Rattus norvegicus (Norway rat) | Ki | 0.1412 | 1 | 2 |
| flutroline | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 2 |
| quinpirole | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| gepirone | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| quinelorane | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| sertindole | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 3 |
| aripiprazole | Rattus norvegicus (Norway rat) | Ki | 0.9804 | 2 | 2 |
| ziprasidone | Rattus norvegicus (Norway rat) | IC50 | 0.1514 | 1 | 1 |
| sertraline hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 1 |
| mizolastine | Rattus norvegicus (Norway rat) | IC50 | 0.3548 | 1 | 1 |
| lerisetron | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| sertraline | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 2 |
| mezilamine | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 2 | 3 |
| tefludazine | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 1 |
| atherospermine | Rattus norvegicus (Norway rat) | Ki | 2.9307 | 1 | 2 |
| ecopipam | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 1 | 1 |
| 6-chloro-2-(1-piperazinyl)pyrazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| pramipexole | Rattus norvegicus (Norway rat) | Ki | 50.0135 | 2 | 2 |
| 2-(n,n-dimethylamino)-6,7-dihydroxytetralin | Rattus norvegicus (Norway rat) | Ki | 0.0570 | 1 | 1 |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | IC50 | 0.1355 | 2 | 3 |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | Ki | 0.1700 | 1 | 1 |
| a 68930 | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 3 | 5 |
| 1,2,3,6-tetrahydro-4-phenyl-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| 2-methoxy-n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 3.3200 | 2 | 2 |
| 2-methoxy-n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | Ki | 3.3433 | 3 | 3 |
| sc 53116 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 34.4300 | 1 | 1 |
| dexmethylphenidate hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.1235 | 2 | 2 |
| chloroethylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 5.1970 | 2 | 2 |
| anonaine | Rattus norvegicus (Norway rat) | IC50 | 68.0000 | 1 | 1 |
| stephenanthrine | Rattus norvegicus (Norway rat) | Ki | 5.2435 | 1 | 2 |
| n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.3195 | 3 | 5 |
| n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | Ki | 1.4933 | 3 | 3 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 0.9300 | 1 | 1 |
| (R)-Roemerine | Rattus norvegicus (Norway rat) | Ki | 0.3507 | 1 | 2 |
| dironyl | Rattus norvegicus (Norway rat) | IC50 | 0.0690 | 1 | 2 |
| cocaine | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| tropisetron | Rattus norvegicus (Norway rat) | Ki | 0.0114 | 2 | 3 |
| 4-phenyl-1-(4-phenylbutyl)piperidine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| sch 23390 | Rattus norvegicus (Norway rat) | IC50 | 0.0010 | 3 | 3 |
| sch 23390 | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 7 | 9 |
| pm 1000 | Rattus norvegicus (Norway rat) | Ki | 3.4707 | 3 | 3 |
| n-(1-methyl-5-indolyl)-n'-(3-methyl-5-isothiazolyl)urea | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| le 300 | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| flupenthixol | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| l 745870 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| notopterol | Rattus norvegicus (Norway rat) | Ki | 1.4220 | 1 | 1 |
| fluvoxamine | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 1 |
| zimeldine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| morphine chloride | Rattus norvegicus (Norway rat) | IC50 | 0.0340 | 2 | 4 |
| a 77636 | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 2.2050 | 2 | 2 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | Ki | 0.8000 | 1 | 1 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 1.0162 | 4 | 4 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | Ki | 0.9175 | 2 | 2 |
| dihydrexidine | Rattus norvegicus (Norway rat) | IC50 | 0.0096 | 2 | 2 |
| dihydrexidine | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 1 | 1 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 0.0470 | 2 | 5 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | Ki | 0.0568 | 3 | 4 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 3 |
| dinapsoline | Rattus norvegicus (Norway rat) | IC50 | 0.0330 | 1 | 1 |
| 2-propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-azacyclopent-1-ena(c)phenanthrene-9,10-diol | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 1 |
| pnu 96415e | Rattus norvegicus (Norway rat) | Ki | 0.4100 | 1 | 1 |
| n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.3680 | 2 | 2 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.6179 | 7 | 7 |
| (5R)-9-bromo-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol | Rattus norvegicus (Norway rat) | IC50 | 0.0043 | 1 | 4 |
| octoclothepine, (s)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 3 | 3 |
| octoclothepine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 2 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 1.0661 | 8 | 12 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.2369 | 13 | 16 |
| olanzapine | Rattus norvegicus (Norway rat) | Ki | 0.0711 | 7 | 7 |
| flumezapine | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
A two-state homology model of the hERG K+ channel: application to ligand binding.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.Journal of medicinal chemistry, , Jan-20, Volume: 38, Issue:2, 1995
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.Journal of medicinal chemistry, , Volume: 26, Issue:4, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.Journal of medicinal chemistry, , Volume: 23, Issue:8, 1980
A two-state homology model of the hERG K+ channel: application to ligand binding.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.Journal of medicinal chemistry, , Volume: 30, Issue:7, 1987
Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.Journal of medicinal chemistry, , 01-11, Volume: 61, Issue:1, 2018
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical anJournal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.Bioorganic & medicinal chemistry letters, , Apr-21, Volume: 8, Issue:8, 1998
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone.Journal of medicinal chemistry, , Aug-05, Volume: 37, Issue:16, 1994
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.Journal of medicinal chemistry, , Oct-14, Volume: 37, Issue:21, 1994
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.Journal of medicinal chemistry, , Volume: 34, Issue:12, 1991
Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines.Journal of medicinal chemistry, , Volume: 29, Issue:1, 1986
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.Bioorganic & medicinal chemistry letters, , Apr-21, Volume: 8, Issue:8, 1998
(+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent.Journal of medicinal chemistry, , Volume: 32, Issue:7, 1989
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
A two-state homology model of the hERG K+ channel: application to ligand binding.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 30, Issue:10, 1987
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies.Bioorganic & medicinal chemistry letters, , Apr-09, Volume: 11, Issue:7, 2001
11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
(R)-11-hydroxy- and (R)-11-hydroxy-10-methylaporphine: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.Journal of medicinal chemistry, , Oct-14, Volume: 37, Issue:21, 1994
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Aporphines as antagonists of dopamine D-1 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3- hydroxyphenyl)ethylamine and N-substituted derivatives.Journal of medicinal chemistry, , Volume: 33, Issue:9, 1990
(+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent.Journal of medicinal chemistry, , Volume: 32, Issue:7, 1989
Dopamine autoreceptor agonists as potential antipsychotics. 1. (Aminoalkoxy)anilines.Journal of medicinal chemistry, , Volume: 31, Issue:8, 1988
Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Aporphines as antagonists of dopamine D-1 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.Journal of medicinal chemistry, , Volume: 24, Issue:9, 1981
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.Journal of medicinal chemistry, , Oct-09, Volume: 51, Issue:19, 2008
Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Resolution of 5,6-dihydroxy-2-(N,N-di-n-propylamino)tetralin in relation to the structural and stereochemical requirements for centrally acting dopamine agonists.Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.Journal of medicinal chemistry, , Volume: 34, Issue:10, 1991
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine.Journal of medicinal chemistry, , Jul-04, Volume: 40, Issue:14, 1997
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
(+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.Journal of medicinal chemistry, , Jan-20, Volume: 38, Issue:2, 1995
Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.Journal of medicinal chemistry, , Dec-09, Volume: 37, Issue:25, 1994
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.Journal of medicinal chemistry, , Volume: 34, Issue:10, 1991
Aporphines as antagonists of dopamine D-1 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
(+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent.Journal of medicinal chemistry, , Volume: 32, Issue:7, 1989
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
(R)-11-hydroxy- and (R)-11-hydroxy-10-methylaporphine: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine.Journal of medicinal chemistry, , Jul-04, Volume: 40, Issue:14, 1997
Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.Journal of medicinal chemistry, , May-23, Volume: 40, Issue:11, 1997
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.Journal of medicinal chemistry, , Jan-20, Volume: 38, Issue:2, 1995
Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.Journal of medicinal chemistry, , May-23, Volume: 40, Issue:11, 1997
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.Journal of medicinal chemistry, , Volume: 34, Issue:10, 1991
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 19, Issue:1, 2009
Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
A structure-activity study of four dopamine D-1 and D-2 receptor antagonists, representing the phenylindan, -indene, and -indole structural classes of compounds.Journal of medicinal chemistry, , Oct-01, Volume: 36, Issue:20, 1993
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
A two-state homology model of the hERG K+ channel: application to ligand binding.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical anJournal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.Journal of medicinal chemistry, , Jun-21, Volume: 39, Issue:13, 1996
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.Journal of medicinal chemistry, , Oct-27, Volume: 38, Issue:22, 1995
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
1-[3-(Diarylamino)propyl]piperidines and related compounds, potential antipsychotic agents with low cataleptogenic profiles.Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.Journal of medicinal chemistry, , Volume: 24, Issue:9, 1981
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998