A carnitine O-palmitoyltransferase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23786]
EC 2.3.1.21;
Carnitine palmitoyltransferase II;
CPT II
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-hydroxyphenylglyoxylic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| amiodarone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| perhexiline | Homo sapiens (human) | IC50 | 72.8000 | 1 | 1 |
| pioglitazone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 0 |
| trimetazidine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4-hydroxyphenylglycine, (s)-isomer | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| rosiglitazone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 0 |
| emeriamine | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| 4-trimethylammonio-3-((tetradecylcarbamoyl)amino)butyrate | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| carnitine O-palmitoyltransferase activity | molecular function | Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. [EC:2.3.1.21] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| carnitine O-octanoyltransferase activity | molecular function | Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. [EC:2.3.1.137, RHEA:17177] |
| acyltransferase activity | molecular function | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| long-chain fatty acid metabolic process | biological process | The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ajp] |
| in utero embryonic development | biological process | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu] |
| fatty acid beta-oxidation | biological process | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] |
| carnitine shuttle | biological process | The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine. [ISBN:0198547684] |
| carnitine metabolic process | biological process | The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |