Proteins > Poly [ADP-ribose] polymerase tankyrase-1
Page last updated: 2024-08-07 23:08:28

Poly [ADP-ribose] polymerase tankyrase-1

A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95271]

Synonyms

EC 2.4.2.30;
ADP-ribosyltransferase diphtheria toxin-like 5;
ARTD5;
Poly [ADP-ribose] polymerase 5A;
Protein poly-ADP-ribosyltransferase tankyrase-1;
2.4.2.-;
TNKS-1;
TRF1-interacting ankyrin-related ADP-ribose polymerase;

Research

Bioassay Publications (35)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (5.71)29.6817
2010's28 (80.00)24.3611
2020's5 (14.29)2.80

Compounds (34)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4'-bromoflavoneHomo sapiens (human)IC500.314612
phenanthridoneHomo sapiens (human)IC500.111112
pj-34Homo sapiens (human)IC501.107746
flavoneHomo sapiens (human)IC500.324324
4-MethoxybenzamideHomo sapiens (human)IC50100.000011
4'-methoxyflavoneHomo sapiens (human)IC500.070912
3',4'-dihydroxyflavoneHomo sapiens (human)IC500.224412
3-methoxyflavoneHomo sapiens (human)IC5010.000011
2'-methoxyflavoneHomo sapiens (human)IC5010.000011
6-methoxyflavoneHomo sapiens (human)IC5010.000011
4'-chloroflavoneHomo sapiens (human)IC500.233712
4'-hydroxyflavoneHomo sapiens (human)IC500.791212
6-chloroflavoneHomo sapiens (human)IC500.591912
e-z cinnamic acidHomo sapiens (human)IC500.685011
7-methoxyflavoneHomo sapiens (human)IC505.000011
6-methylflavoneHomo sapiens (human)IC5010.000011
N-(3-methylphenyl)-4-tetrazolo[1,5-a]quinoxalinamineHomo sapiens (human)IC5012.924422
iwr-1 exoHomo sapiens (human)IC500.651522
N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamideHomo sapiens (human)IC501.616623
apigeninHomo sapiens (human)IC503.131112
luteolinHomo sapiens (human)IC502.399412
3',4',7-trihydroxyflavoneHomo sapiens (human)IC500.637812
rucaparibHomo sapiens (human)IC507.467735
veliparibHomo sapiens (human)IC5032.863834
N-(4-methylphenyl)-4-tetrazolo[1,5-a]quinoxalinamineHomo sapiens (human)IC500.692422
olaparibHomo sapiens (human)IC5010.278578
niraparibHomo sapiens (human)IC5011.317334
iwr-1 endoHomo sapiens (human)IC5022.802266
nms-p118Homo sapiens (human)IC50100.000011
g007-lkHomo sapiens (human)IC500.034388
CCT251545Homo sapiens (human)IC5010.000011
xav939Homo sapiens (human)IC5011.39622324
2-(4-methoxyphenyl)-1H-quinazolin-4-oneHomo sapiens (human)IC500.128033
bmn 673Homo sapiens (human)IC501.900011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
rucaparibHomo sapiens (human)Kd10.000011
veliparibHomo sapiens (human)Kd10.000011
iwr-1 endoHomo sapiens (human)EC502.500011
xav939Homo sapiens (human)Kd0.054022
2-(4-methoxyphenyl)-1H-quinazolin-4-oneHomo sapiens (human)EC5030.000011
bmn 673Homo sapiens (human)Kd0.053011

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
NAD+ ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
nucleotidyltransferase activitymolecular functionCatalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
histone bindingmolecular functionBinding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]
NAD+-protein ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]

Located In

This protein is located in 9 target(s):

TargetCategoryDefinition
Golgi membranecellular componentThe lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
pericentriolar materialcellular componentA network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. [GOC:clt, ISBN:0815316194]
chromosome, telomeric regioncellular componentThe end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear bodycellular componentExtra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
nuclear membranecellular componentEither of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]
mitotic spindle polecellular componentEither of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:vw]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
nuclear porecellular componentA protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. [ISBN:0198547684]

Involved In

This protein is involved in 19 target(s):

TargetCategoryDefinition
protein polyubiquitinationbiological processAddition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [ISBN:0815316194]
mitotic spindle organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:go_curators, GOC:mah]
protein transportbiological processThe directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
Wnt signaling pathwaybiological processThe series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]
regulation of telomere maintenance via telomerasebiological processAny process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]
positive regulation of telomere maintenance via telomerasebiological processAny process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
mRNA transportbiological processThe directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
spindle assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
cell divisionbiological processThe process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
positive regulation of telomerase activitybiological processAny process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [GOC:ai]
protein localization to chromosome, telomeric regionbiological processAny process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. [GOC:BHF, GOC:mah]
protein poly-ADP-ribosylationbiological processThe transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]
protein auto-ADP-ribosylationbiological processThe ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]
positive regulation of canonical Wnt signaling pathwaybiological processAny process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]
positive regulation of telomere cappingbiological processAny process that activates or increases the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
negative regulation of telomere maintenance via telomere lengtheningbiological processAny process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
negative regulation of telomeric DNA bindingbiological processAny process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
negative regulation of maintenance of mitotic sister chromatid cohesion, telomericbiological processAny process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]