Page last updated: 2024-08-07 23:08:28
Poly [ADP-ribose] polymerase tankyrase-1
A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95271]
Synonyms
EC 2.4.2.30;
ADP-ribosyltransferase diphtheria toxin-like 5;
ARTD5;
Poly [ADP-ribose] polymerase 5A;
Protein poly-ADP-ribosyltransferase tankyrase-1;
2.4.2.-;
TNKS-1;
TRF1-interacting ankyrin-related ADP-ribose polymerase;
Research
Bioassay Publications (35)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 28 (80.00) | 24.3611 |
| 2020's | 5 (14.29) | 2.80 |
Compounds (34)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4'-bromoflavone | Homo sapiens (human) | IC50 | 0.3146 | 1 | 2 |
| phenanthridone | Homo sapiens (human) | IC50 | 0.1111 | 1 | 2 |
| pj-34 | Homo sapiens (human) | IC50 | 1.1077 | 4 | 6 |
| flavone | Homo sapiens (human) | IC50 | 0.3243 | 2 | 4 |
| 4-Methoxybenzamide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4'-methoxyflavone | Homo sapiens (human) | IC50 | 0.0709 | 1 | 2 |
| 3',4'-dihydroxyflavone | Homo sapiens (human) | IC50 | 0.2244 | 1 | 2 |
| 3-methoxyflavone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 2'-methoxyflavone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 6-methoxyflavone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 4'-chloroflavone | Homo sapiens (human) | IC50 | 0.2337 | 1 | 2 |
| 4'-hydroxyflavone | Homo sapiens (human) | IC50 | 0.7912 | 1 | 2 |
| 6-chloroflavone | Homo sapiens (human) | IC50 | 0.5919 | 1 | 2 |
| e-z cinnamic acid | Homo sapiens (human) | IC50 | 0.6850 | 1 | 1 |
| 7-methoxyflavone | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 6-methylflavone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| N-(3-methylphenyl)-4-tetrazolo[1,5-a]quinoxalinamine | Homo sapiens (human) | IC50 | 12.9244 | 2 | 2 |
| iwr-1 exo | Homo sapiens (human) | IC50 | 0.6515 | 2 | 2 |
| N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide | Homo sapiens (human) | IC50 | 1.6166 | 2 | 3 |
| apigenin | Homo sapiens (human) | IC50 | 3.1311 | 1 | 2 |
| luteolin | Homo sapiens (human) | IC50 | 2.3994 | 1 | 2 |
| 3',4',7-trihydroxyflavone | Homo sapiens (human) | IC50 | 0.6378 | 1 | 2 |
| rucaparib | Homo sapiens (human) | IC50 | 7.4677 | 3 | 5 |
| veliparib | Homo sapiens (human) | IC50 | 32.8638 | 3 | 4 |
| N-(4-methylphenyl)-4-tetrazolo[1,5-a]quinoxalinamine | Homo sapiens (human) | IC50 | 0.6924 | 2 | 2 |
| olaparib | Homo sapiens (human) | IC50 | 10.2785 | 7 | 8 |
| niraparib | Homo sapiens (human) | IC50 | 11.3173 | 3 | 4 |
| iwr-1 endo | Homo sapiens (human) | IC50 | 22.8022 | 6 | 6 |
| nms-p118 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| g007-lk | Homo sapiens (human) | IC50 | 0.0343 | 8 | 8 |
| CCT251545 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| xav939 | Homo sapiens (human) | IC50 | 11.3962 | 23 | 24 |
| 2-(4-methoxyphenyl)-1H-quinazolin-4-one | Homo sapiens (human) | IC50 | 0.1280 | 3 | 3 |
| bmn 673 | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| rucaparib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| veliparib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| iwr-1 endo | Homo sapiens (human) | EC50 | 2.5000 | 1 | 1 |
| xav939 | Homo sapiens (human) | Kd | 0.0540 | 2 | 2 |
| 2-(4-methoxyphenyl)-1H-quinazolin-4-one | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| bmn 673 | Homo sapiens (human) | Kd | 0.0530 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| NAD+ ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| nucleotidyltransferase activity | molecular function | Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732] |
| histone binding | molecular function | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] |
| NAD+-protein ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243] |
Located In
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| pericentriolar material | cellular component | A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. [GOC:clt, ISBN:0815316194] |
| chromosome, telomeric region | cellular component | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
| mitotic spindle pole | cellular component | Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:vw] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nuclear pore | cellular component | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. [ISBN:0198547684] |
Involved In
This protein is involved in 19 target(s):
| Target | Category | Definition |
|---|---|---|
| protein polyubiquitination | biological process | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [ISBN:0815316194] |
| mitotic spindle organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:go_curators, GOC:mah] |
| protein transport | biological process | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| regulation of telomere maintenance via telomerase | biological process | Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah] |
| positive regulation of telomere maintenance via telomerase | biological process | Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah] |
| positive regulation of transcription by RNA polymerase II | biological process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
| mRNA transport | biological process | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| spindle assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| positive regulation of telomerase activity | biological process | Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [GOC:ai] |
| protein localization to chromosome, telomeric region | biological process | Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. [GOC:BHF, GOC:mah] |
| protein poly-ADP-ribosylation | biological process | The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379] |
| protein auto-ADP-ribosylation | biological process | The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl] |
| positive regulation of canonical Wnt signaling pathway | biological process | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb] |
| positive regulation of telomere capping | biological process | Any process that activates or increases the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] |
| negative regulation of telomere maintenance via telomere lengthening | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] |
| negative regulation of telomeric DNA binding | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] |
| negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] |