A purine nucleoside phosphorylase that is encoded in the genome of Mycobacterium tuberculosis H37Rv. [OMA:P9WP01, PRO:DNx]
PNP;
Pu-NPase;
EC 2.4.2.1;
Inosine phosphorylase;
Inosine-guanosine phosphorylase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| methylthioinosine | Mycobacterium tuberculosis H37Rv | Kd | 12.5892 | 1 | 1 |
| 6-methylthioguanine | Mycobacterium tuberculosis H37Rv | Kd | 316.2280 | 1 | 1 |
| mercaptopurine | Mycobacterium tuberculosis H37Rv | Kd | 79.4328 | 1 | 1 |
| acyclovir | Mycobacterium tuberculosis H37Rv | Kd | 12.5892 | 1 | 1 |
| ganciclovir | Mycobacterium tuberculosis H37Rv | Kd | 15.8489 | 1 | 1 |
| oxypurinol | Mycobacterium tuberculosis H37Rv | Kd | 794.3280 | 1 | 1 |
| allopurinol | Mycobacterium tuberculosis H37Rv | Kd | 1,000.0000 | 1 | 1 |
| 4-hydroxyquinazoline | Mycobacterium tuberculosis H37Rv | Kd | 316.2280 | 1 | 1 |