Prednisolone acetate is a synthetic corticosteroid medication used to treat a variety of inflammatory and autoimmune conditions. It is a prodrug of prednisolone, meaning it is converted to prednisolone in the body. Prednisolone acetate is typically administered topically, but it can also be given orally, intravenously, or intramuscularly. The synthesis of prednisolone acetate involves several steps, starting with the conversion of cortisone to prednisolone. This is followed by the acetylation of the 21-hydroxyl group of prednisolone, which results in the formation of prednisolone acetate. Prednisolone acetate exerts its effects by binding to glucocorticoid receptors, which are located in the cytoplasm of cells. Upon binding, the glucocorticoid receptor-ligand complex translocates to the nucleus and regulates gene expression. This leads to a variety of effects, including the suppression of inflammation, the inhibition of immune cell activation, and the modulation of metabolism. Prednisolone acetate is an important medication for the treatment of a variety of inflammatory and autoimmune conditions, including asthma, allergic rhinitis, inflammatory bowel disease, rheumatoid arthritis, and lupus. It is also used to treat certain types of cancer and to prevent organ rejection after transplantation. Prednisolone acetate is studied extensively to understand its mechanisms of action, its efficacy in treating various conditions, and its potential side effects. This research is important for developing new and improved treatments for inflammatory and autoimmune diseases, as well as for ensuring the safe and effective use of this medication.'
prednisolone acetate: RN given refers to cpd with locant for acetate group in position 21 & (11 beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5834 |
| CHEMBL ID | 1152 |
| CHEBI ID | 8380 |
| SCHEMBL ID | 7999 |
| MeSH ID | M0055043 |
| PubMed CID | 4895 |
| CHEMBL ID | 1519597 |
| MeSH ID | M0055043 |
| Synonym |
|---|
| MLS002207146 |
| MLS001148097 , |
| (11beta)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate |
| pred-g liquifilm |
| pregna-1,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11.beta.)- |
| cortipred |
| component of metimyd |
| predicort |
| meticortelone acetate |
| delcort-e |
| prednidoren |
| nsc10966 |
| prednelan-n |
| pred mild |
| supercortyl |
| pred forte tm 1% |
| durapred |
| econopred |
| component of neo-delta-cortef |
| prediacortine |
| deltilen |
| nsc-10966 |
| prenema |
| sterane im and ia |
| pregna-1,20-dione, 11.beta.,17,21-trihydroxy-, 21-acetate |
| cormalone |
| component of composone |
| component of isopto cetapred |
| nisolone |
| pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)- |
| predalone 50 |
| einecs 200-134-1 |
| nsc 10966 |
| 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate |
| vasocidin ointment |
| pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-acetate |
| pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-acetate |
| econopred plus |
| brn 3111798 |
| cetapred ointment |
| omnipred |
| blephamide liquifilm |
| predonine injection |
| pricortin |
| C08180 |
| prednisolone 21-acetate |
| 52-21-1 |
| prednisolone acetate |
| prednisolone 21-acetate, >=97% |
| econopred (tn) |
| pred forte (tn) |
| prednisolone acetate (jp17/usp/inn) |
| D00980 |
| NCGC00094765-01 |
| smr000058326 |
| MLS000028512 , |
| AC-2176 |
| ster |
| prednisoloni acetas |
| CHEMBL1152 |
| chebi:8380 , |
| P1283 |
| 21-acetoxy-1,4-pregnadiene-11beta,17alpha-diol-3,20-dione |
| [2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| HMS3259O07 |
| AKOS007930677 |
| flo-pred |
| blephamide s.o.p. |
| 4-08-00-03468 (beilstein handbook reference) |
| unii-8b2807733d |
| pred-forte |
| 8b2807733d , |
| prednisolone acetate [usp:jan] |
| pred-g s.o.p. |
| 2-((1s,10s,11s,15s,17s,2r,14r)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8 .7.0.0<2,7>.0<11,15>]heptadeca-3,6-dien-14-yl)-2-oxoethyl acetate |
| [2-[(8s,9s,10r,11s,13s,14s,17r)-10,13-dimethyl-11,17-bis(oxidanyl)-3-oxidanylidene-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxidanylidene-ethyl] ethanoate |
| A828982 |
| acetic acid [2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester |
| MLS002548870 |
| dtxsid3023502 , |
| tox21_111328 |
| dtxcid103502 |
| cas-52-21-1 |
| HMS2234F18 |
| AKOS015960469 |
| ak-tate |
| key-pred |
| articulose-50 |
| ophtho-tate |
| sulphrin component prednisolone acetate |
| prednisolone acetate component of predamide |
| prednisolone acetate [jan] |
| prednisolone acetate component of sulphrin |
| predamide component prednisolone acetate |
| prednisolone acetate [usp monograph] |
| neo-delta-cortef component prednisolone acetate |
| 11.beta.,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate |
| prednisolone acetate [usp impurity] |
| prednisolone acetate [usp-rs] |
| prednisone impurity l [ep] |
| prednisolone acetate [who-dd] |
| prednisolone acetate component of pred-g |
| prednisolone acetate component of isopto cetapred |
| prednisolone acetate component of neo-delta-cortef |
| metimyd component prednisolone acetate |
| pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11.beta.)- |
| pred-g component prednisolone acetate |
| cetapred component prednisolone acetate |
| prednisolone acetate component of blephamide |
| prednisolone acetate [mart.] |
| blephamide s.o.p. component prednisolone acetate |
| prednisolone acetate component of predsulfair |
| prednisoloni acetas [who-ip latin] |
| prednisolone acetate component of cetapred |
| prednisolone acetate [orange book] |
| hydrocortisone acetate impurity c [ep impurity] |
| prednisolone acetate [vandf] |
| isopto cetapred component prednisolone acetate |
| methylprednisolone acetate impurity e [ep impurity] |
| prednisolone impurity c [ep impurity] |
| prednisolone acetate component of metimyd |
| prednisolone acetate component of blephamide s.o.p. |
| prednisolone acetate [green book] |
| blephamide component prednisolone acetate |
| prednisolone acetate [ep monograph] |
| predsulfair component prednisolone acetate |
| prednisolone 21-acetate [mi] |
| prednisolone acetate [who-ip] |
| S2570 |
| NC00470 |
| SCHEMBL7999 |
| tox21_111328_1 |
| NCGC00021925-03 |
| AB00443788-11 |
| CS-4642 |
| Q-201614 |
| inflanefran |
| HY-B1214 |
| AB00443788_13 |
| OPERA_ID_332 |
| prednisolone (21-acetate) |
| mfcd00037710 |
| prednisolone acetate, united states pharmacopeia (usp) reference standard |
| prednisolone 21-acetate, vetranal(tm), analytical standard |
| prednisolone acetate for peak identification, european pharmacopoeia (ep) reference standard |
| prednisolone acetate, pharmaceutical secondary standard; certified reference material |
| prednisolone acetate, european pharmacopoeia (ep) reference standard |
| NCGC00021925-05 |
| LRJOMUJRLNCICJ-JZYPGELDSA-N |
| prednisolone acetate, british pharmacopoeia (bp) reference standard |
| BCP18958 |
| prednisolone acetate (omnipred) |
| DB15566 |
| Q27108063 |
| AS-11673 |
| prednisolone-acetate |
| CCG-268673 |
| prednisolone acetate for peak identification |
| 2-[(1r,3as,3bs,9ar,9bs,10s,11as)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate |
| EN300-19628782 |
| prednisolone acetate (ep monograph) |
| inf-oph |
| pred fort |
| deltastab |
| prednisolone acetate (usp:jan) |
| prednisolone acetate (usp monograph) |
| hydrocortisone acetate impurity c (ep impurity) |
| predcor |
| prednisone impurity l |
| prednisolone acetate (usp impurity) |
| prednisolone acetate pf |
| balpred |
| prednisolone impurity c (ep impurity) |
| diopred |
| prednihexal |
| deltacortilen |
| predalone |
| predni-h |
| prednisolone acetate (usp-rs) |
| predni-pos |
| predniocil |
| hydrocortancyl |
| prednisolone acetate (mart.) |
| predaject |
| prednefrin sf |
| methylprednisolone acetate impurity e (ep impurity) |
| locaseptil-neo |
| hexacortone |
| SR-01000633805-1 |
| smr000460384 |
| MLS000861600 |
| prednisolone-21-acetate |
| BRD-A83567094-001-03-6 |
| CCG-43930 |
| FT-0674006 |
| HMS2802G03 |
| AKOS025149896 |
| CHEMBL1519597 |
| STL450998 |
| 2-{1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl}-2-oxoethyl acetate |
| VS-13418 |
| BBL036317 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " After dexamethasone alcohol (IV) or dexamethasone 21-isonicotinate (IV), the half-life of elimination was similar (53 minutes) for both formulations." | ( Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland. Alvinerie, M; Baggot, JD; Brandon, RA; de Pomyers, H; Toutain, PL, 1984) | 0.27 |
The superior bioavailability and therapeutic effect of prednisolone acetate over prednisor sodium phosphate was described about 15 years ago. Such a process of absorption was different of that described for predniso acetate suspension for which rate of absorption is slower.
Difluprednate provides effective treatment for anterior uveitis. It requires less frequent dosing than prednisolone acetate. This makes it possible to decrease the dosage and duration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results in three heart transplantation models--auricular free graft in mice, abdominal graft in rats and cervical graft in rabbits--suggested that RSM injection in an appropriate dosage prolonged the survival time of cardiac allograft." | ( Effect of radix Salviae miltiorrhizae extract injection on survival of allogeneic heart transplantation. Li, J; Niu, X; Qin, Z; Zhu, H; Zhuang, H, 1990) | 0.28 |
| " The dosage level of treatment was low enough to avoid major hematologic changes." | ( Effect of ophthalmic prednisolone acetate on the canine adrenal gland and hepatic function. Lavach, JD; Macy, DW; Roberts, SM; Severin, GA, 1984) | 0.27 |
| " The requirement that suspension eyedrops and similar dosage forms should be redispersable after sedimentation upon storage is stated in the monographs on eyedrops of the German Pharmacopoeia and can be found in similar contexts in other pharmacopoeias." | ( [Dosage problems in suspension eyedrops]. Diestelhorst, M; Kwon, KA; Süverkrüp, R, ) | 0.13 |
| " A variable dosing pattern with acceptable mean was observed for Chibro-Amuno 3, while the results for Inflanefran-forte were fully satisfactory." | ( [Dosage problems in suspension eyedrops]. Diestelhorst, M; Kwon, KA; Süverkrüp, R, ) | 0.13 |
| "To determine whether a topical ophthalmic diclofenac sodium formulation containing a proprietary polymeric drug delivery system (ISV-205), when dosed concomitantly with 1% prednisolone acetate, is effective in blocking the intraocular pressure (IOP) response in humans." | ( Prevention of corticosteroid-induced intraocular pressure elevation using ISV-205. Stewart, WC, 2003) | 0.32 |
| " Both medications were dosed 4 times per day for 14 days and then BID until the container was empty." | ( A clinical comparison of two different prednisolone acetate formulations in patients undergoing cataract surgery. Gayton, JL, 2005) | 0.33 |
| " This makes it possible to decrease the dosage and duration of topical prednisolone acetate." | ( Intracameral triamcinolone acetonide to control postoperative inflammation following cataract surgery with phacoemulsification. Akova, YA; Borazan, M; Karalezli, A, 2008) | 0.35 |
| " Primary ocular CHV-1 infection was experimentally induced in mature specific pathogen-free beagles by topical ocular inoculation and the presence of reactivatable latency was later confirmed by administration of an immunosuppressive dosage of systemic corticosteroid to the dogs." | ( The effect of topical ocular corticosteroid administration in dogs with experimentally induced latent canine herpesvirus-1 infection. Dubovi, EJ; Kice, NC; Kim, SG; Ledbetter, EC; Matusow, RB, 2010) | 0.36 |
| " However, chronic use of topical corticosteroids dosed at < or = 3 drops daily seemed to be associated with a lower risk of cataract development relative to eyes receiving higher doses over follow-up in the setting of suppressed uveitis." | ( Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids. Dunn, JP; Jabs, DA; Thorne, JE; Woreta, FA, 2010) | 0.36 |
| "Taken together, the MTG-containing ZnO can be a more effective and convenient delivery system for the treatment of hemorrhoid with a reduced dosage interval." | ( Effect of zinc oxide on the rheological and mucoadhesive properties of poloxamer 407-based mucoadhesive thermosensitive gel. Choi, HG; Kim, CK; Kim, HT; Kim, ST; Park, JS; Park, TH, 2010) | 0.36 |
| " Difluprednate provides effective treatment for anterior uveitis and requires less frequent dosing than prednisolone acetate." | ( Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis. Crockett, RS; Davanzo, R; Flynn, TE; Foster, CS; McLeod, K; Vogel, R, 2010) | 0.36 |
| " Dosing was 4 times daily in months 1 to 3, thrice daily in month 4, twice daily in month 5, and once daily in months 6 to 12." | ( Randomized comparison of topical prednisolone acetate 1% versus fluorometholone 0.1% in the first year after descemet membrane endothelial keratoplasty. Bachmann, BO; Kruse, FE; Price, FW; Price, MO; Tourtas, T, 2014) | 0.4 |
| " Dosing was 4 times daily for 2 months, thrice daily for 1 month, twice daily for 1 month, and once daily for 7 months." | ( Loteprednol Etabonate 0.5% Gel Vs. Prednisolone Acetate 1% Solution After Descemet Membrane Endothelial Keratoplasty: Prospective Randomized Trial. Feng, MT; Price, FW; Price, MO; Scanameo, A, 2015) | 0.42 |
| " This was likely the result of low-frequency dosing and short duration of steroid use." | ( Comparison of prednisolone acetate 1.0% and difluprednate ophthalmic emulsion 0.05% after cataract surgery: Incidence of postoperative steroid-induced ocular hypertension. Ernest, P; McBain, M; Mian, SI; Musch, DC; Niziol, LM; Person, E; Tijunelis, MA, 2017) | 0.46 |
| "Five simple, sensitive, and eco-friendly LC and UV spectrophotometric methods have been developed for the simultaneous determination of phenylephrine hydrochloride (PHE) and prednisolone acetate (PRD) in their combined dosage form." | ( Development and Validation of Eco-Friendly Liquid Chromatographic and Spectrophotometric Methods for Simultaneous Determination of Coformulated Drugs: Phenylephrine Hydrochloride and Prednisolone Acetate. El Mously, DA; Elsayed, GM; Hassan, NY; Mostafa, NM, 2017) | 0.46 |
| " The suggested methods were validated in compliance with the ICH guidelines and were successfully applied to determine both drugs in their pure forms, laboratory prepared mixtures and dosage form." | ( Validated Chromatographic Methods for the Simultaneous Determination of Sulfacetamide Sodium and Prednisolone Acetate in their Ophthalmic Suspension. AbdElHamid, G; El-Ragehy, NA; Hegazy, MA; Tawfik, SA, 2017) | 0.46 |
| "Randomised-controlled trials (RCTs) comparing difluprednate and prednisolone acetate regardless of the dosing regimen used." | ( Difluprednate versus Prednisolone Acetate after Cataract Surgery: a Systematic Review and Meta-Analysis. Basiony, A; KhalafAllah, MT; Salama, A, 2019) | 0.51 |
| " However, chronic use of topical corticosteroids dosed at <3 drops daily seemed to be associated with a lower risk of cataract development relative to eyes receiving higher doses over follow-up in the setting of suppressed uveitis." | ( Risk of Cataract Development among Children with Juvenile Idiopathic Arthritis-Related Uveitis Treated with Topical Corticosteroids. Dunn, JP; Jabs, DA; Thorne, JE; Woreta, FA, 2020) | 0.56 |
| Class | Description |
|---|---|
| corticosteroid hormone | Any of a class of steroid hormones that are produced in the adrenal cortex. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| USP1 protein, partial | Homo sapiens (human) | Potency | 14.1254 | 0.0316 | 37.5844 | 354.8130 | AID743255 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.1044 | 0.0052 | 9.4661 | 32.9993 | AID1347411 |
| AR protein | Homo sapiens (human) | Potency | 0.2237 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID1259381; AID743036; AID743040; AID743042; AID743053; AID743054 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.0251 | 0.0013 | 7.7625 | 44.6684 | AID914; AID915 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.7855 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.1654 | 0.0002 | 14.3764 | 60.0339 | AID720691; AID720692; AID720719 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 2.6603 | 0.0015 | 30.6073 | 15,848.9004 | AID1224849 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 3.7111 | 0.0002 | 29.3054 | 16,493.5996 | AID743075; AID743079; AID743080; AID743091 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 43.6486 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| IDH1 | Homo sapiens (human) | Potency | 14.5810 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.1496 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 0.1000 | 9.1916 | 31.6228 | AID1346983 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.0464 | 0.0041 | 9.9848 | 25.9290 | AID504444; AID720524 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 6.3096 | 0.7943 | 21.2757 | 50.1187 | AID624246 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| Interferon beta | Homo sapiens (human) | Potency | 0.1044 | 0.0033 | 9.1582 | 39.8107 | AID1347411 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 3.9811 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.0435 | 0.0041 | 9.9848 | 25.9290 | AID504444; AID720524 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| geminin | Homo sapiens (human) | Potency | 6.5131 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cytokine activity | Interferon beta | Homo sapiens (human) |
| cytokine receptor binding | Interferon beta | Homo sapiens (human) |
| type I interferon receptor binding | Interferon beta | Homo sapiens (human) |
| protein binding | Interferon beta | Homo sapiens (human) |
| chloramphenicol O-acetyltransferase activity | Interferon beta | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| extracellular space | Interferon beta | Homo sapiens (human) |
| extracellular region | Interferon beta | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347412 | qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347414 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID90104 | Potency relative to fluocinolone 16,17-acetonide in the human vasoconstictor test | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Structure-activity relationships in the antiinflammatory steroids: a pattern-recognition approach. |
| AID127352 | Binding affinity against human monoclonal antibody (mAb)-7F2 | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15 | Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis. |
| AID91224 | Antiinflammatory activity measured by using McKenzie-Stoughton human vasoconstrictor assay | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Computer-aided studies of the structure-activity relationships between the structure of some steroids and their antiinflammatory activity. |
| AID346025 | Binding affinity to beta cyclodextrin | 2009 | Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2 | Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID384955 | Intrinsic aqueous solubility at pH 10 by shake-flask method | 2008 | Journal of medicinal chemistry, May-22, Volume: 51, Issue:10 | Molecular characteristics for solid-state limited solubility. |
| AID127350 | Binding affinity against human monoclonal antibody (mAb)-1B3 | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15 | Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis. |
| AID188016 | Anti-inflammatory effect in rat granuloma assay, activity relative to hydrocortisone and hydrocortisone 21-acetate | 1983 | Journal of medicinal chemistry, Mar, Volume: 26, Issue:3 | Structure-activity relationships in the antiinflammatory steroids: a pattern-recognition approach. |
| AID1224864 | HCS microscopy assay (F508del-CFTR) | 2016 | PloS one, , Volume: 11, Issue:10 | Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 82 (14.11) | 18.7374 |
| 1990's | 93 (16.01) | 18.2507 |
| 2000's | 168 (28.92) | 29.6817 |
| 2010's | 204 (35.11) | 24.3611 |
| 2020's | 34 (5.85) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (61.29) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 99 (15.84%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 14 (2.24%) | 6.00% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 234 (37.44%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 278 (44.48%) | 84.16% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Electroretinographic Changes in Healthy Young Men Before and After Induction of Glucose Intolerance by Glucocorticoids Treatment, Hyperphagia and Lack of Exercise [NCT01140932] | 10 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| EuroPainClinics® Study II (Prospective Randomized Double Blinded Trial) [NCT02459392] | 300 participants (Actual) | Interventional | 2021-12-31 | Completed | |||
| Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification [NCT01193504] | Phase 4 | 100 participants (Anticipated) | Interventional | 2010-09-30 | Recruiting | ||
| Efficacy and Tolerability of Systemic Methylprednisolone in Children and Adolescents With Chronic Rhinosinusitis [NCT01205984] | Phase 4 | 48 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| Vestibular Prognosis Assessment of the Idiopathic Sudden Sensorineural Hearing Loss With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids [NCT03974867] | 72 participants (Anticipated) | Interventional | 2019-07-31 | Not yet recruiting | |||
| Effect of Preoperative Administration of Dexamethasone Versus Methylprednisolone in Surgical Extraction of Retained Lower Third Molars [NCT05752305] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2022-01-15 | Completed | ||
| A Phase 1/2a Open-Label Ascending Dose Study to Evaluate the Safety and Effects of LY3884961 in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL) [NCT04127578] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2020-01-03 | Recruiting | ||
| Anti-CD20 Antibody Rituximab in Addition to Prednisolone in Treatment of Warm Antibody Related Autoimmune Hemolytic Anemia. A Randomised Danish Multicenter Trial. [NCT01134432] | Phase 3 | 65 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| [NCT01137084] | 300 participants (Anticipated) | Interventional | 2005-01-31 | Completed | |||
| Steroid Treatment as Anti-inflammatory and Neuroprotective Agent Following Out-of-Hospital Cardiac Arrest. A Randomized Trial [NCT04624776] | Phase 2 | 158 participants (Actual) | Interventional | 2020-10-10 | Completed | ||
| An Investigator Initiated Open Study to Evaluate the Efficacy and Safety of Intra Arterial Infusion for Treatment of Steroid Resistant Acute Hepatic Graft Versus Host Disease (AGVHD) [NCT01140984] | 2 participants (Actual) | Interventional | 2010-09-30 | Terminated(stopped due to technical issues) | |||
| Role of Add-on Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis [NCT05842681] | 30 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | |||
| Intravenous Methylprednisolone Versus High Dose Oral Prednisolone for the Treatment of Infantile Spasms: a Randomized Open-labelled Trial [NCT03876444] | Phase 2/Phase 3 | 128 participants (Anticipated) | Interventional | 2019-04-01 | Recruiting | ||
| First-line Treatment of P53 Mutation With PD-L1 Expression in DLBCL With Anti-PD-1 Mab and R-CHOP: a Randomized, Open, Multicenter Clinical Study [NCT05280626] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-03-25 | Not yet recruiting | ||
| Effect of Corticosteroids On MyocardiaL Injury Among Patients Hospitalized for Community-AcquirEd PneUMonia - COLOSSEUM TRIAL [NCT03745664] | Phase 3 | 122 participants (Anticipated) | Interventional | 2021-01-10 | Recruiting | ||
| A Single-Center, Randomized, Double-Masked, Vehicle and Active-Controlled, Dose-Ranging Phase 2 Study Evaluating the Efficacy and Safety of PRT-2761 for the Treatment of Acute and Chronic Allergic Conjunctivitis Using the Conjunctival Allergen Challenge M [NCT03320434] | Phase 2 | 120 participants (Actual) | Interventional | 2017-10-13 | Completed | ||
| Ruxolitinib and Methylprednisolone as First Line Therapy for Acute Graft Versus Host Disease Following Allogeneic Stem Cell Transplantation [NCT03701698] | Phase 2 | 30 participants (Anticipated) | Interventional | 2018-11-01 | Not yet recruiting | ||
| Efficacy and Safety of Subacromial Corticosteroid Injection in Type-2 Diabetic [NCT03652480] | 20 participants (Actual) | Observational | 2013-03-31 | Completed | |||
| The Effect of a Preoperative Single-dose Methylprednisolone on the Postoperative Rehabilitation After Abdominal Hysterectomy: A Prospective, Double Blinded, Placebo Controlled Study [NCT01106547] | Phase 4 | 55 participants (Anticipated) | Interventional | 2009-08-31 | Completed | ||
| Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; a Prospective Clinician-blinded Observational Study Protocol. [NCT03942861] | 50 participants (Anticipated) | Observational | 2019-02-21 | Recruiting | |||
| A Randomized Clinical Trial Comparing Hyaluronic Acid (Hylan G-F 20) and Corticosteroid (Methylprednisolone Acetate) for Knee Osteoarthritis [NCT01132677] | 78 participants (Anticipated) | Interventional | 2010-05-31 | Enrolling by invitation | |||
| Preemptive Therapy Study of Cetuximab(Erbitux®)Induced Skin Rash Using Doxycycline, Sunscreen, Hydrocortisone and Moisturizer in Colorectal and Head and Neck Cancer Patients [NCT01874860] | Phase 2 | 24 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Comparison Between Intra-articular Pulsed Radiofrequency With Steroids Injection Versus Intra-articular Steroids Injection in Chronic Sacroiliac Joint Arthritis [NCT03564106] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2019-03-01 | Completed | ||
| High-dose Busulfan, High-dose Cyclophosphamide, and Allogeneic Bone Marrow Transplantation for Leukemia, Myelodysplastic Syndromes, Multiple Myeloma and Lymphoma [NCT01177371] | Phase 2 | 13 participants (Actual) | Interventional | 1988-03-31 | Completed | ||
| Effect of Preoperative Intravenous High Dose Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Patients Scheduled for Total Hip-arthroplasty [NCT02445898] | Phase 2/Phase 3 | 64 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Randomized Clinical Trial Comparing Conventional Conservative Treatment for Plantar Fasciopathia With Endoscopic Surgery With Fascial Release. [NCT02448316] | Phase 4 | 30 participants (Actual) | Interventional | 2015-04-01 | Completed | ||
| Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery [NCT03190642] | Phase 4 | 180 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children Who Attend the Emergency Department [NCT03698630] | Phase 4 | 250 participants (Actual) | Interventional | 2011-07-06 | Completed | ||
| Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection: A Double Blind Controlled Study [NCT02403856] | Phase 4 | 136 participants (Actual) | Interventional | 2015-04-04 | Completed | ||
| Cannabidiol for the Treatment of Severe (Grades III/IV) Acute Graft-versus-host Disease [NCT02392780] | Phase 2 | 10 participants (Anticipated) | Interventional | 2015-04-30 | Not yet recruiting | ||
| DEXTENZA Compared to Topical Steroid Therapy Prior to Cataract Surgery in Patients Who Receive Premium Intraocular Lenses [NCT04479748] | Phase 4 | 13 participants (Actual) | Interventional | 2020-10-01 | Completed | ||
| A Randomised Phase II Evaluation of Molecular Guided Therapy for Diffuse Large B-Cell Lymphoma With Acalabrutinib [NCT04546620] | Phase 2 | 453 participants (Anticipated) | Interventional | 2021-10-19 | Recruiting | ||
| Can Injection of Methylprednisoloneacetate 80 mg, in the Cavity After Mastectomy for Primary Breast Cancer, at the Time of Removal of the Drain, Prevent Seroma Formation? [NCT01380912] | 160 participants (Anticipated) | Observational | 2010-08-31 | Recruiting | |||
| Evaluating Clinical and Immunological Effects of Rituximab With Cyclophosphamide Compared to Rituximab Alone in AAV Patients [NCT03942887] | Phase 3 | 100 participants (Anticipated) | Interventional | 2019-05-03 | Recruiting | ||
| To Study the Effect of Adjunctive Oral Methylprednisolone Therapy in Pediatric Urinary Tract Infection [NCT02331862] | Phase 3 | 160 participants (Anticipated) | Interventional | 2015-01-31 | Not yet recruiting | ||
| A Single-center, Prospective, Non-comparative Clinical Trial of Ruxolitinib and Methylprednisolone as a First-line Treatment for Macrophage Activation Syndrome [NCT05137496] | Phase 3 | 40 participants (Anticipated) | Interventional | 2022-06-01 | Not yet recruiting | ||
| MP3-pulses-COVID-19. Methylprednisolone Pulses Versus Dexamethasone According RECOVERY Protocol in Patients With Pneumonia Due to SARS-COV-2 Coronavirus Infection [NCT04780581] | Phase 4 | 127 participants (Actual) | Interventional | 2021-02-01 | Terminated(stopped due to Impossibility of reaching the sample size established by protocol) | ||
| An Open-Label, Single-Arm, Multiple Center Extension Study to Evaluate One Year of Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer With YONSA™ 500 mg (4 x 125 mg qd) With Methylprednisolone (4 mg Bid) [NCT02962284] | Phase 2 | 20 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| Corticosteroids for Acute Migraine. An ED-based, Randomized, Comparative Effectiveness Trial [NCT02847494] | Phase 4 | 220 participants (Actual) | Interventional | 2016-09-01 | Completed | ||
| Health Related Quality of Life and Pain Managment Using Infiltration or Suprascapular Nerve Block Ultrasound Guided in Patients With Glenohumeral Arthirtis [NCT03794505] | Phase 3 | 40 participants (Actual) | Interventional | 2018-04-01 | Completed | ||
| Cyclic Oral Methylprednisolone Trial in Multiple Sclerosis [NCT01305837] | Phase 2 | 30 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Clinical Study of Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of Checkpoint Inhibitor-related Pneumonitis [NCT05280873] | Phase 1 | 48 participants (Anticipated) | Interventional | 2021-10-10 | Recruiting | ||
| Efficacy and Cost-effectiveness of Intra-Articular Ketorolac Injection for Knee Osteoarthritis: A Randomized, Controlled, Double-Blinded Study [NCT03694821] | Phase 4 | 18 participants (Actual) | Interventional | 2018-07-05 | Terminated(stopped due to Low enrollment) | ||
| The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study [NCT02098330] | Phase 3 | 40 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Evaluation of the Efficacy and Safety of Methylprednisolone Combined With the JAK Inhibitors in the Treatment of Toxic Epidermal Necrolysis: Two-arm, Open, Single-center Study [NCT06119490] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2023-07-05 | Recruiting | ||
| Corticosteroid(CS) Injections for the Treatment of Common Upper Extremity Pathologies, With or Without Lidocaine [NCT03704584] | Phase 4 | 62 participants (Actual) | Interventional | 2019-05-14 | Terminated(stopped due to Enrollment and study activities were initially suspended due to COVID-19. The investigator has also left Emory and the study will not resume.) | ||
| Phase II Study of Simvastatin, Zoledronic Acid, Bortezomib, Bendamustine and Methylprednisolone for Relapsed/Refractory Myeloma [NCT01332617] | Phase 2 | 0 participants (Actual) | Interventional | 2011-04-30 | Withdrawn(stopped due to Investigators no longer interested in activating study) | ||
| Feasibility and Safety of Umbilical Cord Blood Cell Transplant Into Injured Spinal Cord: an Open-Labeled, Dose-Escalating Clinical Trial [NCT01354483] | Phase 1/Phase 2 | 20 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Combination Corticosteroids + 5-aminosalicylic Acids Compared to Corticosteroids Alone in the Treatment of Moderate-severe Active Ulcerative Colitis. [NCT01941589] | Phase 4 | 149 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Subcutaneous Injection of TNFα Monoclonal Antibody for Treating Traumatic Acute Spinal Cord Injury [NCT04988425] | Phase 1/Phase 2 | 90 participants (Anticipated) | Interventional | 2022-09-01 | Not yet recruiting | ||
| A Comparative Study of Strategies for Management of Duchenne Myopathy in Assiut University Children Hospital [NCT03633565] | Phase 4 | 45 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | ||
| Phase II Trial of Cisplatin Plus Etoposide Plus Gemcitabine Plus Solumedrol (PEGS) in Peripheral T-Cell Non-Hodgkin's Lymphoma [NCT00109928] | Phase 2 | 34 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| A Phase II, Open-labeled, Ophthalmological External Investigator-blinded, Single-center, Randomized, Superiority, Non Profit, Pilot Clinical Trial to Evaluate the Effects of Atorvastatin on Graves' Orbitopathy (GO) in Hypercholesterolemic Patients With Mo [NCT03110848] | Phase 2 | 88 participants (Actual) | Interventional | 2020-06-01 | Completed | ||
| Manipulation Versus Steroid Injection in the Treatment of Morton's Neuroma [NCT05707572] | 62 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| Randomized, Double-blind, Placebo- and Active Comparator- Controlled Crossover Study in Healthy Male Subjects and an Open Label Study in Healthy Subjects and MS Patients to Assess the Safety, Pharmacokinetics and Pharmacodynamics of 2B3-201 [NCT02048358] | Phase 1 | 47 participants (Actual) | Interventional | 2013-11-30 | Terminated | ||
| Does Injection Site Matter? A Randomized Controlled Trial to Evaluate Efficacy of Knee Intraarticular Injections on Improval of Patient Reported Outcomes. [NCT02176304] | Phase 4 | 60 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| [NCT01281748] | Phase 4 | 83 participants (Actual) | Interventional | 2005-07-31 | Terminated(stopped due to Low rate of enrollment) | ||
| Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata [NCT01167946] | Phase 4 | 42 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas [NCT01189864] | 3,493 participants (Actual) | Observational | 2010-02-01 | Terminated(stopped due to Terminated to initiate FDA IND-cleared study protocol) | |||
| Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study Low Dose Study [NCT01560052] | 503 participants (Actual) | Interventional | 2012-05-05 | Completed | |||
| Oral Megadose Corticosteroid Therapy of Acute Exacerbations of Multiple Sclerosis (OMEGA) [NCT00418145] | Phase 3 | 16 participants (Actual) | Interventional | 2003-09-30 | Terminated(stopped due to low enrollment - data was not analyzed for this study) | ||
| A Randomized, International, Multi Centre Study to Assess the Efficacy and Safety of Intravenous PEG-liposomal Prednisolone Sodium Phosphate (Nanocort®) vs Intravenous Methylprednisolone (Solu-Medrol®) Treatment in Patients With Acute Exacerbation of Rela [NCT01039103] | Phase 2 | 15 participants (Actual) | Interventional | 2009-12-31 | Terminated | ||
| Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management for the Prevention of Refractory Stenosis of the Esophagus and Pharynx- The CORTICAU Study [NCT03760354] | Phase 2 | 30 participants (Anticipated) | Interventional | 2019-02-15 | Not yet recruiting | ||
| Ultrasound-guided Medial Lumbar Bundle Branch Block by Caudal-cranial Approach: Radiographic Comparison of a New Ultrasound-guided Method [NCT05930236] | 40 participants (Anticipated) | Interventional | 2023-04-21 | Recruiting | |||
| A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1) [NCT02953678] | Phase 2 | 71 participants (Actual) | Interventional | 2016-12-30 | Completed | ||
| Evaluation of clINical reCovery After a Relapse: a Pilot Study assEssing the Neuronal Effects of D-Aspartate in RR-MS Subjects Treated With IntErferon Beta 1a 44 mcg TIW (INCREASE) [NCT03387046] | Phase 2 | 7 participants (Actual) | Interventional | 2018-03-26 | Terminated(stopped due to Study was terminated early due to slow recruitment rate.) | ||
| A Prospective, Randomized, Controlled, Open Label, Assessor-blinded, Parallel-group Phase III Clinical Trial to Evaluate the Impact of Tapering Systemic Immunosuppressive Therapy in a Treat-to-target Approach on Maintaining Minimal Disease Activity in Adu [NCT04610476] | Phase 3 | 270 participants (Anticipated) | Interventional | 2020-10-19 | Recruiting | ||
| Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion [NCT03327272] | Phase 3 | 0 participants (Actual) | Interventional | 2018-05-22 | Withdrawn(stopped due to Did not enroll, PI decided not to proceed.) | ||
| Single Arm Study To Assess Comprehensive Infusion Guidance For The Management Of The Infusion- Associated Reactions (IARs) In Relapsing-Remitting Multiple Sclerosis (RRMS) Patients Treated With LEMTRADA [NCT02205489] | Phase 4 | 58 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| A Trial of Prednisolone in Combination With SPI-62 or Placebo in Subjects With Polymyalgia Rheumatica (PMR) [NCT05436652] | Phase 2 | 48 participants (Anticipated) | Interventional | 2022-07-22 | Recruiting | ||
| Evaluation of Intraoperative Use of Dexycu on the Signs and Symptoms of Dry Eye [NCT04184999] | Phase 4 | 40 participants (Actual) | Interventional | 2019-08-10 | Completed | ||
| A Prospective, Randomized, Double-Blind Study to Compare the Effects of Dexamethasone Versus Depo-Medrol When Used in Lumbar Epidural Injections [NCT01397552] | 8 participants (Actual) | Interventional | 2009-09-30 | Terminated(stopped due to Low enrollment, too many subjects getting second injection) | |||
| Phase II Study of Combination of Hyper-CVAD and Dasatinib (NSC-732517) With or Without Allogeneic Stem Cell Transplant in Patients With Philadelphia (Ph) Chromosome Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL) (A BMT Study) [NCT00792948] | Phase 2 | 97 participants (Actual) | Interventional | 2009-09-01 | Active, not recruiting | ||
| MRI Evaluation Assessing Synovitis to Address the Unmet Need for Reliable Endpoints in SLE [NCT03355482] | Phase 2 | 40 participants (Anticipated) | Interventional | 2017-04-10 | Suspended(stopped due to recruitment, funding) | ||
| Effects of Intraoperative Local Steroid Utilization in a Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion [NCT03308084] | Phase 3 | 105 participants (Actual) | Interventional | 2015-11-13 | Completed | ||
| A Phase 3/4, Prospective, Randomized, Active Treatment-Controlled, Parallel-Design, Multicenter Study to Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract [NCT05191706] | Phase 4 | 60 participants (Anticipated) | Interventional | 2022-01-04 | Recruiting | ||
| Glucocorticoid Inflammation Paradox in Human Skeletal Muscle [NCT03529929] | Phase 3 | 0 participants (Actual) | Interventional | 2019-06-01 | Withdrawn(stopped due to withdrawn) | ||
| The Effect of High Dose Steroid and Normobaric Oxygen Therapy on Recent Onset Non-arteritic Anterior Ischemic Optic Neuropathy(NAION); a Randomized Clinical Trial [NCT02439866] | Phase 3 | 90 participants (Anticipated) | Interventional | 2014-02-28 | Recruiting | ||
| A Randomized, Parallel Group, Double-masked, Active-controlled Phase 1/2 Clinical Trial to Evaluate the Efficacy and Safety of Dexamethasone Sodium Phosphate Visulex System for the Treatment of Non-infectious Anterior Uveitis [NCT02309385] | Phase 1/Phase 2 | 44 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Targeting Steroid Resistance During Acute Exacerbations of Chronic Obstructive Pulmonary Disease With Respiratory Failure - The AECOPD Resistance Study [NCT03680495] | 46 participants (Anticipated) | Observational [Patient Registry] | 2017-07-21 | Recruiting | |||
| Evaluation of Ultrasound Guided Platelet Rich Plasma Injection Versus Steroids Injection for Pain Relief in Cases of Partial Rotator Cuff Tears [NCT05317624] | Early Phase 1 | 60 participants (Actual) | Interventional | 2021-08-10 | Completed | ||
| Imatinib for Multiple Sclerosis (MS) Relapses - a Phase II, Randomised Study [NCT03674099] | Phase 2 | 200 participants (Anticipated) | Interventional | 2018-10-01 | Recruiting | ||
| Calcific Tendinitis: Comparing Minimally Invasive Modalities [NCT02367560] | 60 participants (Anticipated) | Interventional | 2015-07-31 | Recruiting | |||
| Effect of Preoperative Intravenous High Dose Methylprednisolone on Complement Activation in Patients Scheduled for Total Knee-arthroplasty [NCT02332616] | Phase 3 | 70 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| An Open-label, Phase 1/2 Study to Evaluate the Safety and Efficacy of Single-dose LY3884961 in Infants With Type 2 Gaucher Disease [NCT04411654] | Phase 1/Phase 2 | 15 participants (Anticipated) | Interventional | 2021-06-29 | Recruiting | ||
| Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis: a Multinational, Randomised, Open Label, Phase III Trial - The iCaD Study [NCT05947669] | Phase 3 | 195 participants (Anticipated) | Interventional | 2023-08-22 | Recruiting | ||
| [NCT02591953] | 22 participants (Actual) | Interventional | 2015-11-30 | Terminated(stopped due to Unable to meet enrollment and follow up criteria) | |||
| Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction [NCT05462730] | Phase 2 | 530 participants (Actual) | Interventional | 2022-11-14 | Active, not recruiting | ||
| Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age: a Point-of-care Testing Guided Randomized, Double-blind, Placebo-controlled Trial [NCT05444699] | Phase 4 | 210 participants (Anticipated) | Interventional | 2022-10-11 | Recruiting | ||
| Transforaminal Epidural Injection in Acute Sciatica [NCT03924791] | 142 participants (Anticipated) | Interventional | 2019-06-01 | Recruiting | |||
| Phase II Study of Ofatumumab in Combination With High Dose Methylprednisolone Followed by Ofatumumab and Lenalidomide Consolidative Therapy for the Treatment of Untreated CLL/SLL The HiLOG Trial [NCT01496976] | Phase 2 | 45 participants (Actual) | Interventional | 2012-03-30 | Active, not recruiting | ||
| A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of COLAL-PRED in the Treatment of Patients With Moderate to Severe Ulcerative Colitis [NCT00676832] | Phase 2 | 190 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Ultrasound Guided Continuous Suprascapular Nerve Block With Oral Gabapentin For Pain Management In Patients With Frozen Shoulder [NCT05037994] | 40 participants (Actual) | Interventional | 2021-04-01 | Completed | |||
| A Phase 3, Multicenter, Randomized, Evaluator-blinded Clinical Trial to Assess the Safety and Efficacy of Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% Compared to Prednisolone Acetate, 1% in the Treatment of Inflammation After Cataract Surgery in [NCT05724446] | Phase 3 | 60 participants (Anticipated) | Interventional | 2022-12-12 | Recruiting | ||
| Chidamide Combines With Etoposide and Methylprednisolone in the Treatment of Hemophagocytic Lymphohistiocytosis [NCT05137522] | 20 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | |||
| Local Steroid Injection vs Wrist Splinting for Carpal Tunnel Syndrome: A Randomized Clinical Trial [NCT02140632] | Phase 4 | 50 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| [NCT02253966] | Phase 2 | 48 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Effect and Security of Steroids Therapy for Patients of IgA Nephropathy With Active Pathological Changes : A Prospective, Randomized, Controlled, Multi-Center Clinical Trial. [NCT02160132] | Phase 2 | 180 participants (Anticipated) | Interventional | 2014-06-30 | Recruiting | ||
| Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand [NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| Effect of High-dose Glucocorticoids on Markers of Inflammation and Bone Metabolism in Patients With Primary Glomerular Disease [NCT04987450] | 40 participants (Anticipated) | Observational | 2018-10-01 | Recruiting | |||
| A Parallel-arm, Single Blind Randomised Controlled Trial Comparing 'AIRWAY PRESSURE RELEASE VENTILATION' and 'LOW-TIDAL VOLUME VENTILATION' in Children With Acute Respiratory Distress Syndrome [NCT02167698] | 52 participants (Actual) | Interventional | 2014-02-28 | Terminated(stopped due to Increased mortality in the intervention arm at 50% enrolment) | |||
| Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial and Data Registry [NCT04151082] | Phase 1/Phase 2 | 15 participants (Actual) | Interventional | 2019-10-31 | Active, not recruiting | ||
| Efficacy and Safety of Methylprednisolone Versus Dexamethasone in Caudal Block for Children Undergoing Hypospadias Surgical Repair: A Bi-center Randomized Controlled Study [NCT05717374] | 80 participants (Anticipated) | Interventional | 2023-02-13 | Recruiting | |||
| The Efficacy and Safety of 36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent Drug-Induced Liver Injury [NCT03266146] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2017-09-02 | Completed | ||
| The Prospective Evaluation of Peri-Operative Glucocorticoid Use in the Management of Cervicofacial Infections of Odontogenic Origin [NCT05951504] | Phase 2/Phase 3 | 29 participants (Actual) | Interventional | 2022-06-22 | Completed | ||
| Corticosteroid Pulse Therapy Effects on MRI Asymptomatic Gadolinium-enhancing Lesions Conversion to a Non-enhancing Black Hole With or Without Treatment in MS Clinic of Booalisina Hospital Sari 2021-2023 [NCT04979650] | Phase 2 | 104 participants (Anticipated) | Interventional | 2021-05-22 | Enrolling by invitation | ||
| The Impact of Dexamethasone Versus Methylprednisolone Upon Neutrophil/Lymphocyte Ratio (NLR) in COVID-19 Diseased Patients Admitted in ICU [NCT04909918] | Phase 3 | 60 participants (Actual) | Interventional | 2021-05-28 | Completed | ||
| Prevention of Development of Transcutaneous Sensitization in Children With Atopic Dermatitis During Their First Year of Life: an Observational Study [NCT04900948] | Phase 4 | 108 participants (Actual) | Interventional | 2017-12-10 | Completed | ||
| Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing Femtosecond Laser-Assisted Cataract Surgery With Premium Intraocular Lens - The ENHANCE Study [NCT04863742] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-04-26 | Recruiting | ||
| Single-blind, Investigator-initiated, Randomized, Controlled Trial to Assess the Safety and Efficacy of Intravenous Corticosteroid Therapy to Treat Patients With Acute Myocarditis With Mildly Reduced Left Ventricular Ejection Fraction [NCT05974462] | Phase 3 | 174 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Evaluation of the Feasibility of Depomedrol Added to Bupivacaine in Ultrasound-guided Genicular Nerve Block in the Combination With Adductor Canal Block for Postoperative Analgesia and Rehabilitation After Reconstructive Knee Surgery. [NCT05893771] | 48 participants (Actual) | Interventional | 2023-06-07 | Completed | |||
| Mechanisms of Neurodynamic Treatments (MONET) [NCT05859412] | 108 participants (Anticipated) | Interventional | 2023-04-13 | Recruiting | |||
| Methylprednisolone Taper After Total Knee Replacement: A Prospective Randomized Trial [NCT05859269] | Phase 4 | 200 participants (Anticipated) | Interventional | 2023-10-16 | Recruiting | ||
| Hypertonic Dextrose Versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Double-blind Randomized Controlled Clinical Trial [NCT04791202] | Phase 3 | 130 participants (Anticipated) | Interventional | 2021-04-01 | Not yet recruiting | ||
| Lateral Elbow Tendinopathy: A Randomized Controlled Trial Examining The Treatment Effect Of Strength Training Combined With Cortico-Steroid Injection, Dry-Needling Or Placebo [NCT02521298] | 60 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| Procollagen-3 Driven Corticosteroids for Persistent Acute Respiratory Distress Syndrome [NCT03371498] | Phase 3 | 356 participants (Anticipated) | Interventional | 2018-12-27 | Recruiting | ||
| High-dose Intravenous Methylprednisolone Therapy in Patients With Graves' Orbitopathy is Associated With the Increased Activity of Factor VIII [NCT03535090] | 26 participants (Actual) | Observational | 2011-01-01 | Completed | |||
| Methylprednisolone Taper to Treat Delayed Post-Operative Recovery After Total Knee Arthroplasty: a Double-Blind Randomized Controlled Trial [NCT05113901] | Phase 4 | 4 participants (Actual) | Interventional | 2022-03-03 | Terminated(stopped due to Extremely low participation, decided to focus on similar study instead) | ||
| Benefit of a Flash Dose of Corticosteroids in Digestive Surgical Oncology: a Randomized, Double Blind, Placebo-controlled Trial [NCT03875690] | Phase 3 | 1,200 participants (Anticipated) | Interventional | 2019-07-02 | Recruiting | ||
| Comparative Study Between the Uses of High Dose Corticosteroid Therapy for Short Duration Versus Low Dose Corticosteroid for Long Duration in Severe Lung Contusion With ARDS [NCT04467892] | Phase 2 | 240 participants (Actual) | Interventional | 2018-01-02 | Completed | ||
| International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones [NCT03007147] | Phase 3 | 475 participants (Anticipated) | Interventional | 2017-08-08 | Recruiting | ||
| Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura [NCT03647852] | 150 participants (Anticipated) | Interventional | 2019-09-01 | Recruiting | |||
| A Randomised Controlled Trial to Compare the Clinical Effectiveness of Lower Extremity Manipulation to That of Steroid Injection in the Treatment of Morton's Neuroma [NCT02304094] | 64 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease [NCT03139604] | Phase 3 | 439 participants (Actual) | Interventional | 2017-07-19 | Completed | ||
| The Efficacy of Nasal Steroids in Treatment of Otitis Media With Effusion: Acomparative Study [NCT03491098] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2018-05-15 | Not yet recruiting | ||
| Mycophenolate Mofetil and Prednisolone Versus Prednisolone Alone in Fibrotic Hypersensitivity Pneumonitis: a Randomized Controlled Trial [NCT05626387] | Phase 4 | 144 participants (Anticipated) | Interventional | 2022-11-23 | Recruiting | ||
| A Prospective, Randomized, Controlled Phase Ⅱ Study of Preventively Use of Methylprednisolone After Split-course Chemoradiotherapy to Reduce the Risk of Radiation-induced Pulmonary Injury For Bulky Local Advanced None-small Cell Lung Cancer [NCT03661567] | Phase 2 | 52 participants (Actual) | Interventional | 2018-08-09 | Terminated(stopped due to slow enrollment) | ||
| A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. [NCT03948191] | Phase 4 | 50 participants (Actual) | Interventional | 2017-10-16 | Completed | ||
| A Prospective, Open-label Trial of Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children [NCT01217099] | 47 participants (Actual) | Interventional | 2007-05-31 | Terminated(stopped due to terminated) | |||
| Double-Masked, Randomized, Parallel Group Study for Evaluation of Non-Inferiority of 0.3%Gatifloxacin/1.0% Prednisolone Association Compared With Their Isolated Administration in the Prevention of Ocular Infection/Inflammation After LASIK Surgery [NCT01218737] | Phase 3 | 101 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation [NCT02495662] | Phase 2 | 30 participants (Actual) | Interventional | 2015-11-30 | Terminated(stopped due to Slow inclusion) | ||
| Clinical Trial of Belimumab Combined With Multi-target Induction Therapy in Adult Patients With Severe Lupus Nephritis [NCT05863936] | Phase 3 | 15 participants (Anticipated) | Interventional | 2023-04-01 | Recruiting | ||
| Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus [NCT04874610] | 15 participants (Actual) | Observational | 2021-08-16 | Completed | |||
| A Phase II Study of Ofatumumab-High Dose Methylprednisolone Followed by Ofatumumab-Alemtuzumab in 17p Deletion CLL [NCT01465334] | Phase 2 | 30 participants (Actual) | Interventional | 2011-12-31 | Terminated(stopped due to Terminated early due to change in practice.) | ||
| The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease, a Double Blind Placebo Controlled Randomized Clinical Trial [NCT02422368] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-09-01 | Withdrawn(stopped due to Do not access to the drug) | ||
| A Phase II Study Evaluating Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone in Patients With Previously Untreated Double and Triple Hit Lymphoma, Double Expressor Lymphoma and High-Gr [NCT04479267] | Phase 2 | 49 participants (Anticipated) | Interventional | 2020-08-21 | Recruiting | ||
| An Open Label Study to Evaluate the Safety and Efficacy of Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Prior Treatment With Methotrexate [NCT01000610] | Phase 4 | 18 participants (Actual) | Interventional | 2008-03-17 | Completed | ||
| A Protocol Based Treatment for Early and Severe Systemic Sclerosis With (Anti-CD20), Rituximab [NCT00379431] | Phase 2 | 9 participants (Actual) | Interventional | 2006-11-27 | Completed | ||
| Phase 4, Randomized Study of Oral Glucocorticosteroid Administration in the Treatment of Acute Severe Asthma Exacerbation in Hospitalized Patients [NCT00627731] | Phase 4 | 50 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Chimeric Anti-CD20 Monoclonal Antibody (Rituximab) for Stage IV Indolent Lymphoma [NCT00577993] | Phase 3 | 210 participants (Actual) | Interventional | 1998-03-16 | Completed | ||
| Impact of the Administration of Systemic Glucocorticoids on Inflammatory Response and Clinical Evolution of Patients Diagnosed With Moderate- Severe Bronchiolitis [NCT02571517] | Phase 4 | 94 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Viral Inception of Asthma: Prospective Study From Infancy to School-age. [NCT00731575] | 200 participants (Anticipated) | Interventional | 2007-06-30 | Active, not recruiting | |||
| Immunomodulatory Effect of Extracorporeal Cytokine Adsorption in Cardiac Surgery [NCT02666703] | Phase 3 | 60 participants (Actual) | Interventional | 2016-02-01 | Completed | ||
| Comparison of Intravenous Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Proliferative Lupus Nephritis [NCT02645565] | Phase 4 | 75 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Effectiveness of Hydrolyzed Collagen Peptide Injection for the Treatment of Collateral Ligament Pain: A Randomized Controlled Trial [NCT05971004] | 62 participants (Actual) | Interventional | 2022-04-13 | Completed | |||
| Treatment With Methylprednisolone in Acute Exacerbations of Multiple Sclerosis: Enhanced Effect With Nighttime Treatment? [NCT00764413] | 57 participants (Actual) | Interventional | 2009-04-30 | Terminated(stopped due to Low inclusion frequency and not enough human resources for completing study) | |||
| Subacromial Injection of Methylprednisolone Versus Ketorolac to Treat Shoulder Impingement: a Double-blind Randomized Controlled Trial [NCT03913702] | Phase 2 | 1 participants (Actual) | Interventional | 2019-09-09 | Terminated(stopped due to Inadequate patient enrollment) | ||
| Phase 2/3 Study of Rituximab for Graves' Ophthalmopathy [NCT00595335] | Phase 2/Phase 3 | 25 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis [NCT03479502] | Phase 4 | 1 participants (Actual) | Interventional | 2018-01-05 | Terminated(stopped due to Lack of personnel to help with recruiting) | ||
| A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis [NCT01838174] | Phase 4 | 37 participants (Actual) | Interventional | 2013-05-31 | Terminated(stopped due to Sponsor requested) | ||
| Efficacy and Safety of Prednisolone and Chloroquine Add on Therapy in Osteoarthritis of the Knee Treated With Fixed Dose Combination of Glucosamine and Chondroitin Sulfate. [NCT00805519] | Phase 4 | 230 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| A Randomized, Parallel, Double-Blind, Placebo-Controlled Dose Regimen Finding Study To Evaluate The Safety And Efficacy Of TRU-015 In Subjects With Active Seropositive Rheumatoid Arthritis On A Stable Background Of Methotrexate [NCT00634933] | Phase 2 | 222 participants (Actual) | Interventional | 2008-03-31 | Terminated(stopped due to The study was terminated on 21 June 2010 due to results not meeting the primary endpoint. No safety reasons contributed to the termination of the study.) | ||
| An Open-Label, Multicenter, Phase 1/2 Study of Tazemetostat as a Single Agent in Subjects With Advanced Solid Tumors or With B-cell Lymphomas and Tazemetostat in Combination With Prednisolone in Subjects With Diffuse Large B Cell Lymphoma [NCT01897571] | Phase 1/Phase 2 | 400 participants (Actual) | Interventional | 2013-06-13 | Completed | ||
| Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of a BI 653048 BS H3PO4 Capsule Formulation Administered as Multiple Doses of 25 mg to 200 mg Once Daily (qd) for 3 Days Assessing Pharmacodynamics as Endotoxin-induced Inflammatory Response of a [NCT02224105] | Phase 1 | 56 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| A Multicenter, Randomized, Double-blind, Placebo-controlled TRial Evaluating Immunosuppressive Treatment in Patients With Chronic Virus-Negative Inflammatory cardiomyopaThY (TRINITY Trial) [NCT05570409] | Phase 2/Phase 3 | 130 participants (Anticipated) | Interventional | 2023-03-28 | Recruiting | ||
| Assessment of the Efficacy of Medrol Dose Pack for Post-Concussive Headaches [NCT04685772] | 25 participants (Anticipated) | Observational [Patient Registry] | 2021-04-01 | Recruiting | |||
| Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease [NCT04509219] | Phase 1 | 10 participants (Anticipated) | Interventional | 2020-04-15 | Recruiting | ||
| The Effect on Wrist Range of Motion With Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures: A Randomized Controlled Trial [NCT03898154] | Phase 4 | 200 participants (Anticipated) | Interventional | 2019-07-10 | Recruiting | ||
| The Outcome of Dexamethasone and Methylprednisolone Treatment for Patients With ARDS Caused by COVID-19 [NCT04499313] | Phase 3 | 60 participants (Anticipated) | Interventional | 2020-08-02 | Recruiting | ||
| A Feasibility Study to Undertake a Definitive Randomised Multi-centre, Double-blind, Double-dummy Controlled Study of a Novel Agent Anakinra vs. Depo-Medrone for Acute Gout Attacks in Patients With Moderate Chronic Kidney Disease [NCT02578394] | Phase 2/Phase 3 | 21 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Effects of Methylprednisolone Plus Ropivacaine Infiltration Before Wound Closure on Laminoplasty or Laminectomy [NCT04493463] | Phase 4 | 132 participants (Actual) | Interventional | 2020-07-31 | Completed | ||
| Syndrome du Tunnel Carpien - Essai Clinique randomisé évaluant l'efficacité de l'Utilisation de l'échographie Lors de l'Infiltration de corticostéroïdes [NCT02036125] | 50 participants (Anticipated) | Interventional | 2013-10-31 | Recruiting | |||
| Zonisamide and Methylprednisolone to Prevent Noise-induced Temporary Hearing Loss [NCT02049073] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2017-10-31 | Withdrawn(stopped due to new data makes this trial unethical) | ||
| Randomised Trial of Intra-articular Injection of Lidocaine Versus Placebo in Inflammatory Arthritis [NCT05302232] | 80 participants (Anticipated) | Interventional | 2022-04-18 | Not yet recruiting | |||
| Comparison of High-dose, Short-term Steroid and Low-dose Long-term Steroid Use in ARDS Caused by COVID-19 - Retrospective Cross-sectional Study [NCT05047874] | 200 participants (Anticipated) | Observational | 2021-09-20 | Recruiting | |||
| An Open-Label, Parallel Group, Controlled Study in Healthy Subjects to Characterize Biological Responses to Immunological Challenges and to Measure the Effect of Marketed Anti-Inflammatory Agents on Those Responses [NCT02252809] | Early Phase 1 | 51 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Comparative Evaluation of Preoperative Methylprednisolone or Ibuprofen on Anesthetic Efficacy of Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis [NCT04157036] | Phase 3 | 3 participants (Actual) | Interventional | 2020-02-01 | Terminated(stopped due to COVID halted recruitment for 2 years. A majority of patients eligible for the study had already taken preoperative analgesics, which disqualified them for the study.) | ||
| A Randomised Clinical Trial Assessing the Efficacy and Safety of Mycophenolate Mofetil Versus Azathioprine for Induction of Remission in Treatment Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome [NCT04933292] | Phase 4 | 78 participants (Anticipated) | Interventional | 2021-06-16 | Recruiting | ||
| Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia: A Randomized, Controlled, 2x2 Factorial Study [NCT04485429] | Phase 3 | 0 participants (Actual) | Interventional | 2020-07-20 | Withdrawn(stopped due to It was not possible to perform the study due to the availability and logistics of porcine heparin) | ||
| Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) [NCT05986422] | Phase 2 | 418 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | ||
| Effect and Security of Steroids Therapy for Patients of IgA Nephropathy With Crescents : A Prospective, Randomized, Controlled, Multi-Center Clinical Trial. [NCT04833374] | Phase 3 | 200 participants (Anticipated) | Interventional | 2021-05-24 | Recruiting | ||
| Open-label Pilot Study of Methylprednisolone for the Treatment of Patients With Friedreich Ataxia (FRDA) [NCT02424435] | Early Phase 1 | 11 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma [NCT06171932] | 60 participants (Anticipated) | Observational [Patient Registry] | 2023-11-26 | Enrolling by invitation | |||
| A Pilot Study Examining Selinexor's Ability to Overcome Resistance in Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy. [NCT04519476] | Phase 1 | 22 participants (Anticipated) | Interventional | 2020-11-01 | Recruiting | ||
| Evaluation of the Efficacy of 2% Cyclosporine in Preventing Graft Rejection [NCT02206789] | 200 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | |||
| Using SMART Design to Develop Dynamic Treatment Regimens for Glucocorticoid Tapering [NCT06072768] | Phase 2 | 200 participants (Anticipated) | Interventional | 2023-03-09 | Recruiting | ||
| Impact of Cyclosporine or Steroid Withdrawal at 3 Months Post Transplantation on Graft Function, Patient Survival and Cardiovascular Surrogate Markers the First 5 Years After Renal Transplantation. [NCT00903188] | Phase 4 | 152 participants (Anticipated) | Interventional | 2008-10-31 | Recruiting | ||
| Comparative Evaluation of the Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in the Treatment of Pediatric and Adult Dermatosis [NCT01011621] | Phase 3 | 170 participants (Anticipated) | Interventional | 2010-02-28 | Not yet recruiting | ||
| Randomised Double-blinded Trial Comparing Efficacy and Safety of Methylprednisolone Per os Versus IV for the Treatment of Multiple Sclerosis Relapses [NCT00984984] | Phase 3 | 200 participants (Anticipated) | Interventional | 2008-03-31 | Recruiting | ||
| To Assess the Role of Sphingosine-1-phosphate in the Pathobiology of Pneumonia: Generate a New Strategy for Treatment of Severe Community-acquired Pneumonia [NCT04007328] | Phase 2/Phase 3 | 400 participants (Anticipated) | Interventional | 2019-06-15 | Recruiting | ||
| (REASON) Double-blind, Randomized Phase II Study to Evaluate the Safety and Efficacy of Acetyl-l-carnitine in the Prevention of Sagopilone-induced Peripheral Neuropathy. [NCT00751205] | Phase 2 | 150 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Evaluation of a New Formulation Useful for the Osteoarthrosis Treatment [NCT00977444] | Phase 2/Phase 3 | 114 participants (Actual) | Interventional | 2007-11-30 | Active, not recruiting | ||
| A Pilot Study To Determine The Toxicity Of The Addition Of Rituximab To The Induction And Consolidation Phases And The Addition Of Rasburicase To The Reduction Phase In Children With Newly Diagnosed Advanced B-Cell Leukemia/Lymphoma Treated With LMB/FAB T [NCT00057811] | Phase 2 | 97 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| Phase II Study of Cyclophosphamide, Prednisone and Rituximab (CPR) in Children, Adolescents and Young Adults With B-lymphocyte Antigen CD20 (CD20) Positive Post-Transplant Lymphoproliferative Disease (PTLD) Following Solid Organ Transplantation (SOT) [NCT00066469] | Phase 2 | 55 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| A Phase II Study of Panobinostat (LBH589) as Second-Line Therapy in Patients With Chronic Graft-Versus-Host Disease [NCT01028313] | Phase 2 | 0 participants (Actual) | Interventional | Withdrawn(stopped due to A decision was made to not move forward with the study. No participants were enrolled or treated.) | |||
| Assessment of Platelet Function in Patients With Chronic Autoimmune Thrombocytopenic Purpura (cAITP) Treated With the Thrombopoietin Receptor (MPL) Agonist Eltrombopag. [NCT00888901] | Phase 4 | 30 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Prospective Donor-specific Cellular Alloresponse Assessment for Immunosuppression Minimization in de Novo Renal Transplantation [NCT02540395] | 184 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| Impact of Obesity on the Pharmacokinetics of Anticancer Therapy in Children With High Risk Acute Lymphoblastic Leukemia (ALL) [NCT00900445] | 0 participants (Actual) | Observational | 2008-03-24 | Withdrawn | |||
| Use of TNF-blocking Therapy in Combination With DMARDs in Patients With Early Rheumatoid Arthritis [NCT00908089] | Phase 4 | 100 participants (Actual) | Interventional | 2003-03-31 | Active, not recruiting | ||
| Corticoids in Severe Community-acquired Pneumonia [NCT00908713] | Phase 4 | 120 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| The Impact of Early Protocol Biopsy in Kidney Transplant Recipients Receiving TAC and MMF; a Prospective Observational Study [NCT02733510] | 200 participants (Anticipated) | Observational | 2016-04-30 | Recruiting | |||
| ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial [NCT05765266] | 45 participants (Anticipated) | Interventional | 2023-08-12 | Not yet recruiting | |||
| Assessing the Efficacy of DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert, When Placed Within the Lower Eye Lid Canaliculus in Comparison to Topical Prednisolone Acetate Following Bilateral Small Incision Lenticule Extraction (SMILE) [NCT04380857] | Phase 4 | 20 participants (Actual) | Interventional | 2020-06-18 | Completed | ||
| Clinical Treatment of Traumatic Optic Neuropathy: Optic Nerve Decompression Randomized Controlled Study [NCT02711982] | 2 participants (Anticipated) | Interventional | 2010-01-31 | Recruiting | |||
| Greater Occipital Nerve Block for Migraine Prophylaxis [NCT00915473] | Phase 4 | 70 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| A Pilot Randomized Controlled Trial of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Neuropathic Pain in the Ankle and the Foot: The PREPLAN Study [NCT02680548] | Early Phase 1 | 8 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia: A Randomized Controlled Pilot Study [NCT04051203] | Phase 1 | 35 participants (Anticipated) | Interventional | 2019-02-01 | Active, not recruiting | ||
| GRAVITAS-309: A Phase 2/3 Study of Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease [NCT03584516] | Phase 2/Phase 3 | 155 participants (Actual) | Interventional | 2019-01-17 | Active, not recruiting | ||
| Glucocorticoid Therapy for Critically Ill Patients With Severe Acute Respiratory Infections Caused by COVID-19: a Prospective, Randomized Controlled Trial [NCT04244591] | Phase 2/Phase 3 | 80 participants (Actual) | Interventional | 2020-01-26 | Completed | ||
| Phenol Neurolysis of Genicular Nerves for Chronic Knee Pain Following Total Knee Arthroplasty: a Pilot Prospective, Randomized, Crossover Trial [NCT03973177] | Phase 4 | 0 participants (Actual) | Interventional | 2019-05-24 | Withdrawn(stopped due to Covid restrictions on recruitment) | ||
| A Prospective Study to Assess the Safety and Effectiveness of Medrol® in Acute Asthma in Indian Patients [NCT00971893] | 0 participants (Actual) | Observational | 2009-10-31 | Withdrawn | |||
| A Phase Ib Feasibility Study of Personalized Kinase Inhibitor Therapy Combined With Induction in Acute Leukemias Who Exhibit In Vitro Kinase Inhibitor Sensitivity [NCT02779283] | Phase 1 | 7 participants (Actual) | Interventional | 2016-01-13 | Completed | ||
| A Phase 2, Randomized, Open-Label Study of Infliximab and Lower Exposure Corticosteroids vs Methylprednisolone and Higher Exposure Oral Corticosteroids for the Management of Immune-Related Severe or Persistent Diarrhea in Patients Treated With Yervoy (Ipi [NCT02763761] | Phase 2 | 0 participants (Actual) | Interventional | 2016-08-16 | Withdrawn(stopped due to Insufficient enrollment) | ||
| Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism and Beta-Cell Dysfunction in Males With the Metabolic Syndrome X: A Randomized, Placebo-controlled, Double-blind Intervention Study With a 2x2 Factorial Design [NCT00721552] | 82 participants (Actual) | Interventional | 2008-10-31 | Completed | |||
| Effects of Volume and Dose of Local Anaesthetic Solution in Epidural Steroidal Injections for Patients With Chronic Lower Back Pain [NCT00887003] | 252 participants (Actual) | Interventional | 2005-05-31 | Completed | |||
| A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy With Immuno-oncology Therapy for Children and Adults With Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma [NCT05675410] | Phase 3 | 1,875 participants (Anticipated) | Interventional | 2023-05-11 | Recruiting | ||
| A Phase 3 Trial Investigating Blinatumomab (NSC# 765986) in Combination With Chemotherapy in Patients With Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients With Localized B-Lymphoblastic Lymphom [NCT03914625] | Phase 3 | 6,720 participants (Anticipated) | Interventional | 2019-07-03 | Recruiting | ||
| Transplantation of Umbilical Cord Blood for Myeloid Leukemia Patients Not in CR With Cyclophosphamide/Fludarabine/Total Body Irradiation Myeloablative Preparative Regimen and UCB NK Cells [NCT00354172] | Phase 2 | 16 participants (Actual) | Interventional | 2006-02-28 | Terminated(stopped due to Competing study was started.) | ||
| A Comparison of Three Different Formulations of Topical Prednisolone Acetate 1% for Control of Post Glaucoma and/or Cataract Surgery Inflammation. [NCT00345046] | Phase 4 | 60 participants (Actual) | Interventional | 2002-09-30 | Completed | ||
| Administration of Methylprednisolone for Prevention of Ovarian Hyper Stimulation Syndrome in In-vitro Fertilization Cycles: A Randomized Controlled Trial [NCT01014104] | Phase 1/Phase 2 | 218 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (TREAT in JIA) [NCT00443430] | Phase 4 | 85 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Effects of Pre-operative Methylprednisolone (125mg iv) After Total Hip Arthroplasty: A Prospective, Randomized, Double-blind, Placebo-controlled Trail [NCT00968903] | Phase 4 | 48 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Comparison of Monthly Pulse ACTH (Acthar Gel) Therapy With Methylprednisolone (MP, Solumedrol) for Long-Term Treatment of Multiple Sclerosis (MS) as an Add on Therapy to Beta-interferons (Avonex, Betaseron or Rebif) [NCT01049451] | Phase 1 | 23 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Methylprednisolone Combined Electric-acupuncture Treatment Effects on Cognitive Function After Surgery for Elderly Patients With General Anesthesia [NCT02535039] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma [NCT00481832] | Phase 2 | 50 participants (Actual) | Interventional | 2007-01-31 | Terminated(stopped due to Accrual Factor) | ||
| Comparison of the Efficacy and Safety of Tocilizumab Versus Methylprednisolone in the Cytokine Release Syndrome of Patients With COVID-19. A Prospective Randomized Controlled Phase II Trial [NCT04377503] | Phase 2 | 30 participants (Actual) | Interventional | 2020-05-01 | Terminated(stopped due to The number of critically ill patients wirh COVID-19 decrease abruptly) | ||
| Preoperative Methylprednisolone in Endovascular Aortic Repair - a Randomized Double Blind Placebo Controlled Clinical Trial [NCT00989729] | 150 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| Phase 2 Clinical Trial for Comprehensive Treatment Program for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Tagraxofusp (SL-401) in Combination With HCVAD/Mini-CVD and VENETOCLAX [NCT04216524] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-05-29 | Recruiting | ||
| A Prospective, Randomized Single-Masked Clinical Trial Comparing OCT and Visual Acuity Outcomes in Subjects Undergoing Cataract Surgery, Who Receive Xibrom Ophthalmic Solution and Standard Presurgical Care vs. Xibrom Ophthalmic Solution Plus Prednisolone [NCT00698724] | Phase 4 | 200 participants (Anticipated) | Interventional | 2008-06-30 | Completed | ||
| The MAGIC Algorithm Probability Guided Preemption of Steroid-refractory Graft-versus-host Disease With Methylprednisolone [NCT05368181] | Phase 2 | 56 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting | ||
| Comparing Subacromial Injection of Platelet-rich Plasma Versus Methylprednisolone in the Treatment of Shoulder Subacromial Impingement Syndrome [NCT02669303] | 19 participants (Actual) | Interventional | 2015-09-30 | Terminated(stopped due to low recruitment rate and high rate of loss-to-followup) | |||
| PreOperative Steroid in Abdominal Wall Reconstruction: A Double-blinded Randomized Clinical Trial [NCT02594241] | 42 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt in Conjunction With Topical Drop Regimen Treating Pain and inflamMation Following Cataract Surgery Compared to SOC Topical Drop Regimen [NCT05626478] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | ||
| Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt in Conjunction With Topical Prednisolone Acetate 1% Treating Pain, and inflamMation Following Corneal Transplant Surgery Compared to Topical Prednisolone Acetate 1%. [NCT04521140] | Phase 4 | 36 participants (Actual) | Interventional | 2020-10-16 | Completed | ||
| Phase II Trial Of Yttrium-90-Ibritumomab Tiuxetan (Zevalin®) Radioimmunotherapy After Cytoreduction With ESHAP Chemotherapy In Patients With Relapsed Follicular Non-Hodgkin's Lymphoma [NCT00732498] | Phase 2 | 28 participants (Actual) | Interventional | 2006-05-15 | Completed | ||
| Low Dose Versus High Dose Steroids in Treatment of Viral Encephalitis [NCT04103684] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-03-30 | Not yet recruiting | ||
| Effectiveness of Transtympanic Steroids in Unilateral Ménière's Disease: a Randomised Controlled Double-Blind Trial [NCT00802529] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| "Are Steroids Efficacious in Hospitalized Patients With Bronchiolitis Who Show an Objective Clinical Improvement After Albuterol (Albuterol Responders)?" [NCT00798616] | 0 participants (Actual) | Interventional | Withdrawn(stopped due to We were unable to enroll a sufficient number of patients due to manpower.) | ||||
| Assessment of Clinical Efficacy of 1% Prednisolone Acetate (Ster ®), Produced by união química, Compared to 1% Prednisolone Acetate (Pred ® Fort), Produced by Allergan, in the Control of Postoperative Inflammation in Cataract Surgery. [NCT01227876] | Phase 3 | 106 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Prospective Comparison of Sirolimus Against Corticosteroids in Treatment of Patients With Active Thyroid Eye Disease [NCT04936854] | Phase 2 | 60 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting | ||
| Corticosteroids and Azathioprine Versus Corticosteroids Alone in IgA Nephropathy: a Randomized Controlled Trial. [NCT00755859] | Phase 4 | 206 participants (Actual) | Interventional | 1998-05-31 | Completed | ||
| Determination of Optimum Duration of Treatment With Bromfenac (Xibrom) Eyedrops Following Cataract Surgery [NCT00758199] | Phase 4 | 49 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| An Observational, Retrospective, Single-center, Clinical Study to Evaluate the Efficacy of Sirolimus (Rapamycin) in Patients With Graves' Disease and Moderate-to-severe and Active Graves' Orbitopathy (GO) [NCT05345119] | 30 participants (Actual) | Observational | 2020-01-15 | Completed | |||
| Phase I/II Study of Hyper-CVAD Plus RAD001 (Everolimus) for Patients With Relapsed or Refractory Acute Lymphocytic Leukemia (ALL) [NCT00968253] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| An Open-label Extension (OLE), Expanded Access Study, to Assess Long-term Safety of SoluMatrix™ Abiraterone Acetate 500mg (4 x 125 mg qd) With Methylprednisolone (4mg Bid) in Patients Who Completed Study Number CHL-AA-201 [NCT02887976] | Phase 3 | 2 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| The Effect of Steroid Pulse Therapy for the Reduction of Acute Rejection Episode in Subclinical Borderline Changes: An Open-Label, Randomized Clinical Trial [NCT02664493] | 154 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Treatment of Chronic Subdural Hematoma by Corticosteroids [NCT02650609] | Phase 3 | 202 participants (Actual) | Interventional | 2016-06-24 | Completed | ||
| Randomized Trial of Plasma Exchange as Adjunctive Therapy for Severe Crescentic GlomerUlonephritis of IgA NEphropathy (RESCUE Study) [NCT02647255] | Phase 2/Phase 3 | 10 participants (Actual) | Interventional | 2016-03-31 | Terminated(stopped due to Due to the rarity and rapid progressive course of the disease, patients were less likely to participate in randomization.) | ||
| Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men [NCT00957801] | Phase 4 | 29 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| A Clinical Safety and Efficacy Comparison of NEVANAC 0.1% to Vehicle Following Cataract Surgery in Diabetic Retinopathy Patients [NCT00782717] | Phase 2 | 263 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Local Steroid Injection in the Treatment of Idiopathic Carpal Tunnel Syndrome: A Randomized Double-blind Placebo-controlled Trial Among Patients Planned for Surgical Treatment [NCT00806871] | Phase 2/Phase 3 | 112 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Hematopoietic Stem Cell Therapy for Patients With Refractory Myasthenia Gravis [NCT00424489] | Phase 1 | 9 participants (Actual) | Interventional | 2002-02-28 | Terminated(stopped due to No participants enrolled for more than two years. No plan to continue study.) | ||
| Phase 4, Randomized Study of Three Months-prednisolone Therapy in the Treatment of Chronic Eosinophilic Pneumonia [NCT00632554] | Phase 4 | 50 participants (Anticipated) | Interventional | 2008-06-30 | Completed | ||
| Effect of Anti-inflammatory Topical Prednisolone Acetate 1%, Nepafenac of 0.1% and Ketorolac Tromethamine 0.4% in Intra-operative Mydriasis in Facetectomies [NCT00865540] | Phase 4 | 30 participants (Actual) | Interventional | 2009-03-31 | Active, not recruiting | ||
| Intra-discal Steroid Injection for MODIC I Discopathy: A Randomized Control Trial [NCT00804531] | Phase 4 | 137 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Role of Doxycycline in the Management of Patients With Chronic Rhinosinusitis With Nasal Polyps [NCT05157412] | Phase 3 | 60 participants (Anticipated) | Interventional | 2022-03-01 | Not yet recruiting | ||
| The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis [NCT04318652] | Phase 4 | 80 participants (Actual) | Interventional | 2018-09-02 | Completed | ||
| Randomized, Prospective Single-center Study Comparing a Rapid Discontinuation of Corticosteroids (Steroid Withdrawal) With Corticosteroid Therapy in Kidney Transplantation Using Mycophenolate Mofetil and Tacrolimus Maintenance Therapy [NCT00596947] | Phase 4 | 18 participants (Actual) | Interventional | 2005-10-31 | Terminated(stopped due to due to low study enrollment) | ||
| A Prospective Randomized Open-label Study to Compare Mycophenolate Mofetil and A Prospective Randomized Open-label Study to Compare Mycophenolate Mofetil and Corticosteroid With Tacrolimus and Corticosteroid as Immunosuppressive Treatment for Lupus Membra [NCT00404794] | Phase 3 | 20 participants (Anticipated) | Interventional | 2005-11-30 | Completed | ||
| Evaluation of Efficacy in the Resolution of Post-Operative Inflammation and Pain in Patients Receiving Omidria and Dexycu, or Omidria and Dextenza Compared to Topical Prednisolone Acetate 1% Following Cataract Surgery [NCT04316936] | Phase 4 | 15 participants (Actual) | Interventional | 2019-12-10 | Completed | ||
| GON-injection for a Sooner and Better Treatment of Cluster Headache: a Double-blind Randomized Controlled Trial [NCT04014634] | Phase 4 | 80 participants (Anticipated) | Interventional | 2019-08-01 | Recruiting | ||
| A Phase I, Randomised, Single-blind Study to Asses the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567 in Healthy Volunteers Using Prednisolone as Positive Control [NCT02760316] | Phase 1 | 64 participants (Anticipated) | Interventional | 2016-05-02 | Completed | ||
| Rituximab Plus Short-term Methylprednisolone Versus Standard Dose Methylprednisolone in Newly Diagnosed Participants With Immune Thrombocytopenia (ITP): A Multicenter, Randomized Phase II Study in China [NCT02757196] | Phase 2 | 112 participants (Anticipated) | Interventional | 2016-05-31 | Not yet recruiting | ||
| Budesonide Inhalation Suspension for Acute Asthma in Children [NCT00393367] | Phase 4 | 179 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| An Open Label, Multicenter, Phase I/II Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease [NCT04220632] | Phase 1/Phase 2 | 1 participants (Actual) | Interventional | 2020-06-18 | Terminated(stopped due to Adverse events of the first patient) | ||
| A Phase IIIB, Multicenter, Randomized, Double-Masked, Parallel-Group, Active-Controlled Study of the Safety and Efficacy of Difluprednate Ophthalmic Emulsion, 0.05% (Durezol™) 4 Times Daily (QID) and Prednisolone Acetate Ophthalmic Suspension, 1.0% (Pred [NCT01124045] | Phase 3 | 80 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Intrathecal Rituximab in Progressive Multiple Sclerosis [NCT02545959] | Phase 2 | 10 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Randomized, Placebo-Controlled Trial of Bilateral 3rd/4th Common Digital Foot Nerve Injections to Treat Restless Legs Syndrome [NCT00656110] | 60 participants (Anticipated) | Interventional | 2008-04-30 | Recruiting | |||
| Topical Epidural Steroid Usage in Patients Undergoing Posterior Lumbar Decompression: A Randomized Control Trial [NCT05058287] | Phase 3 | 150 participants (Anticipated) | Interventional | 2021-11-05 | Recruiting | ||
| Multicenter, Randomized, Double Blind, Clinical Trial to Compare the Clinical and Radiological Efficacy of Equivalent Doses of Methylprednisolone Administered Orally or Intravenously in Patients With Multiple Sclerosis During Relapse [NCT00753792] | Phase 4 | 49 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Ursodeoxycholic Acid Combined With Low Dose Glucocorticoid in the Treatment of PBC With AIH Features II：A Randomized Controlled Open-label Clinical Trial [NCT04617561] | Phase 4 | 90 participants (Anticipated) | Interventional | 2020-11-01 | Recruiting | ||
| Steroid Injection for the Treatment of Greater Trochanteric Pain Syndrome: A Randomized Controlled Trial [NCT00863889] | Phase 4 | 0 participants (Actual) | Interventional | 2009-03-31 | Withdrawn | ||
| An Unusual Association Between Pancreatic Cancer and Purtscher-like Retinopathy: Presentation of a Unique Case [NCT05350384] | 1 participants (Actual) | Observational | 2021-06-18 | Completed | |||
| Steroids and Azathioprine in Early and Advanced IgA Nephropathy: Amendments to a Prospective Randomised Multicenter Trial [NCT01392833] | Phase 3 | 46 participants (Actual) | Interventional | 1999-12-31 | Completed | ||
| Phase I Study of Escalating Doses of Carfilzomib With Hyper-CVAD in Patients With Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma [NCT02293109] | Phase 1 | 10 participants (Actual) | Interventional | 2015-12-17 | Completed | ||
| Phase 1, Open-label, Randomized, Single-dose, 2-treatment, Crossover Be Study Comparing Constituted Methylprednisolone Powder For Oral Suspension 4 Mg/ml To Methylprednisolone 16 Mg Tablet Under Fasting Conditions [NCT01405157] | Phase 1 | 0 participants (Actual) | Interventional | 2012-01-01 | Withdrawn | ||
| Phase 1, Open-label, Randomized, Single-dose, 2-treatment, Crossover Be Study Comparing Constituted Methylprednisolone Powder For Oral Suspension 4 Mg/ml To Methylprednisolone 32 Mg Tablet Under Fed Conditions [NCT01405170] | Phase 1 | 0 participants (Actual) | Interventional | 2011-10-14 | Withdrawn | ||
| A Phase IV Single Blind Placebo-controlled Cross Over Study to Investigate the Efficacy of Greater Occipital Nerve Block With Local Anesthetic and Steroid in Patients With Chronic Migraine [NCT04017741] | Phase 4 | 8 participants (Actual) | Interventional | 2018-02-14 | Completed | ||
| Randomised Trial of Plasma Exchange or High Dose Methyl Prednisolone as Adjunctive Therapy for Severe Renal Vasculitis [NCT01408836] | Phase 2/Phase 3 | 150 participants (Actual) | Interventional | 1995-03-31 | Terminated(stopped due to Completed) | ||
| Comparison Between Standard Dose Methyl Prednisolone and Megadose Methyl Prednisolone as Regards Outcome in SARS.COV.2 Patients in Intensive Care Unit : Retrospective Study [NCT05279482] | 104 participants (Actual) | Observational | 2022-01-19 | Completed | |||
| A Randomized Phase II Study for the Evaluation of Extracorporeal Photopheresis (ECP) in Combination With Corticosteroids for the Initial Treatment of Acute Graft-Versus-Host Disease (GVHD) [NCT00609609] | Phase 2 | 81 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Effects of Pre-operative Methylprednisolone (125mg iv) After Total Knee Arthroplasty: A Prospective, Randomized, Double-blind, Placebo-controlled Trail [NCT00968578] | Phase 4 | 48 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Phase II Study of The Modified Hyper-CVAD Program for Acute Lymphoblastic Leukemia [NCT00671658] | Phase 2 | 220 participants (Actual) | Interventional | 2002-11-30 | Completed | ||
| Effect of Preoperative Intravenous High Dose Methylprednisolone on Immune Signaling in Patients Scheduled for Total Hip-arthroplasty [NCT02542592] | Phase 2/Phase 3 | 64 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Umbilical Cord Blood (UCB) Allogeneic Stem Cell Transplant for Hematologic Malignancies [NCT01093586] | Phase 2 | 14 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| An Open, Prospective/Retrospective, Randomized Controlled Cohort Study to Compare the Efficacy of Different Hormone Doses in the Treatment of 2019-nCoV Severe Pneumonia [NCT04263402] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-02-01 | Recruiting | ||
| Prednisolone-induced Impairment of Glucose Metabolism and Beta-cell Dysfunction and the Protective Effects of Exenatide: a Single-center, Randomized, Double-blind, Placebo-controlled Crossover Study in Healthy Volunteers [NCT00744224] | 8 participants (Anticipated) | Interventional | 2009-02-28 | Completed | |||
| Phase III Randomised Study on Liposomal Cytarabine (DepoCyte®) vs. Intrathecal Triple for CNS-Treatment During Maintenance Therapy in High-Risk Acute Lymphoblastic Leukemia Patients in NOPHO ALL 2008 Treatment Protocol [NCT00991744] | Phase 3 | 100 participants (Anticipated) | Interventional | 2009-01-31 | Suspended(stopped due to Sterility problems in DepoCyte production) | ||
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial [NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| Pilot Randomized, Placebo-Controlled Trial to Evaluate The Effect of Oral Pulsed Methylprednisolone on Seizure Frequency in Pediatric Patients With Idiopathic Intractable Convulsive Epilepsy [NCT04219995] | Phase 1/Phase 2 | 10 participants (Anticipated) | Interventional | 2020-02-03 | Recruiting | ||
| Soluble Tumor Necrosis Factor Receptor: Enbrel® (Etanercept) for the Treatment of Acute Non-Infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Stem Cell Transplantation [NCT00309907] | Phase 2 | 39 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| A Randomized Phase 3 Study of Brentuximab Vedotin (SGN-35) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Young Adults [NCT02166463] | Phase 3 | 600 participants (Actual) | Interventional | 2015-03-19 | Active, not recruiting | ||
| Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for the Treatment of Infectious Keratitis [NCT02717871] | Phase 3 | 35 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Intensified Tyrosine Kinase Inhibitor Therapy (Dasatinib NSC# 732517) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (ALL) [NCT00720109] | Phase 2/Phase 3 | 63 participants (Actual) | Interventional | 2008-07-14 | Completed | ||
| Evaluation of Inhaled Corticosteroid Treatment in Sinusitis [NCT01907204] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Relative Efficacy of Repeat Course of Intravenous methyLprednisolone and Intramuscular ACTH in the Treatment of Acute Relapse of Multiple Sclerosis After Sub Response to Initial Course of Intravenous Methylprednisolone (RECLAIM): a Single Center Pilot Stu [NCT00947895] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2009-10-31 | Terminated(stopped due to Study reached halfway point in approximately one year time period and was halted to analyze data.) | ||
| Lessdrops™ Prophylactic Treatment After Routine Phacoemulsification Compared to Standard Drops Regimen [NCT03578276] | Phase 4 | 35 participants (Actual) | Interventional | 2018-06-22 | Completed | ||
| [NCT00000147] | 0 participants | Interventional | 1988-07-31 | Active, not recruiting | |||
| Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) [NCT00000579] | Phase 3 | 0 participants | Interventional | 1994-09-30 | Completed | ||
| A Controlled Randomized Trial to Study the Efficacy of Adjunctive Methylprednisolone for the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Pediatric AIDS Patients [NCT00000741] | Phase 3 | 0 participants (Actual) | Interventional | Withdrawn | |||
| "Efficacy of Infliximab as Bridging Therapy in the Treatment of Patients Affected by Corticodependent Crohn's Disease Under Standard Treatment With Azathioprine" [NCT00796250] | Phase 3 | 9 participants (Actual) | Interventional | 2003-11-01 | Terminated(stopped due to Due to poor patient recruitment, a decision was made to terminate this trial.) | ||
| Intérêt de la corticothérapie Dans la Pneumocystose Grave du Patient immunodéprimé Non VIH. Essai Prospectif Multicentrique Randomisé Contrôlé : PIC [NCT02944045] | Phase 3 | 222 participants (Anticipated) | Interventional | 2017-02-15 | Recruiting | ||
| Efficacy of Methylprednisolone in Severe Community-acquired Pneumonia，A Multi-center Randomized Controlled Trial [NCT02552342] | Phase 4 | 610 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| Acute Unilateral Vestibulopathy and Corticosteroid Treatment [NCT02912182] | Phase 4 | 78 participants (Actual) | Interventional | 2015-12-31 | Terminated(stopped due to Placebo medication expired) | ||
| Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas [NCT01024322] | 1,189 participants (Actual) | Observational | 2009-10-01 | Terminated(stopped due to Terminated to initiate FDA IND-cleared study protocol) | |||
| Utility of Intramuscular Corticosteroids for Radicular Low Back Pain [NCT00290589] | Phase 3 | 82 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Local Injection of Ozone Versus Methylprednisolone Acetate in Carpal Tunnel Syndrome of Scleroderma Patients. A Single-blind Randomized Clinical Trial [NCT03742466] | 50 participants (Actual) | Interventional | 2018-11-10 | Completed | |||
| A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib [NCT01324596] | Phase 3 | 1,132 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| A Randomized, Multicenter, Open-label, 6-month Study to Explore the Efficacy and Safety of Enteric-coated Mycophenolate Sodium in Combination With Two Corticosteroid Regimens for the Treatment of Lupus Nephritis Flare [NCT00423098] | Phase 2 | 81 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| An Open-label, Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of Chronic Graft Versus Host Disease After TLI/ARG Nonmyeloablative Allogeneic Stem Cell Transplantation [NCT00186628] | Phase 2 | 36 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Safety and Feasibility of Umbilical Cord Blood Cell Transplant Into Injured Spinal Cord: an Open-Labeled, Dose-Escalating Clinical Tiral [NCT01046786] | Phase 1/Phase 2 | 8 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| An Oral Methylprednisolone Taper Within a Multimodal Analgesic Regimen After Total Knee Arthroplasty: a Double-Blind Randomized Placebo-Controlled Trial [NCT05097976] | Phase 4 | 420 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | ||
| Evaluation of the Effect of Octreotide Compared to Placebo in Patients With Inoperable Bowel Obstruction Due to Peritoneal Carcinomatosis [NCT00332696] | Phase 2 | 64 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| A Randomized Trial of Rituximab in Induction Therapy for Living Donor Renal Transplantation [NCT01095172] | Phase 4 | 100 participants (Actual) | Interventional | 2010-11-30 | Active, not recruiting | ||
| High Dose Cyclophosphamide & ATG With Hematopoietic Stem Cell Transplantation in Patients With Refractory Idiopathic Inflammatory Myopathy Diseases: A Phase I Trial [NCT00278564] | Phase 1 | 7 participants (Actual) | Interventional | 2005-09-30 | Terminated(stopped due to high relapse rate) | ||
| An Open-Label, Phase 1 Study to Examine the Pharmacokinetic Interactions Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects [NCT01886209] | Phase 1 | 28 participants (Anticipated) | Interventional | 2013-06-30 | Completed | ||
| A Phase II Study to Evaluate Low-Dose Alemtuzumab as a Glucocorticoid-Sparing Agent for Initial Systemic Treatment of Acute Graft-Versus-Host Disease [NCT00410657] | Phase 2 | 53 participants (Anticipated) | Interventional | 2006-07-31 | Completed | ||
| Macular Edema Nepafenac vs. Difluprednate Uveitis Trial [NCT01939691] | Phase 4 | 9 participants (Actual) | Interventional | 2018-09-12 | Terminated(stopped due to Difficulty enrolling) | ||
| A Double-blind, Two-arm, Multicenter, Randomized Trial to Evaluate Efficacy of Cyclophosphamide Versus Methylprednisolone in Patients With Recent Secondary Progressive Multiple Sclerosis: P.R.OM.E.S.S Study [NCT00241254] | Phase 3 | 138 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Itolizumab in Subjects With Newly Diagnosed Acute Graft Versus Host Disease [NCT05823675] | Phase 1 | 44 participants (Anticipated) | Interventional | 2023-05-19 | Recruiting | ||
| Phase II Study of High-dose Methylprednisolone and Rituximab in Previously Treated Patients With High Risk Chronic B Lymphocytic Leukemia [NCT00558181] | Phase 2 | 29 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| European Multicenter and Open-Label Controlled Randomized Trial to Evaluate the Efficacy of Sequential Treatment With Tacrolimus-Rituximab Versus Steroids Plus Cyclophosphamide in Patients With Primary Membranous Nephropathy (The STARMEN Study) [NCT01955187] | Phase 3 | 86 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Steroid Injections vs. Platelet Rich Plasma Injections in Patients With Plantar Fasciitis: A Comparison of Clinical and Ultrasound Findings [NCT01957631] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2013-06-30 | Withdrawn(stopped due to Lack of funding) | ||
| A Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy [NCT01969019] | Phase 4 | 70 participants (Anticipated) | Interventional | 2010-01-31 | Recruiting | ||
| Antiemetic Corticosteroid Rotation From Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated With Chemotherapy: A Randomized, Single-Blind, Crossover Phase III Trial [NCT01974024] | Phase 3 | 65 participants (Actual) | Interventional | 2013-10-01 | Completed | ||
| A Prospective Randomized 3-arm Trial Comparing Intra-articular Corticosteroid Injection vs Arthrographic Distention vs Arthrographic Distention Plus Intra-articular Corticosteroid Injection in the Treatment of Adhesive Capsulitis [NCT01983527] | 132 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | |||
| Comparing the Effectiveness of Steroid Injection Versus Placebo and Immobilization Versus no Immobilization in Treating Patients With Lateral Epicondylitis [NCT01986465] | Phase 2/Phase 3 | 78 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Multicenter, Randomized, Double-blind Clinical Trial to Compare the Clinical and Radiological Efficacy of 625 mg Versus 1250 mg of Oral Methylprednisolone in Patients With Multiple Sclerosis in Relapse. [NCT01986998] | Phase 4 | 49 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Comparison of Efficacy of Dexamethasone and Methylprednisolone in Moderate to Severe Covid 19 Disease [NCT04603729] | Phase 3 | 100 participants (Actual) | Interventional | 2020-05-30 | Completed | ||
| PhaseIV Study of Intra-articular Methylprednisolone in TMJ Arthralgia [NCT01995019] | Phase 4 | 56 participants (Actual) | Interventional | 2013-12-10 | Completed | ||
| Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars) [NCT04593706] | 40 participants (Anticipated) | Interventional | 2020-11-01 | Not yet recruiting | |||
| Preoperative Glucocorticoid Use in Major Hepatectomy - A Randomized Controlled Trial [NCT01997658] | Phase 2/Phase 3 | 200 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns in Children [NCT02002078] | Phase 4 | 83 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Efficacy of the Intralesional Infusion of Local Anesthetic and Steroids After Major Abdominal Surgery: a Randomized Double Blind Phase III Trial [NCT02002663] | Phase 3 | 120 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Randomised, Multicentre, Open Label, Parallel Group Pragmatic Clinical Trial of Local Steroid Injection Versus Night Splinting in Mild to Moderate Carpal Tunnel Syndrome (CTS) [NCT02038452] | Phase 4 | 234 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Influence of Corticoids on Renal Function in Cardiac Surgery [NCT00879931] | Phase 2 | 80 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Do Intraoperative Topical Corticosteroids Aid in the Prevention of Postoperative Dysphagia Following Elective Anterior Cervical Discectomy and Fusion? A Randomized, Controlled, Double Blinded Clinical Trial [NCT02539394] | 128 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis: a Randomized Controlled Trial [NCT03265405] | Phase 4 | 86 participants (Actual) | Interventional | 2017-04-01 | Completed | ||
| Efficacy and Safety of Difluprednate Ophthalmic Emulsion vs. a Fixed-Combination of Prednisolone Acetate - Phenylephrine Ophthalmic Suspension on Post-operative Inflammation Following Cataract Surgery. [NCT04631315] | Phase 4 | 255 participants (Actual) | Interventional | 2019-03-24 | Completed | ||
| Study on the Association Between the Effect of Glucocorticoid Pulse Therapy on Neuromyelitis Optica and Gene Polymorphism: a Cohort Study [NCT04601142] | 350 participants (Anticipated) | Observational | 2020-10-31 | Recruiting | |||
| Peking University Third Hospital Medical Science Research Ethics Committee [NCT04590183] | 30 participants (Anticipated) | Interventional | 2020-10-01 | Recruiting | |||
| A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Safety, Tolerability and Clinical Effect of Laquinimod in Active Lupus Nephritis Patients, in Combination With Standard of Care (Mycophenolate Mofetil and Steroid [NCT01085097] | Phase 2 | 46 participants (Actual) | Interventional | 2010-09-01 | Completed | ||
| The Efficacy Of Magnesium In Radicular Lower Limb Pain When It Is Added To Local Anesthetics And Steroids In The Transforaminal Epidural Injections. A Comparative Study [NCT04532775] | Phase 1 | 100 participants (Anticipated) | Interventional | 2020-08-30 | Not yet recruiting | ||
| An Open-label Multicenter Trial to Study the Efficacy and Safety of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura [NCT04074187] | Phase 2/Phase 3 | 21 participants (Actual) | Interventional | 2019-10-21 | Completed | ||
| Cadaveric Organ Donor Management: Thyroid and Adrenocortical Hormone Replacement [NCT04528797] | 199 participants (Actual) | Interventional | 2010-09-02 | Completed | |||
| A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis [NCT01201798] | Phase 3 | 111 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Comparison of the Efficacy Between Ultrasound-guided Dextrose Injection Versus Dextrose With Methylprednisolone Injection in Patients With Carpal Tunnel Syndrome: a Prospective, Randomized Double-blind Clinical Trial. [NCT06045013] | Phase 3 | 70 participants (Anticipated) | Interventional | 2023-09-13 | Recruiting | ||
| Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study [NCT06081101] | Early Phase 1 | 80 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Risk Stratification-directed Low-dose Glucocorticoid Prophylaxis for Acute GVHD After Unmanipulated Haploidentical Blood and Marrow Transplantation--a Randomized, Controlled, Clinical Trial [NCT01607580] | 145 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Evaluation of the Bioavailability of Methylprednisolone Succinate Administered Intranasally [NCT05649878] | 8 participants (Actual) | Interventional | 2021-11-05 | Completed | |||
| Non-Invasive Mechanical Ventilation in Elderly Patients Affected by Acute Hypercapnic Respiratory Failure:A Randomized Control Study vs Standard Medical Therapy A Multicentric Randomized Controlled Trial [NCT00600639] | Phase 4 | 82 participants (Actual) | Interventional | 2004-01-31 | Terminated | ||
| Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study [NCT04168112] | Phase 4 | 20 participants (Actual) | Interventional | 2020-02-12 | Completed | ||
| Incretin Physiology and Beta-Cell Function Before and After Treatment With Steroid Hormone in Healthy Individuals [NCT00713440] | 10 participants (Actual) | Interventional | 2008-07-31 | Completed | |||
| A Phase II, Multicentre, Open-label, Master Protocol to Evaluate the Efficacy and Safety of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination With Anticancer Agents in Patients With Advanced/Metastatic Solid Tumours [NCT05489211] | Phase 2 | 670 participants (Anticipated) | Interventional | 2022-09-06 | Recruiting | ||
| A Phase 2 Study of SNDX-5613 in Combination With Chemotherapy for Patients With Relapsed or Refractory KMT2A-Rearranged Infant Leukemia [NCT05761171] | Phase 2 | 78 participants (Anticipated) | Interventional | 2023-11-20 | Recruiting | ||
| Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy [NCT02711449] | Phase 2 | 78 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) [NCT02798068] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| A Randomized Controlled Clinical Trial on the Efficacy and Safety of Glucocorticosteroid in the Patients With Chronic Recurrent Drug-induced Liver Injury [NCT02651350] | Phase 1/Phase 2 | 80 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Efficacy of Intra-operative Subacromial Corticosteroid Injections on Surgical Outcomes After Arthroscopic Shoulder Surgery [NCT02867904] | Phase 4 | 12 participants (Actual) | Interventional | 2016-03-31 | Terminated(stopped due to It was difficult to recruit patients to get the appropriate sample size.) | ||
| Comparison of Corticosteroids Versus Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the Intensive Care Unit: a Multicentre Randomized Controlled Trial [NCT04163536] | Phase 3 | 440 participants (Anticipated) | Interventional | 2021-10-25 | Recruiting | ||
| Desensitization for Preformed Anti-HLA Antibodies in Kidney Transplantation [NCT00908583] | Phase 4 | 44 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Corticosteroids for Cancer Pain [NCT00676936] | Phase 3 | 50 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Phase 1, Open-label, Randomized, Single-dose, 2-treatment, 2 Period Crossover Bioequivalence Study Comparing Constituted Methylprednisolone Powder For Oral Suspension 4 Mg/ml To Methylprednisolone 32 Mg Tablet Under Fasted Conditions [NCT01405131] | Phase 1 | 0 participants (Actual) | Interventional | 2012-01-01 | Withdrawn | ||
| Assessment of Corticosteroid Effect in the Prevention of Facial Palsy After Cerebella-pontine Angle Surgery [NCT00438087] | Phase 3 | 313 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Retrospective Study of Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome [NCT01423864] | Phase 2 | 29 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Comparison Between Prednisolone and Dexamethasone on D28 Mortality in Patients on Oxygen Therapy, With CoViD-19: Multicenter, Randomized, Open-label Non-inferiority Study [NCT04765371] | Phase 3 | 89 participants (Actual) | Interventional | 2021-03-03 | Completed | ||
| A Randomized, Multicentre, Double-blind Study to Evaluate the Efficacy of High-dose Administration of Methylprednisolone in Addition to Standard Treatment, in SARS-CoV2 (COVID-19) Pneumonia Patients [NCT04673162] | Phase 3 | 260 participants (Actual) | Interventional | 2020-12-17 | Completed | ||
| Efficacy of High-dose Corticosteroid Pulses Added to Conventional Oral Corticosteroid Course for Moderate Flares of Ulcerative Colitis. [NCT02921555] | Phase 4 | 75 participants (Actual) | Interventional | 2018-10-11 | Completed | ||
| Assessing the Efficacy and Safety of DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert, When Placed Within the Lower Eye Lid Canaliculus in Pseudo Phakic Patients Undergoing Gas Bubble Repair and Laser Following Retinal Detachment [NCT04464629] | Phase 4 | 7 participants (Actual) | Interventional | 2020-07-14 | Terminated(stopped due to Poor enrollment) | ||
| A Randomized Pilot Trial of a Steroid-free Immunosuppressant Regimen in Pediatric Liver Transplantation [NCT00694408] | Phase 3 | 15 participants (Actual) | Interventional | 2008-06-30 | Terminated(stopped due to Study terminated due to withdrawal from market of Daclizumab) | ||
| A Randomized, Parallel-Cohort Phase 1 Study of Itacitinib in Combination With Corticosteroids for the Treatment of Acute Graft Versus Host Disease [NCT02614612] | Phase 1 | 31 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Evaluation of the Tolerability and Efficacy of Erythropoietin (EPO) Treatment in Spinal Shock: Comparative Study VS Methylprednisolone (MP) [NCT00561067] | Phase 3 | 10 participants (Actual) | Interventional | 2008-04-30 | Terminated(stopped due to Italian Medicines Agency decision) | ||
| Double-Blind, Placebo Controlled, Randomized, Multicenter, Parallel-Group Study to Compare the Efficacy and Safety of Advantan Cream Twice Weekly With Advabase Cream During a Maintenance Phase of 16 Weeks After Successful Treatment of Atopic Dermatitis Wi [NCT00185510] | Phase 4 | 250 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| Can Montelukast Shorten Corticosteroid Therapy In Children With Mild To Moderate Acute Asthma? [NCT00213252] | Phase 2 | 130 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Multisystem Inflammatory Syndrome Therapies in Children (MISTIC) Comparative Effectiveness Study [NCT04898231] | Phase 2/Phase 3 | 180 participants (Anticipated) | Interventional | 2020-12-22 | Active, not recruiting | ||
| A Phase 2b, Double-Blind, Three Arm, Randomized, Placebo Controlled Trial With Restricted Response Adaptive Randomization Testing the Efficacy and Safety of High Dose Methylprednisolone or Equine Anti-Thymocyte Globulin as Treatment for Acute Liver Failur [NCT04862221] | Phase 2 | 163 participants (Anticipated) | Interventional | 2022-02-09 | Recruiting | ||
| A Phase 1, Open-Label, Randomized, Single-Dose, 3-Treatment, Crossover Bioavailability Study Comparing Constituted Methylprednisolone Powder For Oral Suspension 4 Mg/Ml to Methylprednisolone 32 Mg Tablet Under Fasted Conditions [NCT01267201] | Phase 1 | 24 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| Comparison of the Efficacy and Safety of Two Corticosteroid Regimens in the Treatment of Diffuse Lung Disease After Coronavirus Disease 2019 (COVID-19) Pneumonia [NCT04657484] | 130 participants (Actual) | Interventional | 2020-12-01 | Completed | |||
| Comparison of the Effectiveness of the Ultrasound Guided Subacromial, Acromioclavicular With Subacromial Injection and Suprascapular Nerve Block in Patients With Shoulder Impingement Syndrome ; A Randomized Controlled, Single Blind, Clinical Trial [NCT05015322] | Phase 4 | 88 participants (Actual) | Interventional | 2017-01-01 | Completed | ||
| Steroids And Laser Trabeculoplasty (SALT) Trial: Effect of Anti-Inflammatory Treatment on the Efficacy of SLT [NCT00981435] | Phase 4 | 97 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology [NCT02416128] | 0 participants (Actual) | Interventional | 2015-04-30 | Withdrawn(stopped due to No participants enrolled) | |||
| A Two-Part, Multi-Center, Prospective, Phase 2/3 Clinical Study to Evaluate the Safety and Efficacy of GLASSIA as an Add-On Biopharmacotherapy to Conventional Steroid Treatment in Subjects With Acute Graft-Versus-Host Disease With Lower Gastrointestinal I [NCT02956122] | Phase 2/Phase 3 | 1 participants (Actual) | Interventional | 2017-04-26 | Terminated(stopped due to The decision to discontinue the study was based on business reasons.) | ||
| [NCT00000138] | Phase 3 | 0 participants | Interventional | 1989-05-31 | Active, not recruiting | ||
| High-Dose Methotrexate Plus Steroid Followed by Concurrent Whole Brain Chemoradiation With Temozolomide for Immunocompetent Patients With Primary Central Nervous System Lymphoma - a Phase II Study [NCT00455286] | Phase 2 | 25 participants | Interventional | 2006-11-30 | Recruiting | ||
| Phase IV Study of Perioperative Steroid's Effects on Death or MI in High-Risk Patients Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass [NCT00427388] | Phase 4 | 7,507 participants (Actual) | Interventional | 2007-06-30 | Active, not recruiting | ||
| [NCT00480675] | 65 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| [NCT00469781] | Phase 4 | 95 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [NCT00501579] | Phase 3 | 0 participants | Interventional | Completed | |||
| A Randomized, Masked Multi-center Safety & Efficacy Study of the Effects of Preoperative & Postoperative Cataract Surgery Use of Difluprednate Ophthalmic Emulsion, 0.05% Compared to Prednisolone Acetate Ophthalmic Suspension 1% on Visual Acuity & Corneal [NCT01244334] | Phase 4 | 52 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| A Multicenter, Double-blinded, Randomized, Placebo-controlled Trial to Compare the Effectiveness of Intratympanic Injections methylPREDnisolon Versus Placebo in the Treatment of Vertigo Attacks in MENière's Disease (PREDMEN Trial). [NCT05851508] | Phase 3 | 148 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | ||
| Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care [NCT05638633] | Phase 3 | 340 participants (Anticipated) | Interventional | 2022-11-11 | Recruiting | ||
| A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (NSC# 102816) to Chemotherapy in Infants With Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement [NCT02828358] | Phase 2 | 78 participants (Actual) | Interventional | 2017-04-01 | Active, not recruiting | ||
| Mesenchymal Stem Cells Under Basiliximab/Low Dose RATG to Induce Renal Transplant Tolerance [NCT00752479] | Phase 1/Phase 2 | 4 participants (Actual) | Interventional | 2008-05-31 | Terminated(stopped due to Necessity of major revision of the protocol) | ||
| Remission Induction in Very Early Rheumatoid Arthritis: a Comparison of Etanercept Plus Methotrexate Plus Steroid With Standard Therapy [NCT00523692] | Phase 4 | 20 participants (Anticipated) | Interventional | 2007-09-30 | Not yet recruiting | ||
| A Multicentre Placebo-Controlled Evaluation of Prednisolone and/or Valaciclovir for the Treatment of Bell's Palsy [NCT00510263] | Phase 4 | 839 participants (Actual) | Interventional | 2001-05-31 | Completed | ||
| A Phase III Study of Risk Directed Therapy for Infants With Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; NSC#617807) [NCT00557193] | Phase 3 | 218 participants (Actual) | Interventional | 2008-01-15 | Active, not recruiting | ||
| Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants [NCT02935101] | Phase 2 | 4 participants (Actual) | Interventional | 2016-10-31 | Terminated(stopped due to difficulties in recruiting study participants) | ||
| Pilot Study Investigating the Utility of Epidural AlloGen-LI Injection for Treatment of Spinal Stenosis Symptoms [NCT02932020] | 0 participants (Actual) | Interventional | 2016-10-31 | Withdrawn | |||
| Clinical and Radiological Comparison of the Efficacy of Hyaluronic Acid, PRP and Steroid Injections in Partial Rotator Cuff Tears: A Prospective Randomized Study [NCT04681937] | 80 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | |||
| High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab [NCT01211665] | Phase 4 | 3 participants (Actual) | Interventional | 2010-09-30 | Terminated(stopped due to This study was stopped prematurely due to lack of enrollment within a 1-5-year period.) | ||
| DEXTENZA for the Treatment of Post-Surgical Pain and Inflammation ComparEd to StandaRd of Care Topical Cortico-Steroid Treatment In PatientS Who Undergo BilaTeral Pterygium Surgery PERSIST Study [NCT04351737] | Phase 4 | 20 participants (Anticipated) | Interventional | 2020-07-15 | Active, not recruiting | ||
| A PedAL/EuPAL Phase 1/2 Trial of IMGN632 in Pediatric Patients With Relapsed or Refractory Leukemia [NCT05320380] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2023-08-01 | Withdrawn(stopped due to Withdrawn per CS0150757) | ||
| Effects of Peri-Operative Glucosteroid Administration on Outcomes Following Distal Radius Fracture [NCT05655130] | Phase 1 | 60 participants (Anticipated) | Interventional | 2018-11-06 | Active, not recruiting | ||
| An Open-label, Single-arm Study to Describe Glucocorticoid Use in Rheumatoid Arthritis Patients Treated With Tocilizumab in Daily Clinical Practice and to Evaluate Systematic Glucocorticoid Dose Reduction Once Low Disease Activity is Reached (ACT-ALONE) [NCT01219933] | Phase 4 | 68 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [NCT00854061] | Phase 3 | 172 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma [NCT00882895] | Phase 2 | 18 participants (Actual) | Interventional | 2009-05-05 | Active, not recruiting | ||
| Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm [NCT04355247] | Phase 2 | 20 participants (Anticipated) | Interventional | 2020-04-14 | Recruiting | ||
| Matched Unrelated and Haploidentical Bone Marrow Transplantation for Hematologic Malignancies [NCT00003960] | Phase 2 | 36 participants (Anticipated) | Interventional | 1998-04-30 | Completed | ||
| A Phase II Study to Evaluate Efficacy and Tolerability of Methotrexate in Combination With Glucocorticoids for the Treatment of Newly Diagnosed Acute Graft-Versus-Host Disease After Nonmyeloablative Hematopoietic Cell Transplantation [NCT00357084] | Phase 2 | 53 participants (Anticipated) | Interventional | 2006-05-31 | Completed | ||
| Research on the Treatment of Severe Community-acquired Pneumonia in Children [NCT05768204] | Phase 4 | 160 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| Open Randomized Study on the Efficacy of corticoïd Infiltration Versus Physiological Solution Infiltration Versus Feigning of Infiltration Via Sacro-coccygien Hiatus Versus Natural Evolution in Discal Sciatica [NCT01482897] | Phase 3 | 13 participants (Actual) | Interventional | 2011-12-31 | Terminated(stopped due to Enrolment stopped on December 01, 2014 since after 3 years, only 13 patients were included (instead of 274) (Date of last visit last patient : October 3, 2013).) | ||
| Urinary Aquaporin 2 Excretion After Methylprednisolone in Fasting Healthy Humans [NCT00281710] | Phase 4 | 20 participants | Interventional | 2005-10-31 | Completed | ||
| Prospective Phase II Study of Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome (ARDS) After Thoracic Surgery (E-START) [NCT00290602] | Phase 2 | 40 participants | Interventional | 2004-02-29 | Completed | ||
| Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma [NCT00307606] | Phase 4 | 40 participants (Anticipated) | Interventional | 2005-12-31 | Recruiting | ||
| The Efficacy and Safety of Intravenous Pulse Steroids Compared to Standard Oral Steroids in the Treatment of Problematic Hemangiomas in Infants: A Randomized Controlled Trial [NCT00312520] | Phase 3 | 20 participants | Interventional | 2002-07-31 | Completed | ||
| Dropless Pars Plana Vitrectomy Study [NCT05331664] | Phase 4 | 168 participants (Anticipated) | Interventional | 2022-07-25 | Recruiting | ||
| Genomic Effects of Glucocorticoids in Patients With Systemic Lupus Erythematosus [NCT04233164] | Early Phase 1 | 47 participants (Actual) | Interventional | 2020-03-04 | Active, not recruiting | ||
| A Randomized, Controlled Study to Evaluate the Safety and Effectiveness of Treatment [NCT05665270] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-01-30 | Enrolling by invitation | ||
| [NCT00433225] | Phase 4 | 0 participants | Interventional | Completed | |||
| A Masked Comparison of Acular LS Plus Steroid Versus Steroid Alone for the Prevention of Macular Leakage in Cataract Patients [NCT00348244] | Phase 4 | 0 participants | Interventional | Completed | |||
| A Multi-Center, Randomized, Blinded, Parallel-Group Study of AVONEX Compared With AVONEX in Combination With Oral Methotrexate, Intravenous Methylprednisolone, or Both in Subjects With Relapsing Remitting MS Who Have Breakthrough Disease on AVONEX Monothe [NCT00112034] | Phase 4 | 350 participants | Interventional | 2003-06-30 | Completed | ||
| Double-Blind Randomized Placebo-Controlled Trial on Clinical and Biological Effects of Oral Corticosteroids or Doxycyclin in Patients With Nasal Polyposis [NCT00480298] | Phase 2 | 48 participants | Interventional | 2002-11-30 | Completed | ||
| A Multicenter, Randomized, Open Label, Parallel Study to Evaluate and Compare the Efficacy and Safety of FK506MR vs Prograf® in Combination With MMF and Steroids in Patients Undergoing Kidney Transplantation and a Pharmacokinetics Study. [NCT00481819] | Phase 3 | 240 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome [NCT00127985] | Phase 4 | 240 participants (Anticipated) | Interventional | 2005-08-31 | Recruiting | ||
| A Randomised, Placebo-controlled, Parallel Group Single Dose Study of SB681323 in Patients With Active RA to Investigate the CRP Dose Response Relationship [NCT00134693] | Phase 2 | 77 participants (Actual) | Interventional | 2005-06-21 | Completed | ||
| Medication Overuse Headache: A Randomised Double Blind Study of Prednisolone or Placebo in Withdrawal Therapy (Phase 3), and a Randomised 1 Year Follow up by Neurologist or General Physician After Successful Withdrawal Therapy [NCT00135122] | Phase 3 | 100 participants (Actual) | Interventional | 2003-09-30 | Completed | ||
| Assessment of the Efficacy of Glucocorticoids in Improving Post-operative Organ Dysfunction in Patients With Acute Type A Aortic Dissection(GLAD): a Randomized Controlled Trial [NCT05329740] | Phase 4 | 212 participants (Actual) | Interventional | 2022-02-07 | Completed | ||
| Repeated Corticosteroid Injections Around the Greater Occipital Nerve (GON) as Prophylactic Treatment in Chronic Cluster Headache [NCT05324748] | Phase 3 | 50 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | ||
| A Phase I Randomized, Double-blind, Placebo-controlled, Dose-increasing Single Dose Study Evaluating the Safety, Tolerability，Pharmacokinetics and Pharmacodynamics Analysis of Pegloticase in Subjects With Asymptomatic Hyperuricemia [NCT05302388] | Phase 1 | 45 participants (Actual) | Interventional | 2022-04-11 | Completed | ||
| A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma [NCT04759586] | Phase 3 | 244 participants (Anticipated) | Interventional | 2021-10-05 | Recruiting | ||
| The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded Study [NCT02784210] | Phase 2 | 30 participants (Anticipated) | Interventional | 2016-10-05 | Recruiting | ||
| A Randomized, Multicenter, Open-Label Study of Single Dose Filgrastim-SD/01 Versus Daily Filgrastim Following ESHAP Chemotherapy for Non-Hodgkin's Lymphoma [NCT00004192] | Phase 2 | 60 participants (Anticipated) | Interventional | 2000-05-01 | Completed | ||
| Trial of High Dose Immunosuppressive Therapy With Hematopoietic Stem Cell Support in Devic's Disease [NCT00787722] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2009-10-10 | Completed | ||
| Phase II Study of Combination of Thymoglobulin, Cyclosporine, Methylprednisone, and Granulocyte Colony-stimulating Factor (GCSF) in Patients With Newly Diagnosed Aplastic Anemia or With Hypoplastic or Low/Intermediate-1 Risk Myelodysplastic Syndrome [NCT00806598] | Phase 2 | 53 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| A Prospective Randomized Controlled Trial of Early Non-Invasive Positive Pressure Ventilation in Patients With Hypoxemic Respiratory Failure and Malignancies [NCT02464696] | 256 participants (Anticipated) | Interventional | 2015-10-06 | Recruiting | |||
| Lymphodepleting Chemotherapy and T-Cell Suppression Followed By Allogeneic Natural Killer Cells and IL-2 in Patients With Recurrent Ovarian, Fallopian Tube, Primary Peritoneal Cancer and Advanced Metastatic Breast Cancer (MT2009-30) [NCT01105650] | Phase 2 | 13 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Injection of Dorsal Scapular n at Different Levels, Dose it Make Difference? [NCT04693312] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2020-01-01 | Completed | ||
| A Phase 2 Randomized, Investigator-Masked, Comparator-controlled Trial to Evaluate the Safety and Efficacy of NS2 Eye Drops in Patients With Anterior Uveitis [NCT02406209] | Phase 2 | 45 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Multi-center, Randomized, Double Masked, Vehicle Controlled Phase IV Study to Compare the Efficacy, Ocular Safety and Tolerability of a Two Day Treatment With Eye Drops (0.5% Prednisolone Acetate, One Drop Four Times Per Day) in Patients With Intraocular [NCT00170729] | Phase 4 | 62 participants (Actual) | Interventional | 2004-08-17 | Completed | ||
| The Impact of Pre-emptive Large Doses of Methylprednisolone Combined With Gabapentin on Pain Treatment and Convalescence After Total Knee Arthroplasty in Elderly: A Double-blind Randomized Study [NCT04653415] | Phase 4 | 160 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass [NCT00934843] | 77 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| Gene Transfer for Patients With Fanconi Anemia Complementation Group A (FANCA) [NCT01331018] | Phase 1 | 3 participants (Actual) | Interventional | 2012-02-22 | Active, not recruiting | ||
| A Phase III Study to Determine Efficacy and Safety of Low-Dose Glucocorticoids for Initial Treatment of Acute Graft-versus-Host Disease [NCT00929695] | Phase 3 | 164 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| CSP #574 - Evaluate the Safety and Efficacy of Methylprednisolone in Hospitalized Veterans With Severe Community-Acquired Pneumonia [NCT01283009] | Phase 3 | 584 participants (Actual) | Interventional | 2012-01-09 | Completed | ||
| Comparison of Efficacy and Safety of Intravenous Pulsed Methylprednisolone and Oral Methotrexate Versus Intravenous Pulsed Methylprednisolone and Oral Placebo in the Treatment of Active Moderate and Severe Thyroid Eye Disease - a Prospective, Randomized, [NCT00348413] | 80 participants (Anticipated) | Interventional | 2003-06-30 | Completed | |||
| A Randomized Controlled Trial to Evaluate the Efficacy and Safety of Docetaxel Combined With Platinum-based Drugs Compared With Docetaxel Alone for Metastatic Hormone-sensitive Prostate Cancer Patients Carrying DNA Repair Mutation [NCT05461261] | Phase 2 | 50 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Pilot, Phase I, Single Blind Trial to Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers. (PRURITUS- Nimpa Study). [NCT01529320] | Phase 1 | 18 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Phase II Clinical Trial Incorporating Alemtuzumab (Campath-1H) in Combination With FK506 and Methylprednisolone for Treatment of Severe Acute Graft vs Host Disease [NCT00109993] | Phase 2 | 34 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| [NCT00000146] | Phase 3 | 0 participants | Interventional | 1988-07-31 | Active, not recruiting | ||
| [NCT00017628] | Phase 1 | 20 participants | Interventional | 2001-04-30 | Completed | ||
| A Phase III, Randomized, Placebo-Controlled, Multicenter Study of the Safety, Efficacy, and Pharmacokinetics of Oral Beclomethasone 17, 21-Dipropionate (BDP) in Conjunction With Ten Days of High-Dose Prednisone Therapy in the Treatment of Patients With Gr [NCT00043147] | Phase 3 | 0 participants | Interventional | 2002-04-30 | Completed | ||
| Treatment of Patients With Membranous Nephropathy and Renal Insufficiency With Mycophenolate Mofetil and Prednisone: a Pilot Study [NCT00135967] | Phase 2/Phase 3 | 30 participants | Interventional | 2002-05-31 | Completed | ||
| Randomised, Double-Arm, Controlled, Open-Label Study Comparing Calcineurin Inhibitor-Free Immunosuppression (Zenapax®, CellCept® and Prednisolone) and Cyclosporine A Based Immunosuppression (Sandimmun Neoral®, CellCept® and Prednisolone) on the Outcome of [NCT00138970] | Phase 4 | 70 participants | Interventional | 2002-01-31 | Completed | ||
| A Prospective Randomized Open-label Study to Compare Mycophenolate Mofetil and Corticosteroid With Conventional Immunosuppressive Treatment on Proteinuria in Idiopathic Membranous Nephropathy (MN) and Focal Segmental Glomerulosclerosis (FSGS) [NCT00404833] | Phase 3 | 16 participants (Anticipated) | Interventional | 2003-01-31 | Completed | ||
| Phase IV Study of Early RA: a Randomized Magnetic Resonance Imaging Study Comparing the Effects of Methotrexate Alone or in Combination With Infliximab or Intravenous Pulse Methylprednisolone [NCT00396747] | Phase 4 | 45 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| A Phase IV, Randomized, Multi-center Clinical Trial to Compare the Efficacy of Orbital Radiotherapy in Association With Intravenous Glucocorticoids vs Intravenous Glucocorticoids Alone for Moderately Severe and Active Graves' Orbitopathy [NCT03098225] | Phase 4 | 120 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Induction Therapy for Lupus Nephritis With no Added Oral Steroids: An Open Label Randomised Multicentre Controlled Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF [NCT04702256] | Phase 3 | 196 participants (Anticipated) | Interventional | 2021-12-09 | Recruiting | ||
| Treatment of Acute Graft vs. Host Disease With Steroids Plus Daclizumab (Zenapax) or Placebo [NCT00053976] | Phase 3 | 105 participants (Actual) | Interventional | 2001-01-31 | Completed | ||
| Single-Center, Randomized, Double Masked, Two-Period Cross-Over, Three Days Per Period, Phase IV Study to Compare Ocular Safety and Tolerability of Prednisolone Acetate 0.5% Eye Drops Versus Vehicle in Healthy Volunteers [NCT00134992] | Phase 4 | 30 participants | Interventional | 2004-08-31 | Completed | ||
| The Role of Topical Prednisolone Acetate Following Selective Laser Trabeculoplasty [NCT00406042] | 25 participants | Interventional | 2005-09-30 | Completed | |||
| Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease [NCT00152620] | 40 participants | Interventional | 2004-06-30 | Terminated(stopped due to study completed) | |||
| [NCT00407017] | Phase 4 | 0 participants | Interventional | Completed | |||
| A Phase I Trial of BBR 2778 in Combination With Cytarabine, Methylprednisolone and Cisplatin in the Treatment of Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma [NCT00053105] | Phase 1 | 0 participants | Interventional | 2002-02-28 | Active, not recruiting | ||
| A Multi-Center, Randomized, Double Masked, Bioequivalence Study of Tobramycin and Prednisolone Acetate (0.3/1.0%, ISTA) Ophthalmic Suspension Compared to PredForte (1.0% Prednisolone Acetate, Allergan) Ophthalmic Suspension [NCT00198523] | Phase 3 | 132 participants | Interventional | 2005-07-31 | Completed | ||
| Prevention of Post-Extubation Laryngeal Edema With Intravenous Corticosteroids: a Prospective, Double-Blind, Placebo-Controlled Trial. [NCT00199576] | Phase 3 | 670 participants | Interventional | 2000-12-31 | Completed | ||
| the Effect of Single Dose of Etomidate Used During Emergency Intubation on Hemodynamics and Adrenal Cortex: a Randomized Clinical Trial [NCT01792037] | Phase 4 | 90 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery [NCT04200651] | Phase 4 | 25 participants (Actual) | Interventional | 2020-01-13 | Completed | ||
| Randomized, Open-Label Study of Abiraterone Acetate (JNJ-212082) Plus Prednisone With or Without Exemestane in Postmenopausal Women With ER+ Metastatic Breast Cancer Progressing After Letrozole or Anastrozole Therapy [NCT01381874] | Phase 2 | 297 participants (Actual) | Interventional | 2011-08-24 | Completed | ||
| Peri-articular Injections Containing a Corticosteroid During Total Knee Arthroplasty [NCT00492973] | 101 participants (Actual) | Interventional | 2006-03-31 | Completed | |||
| A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy of CRx-102 in Subjects With Symptomatic Knee Osteoarthritis and Optional One-Year Extension [NCT00521989] | Phase 2 | 279 participants (Actual) | Interventional | 2007-08-31 | Terminated(stopped due to CRx-102-006 study results, negative) | ||
| A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Superiority of CRx-102 Over Each of Its Components When Given to Subjects With Active Rheumatoid Arthritis (RA) [NCT00551707] | Phase 2 | 51 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| A California Cooperative Clinical Study Comparing Allogeneic Hematopoietic Cell Transplantation Using Nonmyeloablative Host Conditioning With Total Lymphoid Irradiation and Anti-thymocyte Globulin Versus Best Standard of Care in Acute Myeloid Leukemia (AM [NCT00568633] | Phase 3 | 58 participants (Actual) | Interventional | 2007-08-31 | Terminated(stopped due to Poor accrual) | ||
| Adrenal Cortical Function and Vitamin A Deficiency in Sepsis, Severe Sepsis and Septic Shock: Prospective Randomized, Double Blind Placebo Controlled Clinical Trials [NCT03152474] | Phase 4 | 300 participants (Actual) | Interventional | 1993-02-28 | Completed | ||
| Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis [NCT00682357] | 25 participants (Actual) | Interventional | 2008-05-31 | Completed | |||
| Pilot Study of Methylprednisolone Replacement for Dexamethasone-induced Hiuup Patients [NCT01277731] | 0 participants (Actual) | Interventional | 2010-07-31 | Withdrawn | |||
| Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2 [NCT05736549] | Phase 2 | 66 participants (Anticipated) | Interventional | 2023-02-07 | Recruiting | ||
| [NCT00699803] | Phase 2 | 64 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Azithromycin for Preventing the Development of Upper Respiratory Tract Illness Into Lower Respiratory Tract Symptoms in Children and Oral Corticosteroids for Treating Episodes of Significant Lower Respiratory Tract Symptoms in Children [NCT01272635] | Phase 3 | 607 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| An Open-label, Randomized, Cross-over Interventional Study to Evaluate the Efficacy and Safety of Tocilizumab Versus Corticosteroids in Hospitalised COVID-19 Patients With High Risk of Progression [NCT04345445] | Phase 3 | 310 participants (Anticipated) | Interventional | 2020-04-15 | Not yet recruiting | ||
| Phase II Randomized Double Blind Trial of Methylprednisolone and N-acetylcysteine in Hepatic Resections. [NCT01726465] | Phase 2 | 50 participants (Actual) | Interventional | 2012-11-30 | Terminated(stopped due to The first phase was completed) | ||
| Efficacy and Safety Evaluation of Rapamycin Combined With Methylprednisolone in the Treatment of Hyperthyroidism Exophthalmos: A Randomized, Controlled, Multicenter Clinical Trial. [NCT05532072] | Early Phase 1 | 140 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | ||
| Treatment of Post-surgical Cystoid Macular Edema With Topical Steroids Trial (TEMPEST-1) [NCT01769352] | Phase 2/Phase 3 | 42 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Intraorbital Injection Versus Oral Steroid in Patients With Anterior Idiopathic Orbital Inflammation: A Randomized Clinical Trial [NCT03958344] | Phase 3 | 120 participants (Anticipated) | Interventional | 2022-01-01 | Recruiting | ||
| Extended Follow-up of a Randomized Placebo-controlled Trial of Local Steroid Injection in Carpal Tunnel Syndrome [NCT02652390] | Phase 4 | 111 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Perks of Methylprednisolone for Hospitalized COVID-19 Patients: A Clinical Trial [NCT04559113] | 200 participants (Anticipated) | Interventional | 2020-05-01 | Recruiting | |||
| Maternal Epidural Steroids to Prevent Neonatal Exposure to Hyperthermia and Inflammation [NCT02212210] | Early Phase 1 | 135 participants (Actual) | Interventional | 2012-02-29 | Terminated(stopped due to PI permanently closed accrual for the study based on FDA warning issued in April 2014. Study is closed) | ||
| The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint: A Randomized Control Trial [NCT04177433] | Phase 4 | 90 participants (Anticipated) | Interventional | 2020-12-02 | Recruiting | ||
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics (Biomarkers) of BI 653048 BS H3PO4 Capsule Formulation Administered as Multiple Doses of 25 mg to 200 mg qd for 10 Days. A Randomised, Double-blind Within Dose Groups, Placebo-controlled, Multipl [NCT02217631] | Phase 1 | 140 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| A Proof of Concept Study to Determine the Local Delivery and Efficacy of Intravenously Injected PEG-liposomal Prednisolone Sodium Phosphate (Nanocort) in Atherosclerotic Tissue in Subjects With Peripheral Artery Disease. [NCT01647685] | Phase 1/Phase 2 | 21 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| Efficacy of Moxifloxacin 0.5%/Prednisolone 1% Fixed Combination Compared With Individual Administration of Moxifloxacin 0.5% and Prednisolone 1% in the Prevention of Post Operative Inflammation in Patients Having Lasik Surgery [NCT01603030] | Phase 3 | 66 participants (Anticipated) | Interventional | 2012-06-30 | Not yet recruiting | ||
| Preemptive Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery: a Split-mouth Randomized Triple-blind Clinical Trial [NCT01603498] | 18 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| A Multicentre, Randomised, Double Blind, Double Dummy, Active Comparator Controlled, Parallel Group Study of COLAL-PRED® in the Treatment of Moderate Acute Ulcerative Colitis [NCT00299013] | Phase 3 | 796 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Comparison of Two Strategies Combining Steroids With or Without Immunosuppressants [NCT00307671] | Phase 4 | 108 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| A Randomized, Controlled, Parallel-Group, Multicenter Study of Extracorporeal Photoimmune Therapy With THERAKOS* UVADEX* for the Treatment of Patients With Newly Diagnosed Acute Graft Versus-Host Disease [NCT00282503] | Phase 3 | 19 participants (Actual) | Interventional | 2006-01-31 | Terminated(stopped due to Lack of recruitment) | ||
| A Comparison of Intravenous Versus Oral Administration of Prednisolone in the Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease [NCT00311961] | Phase 4 | 256 participants | Interventional | 2001-06-30 | Completed | ||
| Long Term Tapering or Standard Steroids for Nephrotic Syndrome [NCT00308321] | Phase 4 | 50 participants (Anticipated) | Interventional | 2003-09-30 | Recruiting | ||
| Multicenter, Open-label, Randomized Study on Steroid-free Immunosuppression, in Comparison With Daily Steroid Therapy, in Children With Stable Renal Transplant Function Under Cyclosporine (CyA) and Mycophenolate Mofetil (MMF) [NCT00309218] | Phase 3 | 42 participants (Actual) | Interventional | 1999-03-31 | Completed | ||
| Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis. A Single - Blind, Randomized-controlled Study [NCT06163755] | Phase 2 | 0 participants (Actual) | Interventional | 2018-01-01 | Withdrawn(stopped due to Lack of funding) | ||
| Epidural Steroid Following Discectomy for Herniated Lumbar Disc Reduces Neurological Impairment and Enhances Recovery. A Randomized Study With Two-year Follow-up [NCT01499641] | 200 participants (Actual) | Interventional | 2001-05-31 | Completed | |||
| A Prospective, Multi-Center, Randomized, Double-Masked, Positive-Controlled Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspen [NCT01505088] | Phase 3 | 193 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| The Efficacy of Exercise Therapy Followed by Ultrasound Guided Injection in Patients With a Painful Shoulder - a Randomised Controlled Study With Blinded Observer [NCT01506804] | 99 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
| [NCT01627236] | 120 participants (Anticipated) | Interventional | 2012-12-31 | Recruiting | |||
| Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation: a Randomized Study [NCT01640743] | 58 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| Randomized, Multicentric Study Evaluating the Efficacy and the Safety of Methylprednisolone Bolus in the Treatment of Renal Sarcoidosis [NCT01652417] | 40 participants (Actual) | Interventional | 2012-10-31 | Terminated(stopped due to insufficient recruitment) | |||
| The Effect of Different Intra-articular Injections on Pain and Function in Primary Gonarthrosis [NCT05291793] | 80 participants (Actual) | Interventional | 2020-04-01 | Completed | |||
| Single Center, Randomized, Double-Masked Evaluation of the Efficacy of PredAcetate 1% Ophthalmic Suspension Compared to Pred Acetate 0.12% Ophthalmic Suspension, Lot Etab 0.2% Ophthalmic Suspension, and Placebo in a Modified CAC Model [NCT00689078] | Phase 4 | 36 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen [NCT02199041] | Phase 2 | 24 participants (Actual) | Interventional | 2014-07-11 | Terminated(stopped due to The study was halted early due to slow accrual.) | ||
| Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. [NCT01694134] | Phase 3 | 50 participants (Actual) | Interventional | 2012-07-12 | Completed | ||
| Alternative Treatment Paradigm for Natalizumab Trial [NCT01710228] | Phase 2 | 0 participants (Actual) | Interventional | 2013-07-31 | Withdrawn(stopped due to sponsor stopped) | ||
| A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Kahook Dual Blade Surgery [NCT03933631] | Phase 3 | 142 participants (Anticipated) | Interventional | 2019-05-01 | Recruiting | ||
| Determining Optimal Dose of Corticosteroids in COPD Exacerbations: A Pilot Study [NCT01742338] | Phase 4 | 125 participants (Anticipated) | Interventional | 2012-05-03 | Suspended(stopped due to The study has been suspended to address research staffing and the feasibility of continued recruitment) | ||
| Effect of Steroids on Cerebrospinal Fluid Markers of Inflammation and Neuronal Damage After Surgical Aortic Valve Replacement [NCT01755338] | 30 participants (Actual) | Interventional | 2012-12-31 | Completed | |||
| Phase II, Randomized, Placebo-Controlled, Double-Blind Clinical Trial to Evaluate the Effects and Safety of Infusion of Low-Doses of Methylprednisolone in Early ALI and ARDS in Children [NCT01757899] | Phase 2 | 0 participants (Actual) | Interventional | 2014-01-31 | Withdrawn(stopped due to Technical problems) | ||
| A Randomised, Single Blind, Placebo-Controlled, Cross-over, Phase 1 Methodology Study to Validate the Cantharidin Blister Model in Healthy Male Volunteers [NCT01762787] | Phase 1 | 40 participants (Actual) | Interventional | 2010-08-17 | Completed | ||
| Phase 3 Open Label Randomised Multicentre Controlled Trial of Rituxmab and Mycophenolate Mofetil Without Oral Steroids for the Treatment of Lupus Nephritis [NCT01773616] | Phase 3 | 24 participants (Actual) | Interventional | 2015-04-30 | Terminated(stopped due to Study assessments for patients recruited continuing per protocol so patients receive a minimum of 6 months follow up. No safety concerns have been raised.) | ||
| FDG PET/CT: Reducing False Positive Mediastinal Uptake by Premedicating With Methylprednisolone [NCT01789892] | 0 participants (Actual) | Interventional | 2011-06-30 | Withdrawn(stopped due to no patient accrual) | |||
| Safety and Efficacy of Nonsteroidal Antiinflammatory Drug and Glucocorticoids in Acute Sciatica [NCT01816334] | Phase 4 | 50 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Addition of Pyridoxine to Prednisolone in the Treatment of Infantile Spasms: A Randomized Controlled Trial [NCT01828437] | Phase 3 | 62 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| A Multi-center Randomized Controlled Trial of Efficacy and Safety of Perineural Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain: The Resperist Study [NCT03009500] | Phase 3 | 3 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Study of Visual Recovery After Erythropoietin (EPO) Injection, in Patients With Traumatic Optic Neuropathy (TON) [NCT01783847] | Phase 1/Phase 2 | 117 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Double-blind Randomized Controlled Trial of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis [NCT01809132] | Phase 2/Phase 3 | 104 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| SMART Trial: Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia [NCT03852537] | Phase 2 | 44 participants (Actual) | Interventional | 2019-12-02 | Completed | ||
| Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Cell Transplantation (SCT) for AML With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory and Relapsed Acute Myelogenous Leukemia (AML) in Children: A Children's Oncolo [NCT00553202] | Phase 2 | 158 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Towards a Self-Administered Hearing Protection Regimen [NCT04826237] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-02-09 | Recruiting | ||
| Efficacy of Injectable Methylprednisolone Sodium Succinate in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome Under the New Coronavirus (SARS-CoV2): a Phase IIb, Randomized, Double-blind, Placebo-controlled, Clinical Trial. [NCT04343729] | Phase 2 | 416 participants (Actual) | Interventional | 2020-04-18 | Completed | ||
| A 3-Month Clinical Trial to Assess the Safety and Efficacy of the OZURDEX® Intraocular Implant in Patients With Diabetes Mellitus [NCT01673191] | Phase 2 | 40 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Randomised Evaluation of COVID-19 Therapy (RECOVERY) in Children With PIMS-TS in Switzerland (SWISSPED-RECOVERY) [NCT04826588] | Phase 3 | 76 participants (Actual) | Interventional | 2021-05-23 | Completed | ||
| A Randomized, Controlled, Open-Label Study to Evaluate the Efficacy of Extracorporeal Photopheresis (ECP) Versus Corticosteroids in the Treatment of Patients With Secondary Progressive Multiple Sclerosis (SPMS) [NCT02296346] | 13 participants (Actual) | Interventional | 2014-10-31 | Terminated(stopped due to Low enrollment/PI relocated. New site couldn't reach agreement with manufacturer) | |||
| A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% [NCT01437982] | Phase 4 | 140 participants (Anticipated) | Interventional | 2010-08-05 | Completed | ||
| Efficacy of Peripheral Nerve Blocks for Episodic Migraine Treatment and Prophylaxis [NCT05734625] | Phase 2 | 60 participants (Anticipated) | Interventional | 2023-07-10 | Recruiting | ||
| The Evaluation of the Safety and Efficacy of Sustained Release Dexamethasone Intracanalicular Insert (DEXTENZA) in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia (TENDER) [NCT05620901] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | ||
| Focal Cerebral Arteriopathy Steroid Trial [NCT06040255] | Phase 4 | 80 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | ||
| Single Blind Randomized Controlled Trial to Assess the Safety and Efficacy of High Dose Pulse Intravenous Corticosteroid Therapy to Treat Patients With Complicated/Fulminant Acute Myocarditis [NCT05150704] | Phase 3 | 288 participants (Anticipated) | Interventional | 2021-10-07 | Recruiting | ||
| Glucocorticoid Treatment in Patients Undergoing TAVR to Reduce the Incidence of Atrioventricular Block and Pacemaker Implantation [NCT06076824] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-08-12 | Recruiting | ||
| Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease [NCT04988282] | Phase 4 | 262 participants (Actual) | Interventional | 2021-05-24 | Completed | ||
| Early Short Course Corticosteroids in Hospitalized Patients With COVID-19 [NCT04374071] | 250 participants (Actual) | Observational | 2020-03-12 | Completed | |||
| Medrol® In Contact Dermatitis: A Prospective Study To Assess The Safety And Effectiveness Of Medrol In Contact Dermatitis In Indian Subjects [NCT00929981] | 80 participants (Actual) | Observational | 2009-09-30 | Completed | |||
| A Randomized Controlled Trial of Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy [NCT03018535] | Phase 3 | 76 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | ||
| The Effect of 4.5 Gram Methylprednisolone Administered Once Weekly for 12 Weeks on Bone Metabolism in Graves´ Ophthalmopathy [NCT03122847] | 30 participants (Anticipated) | Observational | 2017-06-07 | Active, not recruiting | |||
| Phase 2/Phase 3 of the Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis. [NCT00947765] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Autologous Hematopoietic Stem Cell Transplant for Patients With Systemic Sclerosis and Cardiac Dysfunction [NCT03593902] | Phase 2/Phase 3 | 9 participants (Actual) | Interventional | 2018-05-17 | Terminated(stopped due to PI Sabbatical) | ||
| Clinical Evaluation of New Treatment Strategy of Mucous Membrane Pemphigoid Using Large Dose of Prednisolone Plus Intra-lesional of Triamcinolone Acetonide Followed by Combination of Mycophenolate Mofetil, Dapsone and Low Dose Prednisolone [NCT04744623] | Phase 2/Phase 3 | 10 participants (Actual) | Interventional | 2020-09-30 | Active, not recruiting | ||
| Prolonged Low Doses of Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome [NCT04323592] | 173 participants (Actual) | Observational [Patient Registry] | 2020-03-23 | Completed | |||
| Clinical Effectiveness of Symptomatic Therapy Compared to Standard Step up Care for the Treatment of Low Impact Psoriatic Oligoarthritis: a 2 Arm Parallel Group Feasibility Study [NCT03797872] | Phase 4 | 1 participants (Actual) | Interventional | 2019-04-17 | Completed | ||
| Effect of Preoperative Intravenous High Dose Methylprednisolone on Endothelial Function in Patients Scheduled for Total Knee-arthroplasty [NCT02332629] | Phase 3 | 70 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Multicenter, Randomized, Observer-blind, Controlled Study of the Anti-IL-6 Receptor Antibody Tocilizumab (TCZ) or Methylprednisolone (MP) Treatment in Patients With Active Moderate-severe Graves' Orbitopathy [NCT04876534] | Phase 2 | 64 participants (Anticipated) | Interventional | 2019-12-18 | Recruiting | ||
| Phase 2 Historically Controlled Trial of Corticosteroids in Young Boys With Duchenne Muscular Dystrophy [NCT02167217] | Phase 2 | 25 participants (Actual) | Interventional | 2014-04-17 | Completed | ||
| Pilot Study in AIDS-Related Lymphomas [NCT00002524] | Phase 2 | 46 participants (Actual) | Interventional | 1993-06-30 | Completed | ||
| A Prospective Randomized Double-blinded Controlled Single Center Clinical Study of the Efficacy and Safety for Tofacitinib Compared With Glucocorticoid in the Remission-reduction Treatment of Active Takayasu's Arteritis [NCT05749666] | Phase 3 | 50 participants (Anticipated) | Interventional | 2023-01-20 | Recruiting | ||
| A Prospective, Multi-Center, Randomized, Double-Masked, Positive Controlled, Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspe [NCT02517619] | Phase 3 | 251 participants (Actual) | Interventional | 2016-01-16 | Completed | ||
| Treatment of Metastatic Prostate Cancer That is Hormone-Independent: Evaluation of the Role of Chemotherapy on the Quality of Life of Patients. Phase II Study [NCT00003682] | Phase 3 | 160 participants (Anticipated) | Interventional | 1998-10-31 | Terminated(stopped due to lack of inclusions) | ||
| Sudden Hearing Loss Multicenter Treatment Trial [NCT00097448] | Phase 3 | 255 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| Phase II Trial of Natalizumab (Tysabri®) Plus Prednisone for Initial Therapy of Acute Graft Versus Host Disease (aGVHD) of the Gastrointestinal Tract [NCT02176031] | Phase 2 | 21 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| STeroids to REduce Systemic Inflammation After Infant Heart Surgery (STRESS) [NCT03229538] | Phase 3 | 1,263 participants (Actual) | Interventional | 2017-10-18 | Completed | ||
| A Randomised, Comparator Controlled, Two Part, Open-label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of Multiple Doses of Otelixizumab in Patients With Thyroid Orbitopathy [NCT01114503] | Phase 2 | 2 participants (Actual) | Interventional | 2010-07-07 | Terminated(stopped due to Clinical study in Graves' ophthalmopathy terminated until there is a better understanding of an efficacious dose with Otelixizumab from other clinical studies.) | ||
| Single Center, Randomized, Double-Blind, Placebo-Controlled Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab [NCT01144143] | Phase 4 | 16 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| Intratympanic Dexamethasone or Methylprednisolone for Sudden Hearing Loss as a Salvage Treatment: a Randomized, Double-blind, Multi-center Study [NCT04129697] | 30 participants (Anticipated) | Interventional | 2020-01-01 | Not yet recruiting | |||
| Comparison of the Efficacy of Two Different Glucocorticoid Regimens for Treatment of Active Moderate-to-severe Graves' Orbitopathy [NCT05793359] | 62 participants (Actual) | Observational [Patient Registry] | 2017-07-25 | Completed | |||
| Efficacy and Safety of Corticosteroids in COVID-19: A Prospective Randomized Controlled Trails [NCT04273321] | 86 participants (Actual) | Interventional | 2020-02-14 | Completed | |||
| Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis. Randomized Controlled Trial. [NCT04942002] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2021-06-15 | Recruiting | ||
| Safety and Efficacy of Topical Loteprednol Etabonate 0.5%, Versus Prednisolone Acetate 1%, for the Treatment of Intraocular Inflammation Following Surgery for Childhood Cataract [NCT01475643] | Phase 3 | 107 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Hyper-CVAD With Liposomal Vincristine (Hyper-CMAD) in Acute Lymphoblastic Leukemia [NCT01319981] | Phase 2 | 31 participants (Actual) | Interventional | 2013-03-05 | Completed | ||
| Evaluation of DEXTENZA on the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids [NCT04426734] | Phase 4 | 30 participants (Anticipated) | Interventional | 2020-07-01 | Not yet recruiting | ||
| Corticosteriods vs. Saline vs. Air Placebo Intra-articular Injections for Knee Osteoarthritis: A Single Blinded Prospective Randomized Trial [NCT02995083] | Early Phase 1 | 0 participants (Actual) | Interventional | 2017-06-30 | Withdrawn(stopped due to Study deemed not feasible) | ||
| Oral Prednisolone Dosing in Children Hospitalized With Asthma [NCT00257933] | Phase 4 | 152 participants (Actual) | Interventional | 2006-02-28 | Completed | ||
| Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial. [NCT05748561] | Phase 2/Phase 3 | 18 participants (Anticipated) | Interventional | 2022-04-05 | Recruiting | ||
| Musculoskeletal Ultrasound Changes in the Plantar Fascia After a Single Injection of Platelet Rich Plasma Compared to Steroid [NCT05339542] | 98 participants (Actual) | Interventional | 2022-03-10 | Completed | |||
| Randomized Controlled Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery [NCT01559675] | 121 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| Dextenza vs Prednisolone Acetate After Cataract Surgery for Patients With Diabetes [NCT04977427] | Phase 4 | 200 participants (Anticipated) | Interventional | 2021-07-31 | Not yet recruiting | ||
| A Pilot Study Investigating the Feasibility and Efficacy of Locoregional Intra-arterial Administration of Methylprednisolone as a Bridge Therapy to Treat Symptomatic Flares in Inflammatory Bowel Disease. [NCT05587673] | Phase 1 | 30 participants (Anticipated) | Interventional | 2022-10-06 | Recruiting | ||
| Comparison of Efficacy and Safety of Two Different Ultrasound-Guided Suprascapular Nerve Block Techniques in Chronic Shoulder Pain: A Prospective Double-Blinded Randomized Controlled Study [NCT04938037] | 80 participants (Anticipated) | Interventional | 2021-06-01 | Recruiting | |||
| A Feasibility Randomised Placebo-controlled Trial With Objective Outcome Measures to Evaluate the Efficacy of Biosimilar Rituximab in Musculoskeletal and Mucocutaneous Systemic Lupus Erythematosus [NCT03054259] | Phase 2 | 30 participants (Anticipated) | Interventional | 2017-09-21 | Recruiting | ||
| Transverse Abdominis Plane Block Using Liposomal Bupivacaine for Post-operative Cesarean Delivery Analgesia- Walking Towards Recovery [NCT04393207] | Phase 4 | 300 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | ||
| Intracanalicular Dexamethasone Insert for Management of Post-operative Pain and Inflammation in Patients Undergoing Vitreoretinal Surgery [NCT04371445] | Phase 4 | 30 participants (Anticipated) | Interventional | 2020-12-01 | Enrolling by invitation | ||
| Evaluation of Sleep EEG Changes in Paediatric Patients With Language Dysfunction: A Follow up Study. Evaluation of Sleep EEG Changes in Paediatric Patients With Language Dysfunction: A Follow up Study. Evaluation of Sleep EEG Changes in Pediatric Patients [NCT05487521] | Phase 3 | 93 participants (Actual) | Interventional | 2020-02-20 | Completed | ||
| Clinical Study of the Effect of Methylprednisolone Combined With Two Hydroxypropyl Theophylline on Respiratory Dynamics During Thoracoscopic Lobectomy [NCT04810819] | 110 participants (Anticipated) | Interventional | 2021-07-01 | Not yet recruiting | |||
| Efficacy and Safety of Immunosuppressive Therapy for IgA Nephropathy With Stage 3 or 4 Chronic Kidney Disease [NCT05510323] | Phase 3 | 208 participants (Anticipated) | Interventional | 2022-08-31 | Not yet recruiting | ||
| The Effectiveness of Pulsed Radiofrequency of the Suprascapular Nerve and Shoulder Joint Compared to Intra-articular Corticosteroid Injection for Hemiplegic Shoulder Pain Management and Functional Improvement. [NCT05563571] | 20 participants (Anticipated) | Interventional | 2022-04-01 | Recruiting | |||
| DEXTENZA VS. PREDNISOLONE ACETATE 1% in the Incidence of Pseudophakic Macular Edema in Patients With Diabetic Retinopathy Undergoing Cataract Surgery [NCT04362241] | Phase 4 | 30 participants (Anticipated) | Interventional | 2020-08-07 | Recruiting | ||
| The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy [NCT01579539] | Phase 3 | 18 participants (Actual) | Interventional | 2013-06-27 | Completed | ||
| Pre-operative Intravenous Steroid in Unilateral Primary Total Knee Replacement for Pain Relief and Recovery: A Double-Blind Randomized Controlled Trial [NCT03082092] | Phase 4 | 60 participants (Actual) | Interventional | 2017-06-01 | Completed | ||
| Autologous Hematopoietic Stem Cell Transplant for Neuromyelitis Optica Spectrum Disorder (NMOSD) [NCT03829566] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2019-11-30 | Withdrawn(stopped due to Discontinued by Investigator) | ||
| Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment [NCT02283996] | Phase 4 | 260 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | ||
| Efficacy and Safety of MEthylprednisolone Administered Intravenously for the Treatment of Patients With Active AnkyLosing spondyLitis (METALL) - a 12-week, Prospective, Open-label, Pilot Study [NCT01790022] | Phase 2 | 20 participants (Actual) | Interventional | 2012-07-31 | Active, not recruiting | ||
| Randomized, Double-Masked, Vehicle Controlled, Clinical Evaluation To Assess The Safety And Efficacy Of Nepafenac Ophthalmic Suspension, 0.3% For Improvement In Clinical Outcomes Among Diabetic Subjects Following Cataract Surgery [NCT01872611] | Phase 3 | 819 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Intradiscal Gelified Ethanol Versus Intradiscal Steroid in Refractory Lumbar Discogenic Pain: a Randomized Single-blind Study [NCT03415828] | 83 participants (Actual) | Interventional | 2018-05-29 | Active, not recruiting | |||
| Phase II Study of Ofatumumab in Combination With High Dose Methylprednisolone Followed by Ofatumumab and Lenalidomide Consolidative Therapy for the Treatment of Relapsed or Refractory CLL/SLL The HiLOG Trial [NCT01497496] | Phase 2 | 29 participants (Actual) | Interventional | 2012-01-26 | Completed | ||
| Dextenza in Pterygium Surgery [NCT04403516] | Phase 4 | 30 participants (Actual) | Interventional | 2020-10-01 | Completed | ||
| Comparison of Dropless Prophylaxis After Routine Phacoemulsification to Standard Drops Regimen [NCT02515045] | Phase 4 | 59 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Prospective, Randomized Clinical Trial of Meibomian Gland Probing Versus Sham Procedure for Refractory Meibomian Gland Dysfunction [NCT02256969] | Phase 4 | 45 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Use of G-CSF Stimulated HLA-Identical Allogeneic Peripheral Blood Stem Cells for Patients With High Risk Acute Myelogenous Leukemia or CML in Blast Crisis [NCT00002833] | Phase 2 | 53 participants (Actual) | Interventional | 1994-10-31 | Completed | ||
| Safety and Effectiveness of Single-dose Subconjunctival Triamcinolone Compared to Topical Prednisolone Eye Drops in Manual Small Incision Cataract Surgery [NCT05248139] | 100 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| Phase II Study of Prednisolone/Methylprednisolone Absorption in Children With Juvenile Dermatomyositis [NCT00004357] | Phase 2 | 6 participants (Actual) | Interventional | 1997-09-30 | Completed | ||
| Phase III Randomized, Double-Blind Study of Methylprednisolone by 24- Versus 48-Hour Infusion Versus Tirilazad for Acute Spinal Cord Injury [NCT00004759] | Phase 3 | 497 participants | Interventional | 1991-12-31 | Completed | ||
| An Open-label Study to Evaluate the Effect of MabThera in Combination With Methotrexate on Disease Activity in Patients With Active Rheumatoid Arthritis After DMARD Treatment Failure [NCT02006706] | Phase 3 | 15 participants (Actual) | Interventional | 2006-08-10 | Completed | ||
| Intra-articular and Intravenous Infliximab in the Treatment of Resistant Seronegative Oligoarthritis of the Knee [NCT01216631] | Phase 2 | 1 participants (Actual) | Interventional | 2010-09-30 | Terminated(stopped due to Unable to recruit) | ||
| Effects of a Multiple Sclerosis Relapse Therapy With Methylprednisolone (MP) During Pregnancy on Offspring Cognitive Function, Stress Sensitivity, Behaviour and Functional and Structural Brain Development [NCT04832269] | 80 participants (Anticipated) | Observational | 2020-10-19 | Recruiting | |||
| De Novo Everolimus Versus Tacrolimus in Combination With Mofetil Mycophenolate and Low Dose Corticosteroids to Reduce Tacrolimus Induced Nephrotoxicity in Liver Transplantation: a Prospective, Multicentric, Randomised Study [NCT02909335] | Phase 3 | 0 participants (Actual) | Interventional | 2016-11-30 | Withdrawn | ||
| [NCT02115997] | Phase 4 | 30 participants (Actual) | Interventional | 2015-07-06 | Completed | ||
| Does Anesthetic Contribute to Symptomatic Relief in Corticosteroid Injections for Knee Osteoarthritis? A Double-Blind Randomized Trial Comparing Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections [NCT02576249] | Phase 4 | 29 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| A Multicenter, Randomized, Open-label, Blinded-assessor, Follow-up, Phase 4 Study in Patients With Rheumatoid Arthritis Who Have Completed the Initial Treatment Part in the NORD-STAR Study and Have Reached Stable Low Disease Activity [NCT02466581] | Phase 4 | 25 participants (Actual) | Interventional | 2015-02-03 | Active, not recruiting | ||
| Preoperative Methylprednisolone on Thoracic Endovascular Repair for Reducing Post-implantation Syndrome [NCT05349071] | 158 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | |||
| Safety and Efficacy of Topical Tacrolimus 0.05% in the Treatment of Ocular Graft-Versus-Host Disease [NCT01977781] | Phase 1 | 40 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Efficacy and Safety of Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis. [NCT05990894] | 248 participants (Actual) | Observational | 2018-01-01 | Completed | |||
| High Dose Steroids for Liver Resection - Effect on Complications and Endothelial Function in the Immediate Postoperative Phase - a Randomized, Doubleblind, Controlled Trial [NCT03403517] | Phase 4 | 174 participants (Actual) | Interventional | 2017-12-11 | Completed | ||
| Safety and Efficacy of KPI-121 1% Ophthalmic Suspension Versus Prednisolone Acetate Ophthalmic Suspension 1% for the Treatment of Inflammation Following Cataract Surgery in Children 0 to 3 Years of Age [NCT03596723] | Phase 3 | 2 participants (Actual) | Interventional | 2018-07-03 | Terminated(stopped due to NDA #210565 did not trigger the need for a Pediatric Research Equity Act study.) | ||
| A Randomized Prospective Study of Early Intensification Versus Alternating Triple Therapy for Patients With Poor Prognosis Lymphoma [NCT00002835] | Phase 3 | 116 participants (Actual) | Interventional | 1995-10-30 | Completed | ||
| [NCT00004785] | Phase 3 | 54 participants | Interventional | 1995-11-30 | Completed | ||
| Phase I/II Study of Idarubicin, Cytarabine, and Nivolumab in Patients With High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) [NCT02464657] | Phase 1/Phase 2 | 44 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Open Randomized Single Centre Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With Severe Lung Injury Secondary to COVID-19 [NCT04341038] | Phase 3 | 84 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | ||
| Physiologic Effects of Stress Dose Corticosteroids in the Management of Inhospital Cardiac Arrest - CORTICA [NCT02790788] | Phase 1/Phase 2 | 100 participants (Actual) | Interventional | 2016-11-04 | Completed | ||
| Efficacy and Safety of Loteprednol 0.5% Gel for Routine Prophylaxis After Photorefractive Keratectomy Compared to Prednisolone Acetate 1% Suspension and Fluorometholone 0.1% Suspension [NCT03123614] | Phase 4 | 131 participants (Actual) | Interventional | 2014-09-19 | Completed | ||
| A Phase 4, Randomized, Double-Masked, Single Center, Placebo-Controlled Adaptive Clinical Trial, Using Prednisolone Sodium Phosphate Ophthalmic Solution, 1%, in Subjects With Allergic Conjunctivitis to Evaluate a Modified Conjunctival Allergen Challenge ( [NCT01534195] | Phase 4 | 11 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Treatment of COVID-19 Pneumonia With Glucocorticoids. A Randomized Controlled Trial [NCT04438980] | Phase 3 | 72 participants (Actual) | Interventional | 2020-05-15 | Completed | ||
| Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease [NCT02339142] | Phase 4 | 100 participants (Anticipated) | Interventional | 2015-01-31 | Not yet recruiting | ||
| Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition (TICSI) [NCT03111810] | Phase 2 | 32 participants (Actual) | Interventional | 2017-05-25 | Completed | ||
| A Multicenter, Open-Label Study to Estimate the Effect Sizes of HRCT Endpoints in Response to GLUCOCORTICOID Induction Therapy in Subjects With Pulmonary Sarcoidosis [NCT03324503] | 8 participants (Actual) | Interventional | 2017-12-08 | Completed | |||
| Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis, Which is Better? A Prospective Study of a Single-blind Randomized Control Trial RCT From the Iraqi Population [NCT04980105] | Phase 3 | 150 participants (Actual) | Interventional | 2020-03-02 | Active, not recruiting | ||
| Hit Hard and Early. The Effect of High Dose Methylprednisolone on Nailfold Capillary Changes and Biomarkers in Early SSc: a 12-week Randomised Explorative Double-blind Placebo-controlled Trial. [NCT03059979] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| Second Affiliated Hospital, College of Medicine, Zhejiang University [NCT04918953] | Phase 2 | 90 participants (Anticipated) | Interventional | 2021-06-02 | Not yet recruiting | ||
| The Efficacy and Safety of R-EPOCH and R-CHOP Regimen for Patients With AIDS Associated CD20+ Diffuse Large B Lymphoma [NCT03045471] | 50 participants (Anticipated) | Observational | 2017-03-01 | Not yet recruiting | |||
| Study of the Excretion of Orally Administered Corticosteroids for the Improval of the Detection of Said Substances in Anti-doping Controls [NCT04791345] | Phase 1 | 50 participants (Anticipated) | Interventional | 2021-02-26 | Recruiting | ||
| Autologous Platelet Rich Fibrin Versus Steroid in Ultrasound-Guided Sacroiliac Joint Injection for Joint Dysfunction (Randomized Comparative Study) [NCT04757740] | Phase 4 | 94 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| The Role of Doxycycline in Management of Moderate to Severe Chronic Rhinosinusitis With Nasal Polyps [NCT02569437] | Phase 2 | 49 participants (Actual) | Interventional | 2014-09-30 | Terminated(stopped due to A high percentage of patients were dropping out of the study and were not able to complete the protocol.) | ||
| Topical Use of Corticosteroid to Prevent Epiretinal Membrane Formation in Eyes With Retinal Tear Undergoing Laser Retinopexy: a Pilot Prospective Clinical Study [NCT02412059] | 200 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Triamcinolone Versus Methylprednisolone in Ultrasound Guided Transversus Abdominis Plane Block in Major Open Abdominal Surgery [NCT04480775] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2020-07-15 | Completed | ||
| Safety and Efficacy of Steroids in the Management of Fulminant Hepatic Failure Due to Hepatitis A Virus in the Pediatric Age Group [NCT02375867] | Phase 4 | 33 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Once a Month High-dose Methylprednisolone During Wash-out Period Between Natalizumab and Fingolimod Treatments in Patients With Multiple Sclerosis: a Randomised, Controlled, Double-blind Trial (NTZ2FTY) [NCT02769689] | Phase 4 | 56 participants (Anticipated) | Interventional | 2019-06-12 | Recruiting | ||
| Intra-Arterial Steroid Administration of De Novo Acute Graft-vs-Host Disease of the Gastrointestinal Tract: A Phase II Study [NCT02425813] | Phase 2 | 0 participants (Actual) | Interventional | 2015-10-31 | Withdrawn(stopped due to Slow Accrual) | ||
| Comparison of the Treatment Efficacy of High-Dose Corticosteroid and Tocilizumab During Clinical Worsening in Patients With COVID-19 Pneumonia [NCT05133635] | Phase 4 | 0 participants (Actual) | Interventional | 2021-02-01 | Withdrawn(stopped due to A recent study suggested a new corticosteroid regime for intensive care unit patients.) | ||
| Corticosteroids in Severe Alcoholic Hepatitis Patients With Early Spontaneous Improvement [NCT03160651] | 140 participants (Anticipated) | Interventional | 2018-02-09 | Recruiting | |||
| Comparison Between Ultrasound Guided Ozone, Platelet-Rich Plasma or Steroid Injection in the Treatment of Sacroiliitis; a Randomized Double Blinded Controlled Study [NCT05914350] | 105 participants (Anticipated) | Interventional | 2023-06-23 | Recruiting | |||
| Investigating Differences in Flare Reaction Incidence and Intensity Following Trigger Finger Injections Using Betamethasone and Methylprednisolone [NCT04900220] | Phase 4 | 66 participants (Actual) | Interventional | 2021-09-15 | Completed | ||
| Genomic Response of Human Immune and Non-Immune Cells to Glucocorticoids [NCT02798523] | Phase 1 | 33 participants (Actual) | Interventional | 2017-01-24 | Completed | ||
| Steroid Versus Platelet Rich Plasma in Ultrasound Guided Sacroiliac Joint Injection for Chronic Low Back Pain [NCT02334475] | 40 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| Effect of Preoperative Intravenous High Dose Methylprednisolone on Glucose Homeostasis in Patients Scheduled for Total Hip- and Knee-arthroplasty [NCT02332603] | Phase 3 | 134 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Randomized, Unicentric, Open, Controlled Clinical Trial, in Phase Iii, to Demonstrate the Effectiveness of Tocilizumab Against Systemic Corticotherapy in Patients Admitted by Covid-19 With Bilateral Pneumonia and Poor Evolution [NCT05002517] | Phase 3 | 60 participants (Anticipated) | Interventional | 2020-09-03 | Active, not recruiting | ||
| Antiviral Treatment in Facial Palsy. Randomized Control Trial [NCT02328079] | 50 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Comparison Of Two Corticosteroid Dosing Regimens For Prevention Of Corneal Transplant Rejection Episodes After Descemet's Membrane Endothelial Keratoplasty [NCT01448213] | Phase 2 | 264 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| A Phase II Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Methylprednisolone as a Treatment for Presumed Hantavirus Cardiopulmonary Syndrome [NCT00128180] | Phase 2 | 66 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A Phase II Study of Rituximab and Temozolomide in Recurrent Primary CNS Lymphoma [NCT00248534] | Phase 2 | 16 participants (Actual) | Interventional | 2005-09-30 | Terminated(stopped due to slow accrual/lack of resources/low priority due to combining 2 consortia) | ||
| Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to a Single Intrabursal Injection of Corticosteroids in Patients With Shoulder Calcific Tendinopathy [NCT01652495] | Phase 4 | 44 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| A Phase 1/2 Trial Evaluating Treatment of Emergent Graft Versus Host Disease (GvHD) With AP1903 After Planned Donor Infusions (DLIs) of T-cells Genetically Modified With the iCasp9 Suicide Gene in Patients With Hematologic Malignancies [NCT01875237] | Phase 1/Phase 2 | 3 participants (Actual) | Interventional | 2013-12-27 | Terminated | ||
| Prospective, Randomized Comparison of Corticosteroid Dosing Regimens Following Endothelial Keratoplasty [NCT01853696] | Phase 4 | 167 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Randomized, Double-Masked, Vehicle Controlled, Clinical Evaluation To Assess The Safety And Efficacy Of Nepafenac Ophthalmic Suspension, 0.3% For Improvement In Clinical Outcomes Among Diabetic Subjects Following Cataract Surgery [NCT01853072] | Phase 3 | 881 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Blood Pressure Profile and NT-proBNP Dynamics in Response to Intravenous Methylprednisolone Pulse Therapy of Severe Graves' Orbitopathy [NCT03590080] | 32 participants (Actual) | Observational | 2011-01-01 | Completed | |||
| Impact of Preoperative Single Corticosteroid Flash on Morbidity After Colorectal Resection: Monocentric Prospective Pilot Study [NCT03437746] | Phase 2 | 78 participants (Actual) | Interventional | 2018-03-01 | Terminated(stopped due to insufficient rate of inclusion) | ||
| Effect of Depo-Medrol Application on the Psoas Muscle After Transpsoas LLIF on Post-operative Hip Flexor Weakness, Thigh Pain and Numbness [NCT05929755] | Phase 4 | 80 participants (Anticipated) | Interventional | 2023-05-12 | Recruiting | ||
| Effect of Methylprednisolone on Systemic Inflammatory Response and Clinical Parameters During Pediatric Congenital Open-Heart Surgery: A Randomized Controlled Trial [NCT05927233] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-04-01 | Recruiting | ||
| The D3 Study: Drug Delivery vs Drops - A Prospective Clinical Study Evaluating Dexycu vs Prednisolone Acetate 1% in Controlling Post-operative Pain and Inflammation in Patients Undergoing Sequential Cataract Surgery [NCT04273282] | Phase 4 | 31 participants (Actual) | Interventional | 2019-12-16 | Completed | ||
| The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy [NCT01451710] | 30 participants (Actual) | Interventional | 2011-03-31 | Completed | |||
| Double-Blind, Randomized, Parallel Group, Multicenter Study of Durolane Compared to Methylprednisolone in Subjects With Osteoarthritis of the Knee [NCT01209364] | Phase 3 | 442 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| High Dose Steroids in Children With Stroke and Unilateral Focal Arteriopathy: Paediatric Arteriopathy Steroid Aspirin (PASTA) Project. A Multicentre Randomized Trial. [NCT03249844] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-01 | Withdrawn(stopped due to discontinuation of the trial) | ||
| Allogeneic Hematopoietic Cell Transplantation of Positively Selected CD34+ Cells and Defined Inoculum of T Cells From Related Haploidentical Donors for Older Patients With Indolent Hematologic Malignancies [NCT00185692] | Phase 2 | 16 participants (Actual) | Interventional | 2000-08-31 | Completed | ||
| Evaluation of a Strategy Based on the 3-month Screening Biopsy to Optimize the Immunosuppression in Renal Transplantation: the I4BiS Study [NCT02444429] | Phase 3 | 346 participants (Anticipated) | Interventional | 2015-09-30 | Recruiting | ||
| A Randomized Prospective Double Masked Controlled Trial Comparing Ketorolac Tromethamine 0.4% and Prednisolone Acetate 1% in Reducing Post-selective Laser Trabeculoplasty Anterior Chamber Flare and Cells. [NCT00478036] | 31 participants (Actual) | Interventional | 2007-05-31 | Terminated(stopped due to insufficient enrollment) | |||
| Effect of Azole/Echinocandin Use on Tacrolimus Pharmacokinetics in Kidney Transplant Recipients [NCT06044558] | 507 participants (Actual) | Observational | 2022-09-01 | Completed | |||
| [NCT00733096] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Steroids in Pediatric Acute Lung Injury/ARDS Trial: A Blinded, Placebo-controlled, Randomized Clinical Trial [NCT01274260] | Phase 2 | 100 participants (Anticipated) | Interventional | 2010-10-31 | Active, not recruiting | ||
| SAAB: Randomized, Double Blind STudy of Corticosteroid Pulse After Ablation [NCT00807586] | Phase 4 | 119 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| A Single-Center, Double-Masked, Randomized, Placebo-Controlled Evaluation of Prednisolone Sodium Phosphate Ophthalmic Solution, 1% Compared to Placebo in a Modified Conjunctival Allergen Challenge (CAC) Model [NCT01730872] | Phase 4 | 16 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| A Randomized International Phase 3 Trial of Imatinib and Chemotherapy With or Without Blinatumomab in Patients With Newly-Diagnosed Philadelphia Chromosome-Positive or Philadelphia Chromosome-Like ABL-Class B-Cell Acute Lymphoblastic Leukemia [NCT06124157] | Phase 3 | 680 participants (Anticipated) | Interventional | 2024-01-22 | Not yet recruiting | ||
| A Phase 1/2 Ascending Dose Study to Evaluate the Safety and Effects on Progranulin Levels of LY3884963 in Patients With Fronto-Temporal Dementia With Progranulin Mutations (FTD-GRN) [NCT04408625] | Phase 1/Phase 2 | 23 participants (Anticipated) | Interventional | 2020-11-09 | Recruiting | ||
| The Effects of Acthar on Synovial Inflammation in Rheumatoid Arthritis: A Pilot Study [NCT03511625] | Phase 3 | 6 participants (Anticipated) | Interventional | 2018-10-02 | Active, not recruiting | ||
| Phase II Study of Infliximab for the Treatment of Ipilimumab Colitis [NCT04305145] | Phase 2 | 42 participants (Anticipated) | Interventional | 2020-08-31 | Recruiting | ||
| High Dose Methylprednisolone Verses Low Dose in Correction of Congenital Acynotic Heart Disease [NCT05103397] | Phase 4 | 75 participants (Anticipated) | Interventional | 2021-10-16 | Recruiting | ||
| Patient PReference, Efficacy, and SaFety of an Intracanalicular DExamenthasone InseRt comparEd to Topical PrednisoloNe in PatienTs UndergoIng SequentiAl PhacoemuLsification With Intraocular Lens Surgery OR Combined Phacoemulsification With IOL and a Minim [NCT04563559] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2020-11-30 | Withdrawn(stopped due to PI decided not to open study) | ||
| Health Sciences University Bursa Yüksek Ihtisas Training and Research Hospital [NCT04847687] | 300 participants (Actual) | Observational | 2021-03-01 | Completed | |||
| Is the Effect of Systemic Steroids Treating Pollen Induced Allergic Rhinitis Mainly Due to a Placebo Effect [NCT04622917] | Phase 4 | 44 participants (Actual) | Interventional | 2019-04-10 | Active, not recruiting | ||
| Randomized Controlled Trial on the Efficacy of Dexamethasone Versus Methyl Prednisolone in Covid-19 Infected Patients With High Oxygen Flow [NCT05062681] | Phase 4 | 60 participants (Anticipated) | Interventional | 2021-09-15 | Recruiting | ||
| Methylprednisolone and Hyaluronic Acid Versus Each Agent Alone to Control Post-extraction Complications of Impacted Mandibular Third Molar [NCT04816253] | 72 participants (Actual) | Interventional | 2021-02-10 | Completed | |||
| [NCT03067753] | Phase 2 | 28 participants (Anticipated) | Interventional | 2016-12-31 | Recruiting | ||
| A Phase I/II Study of High-Dose Deoxyazacytidine, Busulfan, and Cyclophosphamide With Allogeneic Stem Cell Transplantation for Hematologic Malignancies [NCT00002831] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 1995-08-01 | Completed | ||
| Effect on Pain and Inflammation With DEXTENZA Treatment in Patients Undergoing Intravitreal Anti-VEGF Injections [NCT04563299] | Phase 4 | 10 participants (Actual) | Interventional | 2020-12-09 | Terminated(stopped due to Subject Enrollment) | ||
| Niacin (as a Vasodilator), and a Topical Steroid (for Macular Edema), Non-Ischemic CRVO,HRVO,BRVO [NCT00493064] | Phase 2/Phase 3 | 63 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| A Phase II, Randomized, Clinical Trial Assessing Efficacy And Safety Of Oral Prednisolone vs Intravenous Vincristine In The Treatment Of Infantile [NCT00555464] | Phase 2 | 8 participants (Actual) | Interventional | 2007-11-30 | Terminated(stopped due to The introduction of oral propranolol as a highly efficacious agent for infantile hemangiomas) | ||
| Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass [NCT01579513] | 190 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| A Pilot Study: Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas [NCT00624416] | Phase 1/Phase 2 | 10 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| The Effect of Moderate-Dose Steroid Therapy in Sepsis: A Placebo-Controlled, Randomized Study [NCT01275638] | Phase 4 | 55 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| A Phase II, Double-Blind, Placebo-Controlled, Multi-Center, Randomized Withdrawal Design Trial Using Adaptive Randomization Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis [NCT01369745] | Phase 2 | 294 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Effect of Drop-less Surgery Compared to Topical NSAID Alone and Combination of Steroid and NSAID on Central Macular Thickness After Cataract Surgery, a Randomized Controlled Trial [NCT03383328] | Phase 4 | 470 participants (Actual) | Interventional | 2018-02-01 | Completed | ||
| Randomized Controlled Trial of Ultrasound-guided Steroid Injection Versus Wrist Splint in Patients With Carpal Tunnel Syndrome [NCT04515966] | Phase 4 | 70 participants (Anticipated) | Interventional | 2020-12-01 | Recruiting | ||
| Rituximab (RTX) Therapy in Steroid Resistant Patients or Patients Relapsing After Intravenous Steroids With Active TAO [NCT02378298] | Phase 4 | 26 participants (Actual) | Interventional | 2011-12-31 | Active, not recruiting | ||
| High Dose Steroids in Children With Stroke and Unilateral Focal Arteriopathy: A Multicentre Randomized Controlled Trial PASTA (Paediatric Arteriopathy Steroid Aspirin) Trial [NCT04873583] | Phase 3 | 70 participants (Anticipated) | Interventional | 2021-11-16 | Recruiting | ||
| A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy [NCT03959085] | Phase 3 | 4,772 participants (Anticipated) | Interventional | 2019-10-31 | Recruiting | ||
| Improvement in Function and Pain Due to Subacromial Bursitis in Relationship to Dose of Triamcinolone Acetonide and Methylyprednisolone [NCT02242630] | 61 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| The Utility of feNO in the Differential Diagnosis of Chronic Cough: The Response to Anti-inflammatory Therapy With Prednisolone and Montelukast [NCT02479074] | Phase 4 | 49 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| First Line Treatment of Familiar Lymphohistiocytosis by Alemtuzumab (CAMPATH®) [NCT02472054] | Phase 1/Phase 2 | 29 participants (Actual) | Interventional | 2015-06-29 | Completed | ||
| Increased Heart Rhythm in Response to High-dose Intravenous Methylprednisolone Pulse Therapy of Moderate-to-severe Graves' Orbitopathy [NCT04391439] | 40 participants (Actual) | Observational | 2011-01-01 | Completed | |||
| A Randomized, Open-label, Mutli-centre Study to Evaluate Patient Preference With Subcutaneous Administration of Rituximab Versus Intravenous Rituximab in Previously Untreated Patients With CD20+ Diffuse Large B-cell Lymphoma or CD20+ Follicular Non-Hodgki [NCT01724021] | Phase 3 | 743 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial [NCT03289338] | Phase 2/Phase 3 | 36 participants (Actual) | Interventional | 2016-06-01 | Completed | ||
| A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients [NCT03110822] | Phase 1 | 134 participants (Anticipated) | Interventional | 2017-02-01 | Recruiting | ||
| A Phase 2 Study of Weekly 70 mg/m2 Carfilzomib for Multiple Myeloma Patients Refractory to 27 mg/m2 Carfilzomib [NCT02294357] | Phase 2 | 45 participants (Anticipated) | Interventional | 2014-12-31 | Terminated(stopped due to Early termination due to the difficulties to enroll subjects.) | ||
| The Effect of Positive Airway Pressure on Idiopathic Sudden Sensorineural Hearing Loss Comorbided With Obstructive Sleep Apnea: A Clinical Randomized Controlled Study [NCT04192656] | Phase 4 | 102 participants (Anticipated) | Interventional | 2019-11-01 | Recruiting | ||
| Low Dose Versus High Dose Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia : a Multicenter Randomized Blinded Trial [NCT02303587] | 424 participants (Actual) | Interventional | 2014-12-31 | Completed | |||
| Effect of Preoperative Intravenous High Dose Methylprednisolone on Quadriceps Muscle Function in Patients Scheduled for Total Knee-arthroplasty [NCT02319343] | Phase 3 | 70 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Phase III Study to Evaluate the Efficacy and Safety of NPB-01 in Patients With Autoimmune Encephalitis Refractory to Steroid Pulse Therapy [NCT05177939] | Phase 3 | 40 participants (Anticipated) | Interventional | 2022-03-03 | Recruiting | ||
| Multicentre Prospective Open Label Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy. [NCT04662723] | Phase 4 | 878 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| A Multi-Center, Randomized, Double-Masked Evaluation of the Efficacy of Co-Administration of FOV1101-00 (Cyclosporine 0.01% or 0.02%) and Prednisolone Acetate 0.12% (PredMild®) Compared to Prednisolone Acetate 1% Alone or Vehicle Alone in Patients With Mi [NCT00833495] | Phase 2 | 155 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Parasitic Ulcer Treatment Trial Pilot [NCT03484507] | Phase 2 | 49 participants (Actual) | Interventional | 2018-01-01 | Active, not recruiting | ||
| A National Prospective Study of Patients With Hepatitis Induced by Immune Checkpoint Inhibitors; Characterization of Liver Injury, Outcome of Therapy and Randomization to Either Prednisolone or Mycophenolate Mofetil Treatment in Case of Relapse [NCT04810156] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-04-07 | Recruiting | ||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms [NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn(stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| Pre-emptive Scalp Infiltration With Ropivacaine Plus Methylprednisolone vs Ropivacaine Alone for Relief of Postoperative Pain After Craniotomy in Children (RP/MP vs RP) [NCT03636165] | Phase 4 | 90 participants (Anticipated) | Interventional | 2022-09-01 | Not yet recruiting | ||
| Preoperative Single-high Dose Glucocorticoid for Patients Undergoing Hip Fracture Surgery and the Effect on Postoperative Delirium. [NCT02317601] | Phase 4 | 122 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Randomized Controlled Trial of Methylprednisolone Versus Dexamethasone in COVID-19 Pneumonia (MEDEAS Trial) [NCT04636671] | Phase 3 | 690 participants (Actual) | Interventional | 2021-04-14 | Completed | ||
| Effect of Preoperative Low-dose of Methylprednisolone on Postoperative Pain and Immune Functions After Video-assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Trial [NCT03393949] | Phase 4 | 112 participants (Actual) | Interventional | 2015-07-01 | Completed | ||
| Effectiveness and Safety of Efgartigimod in the Acute Phase of Neuromyelitis Optica Spectrum Disorders-a Multicentric, Controlled, Retrospective, Real-Word Study [NCT06118398] | 24 participants (Anticipated) | Observational | 2023-11-05 | Not yet recruiting | |||
| Phase II Study of Horse Anti-Thymocyte Globulin (hATG), Cyclosporine, Methylprednisolone, and GCSF (Filgrastim or Pegfilgrastim) in Patients With Aplastic Anemia (AA), or Low/Int-1 Risk Myelodysplastic Syndrome (MDS) [NCT01624805] | Phase 2 | 100 participants (Anticipated) | Interventional | 2012-06-25 | Recruiting | ||
| CORTERAS STUDY: The Effect of Corticosteroids on Early Recovery After Major Surgery in Elderly Patients [NCT05220319] | Phase 4 | 672 participants (Anticipated) | Interventional | 2022-02-03 | Recruiting | ||
| The Effects of Intraoperative Local and Systemic Corticosteroid Administration on Postoperative Dysphagia After Anterior Cervical Fusion [NCT03311425] | Phase 3 | 140 participants (Actual) | Interventional | 2014-08-01 | Completed | ||
| [NCT02028754] | Phase 4 | 180 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Randomized, Double-blinded, Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections [NCT06000709] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-10-20 | Not yet recruiting | ||
| A Phase 2a Single-arm, Prospective, Open-label Pilot Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant [NCT04046549] | Phase 2 | 25 participants (Actual) | Interventional | 2019-10-30 | Completed | ||
| Yale Steroid Enhanced Versus Exparel Nerveblock TKA Randomized Controlled Trial (RCT) Study [NCT05279092] | Phase 2 | 250 participants (Anticipated) | Interventional | 2022-09-08 | Recruiting | ||
| Comparison of Follow-up and Steroid Treatment Results in Intussusception in Children [NCT05640375] | Phase 1/Phase 2 | 120 participants (Anticipated) | Interventional | 2019-12-24 | Recruiting | ||
| Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis (ITN055AI) [NCT02260934] | Phase 2 | 43 participants (Actual) | Interventional | 2015-07-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||