acth-(4-7)--pro-gly-pro- and Necrosis

acth-(4-7)--pro-gly-pro- has been researched along with Necrosis* in 2 studies

Other Studies

2 other study(ies) available for acth-(4-7)--pro-gly-pro- and Necrosis

Article	Year
Effect of Semax peptide on survival of cultured rat pheochromocytoma cells during oxidative stress. Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:3 We studied the effects of Semax (antiinsulin peptide with neuroprotective effect) on the survival of cultured rat pheochromocytoma cell after oxidative stress induced by short-term incubation with hydrogen peroxide. Studies with fluorescent dyes propidium iodide and Hoechst 33258 showed that cell incubation with hydrogen peroxide led to the formation of damaged cells with characteristic signs of necrosis. Semax dose-dependently reduced the number of cells damaged by oxidative stress. The efficiency of Semax depended on the time of its addition to the culture medium. The results suggest that the neuroprotective effect of Semax in ischemic stroke can be due to its capacity to protect neurons from damage caused by oxidative stress. Topics: Adrenocorticotropic Hormone; Animals; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Dyes; Hydrogen Peroxide; Necrosis; Neuroprotective Agents; Oxidants; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats	2003
[Semax and some glyproline peptides accelerate the healing of acetic ulcers in rats]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2003, Issue:4 Previously we showed that peptides PGP, PG, GP and semax have protective anti-ulcer properties using different models of ulcerogenesis. Semax (MEHFPGP) is a nootropic analogue of adrenocorticotropin 4-7 stabilized by PGP in the C-terminal region. In this study we examined the impact of these peptides on the development and healing of acetic ulcers in rats. The histomorphological and dynamical characteristics of acetic ulcers are most similar to human chronic ulcers. All the peptides were shown to accelerate the process of ulcer cicatrisation in a varying degree (GP semax PG PGP). The dynamics of structural changes in the place of ulcer formation investigated with the use of cytohistological control demonstrated that their anti-ulcer effects can be related to their ability to accelerate ulcer clarification from necrotic tissues and to activate the process of cicatrisation and epithelization. PGP and GP were also shown to reduce the inflammation in the ulcer zone on the fifth day after acetic acid application. Topics: Acetic Acid; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Male; Necrosis; Peptide Fragments; Proline; Rats; Time Factors; Ulcer; Wound Healing	2003

Article

Year

Effect of Semax peptide on survival of cultured rat pheochromocytoma cells during oxidative stress.

Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:3

We studied the effects of Semax (antiinsulin peptide with neuroprotective effect) on the survival of cultured rat pheochromocytoma cell after oxidative stress induced by short-term incubation with hydrogen peroxide. Studies with fluorescent dyes propidium iodide and Hoechst 33258 showed that cell incubation with hydrogen peroxide led to the formation of damaged cells with characteristic signs of necrosis. Semax dose-dependently reduced the number of cells damaged by oxidative stress. The efficiency of Semax depended on the time of its addition to the culture medium. The results suggest that the neuroprotective effect of Semax in ischemic stroke can be due to its capacity to protect neurons from damage caused by oxidative stress.

Topics: Adrenocorticotropic Hormone; Animals; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Dyes; Hydrogen Peroxide; Necrosis; Neuroprotective Agents; Oxidants; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats

2003

[Semax and some glyproline peptides accelerate the healing of acetic ulcers in rats].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2003, Issue:4

Previously we showed that peptides PGP, PG, GP and semax have protective anti-ulcer properties using different models of ulcerogenesis. Semax (MEHFPGP) is a nootropic analogue of adrenocorticotropin 4-7 stabilized by PGP in the C-terminal region. In this study we examined the impact of these peptides on the development and healing of acetic ulcers in rats. The histomorphological and dynamical characteristics of acetic ulcers are most similar to human chronic ulcers. All the peptides were shown to accelerate the process of ulcer cicatrisation in a varying degree (GP semax PG PGP). The dynamics of structural changes in the place of ulcer formation investigated with the use of cytohistological control demonstrated that their anti-ulcer effects can be related to their ability to accelerate ulcer clarification from necrotic tissues and to activate the process of cicatrisation and epithelization. PGP and GP were also shown to reduce the inflammation in the ulcer zone on the fifth day after acetic acid application.

Topics: Acetic Acid; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Male; Necrosis; Peptide Fragments; Proline; Rats; Time Factors; Ulcer; Wound Healing

2003