potassium-permanganate and Necrosis

Topics: Animals; Dental Pulp; Male; Necrosis; Potassium Permanganate; Pulpitis; Rats; Rats, Inbred Strains

Reports of necrosis caused by quaternary ammonium compounds, such as cetrimide, are rare. The case is reported of a 77-year-old woman who was admitted to hospital for four months with cutaneous necrosis of the left foot and leg owing to the topical application of cetrimide powder.

Topics: Aged; Alkanes; Anemia; Anti-Infective Agents, Local; Cloxacillin; Debridement; Eczema; Female; Hemoglobins; Humans; Necrosis; Paraffin; Potassium Permanganate; Quaternary Ammonium Compounds; Skin Diseases; Skin Diseases, Infectious; Skin Tests; Staphylococcal Infections

Potassium permanganate tablets are caustic and it has been suggested that they should be removed straightaway by gastrostomy, immediately after swallowing. Some operators have been impressed by the macroscopic appearance of the stomach and have carried out gastrectomy. However, the lesions were only fairly superficial on pathological examination. In the light of a new case and 21 similar cases, treated at the Fernand Widal hospital, the authors discuss other cases in the literature. They conclude: the extreme rareness of digestive perforation; the absence of toxicity of breakdown products of potassium permanganate. They propose treatment of neutralisation of the permanganate with sodium hyposulphite, gastric lavage and supervision on a surgical unit. In case of perforation, they believe that the operation should be conservative.

Topics: Adult; Aluminum Hydroxide; Animals; Burns, Chemical; Female; Gastric Lavage; Gastric Mucosa; Gastrostomy; Humans; Milk; Necrosis; Potassium Permanganate; Stomach; Stomach Diseases; Stomach Rupture; Suicide, Attempted; Thiosulfates

Topics: Animals; Necrosis; Potassium Permanganate; Skin Diseases, Infectious; Turtles

Topics: Anaphylaxis; Animals; Calcinosis; Calciphylaxis; Connective Tissue; Dihydrotachysterol; Edema; Female; Foot Diseases; Formaldehyde; Hemorrhage; Inflammation; Ischemia; Lead; Necrosis; Pharmacology; Potassium Permanganate; Rats; Serotonin; Stress, Physiological; Thrombosis

Topics: Anti-Infective Agents, Local; Disease; Female; Humans; Necrosis; Potassium Permanganate; Vagina; Vaginal Diseases