Cyclin-T1

A cyclin-T1 that is encoded in the genome of human. [PRO:CNA]

Synonyms

CycT1;
Cyclin-T

Research

Bioassay Publications (69)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (11.59)	29.6817
2010's	48 (69.57)	24.3611
2020's	13 (18.84)	2.80

Compounds (58)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gw8510	Homo sapiens (human)	IC50	0.5400	1	1
indirubin-3'-monoxime	Homo sapiens (human)	IC50	2.4000	1	1
nsc 664704	Homo sapiens (human)	IC50	0.0640	1	1
nu6102	Homo sapiens (human)	IC50	2.5850	2	2
dichlororibofuranosylbenzimidazole	Homo sapiens (human)	Ki	0.3400	1	1
staurosporine	Homo sapiens (human)	IC50	0.0118	5	5
staurosporine	Homo sapiens (human)	Ki	0.0070	1	1
fascaplysine	Homo sapiens (human)	IC50	250.0000	1	1
cercosporamide	Homo sapiens (human)	IC50	0.2200	1	1
birb 796	Homo sapiens (human)	IC50	30.0000	1	1
cyc 202	Homo sapiens (human)	IC50	0.7136	11	15
cyc 202	Homo sapiens (human)	Ki	0.7900	1	1
paullone	Homo sapiens (human)	IC50	0.8100	1	1
2H-pyrazolo[4,3-b]quinoxalin-3-amine	Homo sapiens (human)	IC50	14.1000	1	1
6-bromoindirubin-3'-oxime	Homo sapiens (human)	IC50	0.4500	1	1
purvalanol a	Homo sapiens (human)	IC50	0.0497	1	3
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione	Homo sapiens (human)	IC50	20.0000	1	1
cgp 60474	Homo sapiens (human)	IC50	0.0130	1	1
cgp 74514a	Homo sapiens (human)	IC50	1.4000	1	1
1,4-dimethoxy-10H-acridine-9-thione	Homo sapiens (human)	IC50	20.0000	1	1
bms 387032	Homo sapiens (human)	IC50	0.0103	6	6
harmine	Homo sapiens (human)	IC50	0.7200	1	1
wogonin	Homo sapiens (human)	IC50	0.1927	3	3
alvocidib	Homo sapiens (human)	IC50	0.0243	10	10
alvocidib	Homo sapiens (human)	Ki	0.0030	1	1
su 9516	Homo sapiens (human)	IC50	1.5000	1	1
arcyriaflavin a	Homo sapiens (human)	IC50	20.0000	1	1
palbociclib	Homo sapiens (human)	IC50	34.3390	3	3
palbociclib	Homo sapiens (human)	Ki	0.3640	1	1
olomoucine ii	Homo sapiens (human)	IC50	0.8150	1	1
cyc 116	Homo sapiens (human)	Ki	0.4800	1	1
cvt 313	Homo sapiens (human)	IC50	2.3000	1	1
leucettamine b	Homo sapiens (human)	IC50	10.0000	1	1
nu 6140	Homo sapiens (human)	IC50	5.1000	1	1
pik 75	Homo sapiens (human)	IC50	0.0014	1	1
meridianin a	Homo sapiens (human)	IC50	2.4000	1	1
rgb 286638	Homo sapiens (human)	IC50	0.0010	1	1
at 7519	Homo sapiens (human)	IC50	0.0093	7	7
at 7519	Homo sapiens (human)	Ki	0.1000	1	1
cgp 57380	Homo sapiens (human)	Ki	10.0000	1	1
pha 767491	Homo sapiens (human)	IC50	0.0100	1	1
5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one	Homo sapiens (human)	IC50	0.3000	3	3
pha 848125	Homo sapiens (human)	IC50	7.7000	1	1
azd5438	Homo sapiens (human)	IC50	0.0200	1	1
p276-00	Homo sapiens (human)	IC50	0.0200	3	3
meriolin 3	Homo sapiens (human)	IC50	0.0060	3	3
cink4	Homo sapiens (human)	IC50	10.0000	1	1
ldc067	Homo sapiens (human)	IC50	0.1060	3	3
bs 194	Homo sapiens (human)	IC50	0.0600	2	2
(R)-DRF053	Homo sapiens (human)	IC50	8.0000	1	1
ribociclib	Homo sapiens (human)	IC50	1.1228	4	4
bay 1000394	Homo sapiens (human)	IC50	0.0050	4	4
pha 793887	Homo sapiens (human)	IC50	0.1380	1	1
abemaciclib	Homo sapiens (human)	IC50	0.0734	4	4
abemaciclib	Homo sapiens (human)	Ki	0.0570	1	1
dinaciclib	Homo sapiens (human)	IC50	0.0272	8	8
bs-181	Homo sapiens (human)	IC50	1.7900	1	1
on123300	Homo sapiens (human)	IC50	0.1170	1	1
[4-amino-2-[2-methoxy-4-(4-methyl-1-piperazinyl)anilino]-5-thiazolyl]-(2,6-dichlorophenyl)methanone	Homo sapiens (human)	IC50	0.3170	1	1
ly2857785	Homo sapiens (human)	IC50	0.0110	1	1
THZ531	Homo sapiens (human)	IC50	0.5135	2	2
can 508	Homo sapiens (human)	IC50	17.4050	5	10
can 508	Homo sapiens (human)	Ki	0.3500	1	1
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	Homo sapiens (human)	IC50	14.0000	2	2
ro 3306	Homo sapiens (human)	IC50	14.5000	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
transcription cis-regulatory region binding	molecular function	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
cyclin-dependent protein serine/threonine kinase activator activity	molecular function	Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]
RNA polymerase binding	molecular function	Binding to an RNA polymerase molecule or complex. [GOC:BHF, GOC:mah, GOC:txnOH]
7SK snRNA binding	molecular function	Binding to a 7SK small nuclear RNA (7SK snRNA). [GOC:nhn, PMID:21853533]
DNA-binding transcription factor binding	molecular function	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]
molecular condensate scaffold activity	molecular function	Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. [PMID:28225081]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
cyclin/CDK positive transcription elongation factor complex	cellular component	A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]
P-TEFb complex	cellular component	A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067, Wikipedia:P-TEFb]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
regulation of cyclin-dependent protein serine/threonine kinase activity	biological process	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]
transcription by RNA polymerase II	biological process	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
positive regulation of transcription elongation by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]
positive regulation by host of viral transcription	biological process	Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. [GOC:jl]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
cell division	biological process	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-templated transcription, elongation	biological process	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]