Proteins > Voltage-dependent N-type calcium channel subunit alpha-1B
Page last updated: 2024-08-07 16:57:45

Voltage-dependent N-type calcium channel subunit alpha-1B

A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q00975]

Synonyms

Brain calcium channel III;
BIII;
Calcium channel, L type, alpha-1 polypeptide isoform 5;
Voltage-gated calcium channel subunit alpha Cav2.2

Research

Bioassay Publications (14)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's4 (28.57)29.6817
2010's7 (50.00)24.3611
2020's2 (14.29)2.80

Compounds (33)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
tacrineHomo sapiens (human)IC5017.000011
amitriptylineHomo sapiens (human)IC5012.000011
amoxapineHomo sapiens (human)IC5027.000011
clomipramineHomo sapiens (human)IC509.000011
cyclobenzaprineHomo sapiens (human)IC5010.000011
desipramineHomo sapiens (human)IC5011.000011
imipramineHomo sapiens (human)IC5022.000011
lomerizineHomo sapiens (human)IC502.430011
maprotilineHomo sapiens (human)IC5010.000011
nimodipineHomo sapiens (human)IC5014.000011
nortriptylineHomo sapiens (human)IC5010.000011
promethazineHomo sapiens (human)IC5018.000011
protriptylineHomo sapiens (human)IC5014.000011
trimipramineHomo sapiens (human)IC5011.000011
opipramolHomo sapiens (human)IC5024.000011
mibefradilHomo sapiens (human)IC500.878022
doxepin hydrochlorideHomo sapiens (human)IC5018.000011
flunarizineHomo sapiens (human)IC501.670011
np 118809Homo sapiens (human)IC5019.555022
cilnidipineHomo sapiens (human)IC5017.866733
ith 4012Homo sapiens (human)IC5020.000011
pd 173212Homo sapiens (human)IC500.040011
NNC 55-0396 (free base)Homo sapiens (human)IC507.000011
a 803467Homo sapiens (human)IC5010.000011
ziconotideHomo sapiens (human)IC500.550022
nnc 55-0396Homo sapiens (human)IC507.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bohemineHomo sapiens (human)EC501,000.000011
indirubin-3'-monoximeHomo sapiens (human)EC501,000.000011
olomoucineHomo sapiens (human)EC501,000.000011
cyc 202Homo sapiens (human)EC5027.580011
aftin-4Homo sapiens (human)EC501,000.000011
olomoucine iiHomo sapiens (human)EC5080.000011
2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]ethanolHomo sapiens (human)EC501,000.000011

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
amyloid-beta bindingmolecular functionBinding to an amyloid-beta peptide/protein. [GOC:hjd]
voltage-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
high voltage-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
synapsecellular componentThe junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
voltage-gated calcium channel complexcellular componentA protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
modulation of chemical synaptic transmissionbiological processAny process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]
response to amyloid-betabiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
calcium ion import across plasma membranebiological processThe directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]