Page last updated: 2024-12-05
1,2-diethylbenzene
## 1,2-Diethylbenzene: A Versatile Building Block
1,2-diethylbenzene is an organic compound with the chemical formula C₁₀H₁₄. It's a colorless liquid with a distinct aromatic odor. The molecule consists of a benzene ring with two ethyl groups attached to adjacent carbon atoms (positions 1 and 2).
Here's why it's important for research:
**1. Versatile Intermediate:** 1,2-diethylbenzene serves as a valuable starting material in organic synthesis. Its structure allows for a range of chemical reactions, including:
* **Electrophilic Aromatic Substitution:** The ethyl groups act as electron-donating groups, directing further substitution to specific positions on the benzene ring.
* **Oxidation and Reduction:** The ethyl groups can be oxidized to carboxylic acids or reduced to alkanes, allowing for the creation of diverse functional groups.
* **Catalytic reactions:** 1,2-diethylbenzene can be used as a substrate for various catalytic reactions, such as alkylation, acylation, and hydrogenation.
**2. Applications in Material Science:**
* **Polymer Synthesis:** 1,2-diethylbenzene can be polymerized to form polymers with unique properties. These polymers are used in a variety of applications, including coatings, adhesives, and plastics.
* **Liquid Crystals:** Some derivatives of 1,2-diethylbenzene exhibit liquid crystal properties, making them suitable for use in displays and other electronic devices.
**3. Model System for Studying Molecular Interactions:**
* **Conformational analysis:** The ethyl groups in 1,2-diethylbenzene can adopt different conformations, allowing researchers to study the dynamics and energetics of molecular interactions.
* **Solvent Effects:** 1,2-diethylbenzene can act as a solvent for various organic reactions. Studying its interactions with different solutes provides insights into solvation and reaction mechanisms.
**4. Potential Applications in Medicine and Agriculture:**
* **Pharmaceuticals:** Some derivatives of 1,2-diethylbenzene have shown promising activity against various diseases, including cancer and infections.
* **Pesticides:** Certain 1,2-diethylbenzene derivatives exhibit insecticidal properties and are being explored as potential pesticides.
**5. Research Focus:**
Ongoing research on 1,2-diethylbenzene focuses on:
* **Developing new synthetic methods:** Researchers aim to develop more efficient and sustainable routes to synthesize 1,2-diethylbenzene and its derivatives.
* **Exploring novel applications:** Researchers are constantly seeking new and exciting applications for 1,2-diethylbenzene, especially in materials science, pharmaceuticals, and agriculture.
Overall, 1,2-diethylbenzene is a versatile and valuable compound that plays an important role in various fields of research. Its unique structure and reactivity make it a key building block for developing new materials, drugs, and other important products.
Cross-References
ID Source | ID |
PubMed CID | 8657 |
CHEMBL ID | 3186870 |
MeSH ID | M0178262 |
Synonyms (56)
Synonym |
BIDD:ER0356 |
135-01-3 |
LS-13808 |
hsdb 4081 |
un2049 |
nsc 405068 |
diethylbenzol |
o-diethylbenzene |
brn 1904392 |
einecs 205-170-1 |
brn 1903396 |
einecs 246-874-9 |
ai3-15336 |
benzene, o-diethyl- |
benzene, diethyl- |
inchi=1/c10h14/c1-3-9-7-5-6-8-10(9)4-2/h5-8h,3-4h2,1-2h |
benzene, 1,2-diethyl- |
1,2-diethylbenzene |
1,2-diethylbenzene, technical grade, 92% |
1,2-diethylbenzene, >=99.0% (gc) |
A806866 |
cas-25340-17-4 |
dsstox_rid_78595 |
NCGC00257453-01 |
dsstox_gsid_27866 |
dsstox_cid_7866 |
tox21_303467 |
tox21_202258 |
NCGC00259807-01 |
1,2-diethyl-benzene |
ec 246-874-9 |
9a18z78q73 , |
4-05-00-01067 (beilstein handbook reference) |
unii-9a18z78q73 |
diethylbenzene [un2049] [flammable liquid] |
4-05-00-01065 (beilstein handbook reference) |
25hox6t1lu , |
unii-25hox6t1lu |
FT-0606393 |
FT-0624880 |
AKOS015888421 |
1,2-diethylbenzene [hsdb] |
J-503819 |
DTXSID6052742 |
diethyl benzene |
3,4-diethylbenzene |
1,2-diethyl benzene |
1,2-diethyibenzene |
ortho-diethylbenzene |
CHEMBL3186870 |
mfcd00009258 |
mfcd00792900 |
1,2-diethylbenzene 100 microg/ml in methanol |
benzene, 1,2-diethyl-; benzene, o-diethyl- (8ci); 1,2-diethylbenzene; o-diethylbenzene |
Q2429316 |
EN300-112423 |
Research Excerpts
Toxicity
Excerpt | Reference | Relevance |
" In conclusion, this study demonstrated that 1,2-DEB causes mild foetotoxicity at maternal toxic doses and that the exposure of the developing rat foetus to 1,2-DEB and/or metabolites after maternal administration of 1,2-DEB in late gestation is small." | ( Assessment of the developmental toxicity and placental transfer of 1,2-diethylbenzene in rats. Beydon, D; Fabry, JP; Gallissot, F; Langonné, I; Payan, JP; Sabaté, JP; Saillenfait, AM, 1999) | 0.54 |
Protein Targets (4)
Potency Measurements
Research
Studies (12)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (41.67) | 18.2507 |
2000's | 6 (50.00) | 29.6817 |
2010's | 1 (8.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 32.79
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 32.79 (24.57) | Research Supply Index | 2.56 (2.92) | Research Growth Index | 4.31 (4.65) | Search Engine Demand Index | 42.09 (26.88) | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 12 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |