Page last updated: 2024-12-05

1,2-diethylbenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1,2-Diethylbenzene: A Versatile Building Block

1,2-diethylbenzene is an organic compound with the chemical formula C₁₀H₁₄. It's a colorless liquid with a distinct aromatic odor. The molecule consists of a benzene ring with two ethyl groups attached to adjacent carbon atoms (positions 1 and 2).

Here's why it's important for research:

**1. Versatile Intermediate:** 1,2-diethylbenzene serves as a valuable starting material in organic synthesis. Its structure allows for a range of chemical reactions, including:

* **Electrophilic Aromatic Substitution:** The ethyl groups act as electron-donating groups, directing further substitution to specific positions on the benzene ring.
* **Oxidation and Reduction:** The ethyl groups can be oxidized to carboxylic acids or reduced to alkanes, allowing for the creation of diverse functional groups.
* **Catalytic reactions:** 1,2-diethylbenzene can be used as a substrate for various catalytic reactions, such as alkylation, acylation, and hydrogenation.

**2. Applications in Material Science:**

* **Polymer Synthesis:** 1,2-diethylbenzene can be polymerized to form polymers with unique properties. These polymers are used in a variety of applications, including coatings, adhesives, and plastics.
* **Liquid Crystals:** Some derivatives of 1,2-diethylbenzene exhibit liquid crystal properties, making them suitable for use in displays and other electronic devices.

**3. Model System for Studying Molecular Interactions:**

* **Conformational analysis:** The ethyl groups in 1,2-diethylbenzene can adopt different conformations, allowing researchers to study the dynamics and energetics of molecular interactions.
* **Solvent Effects:** 1,2-diethylbenzene can act as a solvent for various organic reactions. Studying its interactions with different solutes provides insights into solvation and reaction mechanisms.

**4. Potential Applications in Medicine and Agriculture:**

* **Pharmaceuticals:** Some derivatives of 1,2-diethylbenzene have shown promising activity against various diseases, including cancer and infections.
* **Pesticides:** Certain 1,2-diethylbenzene derivatives exhibit insecticidal properties and are being explored as potential pesticides.

**5. Research Focus:**

Ongoing research on 1,2-diethylbenzene focuses on:

* **Developing new synthetic methods:** Researchers aim to develop more efficient and sustainable routes to synthesize 1,2-diethylbenzene and its derivatives.
* **Exploring novel applications:** Researchers are constantly seeking new and exciting applications for 1,2-diethylbenzene, especially in materials science, pharmaceuticals, and agriculture.

Overall, 1,2-diethylbenzene is a versatile and valuable compound that plays an important role in various fields of research. Its unique structure and reactivity make it a key building block for developing new materials, drugs, and other important products.

Cross-References

ID SourceID
PubMed CID8657
CHEMBL ID3186870
MeSH IDM0178262

Synonyms (56)

Synonym
BIDD:ER0356
135-01-3
LS-13808
hsdb 4081
un2049
nsc 405068
diethylbenzol
o-diethylbenzene
brn 1904392
einecs 205-170-1
brn 1903396
einecs 246-874-9
ai3-15336
benzene, o-diethyl-
benzene, diethyl-
inchi=1/c10h14/c1-3-9-7-5-6-8-10(9)4-2/h5-8h,3-4h2,1-2h
benzene, 1,2-diethyl-
1,2-diethylbenzene
1,2-diethylbenzene, technical grade, 92%
1,2-diethylbenzene, >=99.0% (gc)
A806866
cas-25340-17-4
dsstox_rid_78595
NCGC00257453-01
dsstox_gsid_27866
dsstox_cid_7866
tox21_303467
tox21_202258
NCGC00259807-01
1,2-diethyl-benzene
ec 246-874-9
9a18z78q73 ,
4-05-00-01067 (beilstein handbook reference)
unii-9a18z78q73
diethylbenzene [un2049] [flammable liquid]
4-05-00-01065 (beilstein handbook reference)
25hox6t1lu ,
unii-25hox6t1lu
FT-0606393
FT-0624880
AKOS015888421
1,2-diethylbenzene [hsdb]
J-503819
DTXSID6052742
diethyl benzene
3,4-diethylbenzene
1,2-diethyl benzene
1,2-diethyibenzene
ortho-diethylbenzene
CHEMBL3186870
mfcd00009258
mfcd00792900
1,2-diethylbenzene 100 microg/ml in methanol
benzene, 1,2-diethyl-; benzene, o-diethyl- (8ci); 1,2-diethylbenzene; o-diethylbenzene
Q2429316
EN300-112423

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In conclusion, this study demonstrated that 1,2-DEB causes mild foetotoxicity at maternal toxic doses and that the exposure of the developing rat foetus to 1,2-DEB and/or metabolites after maternal administration of 1,2-DEB in late gestation is small."( Assessment of the developmental toxicity and placental transfer of 1,2-diethylbenzene in rats.
Beydon, D; Fabry, JP; Gallissot, F; Langonné, I; Payan, JP; Sabaté, JP; Saillenfait, AM, 1999
)
0.54
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency9.93660.000657.913322,387.1992AID1259377
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency52.88540.003041.611522,387.1992AID1159552; AID1159555
farnesoid X nuclear receptorHomo sapiens (human)Potency7.09210.375827.485161.6524AID743220
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency63.32290.001024.504861.6448AID743215
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's6 (50.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.79 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index42.09 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]