A tubulin--tyrosine ligase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG68]
TTL;
EC 6.3.2.25
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tyrosine | Homo sapiens (human) | Ki | 25.0000 | 1 | 1 |
| 3-nitrotyrosine | Homo sapiens (human) | Ki | 400.0000 | 1 | 1 |
| 3-aminotyrosine | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| tubulin-tyrosine ligase activity | molecular function | Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. [EC:6.3.2.25] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| spindle microtubule | cellular component | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. [ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| spindle microtubule | cellular component | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. [ISBN:0815316194] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| regulation of axon extension | biological process | Any process that modulates the rate, direction or extent of axon extension. [GOC:go_curators] |
| post-translational protein modification | biological process | The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. [GOC:jsg] |
| positive regulation of mitotic cell cycle | biological process | Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb] |
| regulation of metaphase plate congression | biological process | Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb] |
| microtubule cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah] |