Page last updated: 2024-08-07 16:52:35
Histamine H3 receptor
A histamine H3 receptor that is encoded in the genome of mouse. [OMA:P58406, PRO:DNx]
Synonyms
H3R;
HH3R
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| histamine | Mus musculus (house mouse) | Ki | 0.0680 | 1 | 1 |
| n-methylhistamine | Mus musculus (house mouse) | Ki | 0.0190 | 1 | 1 |
| clobenpropit | Mus musculus (house mouse) | IC50 | 0.0010 | 1 | 1 |
| clobenpropit | Mus musculus (house mouse) | Ki | 0.0006 | 1 | 1 |
| imetit | Mus musculus (house mouse) | Ki | 0.0020 | 1 | 1 |
| thioperamide | Mus musculus (house mouse) | Ki | 0.0048 | 1 | 1 |
| pitolisant | Mus musculus (house mouse) | Ki | 0.0140 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| clobenpropit | Mus musculus (house mouse) | EC50 | 0.0017 | 1 | 1 |
| thioperamide | Mus musculus (house mouse) | EC50 | 0.0110 | 1 | 1 |
Investigation of 4-piperidinols as novel H3 antagonists.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 20, Issue:21, 2010
Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009