Page last updated: 2024-12-11

oxi 4503

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Oxi 4503: diphosphate prodrug of cambretastatin A1 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6918546
CHEMBL ID1205402
SCHEMBL ID12677563
MeSH IDM0438341

Synonyms (22)

Synonym
oxi-4503
ca1p
[3-methoxy-2-phosphonooxy-6-[(z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
CHEMBL1205402
oxi4503
oxi 4503
unii-jh6z94glud
jh6z94glud ,
combretastatin a1 diphosphate
1,2-benzenediol, 3-methoxy-6-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, 1,2-bis(dihydrogen phosphate)
combretastatin a-1 bis(phosphate)
288847-35-8
combretastatin a1 diphosphate [who-dd]
DB05143
SCHEMBL12677563
Q27095572
1,2-benzenediol,3-methoxy-6-[(1z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-,1,2-bis(dihydrogen phosphate)
1,2-benzenediol, 3-methoxy-6-[(1z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1,2-bis(dihydrogen phosphate)
HY-16147
CS-0006163
combretastatin a1 phosphate
(z)-3-methoxy-6-(3,4,5-trimethoxystyryl)-1,2-phenylene bis(dihydrogen phosphate)

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
"We have shown for the first time that PAI can observe the pharmacodynamic response of tumor vasculature to drug treatment both longitudinally and at different dose levels."( Longitudinal Photoacoustic Imaging of the Pharmacodynamic Effect of Vascular Targeted Therapy on Tumors.
Beard, P; Johnson, SP; Lythgoe, MF; Ogunlade, O; Pedley, RB, 2019
)
0.51

Compound-Compound Interactions

ExcerptReferenceRelevance
"This pre-clinical study was designed to investigate the effect of various vascular disrupting agents (VDAs) that have undergone or are in clinical evaluation, had on the oxygenation status of tumours and what effects that could have on the combination with radiation."( Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy.
Busk, M; Horsman, MR; Iversen, AB, 2013
)
0.39

Dosage Studied

ExcerptRelevanceReference
" In addition, the effects of continuous, daily and intermittent dosing (1-5 mg/kg) on tumor necrosis and growth were studied by quantitative histological and stereological analysis."( Vascular targeting agent Oxi4503 inhibits tumor growth in a colorectal liver metastases model.
Chan, L; Christophi, C; Malcontenti-Wilson, C; Muralidharan, V; Nikfarjam, M, 2008
)
0.35
" Subcutaneous continuous dosing infusion with Oxi4503 at 1 mg/kg/day reduced tumor growth compared to the controls, but was associated with marked systemic toxicity."( Vascular targeting agent Oxi4503 inhibits tumor growth in a colorectal liver metastases model.
Chan, L; Christophi, C; Malcontenti-Wilson, C; Muralidharan, V; Nikfarjam, M, 2008
)
0.35
" Intermittent dosing with Oxi4503 produced the maximum reduction in tumor growth, minimal toxicity, and a significant improvement in survival."( Vascular targeting agent Oxi4503 inhibits tumor growth in a colorectal liver metastases model.
Chan, L; Christophi, C; Malcontenti-Wilson, C; Muralidharan, V; Nikfarjam, M, 2008
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (34)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (35.29)29.6817
2010's20 (58.82)24.3611
2020's2 (5.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.44 (24.57)
Research Supply Index3.76 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.44)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (10.53%)5.53%
Reviews3 (7.89%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other31 (81.58%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]