Proteins > Melatonin receptor type 1B
Page last updated: 2024-08-07 16:45:19

Melatonin receptor type 1B

A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286]

Synonyms

Mel-1B-R;
Mel1b receptor

Research

Bioassay Publications (67)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (10.45)18.2507
2000's29 (43.28)29.6817
2010's23 (34.33)24.3611
2020's8 (11.94)2.80

Compounds (22)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
melatoninHomo sapiens (human)IC500.00351212
melatoninHomo sapiens (human)Ki0.00046264
methylbufoteninHomo sapiens (human)Ki0.016011
6-chloromelatoninHomo sapiens (human)IC500.002433
6-chloromelatoninHomo sapiens (human)Ki0.000956
6-hydroxymelatoninHomo sapiens (human)Ki0.005511
s20098Homo sapiens (human)IC500.000111
s20098Homo sapiens (human)Ki0.000288
6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-oneHomo sapiens (human)IC5033.000011
6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-oneHomo sapiens (human)Ki9.100012
2-iodomelatoninHomo sapiens (human)IC500.000011
2-iodomelatoninHomo sapiens (human)Ki0.000133
luzindoleHomo sapiens (human)Ki0.033933
2-bromomelatoninHomo sapiens (human)IC500.000122
2-bromomelatoninHomo sapiens (human)Ki0.000034
5-methoxyluzindoleHomo sapiens (human)Ki0.000222
ramelteonHomo sapiens (human)Ki0.000133
ah 001Homo sapiens (human)IC500.001411
4-phenyl-2-propionamidotetralineHomo sapiens (human)Ki0.000733
2-phenylmelatoninHomo sapiens (human)IC500.000122
2-phenylmelatoninHomo sapiens (human)Ki0.000034
iik7Homo sapiens (human)Ki0.000022
5-methoxycarbonylamino-n-acetyltryptamineHomo sapiens (human)IC504.000022
8-methoxy-2-propionamidotetralinHomo sapiens (human)IC500.000511
k 185Homo sapiens (human)Ki0.000544
ucm 454Homo sapiens (human)Ki0.008844
5-hydroxyethoxy-n-acetyltryptamineHomo sapiens (human)IC501.020011
5-hydroxyethoxy-n-acetyltryptamineHomo sapiens (human)Ki0.218023

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
melatoninHomo sapiens (human)EC500.00251212
methylbufoteninHomo sapiens (human)EC500.112011
catechinHomo sapiens (human)EC5047.300011
4,4'-bisphenol fHomo sapiens (human)EC50244.000011
s20098Homo sapiens (human)EC501,932.100199
2-phenylmelatoninHomo sapiens (human)EC507.000011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
melatonin receptor activitymolecular functionCombining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. [GOC:ai, ISBN:0198506732]
G protein-coupled receptor activitymolecular functionCombining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
synapsecellular componentThe junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerbiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
negative regulation of cGMP-mediated signalingbiological processAny process that decreases the rate, frequency or extent of cGMP-mediated signaling. [GOC:BHF, GOC:dph, GOC:tb]
glucose homeostasisbiological processAny process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
camera-type eye developmentbiological processThe process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:go_curators, GOC:mtg_sensu]
negative regulation of neuron apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
negative regulation of vasoconstrictionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction. [GOC:go_curators]
positive regulation of circadian sleep/wake cycle, non-REM sleepbiological processAny process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. [GOC:go_curators]
negative regulation of insulin secretionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
regulation of insulin secretionbiological processAny process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
negative regulation of cytosolic calcium ion concentrationbiological processAny process that decreases the concentration of calcium ions in the cytosol. [GOC:ai]
negative regulation of transmission of nerve impulsebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]
positive regulation of transmission of nerve impulsebiological processAny process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]
regulation of neuronal action potentialbiological processAny process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dph, GOC:isa_complete, GOC:tb]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]