An inositol hexakisphosphate kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHH9]
InsP6 kinase 2;
InsP6K2;
EC 2.7.4.-;
P(i)-uptake stimulator;
PiUS
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 3',4'-dihydroxyflavone | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| 4',6-dihydroxyflavone | Homo sapiens (human) | IC50 | 12.9000 | 1 | 1 |
| naringenin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| eriodictyol | Homo sapiens (human) | IC50 | 25.3000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 5.7000 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 7.1000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| diosmetin | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| genkwanin | Homo sapiens (human) | IC50 | 24.0000 | 1 | 1 |
| 3-methylquercetin | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| rhamnetin | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| 4',7-dihydroxyflavone | Homo sapiens (human) | IC50 | 18.3000 | 1 | 1 |
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| inositol-1,3,4,5,6-pentakisphosphate kinase activity | molecular function | Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. [GOC:elh, PMID:11311242] |
| inositol hexakisphosphate kinase activity | molecular function | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. [GOC:elh, GOC:vw, PMID:16429326] |
| inositol heptakisphosphate kinase activity | molecular function | Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown. [GOC:elh, PMID:16429326] |
| inositol hexakisphosphate 5-kinase activity | molecular function | Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. [MetaCyc:2.7.1.152-RXN, RHEA:12793] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| inositol 5-diphosphate pentakisphosphate 5-kinase activity | molecular function | Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate. [PMID:11502751, PMID:18355727] |
| inositol diphosphate tetrakisphosphate kinase activity | molecular function | Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate. [PMID:10827188, PMID:11502751, PMID:18355727] |
| flavonoid binding | molecular function | Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge. [GOC:sl, PMID:20599706] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| fibrillar center | cellular component | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cell junction | cellular component | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of cell growth | biological process | Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators] |
| positive regulation of peptidyl-serine phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah] |
| positive regulation of apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| inositol phosphate metabolic process | biological process | The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:jl] |
| phosphatidylinositol phosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732] |
| protein stabilization | biological process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| cellular response to flavonoid | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22700048] |
| inositol phosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:mah] |