4-aminobutyrate aminotransferase, mitochondrial

A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P80404]

Synonyms

EC 2.6.1.19;
(S)-3-amino-2-methylpropionate transaminase;
2.6.1.22;
GABA aminotransferase;
GABA-AT;
Gamma-amino-N-butyrate transaminase;
GABA transaminase;
GABA-T;
L-AIBAT

Research

Bioassay Publications (7)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (42.86)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80

Compounds (16)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-hydroxybenzyl alcohol	Homo sapiens (human)	IC50	1,000.0000	1	1
4-hydroxybenzaldehyde	Homo sapiens (human)	IC50	16.5000	1	1
4-hydroxybenzoic acid	Homo sapiens (human)	IC50	1,000.0000	1	1
anthranilic acid	Homo sapiens (human)	IC50	5,000.0000	1	1
4-aminobenzoic acid	Homo sapiens (human)	IC50	1,000.0000	1	1
vanillin	Homo sapiens (human)	IC50	17.1000	1	1
vigabatrin	Homo sapiens (human)	Ki	2,025.0000	2	2
4-hydroxypropiophenone	Homo sapiens (human)	IC50	176.0000	1	1
3-aminobenzoic acid	Homo sapiens (human)	IC50	5,000.0000	1	1
4-hydroxyacetophenone	Homo sapiens (human)	IC50	188.0000	1	1
4-anisaldehyde	Homo sapiens (human)	IC50	1,000.0000	1	1
4-hydroxybenzylamine	Homo sapiens (human)	IC50	15.4000	1	1
gastrodin	Homo sapiens (human)	IC50	1,000.0000	1	1
baicalein	Homo sapiens (human)	IC50	12,800.0000	1	1
helicide	Homo sapiens (human)	IC50	1,000.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gamma-aminobutyric acid	Homo sapiens (human)	Km	1,950.0000	2	2

Enables

This protein enables 7 target(s):

Target	Category	Definition
pyridoxal phosphate binding	molecular function	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732]
succinate-semialdehyde dehydrogenase binding	molecular function	Binding to succinate-semialdehyde dehydrogenase. [GOC:mah]
4-aminobutyrate:2-oxoglutarate transaminase activity	molecular function	Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. [EC:2.6.1.19, GOC:mah]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
(S)-3-amino-2-methylpropionate transaminase activity	molecular function	Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. [EC:2.6.1.22, RHEA:13993]
iron-sulfur cluster binding	molecular function	Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
4-aminobutyrate transaminase complex	cellular component	A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity. [GOC:mah, PMID:15528998]

Involved In

This protein is involved in 23 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
copulation	biological process	The act of sexual union between male and female, involving the transfer of sperm. [ISBN:0721662544]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
gamma-aminobutyric acid metabolic process	biological process	The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [ISBN:0198506732]
gamma-aminobutyric acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai]
response to iron ion	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. [GOC:sm]
negative regulation of gamma-aminobutyric acid secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. [GOC:ef]
cerebellum development	biological process	The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
positive regulation of heat generation	biological process	Any process that activates or increases the rate or extent of heat generation. [GOC:dph, GOC:mah, GOC:tb]
positive regulation of insulin secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
negative regulation of dopamine secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine. [GOC:sl]
response to nicotine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
exploration behavior	biological process	The specific behavior of an organism in response to a novel environment or stimulus. [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]
response to ethanol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
negative regulation of blood pressure	biological process	Any process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]
positive regulation of dopamine metabolic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators]
behavioral response to cocaine	biological process	Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. [GOC:jid]
positive regulation of uterine smooth muscle contraction	biological process	Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. [GOC:go_curators]
positive regulation of inhibitory postsynaptic potential	biological process	Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. [GOC:BHF, GOC:sjp, PMID:18550748]
positive regulation of prolactin secretion	biological process	Any process that activates or increases the frequency, rate or extent of prolactin secretion. [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
positive regulation of aspartate secretion	biological process	Any process that activates or increases the frequency, rate or extent of aspartate secretion. [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
gamma-aminobutyric acid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai]