A sodium channel protein type 2 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99250]
HBSC II;
Sodium channel protein brain II subunit alpha;
Sodium channel protein type II subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| phenytoin | Homo sapiens (human) | IC50 | 72.8333 | 3 | 3 |
| amiodarone | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| amitriptyline | Homo sapiens (human) | IC50 | 11.5500 | 2 | 2 |
| chlorpromazine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| lamotrigine | Homo sapiens (human) | IC50 | 42.3333 | 3 | 3 |
| mexiletine | Homo sapiens (human) | IC50 | 22.9500 | 2 | 2 |
| nifedipine | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| phenobarbital | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| tetracaine | Homo sapiens (human) | IC50 | 0.7950 | 2 | 2 |
| naphthazarin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| tedisamil | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| n-methylpiperidin-4-yl propionate | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cns 5161 | Homo sapiens (human) | IC50 | 1.7500 | 1 | 1 |
| senicapoc | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| ica-121431 | Homo sapiens (human) | IC50 | 0.3165 | 2 | 2 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 0.0220 | 2 | 2 |
| a 803467 | Homo sapiens (human) | IC50 | 7.8625 | 4 | 4 |
| cnv1014802 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| zetekitoxin ab | Homo sapiens (human) | IC50 | 0.0000 | 1 | 1 |
| saxitoxin | Homo sapiens (human) | IC50 | 0.0010 | 1 | 1 |
| gs-458967 | Homo sapiens (human) | IC50 | 4.1500 | 2 | 2 |
| ajmaline | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| calmodulin binding | molecular function | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc] |
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| intercalated disc | cellular component | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910] |
| T-tubule | cellular component | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194] |
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| node of Ranvier | cellular component | An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. [GOC:mh] |
| paranode region of axon | cellular component | An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858] |
| presynaptic membrane | cellular component | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| memory | biological process | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089] |
| determination of adult lifespan | biological process | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. [PMID:25561524, PMID:273723695, PMID:3424805] |
| neuronal action potential | biological process | An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb] |
| dentate gyrus development | biological process | The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| nerve development | biological process | The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| myelination | biological process | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GOC:dgh, GOC:mah] |
| cellular response to hypoxia | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |