Proteinase-activated receptor 2

A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085]

Synonyms

PAR-2;
Coagulation factor II receptor-like 1;
G-protein coupled receptor 11;
Thrombin receptor-like 1

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (25.00)	29.6817
2010's	4 (50.00)	24.3611
2020's	2 (25.00)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
triptolide	Homo sapiens (human)	IC50	0.0185	2	2
2-furoyl-ligrlo-amide	Homo sapiens (human)	IC50	0.1000	1	1
AZ3451	Homo sapiens (human)	IC50	3.3012	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide	Homo sapiens (human)	EC50	5.8500	4	4
2-furoyl-ligrlo-amide	Homo sapiens (human)	EC50	0.2530	6	7

Enables

This protein enables 8 target(s):

Target	Category	Definition
G-protein alpha-subunit binding	molecular function	Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. [GOC:hjd]
protease binding	molecular function	Binding to a protease or a peptidase. [GOC:hjd]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
thrombin-activated receptor activity	molecular function	A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:ai, GOC:pg, PMID:20423334]
G-protein beta-subunit binding	molecular function	Binding to a G-protein beta subunit. [GOC:mah]
signaling receptor activity	molecular function	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
early endosome	cellular component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
pseudopodium	cellular component	A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. [ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 54 target(s):

Target	Category	Definition
T cell activation involved in immune response	biological process	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]
positive regulation of leukocyte chemotaxis	biological process	Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]
positive regulation of cytokine production involved in immune response	biological process	Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add]
positive regulation of glomerular filtration	biological process	Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. [GOC:mtg_cardio]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
blood coagulation	biological process	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128]
negative regulation of tumor necrosis factor-mediated signaling pathway	biological process	Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]
regulation of blood coagulation	biological process	Any process that modulates the frequency, rate or extent of blood coagulation. [GOC:mah]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
positive regulation of actin filament depolymerization	biological process	Any process that activates or increases the frequency, rate or extent of actin depolymerization. [GOC:mah]
positive regulation of pseudopodium assembly	biological process	Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]
negative regulation of chemokine production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of chemokine production	biological process	Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]
positive regulation of type II interferon production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-1 beta production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
positive regulation of interleukin-10 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
positive regulation of interleukin-6 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
positive regulation of interleukin-8 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
positive regulation of superoxide anion generation	biological process	Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah]
positive regulation of toll-like receptor 2 signaling pathway	biological process	Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
negative regulation of toll-like receptor 3 signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
positive regulation of toll-like receptor 3 signaling pathway	biological process	Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
positive regulation of toll-like receptor 4 signaling pathway	biological process	Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
positive regulation of Rho protein signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]
neutrophil activation	biological process	The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]
regulation of canonical NF-kappaB signal transduction	biological process	Any process that modulates the canonical NF-kappaB signaling cascade. [GOC:jl, PMID:12773372]
positive regulation of canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
positive regulation of eosinophil degranulation	biological process	Any process that activates or increases the frequency, rate or extent of eosinophil degranulation. [ISBN:0781735149]
positive regulation of GTPase activity	biological process	Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
cell-cell junction maintenance	biological process	The maintenance of junctions between cells. [GOC:ai]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
regulation of JNK cascade	biological process	Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
negative regulation of JNK cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
positive regulation of JNK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
negative regulation of insulin secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
leukocyte migration	biological process	The movement of a leukocyte within or between different tissues and organs of the body. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
positive regulation of chemotaxis	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]
positive regulation of positive chemotaxis	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]
defense response to virus	biological process	Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
positive regulation of phagocytosis, engulfment	biological process	Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. [GOC:dph]
establishment of endothelial barrier	biological process	The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
thrombin-activated receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, PMID:1672265]
leukocyte proliferation	biological process	The expansion of a leukocyte population by cell division. [GOC:add]
positive regulation of neutrophil mediated killing of gram-negative bacterium	biological process	Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, GOC:mah]
mature conventional dendritic cell differentiation	biological process	The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453]
potassium channel activating, G protein-coupled receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel. [GOC:dos, PMID:9429760]
positive regulation of renin secretion into blood stream	biological process	Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream. [GOC:TermGenie]
regulation of chemokine (C-X-C motif) ligand 2 production	biological process	Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. [GOC:BHF, GOC:mah]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]

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