An intestinal alkaline phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09923]
IAP;
Intestinal alkaline phosphatase;
EC 3.1.3.1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| theophylline | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| leucine | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| phenylalanine | Homo sapiens (human) | IC50 | 61.7333 | 3 | 3 |
| tryptophan | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| homoarginine | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| levamisole | Homo sapiens (human) | IC50 | 205.0420 | 5 | 5 |
| 1-(3,4-dihydroxyphenyl)-2-(1-imidazolyl)ethanone | Homo sapiens (human) | IC50 | 30.2000 | 1 | 1 |
| 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone | Homo sapiens (human) | IC50 | 49.5000 | 1 | 1 |
| 2,5-dimethoxy-n-(quinolin-3-yl)benzenesulfonamide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| protease binding | molecular function | Binding to a protease or a peptidase. [GOC:hjd] |
| alkaline phosphatase activity | molecular function | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| side of membrane | cellular component | A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| dephosphorylation | biological process | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732] |