SUMO-activating enzyme subunit 2

A SUMO-activating enzyme subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBT2]

EC 2.3.2.-;
Anthracycline-associated resistance ARX;
Ubiquitin-like 1-activating enzyme E1B;
Ubiquitin-like modifier-activating enzyme 2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pevonedistat	Homo sapiens (human)	IC50	4.6000	2	2

This protein enables 9 target(s):

Target	Category	Definition
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
transferase activity	molecular function	Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [ISBN:0198506732]
SUMO activating enzyme activity	molecular function	Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:rn, PMID:10187858, PMID:11265250]
SUMO binding	molecular function	Binding to the small ubiquitin-like protein SUMO. [GOC:mah]
small protein activating enzyme binding	molecular function	Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. [GOC:jl]
ubiquitin-like protein conjugating enzyme binding	molecular function	Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

This protein is located in 1 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is part of 1 target(s):

Target	Category	Definition
SUMO activating enzyme complex	cellular component	A conserved heterodimeric complex with SUMO activating enzyme activity. [PMID:15601841]

This protein is involved in 2 target(s):

Target	Category	Definition
protein sumoylation	biological process	The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]
positive regulation of protein sumoylation	biological process	Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]