A chymotrypsin-C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99895]
EC 3.4.21.2;
Caldecrin
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | Ki | 238.7599 | 1 | 12 |
| congo red | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| iodophthalein | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| 3-benzyl-6-chloro-2-pyrone | Homo sapiens (human) | Ki | 76.0000 | 1 | 1 |
| N-tert-butyl-N-[2-(tert-butylamino)-2-oxoethyl]-3-(3,4-dihydro-2H-quinolin-1-yl)propanamide | Homo sapiens (human) | Ki | 31.7500 | 1 | 2 |
| quercetin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| pepstatin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| zd 8321 | Homo sapiens (human) | Ki | 0.1490 | 1 | 1 |
| 4-hydroxy-6-methyl-2-pyrone | Homo sapiens (human) | Ki | 6,309.5700 | 1 | 1 |
| elasnin | Homo sapiens (human) | Ki | 223.8720 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| peptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181] |
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |