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lead radioisotopes

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Lead Radioisotopes: Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56842199
MeSH IDM0012269

Synonyms (4)

Synonym
D007856000
lead radioisotopes
lead, radioactive
hsdb 7412

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The activity intake, effective dose and cancer risk was found lesser than international guidelines and the seafood intake was considered to be safe for human consumption."( Assessment of health safety from ingestion of natural radionuclides in seafoods from a tropical coast, India.
Godwin Wesley, S; Khan, MF, 2011
)
0.37
"4 MBq/m) were well tolerated with early possibly agent-related adverse events being mild, transient, and not dose dependent."( Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab.
Alvarez, RD; Banaga, EP; Bunch, PW; Dobelbower, MC; Lowy, AM; Meredith, RF; Rozgaja, TA; Straughn, JM; Torgue, JJ, 2018
)
0.48
"IP Pb-TCMC-trastuzumab up to 27 MBq/m seems safe for patients with peritoneal carcinomatosis who have failed standard therapies."( Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab.
Alvarez, RD; Banaga, EP; Bunch, PW; Dobelbower, MC; Lowy, AM; Meredith, RF; Rozgaja, TA; Straughn, JM; Torgue, JJ, 2018
)
0.48

Bioavailability

ExcerptReferenceRelevance
" On the other hand, rat pups had higher lead levels in tissues than mice pups, which might be due to a higher bioavailability and/or a lower excretion of lead in rat pups."( Dose dependent transfer of 203lead to milk and tissue uptake in suckling offspring studied in rats and mice.
Hallén, IP; Oskarsson, A, 1993
)
0.29
"Using stable isotope dilution, we determined the bioavailability of soilborne lead (Pb) in human adult volunteers."( Bioavailability of soilborne lead in adults, by stable isotope dilution.
Blum, C; Drexler, J; Graziano, J; Lolacono, N; Maddaloni, M; Manton, W, 1998
)
0.3
"The mussels (Mytilus galloprovincialis) have been evaluated for their bioavailability as biomonitors of trace and toxic elements in coastal water of western Anatolia."( Trace metals and 210Po (210Pb) concentrations in mussels (Mytilus galloprovincialis) consumed at western Anatolia.
Bassari, A; Uğur, A; Yener, G, 2002
)
0.31
" In scallop tissues, Pb was predominantly associated with the insoluble subcellular fraction, suggesting a low bioavailability of Pb for scallop consumers."( Delineation of Pb contamination pathways in two Pectinidae: the variegated scallop Chlamys varia and the king scallop Pecten maximus.
Bustamante, P; Metian, M; Oberhänsli, F; Warnau, M, 2009
)
0.35
" The bioavailability of (210)Pb in soil was determined by means of a sequential extraction procedure (NH(4)OAc, 1M HCl, 6M HCl, and residue)."( 210Pb and stable lead content in fungi: its transfer from soil.
Baeza, A; Guillén, J; Míguez, MP; Ontalba, MA; Soler, F, 2009
)
0.35
" Although surface sediments from Jackfish Bay continue to have elevated PCDD/Fs, with some locations exceeding sediment quality guidelines, they do not appear to be highly bioavailable to benthic fish."( Historical decline and altered congener patterns of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish and sediment in response to process changes at a pulp mill discharging into Jackfish Bay, Lake Superior.
Dahmer, SC; Hall, RI; McMaster, ME; Munkittrick, KR; Servos, MR; Tetreault, GR, 2015
)
0.42

Dosage Studied

ExcerptRelevanceReference
" In dose-response experiments, B16F10 mouse melanoma cells were incubated with liposomes 212Pb/212Bi bound to dextran 70."( In vitro killing of melanoma by liposome-delivered intracellular irradiation.
Parks, NJ; Pikul, SS; Schneider, PD, 1987
)
0.27
" One of their key goals was the establishment of the dose-response relationship between exposure to lead and biologic precursors of adverse health effects."( Historical perspective on lead biokinetic models.
Rabinowitz, M, 1998
)
0.3
"190 were admitted to the clinical research center and fasted overnight prior to dosing with 250 micrograms Pb/70 kg bw (i."( Bioavailability of soilborne lead in adults, by stable isotope dilution.
Blum, C; Drexler, J; Graziano, J; Lolacono, N; Maddaloni, M; Manton, W, 1998
)
0.3
" Multiple dosing of (212)Pb-Herceptin was evaluated in both animal models."( Alpha-particle radioimmunotherapy of disseminated peritoneal disease using a (212)Pb-labeled radioimmunoconjugate targeting HER2.
Abdulla, A; Albert, PS; Brady, ED; Brechbiel, MW; Garmestani, K; Ma, D; Milenic, DE, 2005
)
0.33
"Five dosage levels (7."( Dose escalation and dosimetry of first-in-human α radioimmunotherapy with 212Pb-TCMC-trastuzumab.
Banaga, E; Bunch, P; Fan, J; Fisher, DR; Meredith, R; Morgan, D; Shen, S; Straughn, JM; Torgue, J, 2014
)
0.4
" No studies have been conducted to estimate the levels of radioactivity dosage received from Sri Lankan homemade foods."( Estimation of annual effective dose due to ingestion of radioactive elements in Sri Lankan common meal plans.
Attanayaka, T; Jayasinghe, C; Molligoda, V; Waduge, V, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (764)

TimeframeStudies, This Drug (%)All Drugs %
pre-199041 (5.37)18.7374
1990's77 (10.08)18.2507
2000's242 (31.68)29.6817
2010's346 (45.29)24.3611
2020's58 (7.59)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 8.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index8.33 (24.57)
Research Supply Index6.67 (2.92)
Research Growth Index5.00 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (8.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials5 (0.64%)5.53%
Reviews24 (3.08%)6.00%
Case Studies2 (0.26%)4.05%
Observational0 (0.00%)0.25%
Other749 (96.03%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]