chlorin p6 profile

ID Source	ID
PubMed CID	5489033
SCHEMBL ID	13806510
MeSH ID	M0197276

Synonym
chlorin p6
(17s,18s)-18-(2-carboxyethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2,20-dicarboxylic acid
21h,23h-porphine-2,20-dicarboxylic acid, 18-(2-carboxyethyl)-12-ethenyl-7-ethyl-17,18-dihydro-3,8,13,17-tetramethyl-, (17s-trans)-
22006-68-4
(5z,10z,14z,17s,18s,19e)-18-(2-carboxyethyl)-7-ethyl-3,8,13,17-tetramethyl-12-vinyl-17,18,21,23-tetrahydroporphyrin-2,20-dicarboxylic acid
(17s,18s)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-2-carboxylic acid
SCHEMBL13806510

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (9.38)	18.2507
2000's	16 (50.00)	29.6817
2010's	13 (40.63)	24.3611
2020's	0 (0.00)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	36 (100.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's
formic acid	1	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent	2006	2006	18.0	low	0	1	0
histamine	2	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter	2011	2013	12.0	low	0	0	2
cetyltrimethylammonium ion	1	quaternary ammonium ion		2002	2002	22.0	low	0	1	0
lysine	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	1992	1992	32.0	low	1	0	0
adenosine diphosphate	1	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite	2005	2005	19.0	low	0	1	0
mannitol	1	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent	2006	2006	18.0	low	0	1	0
tryptophan	3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	2007	2017	13.3	low	0	2	1
trichloroacetic acid	1	monocarboxylic acid; organochlorine compound	carcinogenic agent; metabolite; mouse metabolite	2006	2006	18.0	low	0	1	0
n-vinyl-2-pyrrolidinone	1	pyrrolidin-2-ones		2005	2005	19.0	low	0	1	0
4-nitrosodimethylaniline	1	dimethylaniline; nitroso compound; tertiary amino compound		2008	2008	16.0	low	0	1	0
neutral red	1	hydrochloride	acid-base indicator; dye; two-colour indicator	2004	2004	20.0	low	0	1	0
deuterium oxide	1	deuterated compound; water	NMR solvent	2006	2006	18.0	low	0	1	0
sodium azide	1	inorganic sodium salt	antibacterial agent; explosive; mitochondrial respiratory-chain inhibitor; mutagen	2006	2006	18.0	low	0	1	0
chlorin	2			2006	2011	15.5	low	0	1	1
proline	1	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	2015	2015	9.0	low	0	0	1
singlet oxygen	1	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient	2008	2008	16.0	low	0	1	0
carbodiimides	1	carbodiimide		2011	2011	13.0	low	0	0	1
purpurin 18	2			2006	2007	17.5	medium	0	2	0
riboflavin	1	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite	2006	2006	18.0	low	0	1	0
dansylproline	1			2015	2015	9.0	medium	0	0	1
curcumin	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger	2017	2017	7.0	low	0	0	1
ranitidine	1	C-nitro compound; furans; organic sulfide; tertiary amino compound	anti-ulcer drug; drug allergen; environmental contaminant; H2-receptor antagonist; xenobiotic	2011	2011	13.0	low	0	0	1
1-palmitoyl-2-oleoylglycero-3-phosphoglycerol	1	phosphatidylglycerol		2017	2017	7.0	low	0	0	1
phytochlorin	3			2008	2014	13.0	low	0	1	2
cellulose	1	glycoside		2012	2012	12.0	low	0	0	1
phosphatidylcholines	1	1,2-diacyl-sn-glycero-3-phosphocholine		2012	2012	12.0	low	0	0	1
chlorophyll a	1	chlorophyll; methyl ester	cofactor	1998	1998	26.0	low	1	0	0
chlorin e4	1			2008	2008	16.0	medium	0	1	0
warfarin	1	benzenes; hydroxycoumarin; methyl ketone		2007	2007	17.0	low	0	1	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's
Adenocarcinoma	2	2004	2005	19.5	low	0	2	0
Adenocarcinoma, Basal Cell	2	2004	2005	19.5	low	0	2	0
Benign Neoplasms	1	2012	2012	12.0	low	0	0	1
Breast Cancer	1	2004	2004	20.0	low	0	1	0
Breast Neoplasms	1	2004	2004	20.0	low	0	1	0
Cancer of Colon	2	2004	2005	19.5	low	0	2	0
Cancer of Liver	1	2008	2008	16.0	low	0	1	0
Cancer of Mouth	5	2006	2017	12.4	low	0	1	4
Cancer of Nasopharynx	1	2005	2005	19.0	low	0	1	0
Cancer of Skin	1	1992	1992	32.0	low	1	0	0
Cancer of the Tongue	1	2014	2014	10.0	low	0	0	1
Carcinoma, Epidermoid	4	2006	2014	13.0	low	0	1	3
Carcinoma, Hepatocellular	1	2008	2008	16.0	low	0	1	0
Carcinoma, Squamous Cell	4	2006	2014	13.0	low	0	1	3
Colonic Neoplasms	2	2004	2005	19.5	low	0	2	0
Dermatitis, Contact, Phototoxic	1	2004	2004	20.0	low	0	1	0
Disease Models, Animal	1	2013	2013	11.0	low	0	0	1
Experimental Mammary Neoplasms	1	1995	1995	29.0	low	1	0	0
Experimental Neoplasms	2	2010	2016	11.0	low	0	1	1
Experimental Radiation Injuries	1	1998	1998	26.0	low	1	0	0
Glial Cell Tumors	1	1992	1992	32.0	low	1	0	0
Glioma	1	1992	1992	32.0	low	1	0	0
Hepatocellular Carcinoma	1	2008	2008	16.0	low	0	1	0
Leukemia L 1210	1	1995	1995	29.0	low	1	0	0
Liver Neoplasms	1	2008	2008	16.0	low	0	1	0
Mouth Neoplasms	5	2006	2017	12.4	low	0	1	4
Nasopharyngeal Neoplasms	1	2005	2005	19.0	low	0	1	0
Necrosis	2	1992	2011	22.5	low	1	0	1
Neoplasms	1	2012	2012	12.0	low	0	0	1
Skin Neoplasms	1	1992	1992	32.0	low	1	0	0
Tongue Neoplasms	1	2014	2014	10.0	low	0	0	1

Extracellular pH influences the mode of cell death in human colon adenocarcinoma cells subjected to photodynamic treatment with chlorin p6.
Journal of photochemistry and photobiology. B, Biology, , Nov-01, Volume: 81, Issue:2, 2005

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Microscopic analysis of the localization of two chlorin-based photosensitizers in OSC19 tumors in the mouse oral cavity.
Lasers in surgery and medicine, , Volume: 46, Issue:3, 2014

Photodynamic treatment of oral squamous cell carcinoma in hamster cheek pouch model using chlorin p6-histamine conjugate.
Photodiagnosis and photodynamic therapy, , Volume: 10, Issue:1, 2013

Tumor regression induced by photodynamic treatment with chlorin p(6) in hamster cheek pouch model of oral carcinogenesis: Dependence of mode of tumor cell death on the applied drug dose.
Oral oncology, , Volume: 47, Issue:6, 2011

Evaluation of chlorin p6 for photodynamic treatment of squamous cell carcinoma in the hamster cheek pouch model.
Oral oncology, , Volume: 42, Issue:1, 2006

Extracellular pH influences the mode of cell death in human colon adenocarcinoma cells subjected to photodynamic treatment with chlorin p6.
Journal of photochemistry and photobiology. B, Biology, , Nov-01, Volume: 81, Issue:2, 2005

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Effectiveness of a lysyl chlorin p6/chlorin p6 mixture in photodynamic therapy of the subcutaneous 9L glioma in the rat.
Cancer research, , Mar-01, Volume: 52, Issue:5, 1992

Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 18, Issue:1, 2008

Iodinated chlorin p
Chemico-biological interactions, , Nov-01, Volume: 277, 2017

Photodynamic treatment of oral squamous cell carcinoma in hamster cheek pouch model using chlorin p6-histamine conjugate.
Photodiagnosis and photodynamic therapy, , Volume: 10, Issue:1, 2013

Tumor regression induced by photodynamic treatment with chlorin p(6) in hamster cheek pouch model of oral carcinogenesis: Dependence of mode of tumor cell death on the applied drug dose.
Oral oncology, , Volume: 47, Issue:6, 2011

Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells.
Cancer chemotherapy and pharmacology, , Volume: 68, Issue:2, 2011

Evaluation of chlorin p6 for photodynamic treatment of squamous cell carcinoma in the hamster cheek pouch model.
Oral oncology, , Volume: 42, Issue:1, 2006

Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel Chlorin e6 photosensitizer Fotolon.
International journal of oncology, , Volume: 26, Issue:6, 2005

Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells.
Cancer chemotherapy and pharmacology, , Volume: 68, Issue:2, 2011

Effectiveness of a lysyl chlorin p6/chlorin p6 mixture in photodynamic therapy of the subcutaneous 9L glioma in the rat.
Cancer research, , Mar-01, Volume: 52, Issue:5, 1992

Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 22, Issue:11, 2012

Effectiveness of a lysyl chlorin p6/chlorin p6 mixture in photodynamic therapy of the subcutaneous 9L glioma in the rat.
Cancer research, , Mar-01, Volume: 52, Issue:5, 1992

Microscopic analysis of the localization of two chlorin-based photosensitizers in OSC19 tumors in the mouse oral cavity.
Lasers in surgery and medicine, , Volume: 46, Issue:3, 2014

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Extracellular pH influences the mode of cell death in human colon adenocarcinoma cells subjected to photodynamic treatment with chlorin p6.
Journal of photochemistry and photobiology. B, Biology, , Nov-01, Volume: 81, Issue:2, 2005

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Microscopic analysis of the localization of two chlorin-based photosensitizers in OSC19 tumors in the mouse oral cavity.
Lasers in surgery and medicine, , Volume: 46, Issue:3, 2014

Photodynamic treatment of oral squamous cell carcinoma in hamster cheek pouch model using chlorin p6-histamine conjugate.
Photodiagnosis and photodynamic therapy, , Volume: 10, Issue:1, 2013

Tumor regression induced by photodynamic treatment with chlorin p(6) in hamster cheek pouch model of oral carcinogenesis: Dependence of mode of tumor cell death on the applied drug dose.
Oral oncology, , Volume: 47, Issue:6, 2011

Evaluation of chlorin p6 for photodynamic treatment of squamous cell carcinoma in the hamster cheek pouch model.
Oral oncology, , Volume: 42, Issue:1, 2006

Extracellular pH influences the mode of cell death in human colon adenocarcinoma cells subjected to photodynamic treatment with chlorin p6.
Journal of photochemistry and photobiology. B, Biology, , Nov-01, Volume: 81, Issue:2, 2005

Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, , Volume: 3, Issue:2, 2004

Photodynamic treatment of oral squamous cell carcinoma in hamster cheek pouch model using chlorin p6-histamine conjugate.
Photodiagnosis and photodynamic therapy, , Volume: 10, Issue:1, 2013

Effectiveness of a lysyl chlorin p6/chlorin p6 mixture in photodynamic therapy of the subcutaneous 9L glioma in the rat.
Cancer research, , Mar-01, Volume: 52, Issue:5, 1992

Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 18, Issue:1, 2008

Photosensitization with derivatives of chlorin p6.
Journal of photochemistry and photobiology. B, Biology, , Volume: 28, Issue:1, 1995

Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 18, Issue:1, 2008

Photosensitization with derivatives of chlorin p6.
Journal of photochemistry and photobiology. B, Biology, , Volume: 28, Issue:1, 1995

Iodinated chlorin p
Chemico-biological interactions, , Nov-01, Volume: 277, 2017

Photodynamic treatment of oral squamous cell carcinoma in hamster cheek pouch model using chlorin p6-histamine conjugate.
Photodiagnosis and photodynamic therapy, , Volume: 10, Issue:1, 2013

Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells.
Cancer chemotherapy and pharmacology, , Volume: 68, Issue:2, 2011

Tumor regression induced by photodynamic treatment with chlorin p(6) in hamster cheek pouch model of oral carcinogenesis: Dependence of mode of tumor cell death on the applied drug dose.
Oral oncology, , Volume: 47, Issue:6, 2011

Evaluation of chlorin p6 for photodynamic treatment of squamous cell carcinoma in the hamster cheek pouch model.
Oral oncology, , Volume: 42, Issue:1, 2006

Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel Chlorin e6 photosensitizer Fotolon.
International journal of oncology, , Volume: 26, Issue:6, 2005

Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 22, Issue:11, 2012

Chlorin p6-Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy.
Journal of medicinal chemistry, , 05-26, Volume: 59, Issue:10, 2016

Studies on preparation and photodynamic mechanism of chlorin P6-13,15-N-(cyclohexyl)cycloimide (Chlorin-H) and its antitumor effect for photodynamic therapy in vitro and in vivo.
Bioorganic & medicinal chemistry, , Sep-01, Volume: 18, Issue:17, 2010