Page last updated: 2024-08-07 17:12:30
Dihydrofolate reductase
[no definition available]
Synonyms
EC 1.5.1.3
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| trimethoprim | Streptococcus pneumoniae TIGR4 | IC50 | 64.1815 | 2 | 6 |
| iclaprim | Streptococcus pneumoniae TIGR4 | IC50 | 60.4844 | 1 | 5 |
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase.Journal of medicinal chemistry, , Sep-06, Volume: 50, Issue:18, 2007
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 13, Issue:23, 2003