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D-amino-acid oxidase
A D-amino-acid oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14920]
Synonyms
DAAO;
DAMOX;
DAO;
EC 1.4.3.3
Research
Bioassay Publications (16)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 13 (81.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
Compounds (33)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| benzoic acid | Homo sapiens (human) | IC50 | 62.1723 | 4 | 4 |
| benzoic acid | Homo sapiens (human) | Ki | 22.2800 | 5 | 5 |
| malonic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 2 | 2 |
| niacin | Homo sapiens (human) | IC50 | 1,125.0000 | 1 | 1 |
| kojic acid | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| 3-hydroxy-2-oxoindole | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| thiophene-3-carboxylic acid | Homo sapiens (human) | IC50 | 26.5333 | 3 | 3 |
| thiophene-3-carboxylic acid | Homo sapiens (human) | Ki | 17.8200 | 3 | 3 |
| 3-aminobenzoic acid | Homo sapiens (human) | IC50 | 392.0000 | 1 | 1 |
| adrenalone | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 5-chlorosalicylic acid | Homo sapiens (human) | IC50 | 3,671.0000 | 1 | 1 |
| 5-methylpyrazole-3-carboxylic acid | Homo sapiens (human) | IC50 | 0.7643 | 3 | 3 |
| 3-aminopyridine | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| thiophene-2-carboxylate | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| 2-hydroxy benzimidazole | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2-pyrrolecarboxylic acid | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 3-hydroxypicolinic acid | Homo sapiens (human) | IC50 | 2,478.0000 | 1 | 1 |
| 3-hydroxy-1-benzopyran-2-one | Homo sapiens (human) | IC50 | 0.4726 | 3 | 3 |
| 3-hydroxy-1-benzopyran-2-one | Homo sapiens (human) | Ki | 1.0310 | 4 | 4 |
| oxiniacic acid | Homo sapiens (human) | IC50 | 2,500.0000 | 1 | 1 |
| 6-aminonicotinic acid | Homo sapiens (human) | IC50 | 2,500.0000 | 1 | 1 |
| 2,3-dihydroxypyridine | Homo sapiens (human) | IC50 | 1.1500 | 1 | 1 |
| 5-hydroxynicotinic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 5-fluorosalicylic acid | Homo sapiens (human) | IC50 | 1,045.0000 | 1 | 1 |
| indole-2-carboxylic acid | Homo sapiens (human) | IC50 | 0.7450 | 1 | 1 |
| 2-aminonicotinic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 3-aminopicolinic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 5-aminonicotinic acid | Homo sapiens (human) | IC50 | 2,500.0000 | 2 | 2 |
| crotonic acid | Homo sapiens (human) | IC50 | 477.5000 | 2 | 2 |
| 3-coumaric acid | Homo sapiens (human) | IC50 | 8,134.5000 | 2 | 2 |
| pseudoginsenoside f11 | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-hydroxyquinolin-2(1h)-one | Homo sapiens (human) | IC50 | 0.1671 | 5 | 7 |
| 6-Chlorobenzo[d]isoxazol-3-ol | Homo sapiens (human) | IC50 | 0.1653 | 4 | 4 |
| ceftriaxone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| mofegiline | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| sun | Homo sapiens (human) | IC50 | 4.4435 | 6 | 9 |
| sun | Homo sapiens (human) | Ki | 0.0341 | 3 | 3 |
Drugs with Activation Measurements
Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.Journal of medicinal chemistry, , May-09, Volume: 56, Issue:9, 2013
Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.Journal of medicinal chemistry, , May-09, Volume: 56, Issue:9, 2013
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors.Journal of medicinal chemistry, , May-09, Volume: 56, Issue:9, 2013
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| D-amino-acid oxidase activity | molecular function | Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. [EC:1.4.3.3] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| FAD binding | molecular function | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| peroxisomal matrix | cellular component | The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. [GOC:curators, ISBN:0815316194] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cell projection | cellular component | A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
| presynaptic active zone | cellular component | A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|
| proline catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732] |
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| D-amino acid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. [GOC:ai, GOC:jsg] |
| D-serine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:imk] |
| dopamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732] |
| D-alanine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine. [GOC:ecd] |
| D-serine metabolic process | biological process | The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. [CHEBI:16523, GOC:jsg, GOC:mah] |
| neutrophil-mediated killing of gram-negative bacterium | biological process | The directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, ISBN:0781765196] |