4-phenylbutyric acid has been researched along with Necrosis in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis." | 3.85 | Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. ( Aoyama, T; Arai, K; Ikejima, K; Kon, K; Kusama, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, H | 1 |
| Tang, HB | 1 |
| Kang, J | 1 |
| Shan, L | 1 |
| Song, H | 1 |
| Zhu, K | 1 |
| Wang, J | 1 |
| Ju, G | 1 |
| Wang, YZ | 1 |
| Kusama, H | 1 |
| Kon, K | 1 |
| Ikejima, K | 1 |
| Arai, K | 1 |
| Aoyama, T | 1 |
| Uchiyama, A | 1 |
| Yamashina, S | 1 |
| Watanabe, S | 1 |
| Appelskog, IB | 1 |
| Ammerpohl, O | 1 |
| Svechnikova, IG | 1 |
| Lui, WO | 1 |
| Almqvist, PM | 1 |
| Ekström, TJ | 1 |
3 other studies available for 4-phenylbutyric acid and Necrosis
| Article | Year |
|---|---|
Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic R | 2015 |
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injur | 2017 |
Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Down-Regulation; Enzyme I | 2004 |