Page last updated: 2024-08-07 23:02:48
Monoglyceride lipase
A monoglyceride lipase that is encoded in the genome of mouse. [OMA:O35678, PRO:DNx]
Synonyms
MGL;
EC 3.1.1.23;
Monoacylglycerol lipase;
MAGL
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
Compounds (7)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 2-amino-4-picoline | Mus musculus (house mouse) | IC50 | 0.1600 | 1 | 1 |
| arl-67156 | Mus musculus (house mouse) | Ki | 12.0000 | 1 | 1 |
| urb602 | Mus musculus (house mouse) | IC50 | 19.7900 | 1 | 1 |
| ly2183240 | Mus musculus (house mouse) | IC50 | 0.0045 | 1 | 3 |
| jzl 184 | Mus musculus (house mouse) | IC50 | 0.1355 | 4 | 4 |
| sar127303 | Mus musculus (house mouse) | IC50 | 0.0038 | 1 | 1 |
| mjn110 | Mus musculus (house mouse) | IC50 | 0.1000 | 2 | 2 |
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 41, 2021
Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).European journal of medicinal chemistry, , Volume: 63, 2013
The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 21, Issue:22, 2011
Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017