Caspase-7

A caspase-7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P55210]

Synonyms

CASP-7;
EC 3.4.22.60;
Apoptotic protease Mch-3;
CMH-1;
ICE-like apoptotic protease 3;
ICE-LAP3

Research

Bioassay Publications (14)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (50.00)	29.6817
2010's	7 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (198)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
dihydroxyphenylalanine	Homo sapiens (human)	Potency	15.8489	1
4-amino-1,8-naphthalimide	Homo sapiens (human)	Potency	7.9433	1
amsacrine	Homo sapiens (human)	Potency	15.8489	1
bithionol	Homo sapiens (human)	Potency	31.6228	1
dipyridamole	Homo sapiens (human)	Potency	3.9811	1
ellipticine	Homo sapiens (human)	Potency	12.5893	1
gossypol	Homo sapiens (human)	Potency	16.1303	3
harmaline	Homo sapiens (human)	Potency	11.2947	1
harmalol	Homo sapiens (human)	Potency	12.5893	1
hexachlorophene	Homo sapiens (human)	Potency	31.6228	1
juglone	Homo sapiens (human)	Potency	1.0000	1
mesalamine	Homo sapiens (human)	Potency	16.5311	1
pomiferin	Homo sapiens (human)	Potency	39.8107	1
propidium	Homo sapiens (human)	Potency	2.5119	1
triamterene	Homo sapiens (human)	Potency	12.8127	1
reserpine	Homo sapiens (human)	Potency	7.9433	1
9,10-dimethyl-1,2-benzanthracene	Homo sapiens (human)	Potency	31.6228	1
quinacrine monohydrochloride	Homo sapiens (human)	Potency	3.9811	1
benzanthrone	Homo sapiens (human)	Potency	15.8489	1
7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione	Homo sapiens (human)	Potency	10.0000	1
acriflavine chloride	Homo sapiens (human)	Potency	3.1623	1
aminacrine	Homo sapiens (human)	Potency	12.5893	1
xanthone	Homo sapiens (human)	Potency	25.1189	1
uvitex swn	Homo sapiens (human)	Potency	12.5893	1
1,2-diaminobenzene	Homo sapiens (human)	Potency	31.6228	1
pyrazolanthrone	Homo sapiens (human)	Potency	3.1623	1
benzo(k)fluoranthene	Homo sapiens (human)	Potency	6.3096	1
lithocholic acid	Homo sapiens (human)	Potency	12.5893	1
rhein	Homo sapiens (human)	Potency	25.1189	1
plumbagin	Homo sapiens (human)	Potency	19.9526	1
2-anthramine	Homo sapiens (human)	Potency	31.6228	1
ethidium bromide	Homo sapiens (human)	Potency	6.3096	1
coralyne	Homo sapiens (human)	Potency	3.9811	1
flupirtine	Homo sapiens (human)	Potency	10.0000	1
topotecan hydrochloride	Homo sapiens (human)	Potency	6.5812	1
toxoflavin	Homo sapiens (human)	Potency	3.7636	3
7-amino-4-methylcoumarin	Homo sapiens (human)	Potency	25.1189	1
coumarin 7	Homo sapiens (human)	Potency	0.1585	1
harmol hydrochloride	Homo sapiens (human)	Potency	15.8489	1
quercetin 5,7,3',4'-tetramethyl ether	Homo sapiens (human)	Potency	25.1189	1
10-hydroxycamptothecin	Homo sapiens (human)	Potency	15.8489	1
7-amino-4-trifluoromethylcoumarin	Homo sapiens (human)	Potency	3.9811	1
6-(6-methoxy-1,3-benzodioxol-5-yl)-7-furo[3,2-g][1]benzopyranone	Homo sapiens (human)	Potency	19.9526	1
furamidine	Homo sapiens (human)	Potency	3.9811	1
methotrexate	Homo sapiens (human)	Potency	15.8489	1
isoteolin	Homo sapiens (human)	Potency	31.6228	1
harmalol hydrochloride	Homo sapiens (human)	Potency	3.1623	1
raubasine	Homo sapiens (human)	Potency	25.1189	1
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
nsc 663284	Homo sapiens (human)	Potency	3.1623	1
nsc354961	Homo sapiens (human)	Potency	3.9811	1
dactinomycin	Homo sapiens (human)	Potency	31.6228	1
riboflavin	Homo sapiens (human)	Potency	31.6228	1
2-Methylindole-3-acetic acid	Homo sapiens (human)	Potency	39.8107	1
2-amino-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylic acid methyl ester	Homo sapiens (human)	Potency	15.8489	1
6-amino-2-methyl-8-phenyl-1,6,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile	Homo sapiens (human)	Potency	15.8489	1
2-imino-N,8-dimethyl-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamide	Homo sapiens (human)	Potency	1.5849	1
LSM-19079	Homo sapiens (human)	Potency	15.8489	1
3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamide	Homo sapiens (human)	Potency	19.9526	1
2-[[2-[[4-(2-furanylmethyl)-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide	Homo sapiens (human)	Potency	39.8107	1
5-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	31.6228	1
5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid	Homo sapiens (human)	Potency	25.1189	1
11-[2-(4-morpholinyl)ethylamino]-7,8,9,10-tetrahydrobenzimidazolo[1,2-b]isoquinoline-6-carbonitrile	Homo sapiens (human)	Potency	10.0000	1
3-(benzenesulfonyl)-2-imino-1-(2-oxolanylmethyl)-5-dipyrido[1,2-d-3',4'-f]pyrimidinone	Homo sapiens (human)	Potency	12.5893	1
6-ethoxy-3-[[2-oxolanylmethyl-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]amino]methyl]-1H-quinolin-2-one	Homo sapiens (human)	Potency	31.6228	1
N-[2,5-dimethoxy-4-[[oxo(thiophen-2-yl)methyl]amino]phenyl]-2-furancarboxamide	Homo sapiens (human)	Potency	39.8107	1
9,10-dimethoxy-2,4,6,7-tetrahydro-[1,3]oxazino[4,3-a]isoquinoline-1-carbonitrile	Homo sapiens (human)	Potency	31.6228	1
6-methyl-2-[4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-3-quinolinecarbonitrile	Homo sapiens (human)	Potency	31.6228	1
[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone	Homo sapiens (human)	Potency	39.8107	1
5,7-dimethyl-2-(1-pyrrolidinyl)-3-quinolinecarbonitrile	Homo sapiens (human)	Potency	25.1189	1
2-[[2-(1-azepanyl)-2-oxoethyl]thio]-6-methoxy-3-quinolinecarbonitrile	Homo sapiens (human)	Potency	31.6228	1
8-[2-(4-methoxyphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane	Homo sapiens (human)	Potency	31.6228	1
6-methoxy-3-[[[1-(2-methoxyethyl)-5-tetrazolyl]methyl-(3-pyridinylmethyl)amino]methyl]-1H-quinolin-2-one	Homo sapiens (human)	Potency	31.6228	1
3-[3,4-dihydro-1H-isoquinolin-2-yl-[1-(2-methylbutan-2-yl)-5-tetrazolyl]methyl]-7-methoxy-1H-quinolin-2-one	Homo sapiens (human)	Potency	12.5893	1
N-[(1,3-dimethyl-4-pyrazolyl)methyl]-5-(2-furanyl)-N-methyl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	31.6228	1
6-methoxy-3-[[2-oxolanylmethyl-[[1-(phenylmethyl)-5-tetrazolyl]methyl]amino]methyl]-1H-quinolin-2-one	Homo sapiens (human)	Potency	31.6228	1
3-[[cyclopentyl-[[1-[(4-methoxyphenyl)methyl]-5-tetrazolyl]methyl]amino]methyl]-7-methyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	39.8107	1
5,8-dimethoxy-4-(4-methyl-1-piperazinyl)-2-(trifluoromethyl)quinoline	Homo sapiens (human)	Potency	25.1189	1
N-(2,1,3-benzothiadiazol-4-yl)-3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamide	Homo sapiens (human)	Potency	31.6228	1
5-amino-2-(4-methylphenyl)isoindole-1,3-dione	Homo sapiens (human)	Potency	25.1189	1
(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]methanone	Homo sapiens (human)	Potency	19.9526	1
2-cyano-N-(2-furanylmethyl)-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetamide	Homo sapiens (human)	Potency	31.6228	1
LSM-27020	Homo sapiens (human)	Potency	25.1189	1
2-cyano-2-[3-[4-(phenylmethyl)-1-piperazinyl]-2-quinoxalinyl]acetic acid 2-methoxyethyl ester	Homo sapiens (human)	Potency	25.1189	1
N-ethyl-2-imino-10-methyl-1-[(4-methylphenyl)methyl]-5-oxo-3-dipyrido[3,4-c-1',2'-f]pyrimidinecarboxamide	Homo sapiens (human)	Potency	1.5849	1
5-(2,4-dimethoxyphenyl)-7-(3,4-dimethoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine	Homo sapiens (human)	Potency	31.6228	1
3-methyl-N-(1-propyl-3-pyrazolo[3,4-b]quinolinyl)butanamide	Homo sapiens (human)	Potency	25.1189	1
LSM-32147	Homo sapiens (human)	Potency	25.1189	1
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid hexyl ester	Homo sapiens (human)	Potency	31.6228	1
2-[2-(dimethylamino)ethylthio]-6,6-dimethyl-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidin-4-amine	Homo sapiens (human)	Potency	15.8489	1
3-[[2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-1-oxoethyl]amino]-6-methyl-1H-indole-2-carboxylic acid methyl ester	Homo sapiens (human)	Potency	31.6228	1
N-(1,8-dimethyl-3-pyrazolo[3,4-b]quinolinyl)propanamide	Homo sapiens (human)	Potency	12.5893	1
2-(3-methylphenyl)sulfonyl-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetonitrile	Homo sapiens (human)	Potency	15.8489	1
N-(1-ethyl-7-methyl-3-pyrazolo[3,4-b]quinolinyl)-2-furancarboxamide	Homo sapiens (human)	Potency	15.8489	1
1-(thiophen-2-ylmethyl)-3-thiophen-2-ylsulfonyl-2-pyrrolo[3,2-b]quinoxalinamine	Homo sapiens (human)	Potency	25.1189	1
N-(1,7-dimethyl-3-pyrazolo[3,4-b]quinolinyl)acetamide	Homo sapiens (human)	Potency	25.1189	1
5-(3-methoxyphenyl)-N-(2-oxolanylmethyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	31.6228	1
1-(4-methylphenyl)spiro[1,3-diazinane-5,4'-2,3,3a,5-tetrahydro-1H-pyrrolo[1,2-a]quinoline]-2,4,6-trione	Homo sapiens (human)	Potency	25.1189	1
8-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-1,3-dimethyl-7-[2-(4-morpholinyl)ethyl]purine-2,6-dione	Homo sapiens (human)	Potency	12.5893	1
N,N-diethyl-2-oxo-1H-benzo[cd]indole-6-sulfonamide	Homo sapiens (human)	Potency	25.1189	1
6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-one	Homo sapiens (human)	Potency	0.5012	1
6-(4-morpholinyl)naphthalene-2,3-dicarbonitrile	Homo sapiens (human)	Potency	25.1189	1
3-(5-methoxy-2,2-dimethyl-1-benzopyran-8-yl)-3-oxopropanoic acid	Homo sapiens (human)	Potency	25.1189	1
1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-2-benzo[cd]indolone	Homo sapiens (human)	Potency	25.1189	1
5-[2-(6-hydroxy-3-methyl-2-benzofuranyl)-2-oxoethyl]-2-furancarboxylic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
2-[[oxo(thiophen-2-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester	Homo sapiens (human)	Potency	25.1189	1
N-(2-ethylphenyl)-2-methoxy-5-methylbenzenesulfonamide	Homo sapiens (human)	Potency	15.8489	1
curcumin	Homo sapiens (human)	Potency	12.5893	1
4-[[[2,3-bis(2-pyridinyl)-6-quinoxalinyl]amino]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	15.8489	1
N-[4-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]phenyl]propanamide	Homo sapiens (human)	Potency	25.1189	1
7-(difluoromethyl)-N-(5-methyl-3-isoxazolyl)-5-(4-methylphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	19.9526	1
N-(2-furanylmethyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	15.8489	1
N-(2-furanylmethyl)-5-thiophen-2-yl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	25.1189	1
ym-90709	Homo sapiens (human)	Potency	25.1189	1
6-bromo-3-(4-morpholinyl)-4-phenyl-1H-quinolin-2-one	Homo sapiens (human)	Potency	31.6228	1
3,5-dimethyl-N-[2-(methylthio)phenyl]-4-isoxazolecarboxamide	Homo sapiens (human)	Potency	12.5893	1
2-[[2-(3,4-dimethylanilino)-2-oxoethyl]thio]acetamide	Homo sapiens (human)	Potency	19.9526	1
N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamide	Homo sapiens (human)	Potency	5.0119	1
2-[[4-cyano-6,6,7-trimethyl-1-(4-morpholinyl)-5,8-dihydro-2,7-naphthyridin-3-yl]thio]acetic acid methyl ester	Homo sapiens (human)	Potency	3.1623	1
4-(dimethylsulfamoyl)-N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamide	Homo sapiens (human)	Potency	31.6228	1
1-ethyl-N-[3-(4-morpholinyl)propyl]-2-oxo-6-benzo[cd]indolesulfonamide	Homo sapiens (human)	Potency	15.8489	1
1-[2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl]-3-phenylurea	Homo sapiens (human)	Potency	25.1189	1
4-(3,4-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester	Homo sapiens (human)	Potency	25.1189	1
3-[1-(3-methoxypropyl)-5-thiophen-2-yl-2-pyrrolyl]propanoic acid	Homo sapiens (human)	Potency	15.8489	1
4-amino-2-[[4-(1-azepanylsulfonyl)phenyl]-oxomethyl]isoindole-1,3-dione	Homo sapiens (human)	Potency	12.5893	1
3-[5-(2,5-dimethyl-1-phenyl-3-pyrrolyl)-1,3,4-oxadiazol-2-yl]-1-benzopyran-2-one	Homo sapiens (human)	Potency	15.8489	1
2-(2-oxo-1-benzo[cd]indolyl)-N-(2-oxolanylmethyl)acetamide	Homo sapiens (human)	Potency	25.1189	1
2-cyano-N-(phenylmethyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamide	Homo sapiens (human)	Potency	25.1189	1
2-(3,4-dimethoxyphenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) ester	Homo sapiens (human)	Potency	31.6228	1
3-(4-methylphenyl)sulfonyl-1-(3-oxolanylmethyl)-2-pyrrolo[3,2-b]quinoxalinamine	Homo sapiens (human)	Potency	25.1189	1
1,4-dimethoxy-10H-acridine-9-thione	Homo sapiens (human)	Potency	25.1189	1
9-chloro-6-methylindolo[3,2-b]quinoxaline	Homo sapiens (human)	Potency	31.6228	1
3-[2-[butyl(methyl)amino]ethyl]-6-(4-morpholinyl)-2-sulfanylidene-1H-quinazolin-4-one	Homo sapiens (human)	Potency	31.6228	1
4-[2-[(1'-acetyl-4-oxo-6-spiro[3,4-dihydro-2H-1-benzopyran-2,4'-piperidine]yl)oxy]-1-oxoethyl]-1-piperazinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-10-[2-(4-morpholinyl)ethyl]-4,5,7,9-tetrahydro-2H-acridine-1,8-dione	Homo sapiens (human)	Potency	15.8489	1
2-chloro-6-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinone	Homo sapiens (human)	Potency	15.8489	1
N-[2-(3,4-diethoxyphenyl)ethyl]-1-[6-(4-morpholinyl)-3-pyridazinyl]-4-piperidinecarboxamide	Homo sapiens (human)	Potency	15.8489	1
4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester	Homo sapiens (human)	Potency	25.1189	1
gw 7647	Homo sapiens (human)	Potency	39.8107	1
sto 609	Homo sapiens (human)	Potency	3.9811	1
1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-(2-methylpropyl)purine-2,6-dione	Homo sapiens (human)	Potency	31.6228	1
N-(2-furanylmethyl)-2-[[5-[(2-methyl-1H-indol-3-yl)methyl]-1,3,4-oxadiazol-2-yl]thio]acetamide	Homo sapiens (human)	Potency	19.9526	1
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	Homo sapiens (human)	Potency	31.6228	1
fraxetin	Homo sapiens (human)	Potency	17.9008	1
bilirubin	Homo sapiens (human)	Potency	19.9526	1
scopoletin	Homo sapiens (human)	Potency	3.4173	1
hymecromone	Homo sapiens (human)	Potency	12.5893	1
esculetin	Homo sapiens (human)	Potency	5.9622	1
7-hydroxycoumarin	Homo sapiens (human)	Potency	15.8489	1
yangonin	Homo sapiens (human)	Potency	31.6228	1
3,7,4'-trihydroxyflavone	Homo sapiens (human)	Potency	12.5893	1
fisetin	Homo sapiens (human)	Potency	17.9008	1
morin	Homo sapiens (human)	Potency	15.8489	1
blebbistatin	Homo sapiens (human)	Potency	31.6228	1
3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-2-methyl-1-benzopyran-4-one	Homo sapiens (human)	Potency	25.1189	1
4-methyl-2,3-dihydro-1,4-benzothiazine-6-carboxylic acid methyl ester	Homo sapiens (human)	Potency	25.1189	1
8-(diethylaminomethyl)-7-hydroxy-4-phenyl-1-benzopyran-2-one	Homo sapiens (human)	Potency	15.8489	1
irl 2500	Homo sapiens (human)	Potency	21.1069	3
ly 320135	Homo sapiens (human)	Potency	25.1189	1
6,7-dihydroxyflavone	Homo sapiens (human)	Potency	25.1189	1
5,7-dihydroxy-4-methylcoumarin	Homo sapiens (human)	Potency	25.1189	1
7-hydroxy-4-phenyl-8-(1-piperidinylmethyl)-1-benzopyran-2-one	Homo sapiens (human)	Potency	3.1623	1
isoalloxazine	Homo sapiens (human)	Potency	15.8489	1
2-(5,7-dihydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)acetic acid ethyl ester	Homo sapiens (human)	Potency	15.8489	1
6-ethyl-7-hydroxy-4-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-1-benzopyran-2-one	Homo sapiens (human)	Potency	10.0000	1
7-hydroxy-6-(4-morpholinylmethyl)-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-4-one	Homo sapiens (human)	Potency	25.1189	1
3-(1-benzimidazolyl)-6-ethyl-7-hydroxy-1-benzopyran-4-one	Homo sapiens (human)	Potency	31.6228	1
3,7-dihydroxyflavone	Homo sapiens (human)	Potency	15.8489	1
papaveroline	Homo sapiens (human)	Potency	3.1623	1
3,5-di-tert-butylchalcone 4'-carboxylic acid	Homo sapiens (human)	Potency	39.8107	1
nitrofurantoin	Homo sapiens (human)	Potency	31.6228	1
bvt.948	Homo sapiens (human)	Potency	10.0000	1
LSM-6455	Homo sapiens (human)	Potency	25.1189	1
sepiapterin	Homo sapiens (human)	Potency	12.5893	1
hematein	Homo sapiens (human)	Potency	25.1189	1
7-hydroxyquinoline	Homo sapiens (human)	Potency	15.8489	1

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
isoquinoline-1,3,4-trione	Homo sapiens (human)	IC50	0.8058	2	6
n-methylisatin	Homo sapiens (human)	IC50	50.0000	1	1
1,2-benzisothiazoline-3-one	Homo sapiens (human)	IC50	137.4000	1	1
acetyl-aspartyl-glutamyl-valyl-aspartal	Homo sapiens (human)	IC50	0.0560	10	15
5-Nitroisatin	Homo sapiens (human)	IC50	3.0000	1	1
n-acetyltyrosyl-valyl-alanyl-aspartyl aldehyde	Homo sapiens (human)	IC50	0.0082	2	2
benzyloxycarbonyl-phe-ala-fluormethylketone	Homo sapiens (human)	IC50	100.0000	1	1
grassystatin a	Homo sapiens (human)	IC50	5.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-carboxyarabinitol 1-phosphate	Homo sapiens (human)	EC50	4.5000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-hydroxyanthranilic acid	Homo sapiens (human)	AC50	6.1400	1	0
3,3',4,5'-tetrahydroxystilbene	Homo sapiens (human)	AC50	70.0000	1	0
stictic acid	Homo sapiens (human)	AC50	44.3300	1	0
(R)-Roemerine	Homo sapiens (human)	AC50	1.5100	1	0
hematoxylin	Homo sapiens (human)	AC50	68.4900	1	0
1,3(2h,4h)-isoquinolinedione	Homo sapiens (human)	AC50	1.3200	1	0
3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone	Homo sapiens (human)	AC50	9.6500	1	0
1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione	Homo sapiens (human)	AC50	0.3710	1	0
myricetin	Homo sapiens (human)	AC50	5.4000	1	0
4-[(3aR,4S,9bS)-8-[(4-methoxyphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid	Homo sapiens (human)	AC50	70.0000	1	0
xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside	Homo sapiens (human)	AC50	30.9300	1	0
MK-8353	Homo sapiens (human)	Activity	0.1850	1	1
galloflavin	Homo sapiens (human)	AC50	2.3500	1	0

Enables

This protein enables 8 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
aspartic-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [ISBN:0198506732]
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
cysteine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
cysteine-type endopeptidase activity involved in apoptotic process	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. [GOC:mtg_apoptosis]
cysteine-type endopeptidase activity involved in execution phase of apoptosis	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. [GOC:mtg_apoptosis, Wikipedia:Caspase]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 4 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 17 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
heart development	biological process	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
response to UV	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb]
protein processing	biological process	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
defense response to bacterium	biological process	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
fibroblast apoptotic process	biological process	Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]
striated muscle cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]
neuron apoptotic process	biological process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]
protein maturation	biological process	Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai]
lymphocyte apoptotic process	biological process	Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
cellular response to staurosporine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. [GOC:mah]
execution phase of apoptosis	biological process	A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:mtg_apoptosis, PMID:21760595]
positive regulation of plasma membrane repair	biological process	Any process that activates or increases the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]
positive regulation of neuron apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]

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