Proteins > Caspase-7
Page last updated: 2024-08-07 16:51:15

Caspase-7

A caspase-7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P55210]

Synonyms

CASP-7;
EC 3.4.22.60;
Apoptotic protease Mch-3;
CMH-1;
ICE-like apoptotic protease 3;
ICE-LAP3

Research

Bioassay Publications (14)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Compounds (198)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
dihydroxyphenylalanineHomo sapiens (human)Potency15.848910
4-amino-1,8-naphthalimideHomo sapiens (human)Potency7.943310
amsacrineHomo sapiens (human)Potency15.848910
bithionolHomo sapiens (human)Potency31.622810
dipyridamoleHomo sapiens (human)Potency3.981110
ellipticineHomo sapiens (human)Potency12.589310
gossypolHomo sapiens (human)Potency16.130330
harmalineHomo sapiens (human)Potency11.294710
harmalolHomo sapiens (human)Potency12.589310
hexachloropheneHomo sapiens (human)Potency31.622810
jugloneHomo sapiens (human)Potency1.000010
mesalamineHomo sapiens (human)Potency16.531110
pomiferinHomo sapiens (human)Potency39.810710
propidiumHomo sapiens (human)Potency2.511910
triamtereneHomo sapiens (human)Potency12.812710
reserpineHomo sapiens (human)Potency7.943310
9,10-dimethyl-1,2-benzanthraceneHomo sapiens (human)Potency31.622810
quinacrine monohydrochlorideHomo sapiens (human)Potency3.981110
benzanthroneHomo sapiens (human)Potency15.848910
7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dioneHomo sapiens (human)Potency10.000010
acriflavine chlorideHomo sapiens (human)Potency3.162310
aminacrineHomo sapiens (human)Potency12.589310
xanthoneHomo sapiens (human)Potency25.118910
uvitex swnHomo sapiens (human)Potency12.589310
1,2-diaminobenzeneHomo sapiens (human)Potency31.622810
pyrazolanthroneHomo sapiens (human)Potency3.162310
benzo(k)fluorantheneHomo sapiens (human)Potency6.309610
lithocholic acidHomo sapiens (human)Potency12.589310
rheinHomo sapiens (human)Potency25.118910
plumbaginHomo sapiens (human)Potency19.952610
2-anthramineHomo sapiens (human)Potency31.622810
ethidium bromideHomo sapiens (human)Potency6.309610
coralyneHomo sapiens (human)Potency3.981110
flupirtineHomo sapiens (human)Potency10.000010
topotecan hydrochlorideHomo sapiens (human)Potency6.581210
toxoflavinHomo sapiens (human)Potency3.763630
7-amino-4-methylcoumarinHomo sapiens (human)Potency25.118910
coumarin 7Homo sapiens (human)Potency0.158510
harmol hydrochlorideHomo sapiens (human)Potency15.848910
quercetin 5,7,3',4'-tetramethyl etherHomo sapiens (human)Potency25.118910
10-hydroxycamptothecinHomo sapiens (human)Potency15.848910
7-amino-4-trifluoromethylcoumarinHomo sapiens (human)Potency3.981110
6-(6-methoxy-1,3-benzodioxol-5-yl)-7-furo[3,2-g][1]benzopyranoneHomo sapiens (human)Potency19.952610
furamidineHomo sapiens (human)Potency3.981110
methotrexateHomo sapiens (human)Potency15.848910
isoteolinHomo sapiens (human)Potency31.622810
harmalol hydrochlorideHomo sapiens (human)Potency3.162310
raubasineHomo sapiens (human)Potency25.118910
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl esterHomo sapiens (human)Potency25.118910
nsc 663284Homo sapiens (human)Potency3.162310
nsc354961Homo sapiens (human)Potency3.981110
dactinomycinHomo sapiens (human)Potency31.622810
riboflavinHomo sapiens (human)Potency31.622810
2-Methylindole-3-acetic acidHomo sapiens (human)Potency39.810710
2-amino-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylic acid methyl esterHomo sapiens (human)Potency15.848910
6-amino-2-methyl-8-phenyl-1,6,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrileHomo sapiens (human)Potency15.848910
2-imino-N,8-dimethyl-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamideHomo sapiens (human)Potency1.584910
LSM-19079Homo sapiens (human)Potency15.848910
3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamideHomo sapiens (human)Potency19.952610
2-[[2-[[4-(2-furanylmethyl)-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamideHomo sapiens (human)Potency39.810710
5-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamideHomo sapiens (human)Potency31.622810
5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acidHomo sapiens (human)Potency25.118910
11-[2-(4-morpholinyl)ethylamino]-7,8,9,10-tetrahydrobenzimidazolo[1,2-b]isoquinoline-6-carbonitrileHomo sapiens (human)Potency10.000010
3-(benzenesulfonyl)-2-imino-1-(2-oxolanylmethyl)-5-dipyrido[1,2-d-3',4'-f]pyrimidinoneHomo sapiens (human)Potency12.589310
6-ethoxy-3-[[2-oxolanylmethyl-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]amino]methyl]-1H-quinolin-2-oneHomo sapiens (human)Potency31.622810
N-[2,5-dimethoxy-4-[[oxo(thiophen-2-yl)methyl]amino]phenyl]-2-furancarboxamideHomo sapiens (human)Potency39.810710
9,10-dimethoxy-2,4,6,7-tetrahydro-[1,3]oxazino[4,3-a]isoquinoline-1-carbonitrileHomo sapiens (human)Potency31.622810
6-methyl-2-[4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-3-quinolinecarbonitrileHomo sapiens (human)Potency31.622810
[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanoneHomo sapiens (human)Potency39.810710
5,7-dimethyl-2-(1-pyrrolidinyl)-3-quinolinecarbonitrileHomo sapiens (human)Potency25.118910
2-[[2-(1-azepanyl)-2-oxoethyl]thio]-6-methoxy-3-quinolinecarbonitrileHomo sapiens (human)Potency31.622810
8-[2-(4-methoxyphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decaneHomo sapiens (human)Potency31.622810
6-methoxy-3-[[[1-(2-methoxyethyl)-5-tetrazolyl]methyl-(3-pyridinylmethyl)amino]methyl]-1H-quinolin-2-oneHomo sapiens (human)Potency31.622810
3-[3,4-dihydro-1H-isoquinolin-2-yl-[1-(2-methylbutan-2-yl)-5-tetrazolyl]methyl]-7-methoxy-1H-quinolin-2-oneHomo sapiens (human)Potency12.589310
N-[(1,3-dimethyl-4-pyrazolyl)methyl]-5-(2-furanyl)-N-methyl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamideHomo sapiens (human)Potency31.622810
6-methoxy-3-[[2-oxolanylmethyl-[[1-(phenylmethyl)-5-tetrazolyl]methyl]amino]methyl]-1H-quinolin-2-oneHomo sapiens (human)Potency31.622810
3-[[cyclopentyl-[[1-[(4-methoxyphenyl)methyl]-5-tetrazolyl]methyl]amino]methyl]-7-methyl-1H-quinolin-2-oneHomo sapiens (human)Potency39.810710
5,8-dimethoxy-4-(4-methyl-1-piperazinyl)-2-(trifluoromethyl)quinolineHomo sapiens (human)Potency25.118910
N-(2,1,3-benzothiadiazol-4-yl)-3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamideHomo sapiens (human)Potency31.622810
5-amino-2-(4-methylphenyl)isoindole-1,3-dioneHomo sapiens (human)Potency25.118910
(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]methanoneHomo sapiens (human)Potency19.952610
2-cyano-N-(2-furanylmethyl)-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetamideHomo sapiens (human)Potency31.622810
LSM-27020Homo sapiens (human)Potency25.118910
2-cyano-2-[3-[4-(phenylmethyl)-1-piperazinyl]-2-quinoxalinyl]acetic acid 2-methoxyethyl esterHomo sapiens (human)Potency25.118910
N-ethyl-2-imino-10-methyl-1-[(4-methylphenyl)methyl]-5-oxo-3-dipyrido[3,4-c-1',2'-f]pyrimidinecarboxamideHomo sapiens (human)Potency1.584910
5-(2,4-dimethoxyphenyl)-7-(3,4-dimethoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidineHomo sapiens (human)Potency31.622810
3-methyl-N-(1-propyl-3-pyrazolo[3,4-b]quinolinyl)butanamideHomo sapiens (human)Potency25.118910
LSM-32147Homo sapiens (human)Potency25.118910
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid hexyl esterHomo sapiens (human)Potency31.622810
2-[2-(dimethylamino)ethylthio]-6,6-dimethyl-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidin-4-amineHomo sapiens (human)Potency15.848910
3-[[2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-1-oxoethyl]amino]-6-methyl-1H-indole-2-carboxylic acid methyl esterHomo sapiens (human)Potency31.622810
N-(1,8-dimethyl-3-pyrazolo[3,4-b]quinolinyl)propanamideHomo sapiens (human)Potency12.589310
2-(3-methylphenyl)sulfonyl-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetonitrileHomo sapiens (human)Potency15.848910
N-(1-ethyl-7-methyl-3-pyrazolo[3,4-b]quinolinyl)-2-furancarboxamideHomo sapiens (human)Potency15.848910
1-(thiophen-2-ylmethyl)-3-thiophen-2-ylsulfonyl-2-pyrrolo[3,2-b]quinoxalinamineHomo sapiens (human)Potency25.118910
N-(1,7-dimethyl-3-pyrazolo[3,4-b]quinolinyl)acetamideHomo sapiens (human)Potency25.118910
5-(3-methoxyphenyl)-N-(2-oxolanylmethyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamideHomo sapiens (human)Potency31.622810
1-(4-methylphenyl)spiro[1,3-diazinane-5,4'-2,3,3a,5-tetrahydro-1H-pyrrolo[1,2-a]quinoline]-2,4,6-trioneHomo sapiens (human)Potency25.118910
8-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-1,3-dimethyl-7-[2-(4-morpholinyl)ethyl]purine-2,6-dioneHomo sapiens (human)Potency12.589310
N,N-diethyl-2-oxo-1H-benzo[cd]indole-6-sulfonamideHomo sapiens (human)Potency25.118910
6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-oneHomo sapiens (human)Potency0.501210
6-(4-morpholinyl)naphthalene-2,3-dicarbonitrileHomo sapiens (human)Potency25.118910
3-(5-methoxy-2,2-dimethyl-1-benzopyran-8-yl)-3-oxopropanoic acidHomo sapiens (human)Potency25.118910
1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-2-benzo[cd]indoloneHomo sapiens (human)Potency25.118910
5-[2-(6-hydroxy-3-methyl-2-benzofuranyl)-2-oxoethyl]-2-furancarboxylic acid ethyl esterHomo sapiens (human)Potency25.118910
2-[[oxo(thiophen-2-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl esterHomo sapiens (human)Potency25.118910
N-(2-ethylphenyl)-2-methoxy-5-methylbenzenesulfonamideHomo sapiens (human)Potency15.848910
curcuminHomo sapiens (human)Potency12.589310
4-[[[2,3-bis(2-pyridinyl)-6-quinoxalinyl]amino]-oxomethyl]-1-piperazinecarboxylic acid ethyl esterHomo sapiens (human)Potency15.848910
N-[4-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]phenyl]propanamideHomo sapiens (human)Potency25.118910
7-(difluoromethyl)-N-(5-methyl-3-isoxazolyl)-5-(4-methylphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamideHomo sapiens (human)Potency19.952610
N-(2-furanylmethyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamideHomo sapiens (human)Potency15.848910
N-(2-furanylmethyl)-5-thiophen-2-yl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamideHomo sapiens (human)Potency25.118910
ym-90709Homo sapiens (human)Potency25.118910
6-bromo-3-(4-morpholinyl)-4-phenyl-1H-quinolin-2-oneHomo sapiens (human)Potency31.622810
3,5-dimethyl-N-[2-(methylthio)phenyl]-4-isoxazolecarboxamideHomo sapiens (human)Potency12.589310
2-[[2-(3,4-dimethylanilino)-2-oxoethyl]thio]acetamideHomo sapiens (human)Potency19.952610
N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamideHomo sapiens (human)Potency5.011910
2-[[4-cyano-6,6,7-trimethyl-1-(4-morpholinyl)-5,8-dihydro-2,7-naphthyridin-3-yl]thio]acetic acid methyl esterHomo sapiens (human)Potency3.162310
4-(dimethylsulfamoyl)-N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamideHomo sapiens (human)Potency31.622810
1-ethyl-N-[3-(4-morpholinyl)propyl]-2-oxo-6-benzo[cd]indolesulfonamideHomo sapiens (human)Potency15.848910
1-[2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl]-3-phenylureaHomo sapiens (human)Potency25.118910
4-(3,4-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl esterHomo sapiens (human)Potency25.118910
3-[1-(3-methoxypropyl)-5-thiophen-2-yl-2-pyrrolyl]propanoic acidHomo sapiens (human)Potency15.848910
4-amino-2-[[4-(1-azepanylsulfonyl)phenyl]-oxomethyl]isoindole-1,3-dioneHomo sapiens (human)Potency12.589310
3-[5-(2,5-dimethyl-1-phenyl-3-pyrrolyl)-1,3,4-oxadiazol-2-yl]-1-benzopyran-2-oneHomo sapiens (human)Potency15.848910
2-(2-oxo-1-benzo[cd]indolyl)-N-(2-oxolanylmethyl)acetamideHomo sapiens (human)Potency25.118910
2-cyano-N-(phenylmethyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamideHomo sapiens (human)Potency25.118910
2-(3,4-dimethoxyphenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) esterHomo sapiens (human)Potency31.622810
3-(4-methylphenyl)sulfonyl-1-(3-oxolanylmethyl)-2-pyrrolo[3,2-b]quinoxalinamineHomo sapiens (human)Potency25.118910
1,4-dimethoxy-10H-acridine-9-thioneHomo sapiens (human)Potency25.118910
9-chloro-6-methylindolo[3,2-b]quinoxalineHomo sapiens (human)Potency31.622810
3-[2-[butyl(methyl)amino]ethyl]-6-(4-morpholinyl)-2-sulfanylidene-1H-quinazolin-4-oneHomo sapiens (human)Potency31.622810
4-[2-[(1'-acetyl-4-oxo-6-spiro[3,4-dihydro-2H-1-benzopyran-2,4'-piperidine]yl)oxy]-1-oxoethyl]-1-piperazinecarboxylic acid ethyl esterHomo sapiens (human)Potency25.118910
9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-10-[2-(4-morpholinyl)ethyl]-4,5,7,9-tetrahydro-2H-acridine-1,8-dioneHomo sapiens (human)Potency15.848910
2-chloro-6-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinoneHomo sapiens (human)Potency15.848910
N-[2-(3,4-diethoxyphenyl)ethyl]-1-[6-(4-morpholinyl)-3-pyridazinyl]-4-piperidinecarboxamideHomo sapiens (human)Potency15.848910
4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl esterHomo sapiens (human)Potency25.118910
gw 7647Homo sapiens (human)Potency39.810710
sto 609Homo sapiens (human)Potency3.981110
1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-(2-methylpropyl)purine-2,6-dioneHomo sapiens (human)Potency31.622810
N-(2-furanylmethyl)-2-[[5-[(2-methyl-1H-indol-3-yl)methyl]-1,3,4-oxadiazol-2-yl]thio]acetamideHomo sapiens (human)Potency19.952610
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acidHomo sapiens (human)Potency31.622810
fraxetinHomo sapiens (human)Potency17.900810
bilirubinHomo sapiens (human)Potency19.952610
scopoletinHomo sapiens (human)Potency3.417310
hymecromoneHomo sapiens (human)Potency12.589310
esculetinHomo sapiens (human)Potency5.962210
7-hydroxycoumarinHomo sapiens (human)Potency15.848910
yangoninHomo sapiens (human)Potency31.622810
3,7,4'-trihydroxyflavoneHomo sapiens (human)Potency12.589310
fisetinHomo sapiens (human)Potency17.900810
morinHomo sapiens (human)Potency15.848910
blebbistatinHomo sapiens (human)Potency31.622810
3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-2-methyl-1-benzopyran-4-oneHomo sapiens (human)Potency25.118910
4-methyl-2,3-dihydro-1,4-benzothiazine-6-carboxylic acid methyl esterHomo sapiens (human)Potency25.118910
8-(diethylaminomethyl)-7-hydroxy-4-phenyl-1-benzopyran-2-oneHomo sapiens (human)Potency15.848910
irl 2500Homo sapiens (human)Potency21.106930
ly 320135Homo sapiens (human)Potency25.118910
6,7-dihydroxyflavoneHomo sapiens (human)Potency25.118910
5,7-dihydroxy-4-methylcoumarinHomo sapiens (human)Potency25.118910
7-hydroxy-4-phenyl-8-(1-piperidinylmethyl)-1-benzopyran-2-oneHomo sapiens (human)Potency3.162310
isoalloxazineHomo sapiens (human)Potency15.848910
2-(5,7-dihydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)acetic acid ethyl esterHomo sapiens (human)Potency15.848910
6-ethyl-7-hydroxy-4-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-1-benzopyran-2-oneHomo sapiens (human)Potency10.000010
7-hydroxy-6-(4-morpholinylmethyl)-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-4-oneHomo sapiens (human)Potency25.118910
3-(1-benzimidazolyl)-6-ethyl-7-hydroxy-1-benzopyran-4-oneHomo sapiens (human)Potency31.622810
3,7-dihydroxyflavoneHomo sapiens (human)Potency15.848910
papaverolineHomo sapiens (human)Potency3.162310
3,5-di-tert-butylchalcone 4'-carboxylic acidHomo sapiens (human)Potency39.810710
nitrofurantoinHomo sapiens (human)Potency31.622810
bvt.948Homo sapiens (human)Potency10.000010
LSM-6455Homo sapiens (human)Potency25.118910
sepiapterinHomo sapiens (human)Potency12.589310
hemateinHomo sapiens (human)Potency25.118910
7-hydroxyquinolineHomo sapiens (human)Potency15.848910

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
isoquinoline-1,3,4-trioneHomo sapiens (human)IC500.805826
n-methylisatinHomo sapiens (human)IC5050.000011
1,2-benzisothiazoline-3-oneHomo sapiens (human)IC50137.400011
acetyl-aspartyl-glutamyl-valyl-aspartalHomo sapiens (human)IC500.05601015
5-NitroisatinHomo sapiens (human)IC503.000011
n-acetyltyrosyl-valyl-alanyl-aspartyl aldehydeHomo sapiens (human)IC500.008222
benzyloxycarbonyl-phe-ala-fluormethylketoneHomo sapiens (human)IC50100.000011
grassystatin aHomo sapiens (human)IC505.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
2-carboxyarabinitol 1-phosphateHomo sapiens (human)EC504.500022

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3-hydroxyanthranilic acidHomo sapiens (human)AC506.140010
3,3',4,5'-tetrahydroxystilbeneHomo sapiens (human)AC5070.000010
stictic acidHomo sapiens (human)AC5044.330010
(R)-RoemerineHomo sapiens (human)AC501.510010
hematoxylinHomo sapiens (human)AC5068.490010
1,3(2h,4h)-isoquinolinedioneHomo sapiens (human)AC501.320010
3-Hydroxy-1-(4-hydroxyphenyl)-1-propanoneHomo sapiens (human)AC509.650010
1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dioneHomo sapiens (human)AC500.371010
myricetinHomo sapiens (human)AC505.400010
4-[(3aR,4S,9bS)-8-[(4-methoxyphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acidHomo sapiens (human)AC5070.000010
xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-GlucopyranosideHomo sapiens (human)AC5030.930010
MK-8353Homo sapiens (human)Activity0.185011
galloflavinHomo sapiens (human)AC502.350010

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
RNA bindingmolecular functionBinding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
aspartic-type endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [ISBN:0198506732]
cysteine-type endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
peptidase activitymolecular functionCatalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
cysteine-type peptidase activitymolecular functionCatalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
cysteine-type endopeptidase activity involved in apoptotic processmolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. [GOC:mtg_apoptosis]
cysteine-type endopeptidase activity involved in execution phase of apoptosismolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. [GOC:mtg_apoptosis, Wikipedia:Caspase]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 4 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 17 target(s):

TargetCategoryDefinition
proteolysisbiological processThe hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
apoptotic processbiological processA programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
heart developmentbiological processThe process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
response to UVbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb]
protein processingbiological processAny protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
protein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
defense response to bacteriumbiological processReactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
fibroblast apoptotic processbiological processAny apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]
striated muscle cell differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]
neuron apoptotic processbiological processAny apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]
protein maturationbiological processAny process leading to the attainment of the full functional capacity of a protein. [GOC:ai]
lymphocyte apoptotic processbiological processAny apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
cellular response to staurosporinebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. [GOC:mah]
execution phase of apoptosisbiological processA stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:mtg_apoptosis, PMID:21760595]
positive regulation of plasma membrane repairbiological processAny process that activates or increases the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]
positive regulation of neuron apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]