Page last updated: 2024-10-24

carmustine and Necrosis

carmustine has been researched along with Necrosis in 21 studies

Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"The outcome after treatment for glioblastoma remains poor."6.69Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme: a phase II study. ( Altavilla, G; Brandes, AA; Carollo, C; Chierichetti, F; Ermani, M; Florentino, MV; Rigon, A; Turazzi, S; Zampieri, P, 1998)
"During follow-up, local disease progression was observed in 27 patients, and 23 of them died."5.35Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme. ( Albright, RE; Breneman, JC; Darakchiev, BJ; Warnick, RE, 2008)
" Here we examine the extent of β-GUS release in small C6 glioma tumors after a single treatment of doxorubicin (DOX), carmustine (BCNU) and tumor necrosis factor α (TNF-α) with positron emission tomography (PET) and the tracer 1-O-(4-(2-fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-d-glucopyronuronate, [(18)F]FEAnGA, which has been proven to be selective for extracellular β-GUS."3.78Induction of β-glucuronidase release by cytostatic agents in small tumors. ( Antunes, IF; de Vries, EF; Di Gialleonardo, V; Dierckx, RA; Elsinga, PH; Haisma, HJ; van Waarde, A; Willemsen, AT, 2012)
"Diquat administration produces hepatic necrosis in male Fischer-344 rats, and minimally in male Sprague-Dawley rats, with massive oxidant stress observable in both strains as evidenced by increased biliary efflux of glutathione disulfide (GSSG)."3.67Effect of BCNU pretreatment on diquat-induced oxidant stress and hepatotoxicity. ( Smith, CV, 1987)
"Carmustine 80 mg/m(2) was given during RT, then every 8 weeks for 6 cycles."2.74Phase I three-dimensional conformal radiation dose escalation study in newly diagnosed glioblastoma: Radiation Therapy Oncology Group Trial 98-03. ( Curran, WJ; Diaz, A; Gilbert, MR; Kresel, JJ; Mehta, MP; Michalski, JM; Moughan, J; Purdy, J; Simpson, J; Tsien, C, 2009)
"The outcome after treatment for glioblastoma remains poor."2.69Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme: a phase II study. ( Altavilla, G; Brandes, AA; Carollo, C; Chierichetti, F; Ermani, M; Florentino, MV; Rigon, A; Turazzi, S; Zampieri, P, 1998)
"Radiation necrosis impacts the quality of life in cancer survivors, and it is essential to detect and effectively treat this entity as early as possible."2.49Cerebral radiation necrosis: a review of the pathobiology, diagnosis and management considerations. ( Marko, NF; Rahmathulla, G; Weil, RJ, 2013)
"During follow-up, local disease progression was observed in 27 patients, and 23 of them died."1.35Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme. ( Albright, RE; Breneman, JC; Darakchiev, BJ; Warnick, RE, 2008)
" With local delivery of O6BG, the MTD of BCNU in combination with O6BG was increased."1.31Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model. ( Biser-Rohrbaugh, A; Bunton, TE; Carson, BS; Gabikian, P; Guarnieri, M; Tyler, BM; Weingart, J; Wu, QZ, 2002)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199011 (52.38)18.7374
1990's3 (14.29)18.2507
2000's4 (19.05)29.6817
2010's3 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rahmathulla, G1
Marko, NF1
Weil, RJ1
Tsien, C1
Moughan, J1
Michalski, JM1
Gilbert, MR1
Purdy, J1
Simpson, J1
Kresel, JJ1
Curran, WJ1
Diaz, A1
Mehta, MP1
Rusthoven, KE1
Olsen, C1
Franklin, W1
Kleinschmidt-DeMasters, BK2
Kavanagh, BD1
Gaspar, LE1
Lillehei, K1
Waziri, A1
Damek, DM1
Chen, C1
Antunes, IF1
Haisma, HJ1
Elsinga, PH1
Di Gialleonardo, V1
van Waarde, A1
Willemsen, AT1
Dierckx, RA1
de Vries, EF1
Guarnieri, M1
Biser-Rohrbaugh, A1
Tyler, BM1
Gabikian, P1
Bunton, TE1
Wu, QZ1
Weingart, J1
Carson, BS1
Darakchiev, BJ1
Albright, RE1
Breneman, JC1
Warnick, RE1
Moore, JV1
Kokunai, T1
Kuwamura, K1
Brandes, AA1
Rigon, A1
Zampieri, P1
Ermani, M1
Carollo, C1
Altavilla, G1
Turazzi, S1
Chierichetti, F1
Florentino, MV1
Antunes, F1
Cadenas, E1
Mahaley, MS1
Vogel, FS1
Burger, P1
Ghatak, NR1
Tonn, JC1
Roosen, K1
Schachenmayr, W1
Nagahiro, S1
Yamamoto, YL1
Diksic, M1
Mitsuka, S1
Sugimoto, S1
Feindel, W1
Rosenblum, MK1
Delattre, JY1
Walker, RW1
Shapiro, WR1
Di Chiro, G1
Oldfield, E1
Wright, DC1
De Michele, D1
Katz, DA1
Patronas, NJ1
Doppman, JL1
Larson, SM1
Ito, M1
Kufta, CV1
Steen, RG1
Tamargo, RJ1
McGovern, KA1
Rajan, SS1
Brem, H1
Wehrle, JP1
Glickson, JD1
Sijens, PE1
Bovee, WM1
Smith, CV1
Théron, J1
Villemure, JG1
Worthington, C1
Tyler, JL1
Loth, TS1
Eversmann, WW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase I/II Radiation Dose Escalation Study Applying Conformal Radiation Therapy in Supratentorial Glioblastoma Multiforme[NCT00003417]Phase 1/Phase 240 participants (Anticipated)Interventional1998-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for carmustine and Necrosis

ArticleYear
Cerebral radiation necrosis: a review of the pathobiology, diagnosis and management considerations.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:4

    Topics: Anticoagulants; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brachytherapy; Brain Neoplas

2013

Trials

2 trials available for carmustine and Necrosis

ArticleYear
Phase I three-dimensional conformal radiation dose escalation study in newly diagnosed glioblastoma: Radiation Therapy Oncology Group Trial 98-03.
    International journal of radiation oncology, biology, physics, 2009, Mar-01, Volume: 73, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain; Carmustine; Combined Modality Therapy; Drug A

2009
Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme: a phase II study.
    Cancer, 1998, Jan-15, Volume: 82, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytog

1998

Other Studies

18 other studies available for carmustine and Necrosis

ArticleYear
Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation series.
    International journal of radiation oncology, biology, physics, 2011, Sep-01, Volume: 81, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Colorado;

2011
Induction of β-glucuronidase release by cytostatic agents in small tumors.
    Molecular pharmaceutics, 2012, Nov-05, Volume: 9, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine

2012
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Dose-Resp

2002
Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme.
    Journal of neurosurgery, 2008, Volume: 108, Issue:2

    Topics: Age Factors; Aged; Antineoplastic Agents, Alkylating; Brachytherapy; Brain; Brain Neoplasms; Carmust

2008
Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs.
    British journal of cancer, 1984, Volume: 49, Issue:1

    Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Cyclophosphamide; Dactinomycin; Doxorubic

1984
Effect of perfluorochemicals on BCNU chemotherapy: preliminary study in a rat brain tumor model.
    Surgical neurology, 1982, Volume: 18, Issue:4

    Topics: Animals; Brain; Brain Neoplasms; Carmustine; Drug Combinations; Drug Therapy, Combination; Fluorocar

1982
Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state.
    Free radical biology & medicine, 2001, May-01, Volume: 30, Issue:9

    Topics: 2,2'-Dipyridyl; Apoptosis; Carmustine; Chelating Agents; Deferoxamine; Diamide; Enzyme Inhibitors; F

2001
Neuropathology of tissues from patients treated by the Brain Tumor Study Group.
    National Cancer Institute monograph, 1977, Volume: 46

    Topics: Adult; Anaplasia; Brain Neoplasms; Carmustine; Female; Glioma; Humans; Male; Necrosis; Radiation Inj

1977
Brain necroses after intraarterial chemotherapy and irradiation of malignant gliomas--a complication of both ACNU and BCNU?
    Journal of neuro-oncology, 1991, Volume: 11, Issue:3

    Topics: Brain; Brain Diseases; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therap

1991
Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography.
    Neurosurgery, 1991, Volume: 29, Issue:1

    Topics: Aminobutyrates; Amygdala; Animals; Antipyrine; Autoradiography; Blood-Brain Barrier; Carbon Radioiso

1991
Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: a pathological study.
    Journal of neuro-oncology, 1989, Volume: 7, Issue:3

    Topics: Brain Diseases; Brain Neoplasms; Carmustine; Combined Modality Therapy; Glioma; Humans; Infusions, I

1989
Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies.
    AJR. American journal of roentgenology, 1988, Volume: 150, Issue:1

    Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Carmustine; Child; Child, Preschool; Deoxyglucose;

1988
In vivo 31P nuclear magnetic resonance spectroscopy of subcutaneous 9L gliosarcoma: effects of tumor growth and treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea on tumor bioenergetics and histology.
    Cancer research, 1988, Feb-01, Volume: 48, Issue:3

    Topics: Animals; Carmustine; Energy Metabolism; Extracellular Space; Glioma; Magnetic Resonance Spectroscopy

1988
In vivo 31P nuclear magnetic resonance spectroscopy of subcutaneous 9L gliosarcoma: effects of tumor growth and treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea on tumor bioenergetics and histology.
    Cancer research, 1988, Oct-01, Volume: 48, Issue:19

    Topics: Animals; Brain Neoplasms; Carmustine; Glioma; Humans; Magnetic Resonance Spectroscopy; Necrosis; Rat

1988
Effect of BCNU pretreatment on diquat-induced oxidant stress and hepatotoxicity.
    Biochemical and biophysical research communications, 1987, Apr-14, Volume: 144, Issue:1

    Topics: Animals; Carmustine; Diquat; Glutathione; Glutathione Disulfide; Glutathione Reductase; Lipid Peroxi

1987
Superselective intracerebral chemotherapy of malignant tumours with BCNU. Neuroradiological considerations.
    Neuroradiology, 1986, Volume: 28, Issue:2

    Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Carmustine; Carotid Artery, Internal; Catheterization;

1986
Treatment methods for extravasations of chemotherapeutic agents: a comparative study.
    The Journal of hand surgery, 1986, Volume: 11, Issue:3

    Topics: Animals; Antidotes; Antineoplastic Agents; Carmustine; Dactinomycin; Debridement; Disease Models, An

1986
Intracarotid BCNU leukoencephalopathy.
    Cancer, 1986, Apr-01, Volume: 57, Issue:7

    Topics: Astrocytoma; Autopsy; Brain; Brain Neoplasms; Carmustine; Carotid Artery, Internal; Humans; Infusion

1986