Proteins > Free fatty acid receptor 1
Page last updated: 2024-08-07 15:22:31

Free fatty acid receptor 1

A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842]

Synonyms

G-protein coupled receptor 40

Research

Bioassay Publications (57)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (10.53)29.6817
2010's45 (78.95)24.3611
2020's6 (10.53)2.80

Compounds (18)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gw9508Homo sapiens (human)Ki0.218811
tak-875Homo sapiens (human)Ki0.018322
amg-837Homo sapiens (human)Ki0.021922
tug-469Homo sapiens (human)Ki0.005911

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
lauric acidHomo sapiens (human)EC506.727833
pioglitazoneHomo sapiens (human)EC50812.831011
16-hydroxypalmitic acidHomo sapiens (human)EC5020.893011
thiophenoxyacetic acidHomo sapiens (human)EC500.006011
rosiglitazoneHomo sapiens (human)EC5011.481511
12-hydroxydodecanoic acidHomo sapiens (human)EC50100.000011
3-hydroxydodecanoic acidHomo sapiens (human)EC50100.000011
docosahexaenoateHomo sapiens (human)EC5023.850022
ricinoleic acidHomo sapiens (human)EC5011.481511
linoleic acidHomo sapiens (human)EC502.171656
gamma-linolenic acidHomo sapiens (human)EC504.620011
alpha-linolenic acidHomo sapiens (human)EC505.067345
gw9508Homo sapiens (human)EC502.69742222
tak-875Homo sapiens (human)EC500.23183131
tak-875Homo sapiens (human)Kd0.008222
amg-837Homo sapiens (human)EC500.56831717
amg-837Homo sapiens (human)Kd0.001911
tug-469Homo sapiens (human)EC500.021888
tug-891Homo sapiens (human)EC5039.015444
am 1638Homo sapiens (human)EC500.20931313
am 1638Homo sapiens (human)Kd0.005011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gw9508Homo sapiens (human)Activity0.223011
am 1638Homo sapiens (human)fEC500.000111

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
G protein-coupled receptor activitymolecular functionCombining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
lipid bindingmolecular functionBinding to a lipid. [GOC:ai]
bioactive lipid receptor activitymolecular functionCombining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 11 target(s):

TargetCategoryDefinition
phospholipase C-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
positive regulation of cytosolic calcium ion concentrationbiological processAny process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
insulin secretionbiological processThe regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. [GOC:mah, ISBN:0198506732]
negative regulation of interleukin-1 beta productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
glucose homeostasisbiological processAny process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
positive regulation of calcium ion transportbiological processAny process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
response to fatty acidbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:lp]
ion channel modulating, G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel. [GOC:dos]
ligand-gated ion channel signaling pathwaybiological processThe series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription. [GOC:bhm, PMID:25869137]
positive regulation of insulin secretionbiological processAny process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]