Page last updated: 2024-12-06
isopropyl 4,4'-dibromobenzilate
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
isopropyl 4,4'-dibromobenzilate: active substance in fumigant strips for mites [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 28936 |
| CHEMBL ID | 1867780 |
| SCHEMBL ID | 73839 |
| MeSH ID | M0115291 |
Synonyms (62)
| Synonym |
|---|
| BIDD:ER0060 |
| ai3-27552 |
| gs-19851 |
| caswell no. 511a |
| nanogen index code bst (1-012) |
| geigy gs-19851 |
| 4-bromo-alpha-(4-bromophenyl)-alpha-hydroxybenzeneacetic acid 1-methyl ethyl ester |
| bromopropylate [ansi:bsi:iso] |
| isopropyl 4,4'-dibromobenzilate |
| nsc 195087 |
| geigy 19851 |
| isopropyl dibromobenzilate |
| 4,4'-dibromobenzilic acid isopropyl ester |
| phenisobromolate |
| einecs 242-070-7 |
| folbex va |
| epa pesticide chemical code 028802 |
| ascarol 2e |
| neoron |
| benzilic acid, 4,4'-dibromo-, isopropyl ester |
| ent 27552 |
| benzeneacetic acid, 4-bromo-alpha-(4-bromophenyl)-alpha-hydroxy-1-methylethyl ester |
| 1-methylethyl 4-bromo-alpha-(4-bromophenyl)-alpha-hydroxybenzeneacetate |
| acarol |
| hsdb 1731 |
| isopropyl bromobenzilate |
| ciba-geigy gs 19851 |
| brn 2152560 |
| bromopropylate |
| benzeneacetic acid, 4-bromo-.alpha.-(4-bromophenyl)-.alpha.-hydroxy-, 1-methylethyl ester |
| benzeneacetic acid, 4-bromo-alpha-(4-bromophenyl)-alpha-hydroxy-, 1-methylethyl ester |
| inchi=1/c17h16br2o3/c1-11(2)22-16(20)17(21,12-3-7-14(18)8-4-12)13-5-9-15(19)10-6-13/h3-11,21h,1-2h |
| isopropyl bis(4-bromophenyl)(hydroxy)acetate |
| NCGC00164292-01 |
| OPREA1_388036 |
| 18181-80-1 |
| propan-2-yl 2,2-bis(4-bromophenyl)-2-hydroxyacetate |
| AKOS005462224 |
| unii-3u468zm257 |
| 3u468zm257 , |
| STK528927 |
| propan-2-yl bis(4-bromophenyl)(hydroxy)acetate |
| FT-0630449 |
| bromopropylate [hsdb] |
| 1-methylethyl 4-bromo-.alpha.-(4-bromophenyl)-.alpha.-hydroxybenzeneacetate |
| bromopropylate [mi] |
| bromopropylate [iso] |
| SCHEMBL73839 |
| CHEMBL1867780 |
| isopropyl 2,2-bis(4-bromophenyl)-2-hydroxyacetate |
| gs 19851 |
| isopropyl bis(4-bromophenyl)(hydroxy)acetate # |
| bromobropylate |
| DTXSID1034397 |
| bromopropylate, pestanal(r), analytical standard |
| bromopropylate 10 microg/ml in acetonitrile |
| bromopropylate 100 microg/ml in cyclohexane |
| J-011635 |
| Q2926021 |
| CS-0014139 |
| HY-B2044 |
| bromopropylate 1000 microg/ml in acetone |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compounds were tested at their respective maximum field recommended concentration (MFRC), and, when strong lethal effects were observed, a dose-response assay with a dilution series of the MFRC was undertaken to calculate LC(50) values." | ( Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. Besard, L; Cuvelier, X; Mommaerts, V; Smagghe, G; Sterk, G; Vandeven, J, 2010) | 0.36 |
| " For oral exposures via treated sugar water, the dose-response assay showed the LC(50) values for abamectin, bifenazate, bifenthrin and etoxazole to be 1/15 MFRC (1." | ( Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. Besard, L; Cuvelier, X; Mommaerts, V; Smagghe, G; Sterk, G; Vandeven, J, 2010) | 0.36 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (13)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 0.0251 | 27.9203 | 501.1870 | AID651751 |
| AR protein | Homo sapiens (human) | Potency | 39.8107 | 0.0002 | 21.2231 | 8,912.5098 | AID588515; AID588516 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 39.8107 | 0.0002 | 14.3764 | 60.0339 | AID588533 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 40.0749 | 0.0008 | 17.5051 | 59.3239 | AID588544; AID588546 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 1.9953 | 0.0054 | 28.0263 | 1,258.9301 | AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 50.1187 | 0.0002 | 29.3054 | 16,493.5996 | AID588513 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 47.3935 | 0.0010 | 24.5048 | 61.6448 | AID588534; AID588535 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 35.4813 | 0.0010 | 19.4141 | 70.9645 | AID588536 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 50.1187 | 0.0100 | 39.5371 | 1,122.0200 | AID588547 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 4.4668 | 24.8329 | 44.6684 | AID651749 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 61.1306 | 0.0006 | 27.2152 | 1,122.0200 | AID651741 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 70.7946 | 0.0023 | 19.5956 | 74.0614 | AID651743 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 31.6228 | 0.0158 | 23.5273 | 44.6684 | AID651778 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (170)
Molecular Functions (47)
Ceullar Components (19)
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1104386 | Toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 500 mg a.i./l, po administered through sugar water for 11 weeks measured once a week for 11 weeks relative to control | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104433 | Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 500 mg a.i./l, po administered through pollen for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104375 | Toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 500 mg a.i./l, po administered through pollen for 11 weeks measured once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104455 | Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 500 mg a.i./l, po administered through sugar water for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104410 | Contact toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 500 mg a.i./l applied on the dorsal thorax for 11 weeks measured once a week for 11 weeks relative to control | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104481 | Contact toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 500 mg a.i./l applied on the dorsal thorax for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (20)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.21
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.21) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (4.55%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 21 (95.45%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||